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Journal Articles

MLN0128, a Second-Generation mTOR Kinase Inhibitor, Disrupts Survival Signaling and Triggers Apoptosis in AML

Zhihong Zeng, MD, Rui-Yu Wang, MD PhD, Yuexi Shi, MD, Yihua Qiu, MD, Duncan H Mak, MS, Kevin Coombes, PhD, Suk Young Yoo, PhD, Katti Jessen, Yi Liu, PhD, Christian Rommel, PhD, Hagop M. Kantarjian, MD, Steven M. Kornblau, MD, David Fruman, PhD, Michael Andreeff, MD PhD, Marina Konopleva, MD PhD

Blood (2014) 124 (21): 3613.

https://doi.org/10.1182/blood.V124.21.3613.3613

Published: 2014

Journal Articles

Cooperative Targeting of Bcl-2 Family Proteins By ABT-199 (GDC-0199) and Tyrosine Kinase Inhibitors to Eradicate Blast Crisis CML and CML Stem/Progenitor Cells

Bing Z Carter, PhD, Po Yee Mak, Hong Mu, MD PhD, Hongsheng Zhou, Duncan H Mak, M.S., Wendy D. Schober, MLT (ASCP), Joel Leverson, PhD, Bin Zhang, PhD, Ravi Bhatia, MD, Marina Konopleva, MD PhD, Jorge E. Cortes, Michael Andreeff, MD PhD

Blood (2014) 124 (21): 512.

https://doi.org/10.1182/blood.V124.21.512.512

Published: 2014

Journal Articles

Combination of Tyrosine Kinase Inhibitor with β-Catenin/CBP Modulator C82 Reverses TKI Resistance, Eradicates Quiescent CML Stem/Progenitors Cells, and Overcomes MSC-Associated Microenvironmental Protection

Hongsheng Zhou, MDPhD, Po Yee Mak, Hong Mu, MD PhD, Duncan H Mak, MS, Hiroyuki Kouji, Marina Konopleva, MD PhD, Jorge E. Cortes, Michael Andreeff, MD PhD, Bing Z Carter, PhD

Blood (2014) 124 (21): 401.

https://doi.org/10.1182/blood.V124.21.401.401

Published: 2014

Journal Articles

ARC Suppresses Cell Death By Antagonizing p53 Function and Suppressing TRAIL In AML Cells

Po Yee Mak, M.S., Duncan H Mak, M.S., Kensuke Kojima, MD, PhD, Archana Dilip, MS, Vivian R Ruvolo, MA, Rodrigo Jacamo, PhD, Michael Andreeff, MD, PhD, Bing Z Carter, PhD

Blood (2013) 122 (21): 2688.

https://doi.org/10.1182/blood.V122.21.2688.2688

Published: 2013

Journal Articles

Single-Cell Mass Cytometry Reveals Phenotypic and Functional Heterogeneity In Acute Myeloid Leukemia At Diagnosis and In Remission

Lina Han, PhD, Zhihong Zeng, MD, Peng Qiu, PhD, Jeffrey L. Jorgensen, MD, PhD, Duncan H Mak, M.S., Jared K Burks, PhD, Teresa McQueen, BS, Farhad Ravandi, MD, Gail J Roboz, MD, Hagop M. Kantarjian, MD, Steven M. Kornblau, MD, Monica L. Guzman, PhD, Michael Andreeff, MD, PhD, Marina Konopleva, MD, PhD

Blood (2013) 122 (21): 1311.

https://doi.org/10.1182/blood.V122.21.1311.1311

Published: 2013

Journal Articles

Activation Of p53 By MDM2-Inhibition Sensitizes Quiescent Blast Crisis CML Stem/Progenitor Cells To Bcl-2 Inhibitor- and Tyrosine Kinase Inhibitor-Induced Cell Death

Bing Z Carter, PhD, Po Yee Mak, M.S., Duncan H Mak, M.S., Marina Konopleva, MD, PhD, Jorge Cortes, MD, Michael Andreeff, MD, PhD

Blood (2013) 122 (21): 1476.

https://doi.org/10.1182/blood.V122.21.1476.1476

Published: 2013

Journal Articles

ARC Is Regulated by MAPK and PI3K and Confers Drug Resistance and Survival Advantage to AML in Vitro and in Vivo

Po Yee Mak, M.S., Duncan H Mak, M.S., Yuexi Shi, Vivian Ruvolo, Rodrigo Jacamo, Ph.D, Michael Andreeff, MD, PhD, Bing Z Carter, Ph.D

