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Karen S. Flatten
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Journal Articles

Topoisomerase I-DNA Covalent Complexes in Myeloid Malignancies: A Potential Biomarker for Topoisomerase I Inhibitor Sensitivity

Mira A. Kohorst, MD, Karen S. Flatten, Kevin L. Peterson, Paula A. Schneider, Cristina Correia, Keith W. Pratz, MD, B. Douglas Smith, MD, Scott H. Kaufmann, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5146.
https://doi.org/10.1182/blood-2018-99-115667
Published: 2018
Journal Articles

4EBP1/c-MYC/PUMA and NF-κB/EGR1/BIM pathways underlie cytotoxicity of mTOR dual inhibitors in malignant lymphoid cells

Seongseok Yun, Nicole D. Vincelette, Katherine L. B. Knorr, Luciana L. Almada, Paula A. Schneider, Kevin L. Peterson, Karen S. Flatten, Haiming Dai, Keith W. Pratz, Allan D. Hess, B. Douglas Smith, Judith E. Karp, Andrea E. Wahner Hendrickson, Martin E. Fernandez-Zapico, Scott H. Kaufmann
Journal: Blood
Blood (2016) 127 (22): 2711–2722.
https://doi.org/10.1182/blood-2015-02-629485
Published: 2016
Includes: Supplemental data
Journal Articles

MTH1 Inhibitor-Induced Cytotoxicity in Acute Myeloid Leukemia

Mithun Vinod Shah, MD PhD, Karen S. Flatten, B. Douglas Smith, MD, Allan D. Hess, PhD, Scott H. Kaufmann, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1273.
https://doi.org/10.1182/blood.V126.23.1273.1273
Published: 2015
Journal Articles

mTOR Dual Inhibitor Induced Cytotoxicity Depends on 4EBP1/c-Myc/Puma and NFkB/Egr-1/Bim Pathways in Human Lymphoid Malignancies

Seongseok Yun, MD PhD, Nicole D. Vincelette, Katherine L. B. Knorr, PhD, Luciana L. Almada, PhD, Paula A. Schneider, Kevin L. Peterson, PhD, Karen S. Flatten, Allan D. Hess, PhD, B. Douglas Smith, MD, Judith E. Karp, MD, Martin E. Fernandez-Zapico, MD, Scott H. Kaufmann, MD PhD
Journal: Blood
Blood (2015) 126 (23): 3705.
https://doi.org/10.1182/blood.V126.23.3705.3705
Published: 2015
Journal Articles

Dual mTORC1/mTORC2 inhibition diminishes Akt activation and induces Puma-dependent apoptosis in lymphoid malignancies

Mamta Gupta, Andrea E. Wahner Hendrickson, Seong Seok Yun, Jing Jing Han, Paula A. Schneider, Brian D. Koh, Mary J. Stenson, Linda E. Wellik, Jennifer C. Shing, Kevin L. Peterson, Karen S. Flatten, Allan D. Hess, B. Douglas Smith, Judith E. Karp, Sharon Barr, Thomas E. Witzig, Scott H. Kaufmann
Journal: Blood
Blood (2012) 119 (2): 476–487.
https://doi.org/10.1182/blood-2011-04-346601
Published: 2012
Includes: Supplemental data