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Joyce James
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Journal Articles

Final Results of A Phase 1 Study Investigating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Quizartinib (AC220) Administered Daily to Patients with Relapsed or Refractory Acute Myeloid Leukemia Irrespective of FLT3-ITD Status

Jorge E. Cortes, MD, Hagop M. Kantarjian, MD, James M. Foran, MD, FRCPC, Darejan Ghirdaladze, Mamia Zodelava, Gautam Borthakur, M.D., Guy Gammon, MD, Denise Trone, Robert C Armstrong, Ph.D., Joyce James, Mark J. Levis, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 1507.
https://doi.org/10.1182/blood.V120.21.1507.1507
Published: 2012
Journal Articles

Absorption, Metabolism, and Excretion of Quizartinib (AC220), a FLT3 Tyrosine Kinase Inhibitor for Treatment of Acute Myeloid Leukemia, in Healthy Male Volunteers

Jianke Li, Gayle Bresnahan, Guy Gammon, MD, Madhu Sanga, PhD, Christine Hale, MD, Tadashi Hashimoto, MSc, Stanley Gill, PhD, Joyce James
Journal: Blood
Blood (2012) 120 (21): 4327.
https://doi.org/10.1182/blood.V120.21.4327.4327
Published: 2012
Journal Articles

A Phase II Open-Label, Ac220 Monotherapy Efficacy Study In Patients with Refractory/Relapsed Flt3-Itd Positive Acute Myeloid Leukemia: Updated Interim Results

Jorge E. Cortes, Alexander E Perl, MD, Catherine C. Smith, MD, Tibor Kovacsovics, MD, Herve Dombret, Hartmut Dohner, MD, Bjorn Steffen, MD, Arnaud Pigneux, MD, PhD, Philippe Rousselot, MD, PhD, Juergen Krauter, MD, Giovanni Martinelli, MD, Elihu H. Estey, MD, Alan K Burnett, MD, Anthony D. Ho, Norbert Ifrah, Theo de Witt, MD, Robert Corringham, MD, Joyce James, PhD, David Lilienfeld, MD, Eugen Leo, MD, PhD, MBA, Guy Gammon, MD, Mark J. Levis, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 2576.
https://doi.org/10.1182/blood.V118.21.2576.2576
Published: 2011
Journal Articles

AC220, a Potent, Selective, Second Generation FLT3 Receptor Tyrosine Kinase (RTK) Inhibitor, in a First-in-Human (FIH) Phase 1 AML Study.

Jorge Cortes, MD, James Foran, MD, Darejan Ghirdaladze, MD, PhD, Marcel P DeVetten, MD, Mamia Zodelava, MD, PhD, Peter Holman, MD, Mark J Levis, MD, PhD, Hagop M Kantarjian, MD, Gautam Borthakur, MD, Joyce James, PhD, Patrick P Zarringkar, PhD, Ruwanthi N Gunawardane, PhD, Robert C Armstrong, PhD, Norman M Padre, Wendell Wierenga, PhD, Robert Corringham, MD, Mohit Trikha, PhD
Journal: Blood
Blood (2009) 114 (22): 636.
https://doi.org/10.1182/blood.V114.22.636.636
Published: 2009
Journal Articles

AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)

Patrick P. Zarrinkar, Ruwanthi N. Gunawardane, Merryl D. Cramer, Michael F. Gardner, Daniel Brigham, Barbara Belli, Mazen W. Karaman, Keith W. Pratz, Gabriel Pallares, Qi Chao, Kelly G. Sprankle, Hitesh K. Patel, Mark Levis, Robert C. Armstrong, Joyce James, Shripad S. Bhagwat
Journal: Blood
Blood (2009) 114 (14): 2984–2992.
https://doi.org/10.1182/blood-2009-05-222034
Published: 2009
Includes: Supplemental data
Journal Articles

AC220 Is a Uniquely Potent and Selective Second-Generation FLT3 Inhibitor

Patrick P Zarrinkar, PhD, Robert C Armstrong, Ph.D., Ruwanthi N Gunawardane, Ph.D., Joyce James, PhD, Mazen W Karaman, Ph.D., Shripad S Bhagwat, PhD
Journal: Blood
Blood (2008) 112 (11): 859.
https://doi.org/10.1182/blood.V112.11.859.859
Published: 2008
Journal Articles

Clinical Pharmacokinetics and FLT3 Phosphorylation of AC220, a Highly Potent and Selective Inhibitor of FLT3

Joyce James, PhD, Keith Pratz, Adam Stine, Julius L Apuy, PhD, Darren E Insko, PhD, Robert C Armstrong, Ph.D., Patrick P Zarrinkar, PhD, Donald Small, MD, PhD, Wendell Wierenga, PhD, Mark J. Levis, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 2637.
https://doi.org/10.1182/blood.V112.11.2637.2637
Published: 2008
Journal Articles

Human Pharmacokinetics of AC220, a Potent and Selective Class III Receptor Tyrosine Kinase Inhibitor.

Jorge Cortes, James M. Foran, Marcel P. Devetten, Francis J. Giles, Joyce James, Patrick P. Zarrinkar, Michael H. Silverman, Kerry A. Kelly, Norman M. Padre, Shripad Bhagwat, Wendell Wierenga
Journal: Blood
Blood (2007) 110 (11): 1597.
https://doi.org/10.1182/blood.V110.11.1597.1597
Published: 2007