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Journal Articles

Acute Lymphoblastic Leukemia Is a Bcl-2 Dependent Disease: Proteomic Profiling and Pre-Clinical Efficacy Of a Selective Bcl-2 Antagonist ABT-199

Blood (2013) 122 (21): 3919.

https://doi.org/10.1182/blood.V122.21.3919.3919

Published: 2013

Journal Articles

Targeting The Mitochondrial ClpP As a Novel Therapeutic Strategy For Acute Myeloid Leukemia

Alicia Cole, PhD, Zezhou Wang, PhD, Rachel Mattson, Etienne Coyaud, PhD, Rose Hurren, Marcela Gronda, MSc, Fengshu Lin, PhD, Neil Maclean, BSc, Elisa Leung, BSc, Yihua Qiu, MD, Nianxiang Zhang, PhD, Kevin R. Coombes, PhD, Mark D. Minden, MD PhD, Walid A. Houry, PhD, Zenyaho Hao, PhD, Steven M. Kornblau, MD, Brian Raught, PhD, Aaron Schimmer, PhD, MD

Blood (2013) 122 (21): 3937.

https://doi.org/10.1182/blood.V122.21.3937.3937

Published: 2013

Journal Articles

Recurrent Patterns Of Histone Methylation and Acetylation Regulating Protein Expression In Acute Myelogenous Leukemia (AML)

Steven M. Kornblau, MD, Chenyu W Hu, Yihua Qiu, MD, Suk Young Yoo, PhD, Nianxiang Zhang, PhD, Farhad Ravandi, MD, Guillermo Garcia-Manero, MD, Amina A Qutub, PhD, Kevin R. Coombes, PhD

Blood (2013) 122 (21): 3733.

https://doi.org/10.1182/blood.V122.21.3733.3733

Published: 2013

Journal Articles

Hippo Pathway (HP) Activity In Acute Myelogenous Leukemia (AML): Different Prognostic Implications Of TAZ versus YAP Inactivation By Phosphorylation

Steven M. Kornblau, MD, Chenyu W Hu, Yi Hua Qiu, MD, Suk Young Yoo, PhD, Nianxiang Zhang, PhD, Tapan M. Kadia, MD, Alessandra Ferrajoli, MD, Kevin R. Coombes, PhD, Amina A Qutub, PhD

Blood (2013) 122 (21): 1337.

https://doi.org/10.1182/blood.V122.21.1337.1337

Published: 2013

Journal Articles

Survival Prediction In High Dimensional Datasets – Comparative Evaluation Of Lasso Regularization and Random Survival Forests

Erel Joffe, MD MSc, Kevin R. Coombes, PhD, Yi Hua Qiu, MD, Suk Young Yoo, PhD, Nianxiang Zhang, PhD, Elmer V Bernstam, MD MS, Steven M. Kornblau, MD

Blood (2013) 122 (21): 1728.

https://doi.org/10.1182/blood.V122.21.1728.1728

Published: 2013

Journal Articles

Identification of distinct protein Signatures Associated with genetic Abnormalities In Acute Lymphoblastic Leukemia

Roland P. Kuiper, PhD, Blanca Scheijen, PhD, Agata Pastorczak, MD, Simon V. van Reijmersdal, BSc, Deborah A. Thomas, MD, Niangxiang Zhang, PhD, Kevin R. Coombes, PhD, Hagop M. Kantarjian, MD, Elias J. Jabbour, MD, Eveline S.J.M De Bont, MD, PhD, Frank N. van Leeuwen, PhD, Steven M. Kornblau, MD

Blood (2013) 122 (21): 1313.

https://doi.org/10.1182/blood.V122.21.1313.1313

Published: 2013

Journal Articles

A Global Proteomic Pathway Map In Acute Myeloid Leukemia (AML)

Chenyu W Hu, Amina A Qutub, PhD, Yihua Qiu, MD, Suk Young Yoo, PhD, Nianxiang Zhang, PhD, Naveen Pammaraju, MD, Courtney D. DiNardo, MD, Kevin R. Coombes, PhD, Steven M. Kornblau, MD

Blood (2013) 122 (21): 1302.

https://doi.org/10.1182/blood.V122.21.1302.1302

Published: 2013

Journal Articles

Phosphorylation Of GSK3β Is Associated With Inferior Survival In Acute Myeloid Leukemia and Is An Indicator Of AKT Activation In AML Blasts and Bone Marrow Mesenchymal Stem Cells

Peter P. Ruvolo, PhD, Rui-yu Wang, MD, PhD, Vivian R Ruvolo, MA, Rodrigo Jacamo, PhD, Teresa McQueen, BS, Gautam Borthakur, MD, Yihua Qiu, MD, Kevin R. Coombes, PhD, Nianxiang Zhang, Elizabeth J Shpall, MD, Richard E Champlin, MD, Ramiro Garzon, MD, Guido Marcucci, MD, Carlo M. Croce, MD, Marina Konopleva, MD, PhD, Michael Andreeff, MD, PhD, Steven M. Kornblau, MD

Blood (2013) 122 (21): 2551.