Blood (2012) 120 (21): 893.

https://doi.org/10.1182/blood.V120.21.893.893

Published: 2012

Journal Articles

Apoptosis Repressor with Caspase Recruitment Domain Is Regulated by the cIAP1-NIK Axis and Confers Resistance to SMAC Mimetic Birinapant-Induced Cell Death in AML

Bing Z. Carter, Ph.D, Po Yee Mak, M.S., Duncan H. Mak, M.S., Vivian Ruvolo, Rodrigo Jacamo, Ph.D, Steven M. Kornblau, MD, PhD, Michael Andreeff, MD, PhD

Blood (2012) 120 (21): 534.

https://doi.org/10.1182/blood.V120.21.534.534

Published: 2012

Journal Articles

Apoptosis Repressor with Caspase Recruitment Domain (ARC) Increases AML Cell Migration and Adhesion in Vitro and in Vivo by Regulating Leukemia-Stroma Interactions.

Bing Z Carter, Ph.D, Po Yee Mak, M.S., Ye Chen, PhD, Rodrigo Jacamo, Ph.D, Vivian Ruvolo, Duncan H Mak, M.S., Teresa McQueen, Marina Konopleva, MD, PhD, Steven M. Kornblau, MD, PhD, Michael Andreeff, MD, PhD

Blood (2012) 120 (21): 2626.

https://doi.org/10.1182/blood.V120.21.2626.2626

Published: 2012

Journal Articles

Survivin is highly expressed in CD34 + 38 − leukemic stem/progenitor cells and predicts poor clinical outcomes in AML

Bing Z. Carter, Yihua Qiu, Xuelin Huang, Lixia Diao, Nianxiang Zhang, Kevin R. Coombes, Duncan H. Mak, Marina Konopleva, Jorge Cortes, Hagop M. Kantarjian, Gordon B. Mills, Michael Andreeff, Steven M. Kornblau

Blood (2012) 120 (1): 173–180.

https://doi.org/10.1182/blood-2012-02-409888

Published: 2012

Includes: Supplemental data

Journal Articles

MRx102, a Novel Triptolide Analogue, Has Low Nanomolar Activity Against AML Stem/Progenitor Cells in Vitro and in a Murine Model of AML

Bing Z Carter, Ph.D., Duncan H Mak, M.S., Yuxie Shi, John M. Fidler, Ph.D., Rong Chen, PhD, Xiaoyang Ling, PhD, William Plunkett, PhD, Michael Andreeff, M.D., Ph.D.

Blood (2011) 118 (21): 1547.

https://doi.org/10.1182/blood.V118.21.1547.1547

Published: 2011

Journal Articles

Survivin Is Highly Expressed in AML Stem Cells and Predicts Poor Clinical Outcome

Bing Z Carter, Ph.D., Yihua Qiu, Xielin Huang, PhD, Lixia Diao, PhD, Nianxiang Zhang, Kevin R Coombes, Duncan H Mak, M.S., Marina Konopleva, MD, PhD, Jorge E. Cortes, Hagop M. Kantarjian, Michael Andreeff, M.D., Ph.D., Steven M. Kornblau, MD

Blood (2011) 118 (21): 238.

https://doi.org/10.1182/blood.V118.21.238.238

Published: 2011

Journal Articles

Antagonizing IAPs by SMAC Mimetic TL32711 Induces Apoptosis in AML Cells Including AML Stem/Progenitor Cells Alone and in Combination with Chemotherapy

Bing Z Carter, Ph.D., Duncan H Mak, M.S., Yihua Qiu, Steven M. Kornblau, MD, Po Yee Mak, MS, David Weng, Mark A McKinlay, Michael Andreeff, M.D., Ph.D.

Blood (2011) 118 (21): 66.

https://doi.org/10.1182/blood.V118.21.66.66

Published: 2011

Journal Articles

Expression of ARC (apoptosis repressor with caspase recruitment domain), an antiapoptotic protein, is strongly prognostic in AML

Bing Z. Carter, Yi Hua Qiu, Nianxiang Zhang, Kevin R. Coombes, Duncan H. Mak, Deborah A. Thomas, Farhad Ravandi, Hagop M. Kantarjian, Erich Koller, Michael Andreeff, Steven M. Kornblau

Blood (2011) 117 (3): 780–787.

https://doi.org/10.1182/blood-2010-04-280503

Published: 2011

Includes: Supplemental data

Journal Articles

Preclinical Development of Triptolide Derivative MRx102 as a Therapeutic Agent for Acute Myeloid Leukemia

John M. Fidler, Ph.D., Jinhua An, Ph.D., John H. Musser, Ph.D., Duncan H. Mak, M.S., Bing Carter, Ph.D., Michael Andreeff, MD, PhD

Blood (2010) 116 (21): 3271.

https://doi.org/10.1182/blood.V116.21.3271.3271

Published: 2010

Journal Articles

Targeting XIAP and ARC (apoptosis repressor with caspase recruitment domain) Overcomes Imatinib Resitance In Blast Crisis CML Cells.