https://doi.org/10.1182/blood.V122.21.2551.2551

Published: 2013

Journal Articles

Classification Of Acute Myelogenous Leukemia (AML) Based On Functionally Related Proteins Groups

Steven M. Kornblau, MD, Chenyu W Hu, Suk Young Yoo, PhD, Yihua Qiu, MD, Nianxiang Zhang, PhD, Gautam Borthakur, MD, Naval G. Daver, MD, Amina A Qutub, PhD, Kevin R. Coombes, PhD

Blood (2013) 122 (21): 492.

https://doi.org/10.1182/blood.V122.21.492.492

Published: 2013

Journal Articles

Transglutaminase2 Expression in Acute Myeloid Leukemia: Association with Adhesion Molecule Expression and Leukemic Blast Motility

Steven M. Kornblau, MD, PhD, Andrew Pierce, Stefan Meyer, Farhad Ravandi, MD, Gautam Borthakur, M.D., Kevin R. Coombes, PhD, Nianxiang Zhang, Anthony Whetton

Blood (2012) 120 (21): 1427.

https://doi.org/10.1182/blood.V120.21.1427.1427

Published: 2012

Journal Articles

Proteomic Profiling of Smad Proteins Expression in AML: Pan Expression with High Phosphorylation Is Prognostically Adverse

Young Kwang Chae, MD, MPH, Nianxiang Zhang, Yihua Qiu, Tapan M. Kadia, M.D., Alessandra Ferrajoli, M.D., Kevin R. Coombes, PhD, Steven M. Kornblau, MD, PhD

Blood (2012) 120 (21): 891.

https://doi.org/10.1182/blood.V120.21.891.891

Published: 2012

Journal Articles

Prognostic Impact and Targeting of CRM1 in Acute Myeloid Leukemia

Kensuke Kojima, MD, PhD, Steven M. Kornblau, MD, PhD, Vivian Ruvolo, Seshagiri Duvvuri, Richard E Davis, MD, Min Zhang, Ph.D., Zhiqiang Wang, Ph.D., Kevin R. Coombes, PhD, Nianxiang Zhang, Yi Hua Qiu, MD, Jared K. Burks, Peter P. Ruvolo, PhD, Sharon Shacham, PhD MBA, Michael Kauffman, MD, Ph.D., Michael Andreeff, MD, PhD

Blood (2012) 120 (21): 870.

https://doi.org/10.1182/blood.V120.21.870.870

Published: 2012

Journal Articles

Proteomic Profiling of AML Bone Marrow-Derived Mesenchymal Stem Cells (MSC) Reveals Marked Differences From Normal MSC.

Rui-yu Wang, MD, PhD, Yi Hua Qiu, MD, Suk Young Yoo, PhD, Teresa McQueen, BS, Ye Chen, PhD, Zhihong Zeng, MD, Kevin R. Coombes, PhD, Wendy D. Schober, MLT (ASCP), Marina Konopleva, MD, PhD, Steven M. Kornblau, MD, PhD, Michael Andreeff, MD, PhD

Blood (2012) 120 (21): 2355.

https://doi.org/10.1182/blood.V120.21.2355.2355

Published: 2012

Journal Articles

Role for PP2A Regulatory Subunit B55α as A Regulator of AKT and Other Signaling Pathways In AML.

Peter P. Ruvolo, PhD, YiHua Qui, MD, Kevin R Coombes, PhD, Nianxiang Zhang, PhD, Vivian Ruvolo, MA, Marina Konopleva, MD, PhD, Michael Andreeff, MD, PhD, Steven M. Kornblau, MD

Blood (2010) 116 (21): 1668.

https://doi.org/10.1182/blood.V116.21.1668.1668

Published: 2010

Journal Articles

Expression of Apoptosis Repressor with Caspase Recruitment Domain (ARC), An Antiapoptotic Protein, Is Strongly Prognostic in Acute Myeloid Leukemia (AML).

Bing Z. Carter, PhD, Nianxiang Zhang, PhD, Kevin R. Coombes, PhD, Duncan H. Mak, YiHua Qiu, MD, MS, Deborah A. Thomas, MD, Farhad Ravandi, MD, Hagop Kantarjian, MD, Michael Andreeff, MD, PhD, Steven M. Kornblau, MD

Blood (2009) 114 (22): 400.

https://doi.org/10.1182/blood.V114.22.400.400

Published: 2009

Journal Articles

Expression and Prognostic Impact of Candidate Suppressor Sequence-Specific Single-Stranded DNA Binding Protein (SSBP2) in AML Using Reverse Phase Proteins Arrays (RPPA).

Steven M. Kornblau, MD, YiHua Qiu, MD, Wenjing Chen, MD, Hong Liang, MD, Farhad Ravandi, MD, Kevin R. Coombes, PhD, Lalitha Nagarajan, PhD

Blood (2007) 110 (11): 2394.

https://doi.org/10.1182/blood.V110.11.2394.2394

Published: 2007

Journal Articles

P53 Protein Expression Levels Are Prognostic in AML and Predict for Mutational Status.

Steven M. Kornblau, MD, Joseph Barnett, BS, YiHua Qiu, MD, Wenjing Chen, MD, Stefan Faderl, MD, Kevin R. Coombes, Phd, Michael Andreeff, MD

Blood (2007) 110 (11): 2397.

https://doi.org/10.1182/blood.V110.11.2397.2397

Published: 2007

Journal Articles

Protein Expression Signatures Determined by Reverse Phase Proteins Arrays (RPPA) Accurately Predict FLT3-ITD Mutation Status in AML.

Steven M. Kornblau, MD, YiHua Qiu, MD, Wenjing Chen, MD, Srdan Verstovsek, MD, Kevin R. Coombes, PhD, Gordon B. Mills, MD, PhD

Blood (2007) 110 (11): 2398.

https://doi.org/10.1182/blood.V110.11.2398.2398

Published: 2007

Journal Articles

High Throughput Proteomic Analysis of 559 Acute Myelogenous Leukemia (AML) Patient Samples on a Single Slide Using Reverse Phase Proteins Arrays (RPPA): Analysis of Signal Transduction Pathway (STP) and Apoptosis Regulating Proteins.

Steven M. Kornblau, MD, YiHua Qiu, MD, MS, Raoul Tibes, MD, Wenjing Chen, MD, MS, Elizabeth Lemker, Michael Andreeff, MD, PhD, Kevin R. Coombes, PhD, Gordon B. Mills, MD, PhD

Blood (2006) 108 (11): 107.

https://doi.org/10.1182/blood.V108.11.107.107

Published: 2006

Journal Articles

MicroRNA Signatures Associated with Cytogenetics and Outcome in Acute Myeloid Leukemia.

Ramiro Garzon, MD, Stefano Volinia, PhD, Chang G. Liu, PhD, Flavia Pichiorri, PhD, Tiziana Palumbo, PhD, Muller Fabbri, MD, Amelia Cimmino, MD, PhD, Hansjuerg Alder, PhD, Neal Flomenberg, MD, Kevin R. Coombes, PhD, George A. Calin, MD, PhD, Michael Andreeff, MD, PhD, Carlo M. Croce, MD

Blood (2006) 108 (11): 151.

https://doi.org/10.1182/blood.V108.11.151.151

Published: 2006

NARROW

Acute Lymphoblastic Leukemia Is a Bcl-2 Dependent Disease: Proteomic Profiling and Pre-Clinical Efficacy Of a Selective Bcl-2 Antagonist ABT-199

Targeting The Mitochondrial ClpP As a Novel Therapeutic Strategy For Acute Myeloid Leukemia

Recurrent Patterns Of Histone Methylation and Acetylation Regulating Protein Expression In Acute Myelogenous Leukemia (AML)

Hippo Pathway (HP) Activity In Acute Myelogenous Leukemia (AML): Different Prognostic Implications Of TAZ versus YAP Inactivation By Phosphorylation

Survival Prediction In High Dimensional Datasets – Comparative Evaluation Of Lasso Regularization and Random Survival Forests

Identification of distinct protein Signatures Associated with genetic Abnormalities In Acute Lymphoblastic Leukemia

A Global Proteomic Pathway Map In Acute Myeloid Leukemia (AML)

Phosphorylation Of GSK3β Is Associated With Inferior Survival In Acute Myeloid Leukemia and Is An Indicator Of AKT Activation In AML Blasts and Bone Marrow Mesenchymal Stem Cells

Classification Of Acute Myelogenous Leukemia (AML) Based On Functionally Related Proteins Groups

Transglutaminase2 Expression in Acute Myeloid Leukemia: Association with Adhesion Molecule Expression and Leukemic Blast Motility

Proteomic Profiling of Smad Proteins Expression in AML: Pan Expression with High Phosphorylation Is Prognostically Adverse

Prognostic Impact and Targeting of CRM1 in Acute Myeloid Leukemia

Proteomic Profiling of AML Bone Marrow-Derived Mesenchymal Stem Cells (MSC) Reveals Marked Differences From Normal MSC.

Role for PP2A Regulatory Subunit B55α as A Regulator of AKT and Other Signaling Pathways In AML.

Expression of Apoptosis Repressor with Caspase Recruitment Domain (ARC), An Antiapoptotic Protein, Is Strongly Prognostic in Acute Myeloid Leukemia (AML).

Expression and Prognostic Impact of Candidate Suppressor Sequence-Specific Single-Stranded DNA Binding Protein (SSBP2) in AML Using Reverse Phase Proteins Arrays (RPPA).

P53 Protein Expression Levels Are Prognostic in AML and Predict for Mutational Status.

Protein Expression Signatures Determined by Reverse Phase Proteins Arrays (RPPA) Accurately Predict FLT3-ITD Mutation Status in AML.

High Throughput Proteomic Analysis of 559 Acute Myelogenous Leukemia (AML) Patient Samples on a Single Slide Using Reverse Phase Proteins Arrays (RPPA): Analysis of Signal Transduction Pathway (STP) and Apoptosis Regulating Proteins.

MicroRNA Signatures Associated with Cytogenetics and Outcome in Acute Myeloid Leukemia.

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American Society of Hematology

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American Society of Hematology

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