Bing Carter, Ph.D., Duncan H. Mak, M.S., Wendy D. Schober, Marina Konopleva, MD, PhD, Jorge E. Cortes, MD, Hagop M. Kantarjian, MD, Erich Koller, Ziwei Huang, John C. Reed, MD, PhD, Michael Andreeff, M.D., Ph.D.

Blood (2010) 116 (21): 3415.

https://doi.org/10.1182/blood.V116.21.3415.3415

Published: 2010

Journal Articles

MDM2 Inhibitor Nutlin-3a Triggers Autophagic Cell Death In Addition to Apoptosis In Leukemia Cell Lines with Wild-Type p53

Seshagiri Duvvuri, Vivian Ruvolo, Duncan H. Mak, M.S., Kensuke Kojima, MD, PhD, Marina Konopleva, MD, PhD, Michael Andreeff, MD, PhD, Gautam Borthakur, MD

Blood (2010) 116 (21): 3300.

https://doi.org/10.1182/blood.V116.21.3300.3300

Published: 2010

Journal Articles

SMAC-Mimetic BV-6 Sensitizes Therapeutic Agents-Induced Apoptosis In AML Cells

Duncan H Mak, M.S., Christa Manton, Michael Andreeff, MD, PhD, Bing Z Carter, Ph.D.

Blood (2010) 116 (21): 2177.

https://doi.org/10.1182/blood.V116.21.2177.2177

Published: 2010

Journal Articles

Simultaneous activation of p53 and inhibition of XIAP enhance the activation of apoptosis signaling pathways in AML

Bing Z. Carter, Duncan H. Mak, Wendy D. Schober, Erich Koller, Clemencia Pinilla, Lyubomir T. Vassilev, John C. Reed, Michael Andreeff

Blood (2010) 115 (2): 306–314.

https://doi.org/10.1182/blood-2009-03-212563

Published: 2010

Includes: Supplemental data

Journal Articles

Expression of Apoptosis Repressor with Caspase Recruitment Domain (ARC), An Antiapoptotic Protein, Is Strongly Prognostic in Acute Myeloid Leukemia (AML).

Bing Z. Carter, PhD, Nianxiang Zhang, PhD, Kevin R. Coombes, PhD, Duncan H. Mak, YiHua Qiu, MD, MS, Deborah A. Thomas, MD, Farhad Ravandi, MD, Hagop Kantarjian, MD, Michael Andreeff, MD, PhD, Steven M. Kornblau, MD

Blood (2009) 114 (22): 400.

https://doi.org/10.1182/blood.V114.22.400.400

Published: 2009

NARROW

MLN0128, a Second-Generation mTOR Kinase Inhibitor, Disrupts Survival Signaling and Triggers Apoptosis in AML

Cooperative Targeting of Bcl-2 Family Proteins By ABT-199 (GDC-0199) and Tyrosine Kinase Inhibitors to Eradicate Blast Crisis CML and CML Stem/Progenitor Cells

Combination of Tyrosine Kinase Inhibitor with β-Catenin/CBP Modulator C82 Reverses TKI Resistance, Eradicates Quiescent CML Stem/Progenitors Cells, and Overcomes MSC-Associated Microenvironmental Protection

ARC Suppresses Cell Death By Antagonizing p53 Function and Suppressing TRAIL In AML Cells

Single-Cell Mass Cytometry Reveals Phenotypic and Functional Heterogeneity In Acute Myeloid Leukemia At Diagnosis and In Remission

Activation Of p53 By MDM2-Inhibition Sensitizes Quiescent Blast Crisis CML Stem/Progenitor Cells To Bcl-2 Inhibitor- and Tyrosine Kinase Inhibitor-Induced Cell Death

ARC Is Regulated by MAPK and PI3K and Confers Drug Resistance and Survival Advantage to AML in Vitro and in Vivo

Apoptosis Repressor with Caspase Recruitment Domain Is Regulated by the cIAP1-NIK Axis and Confers Resistance to SMAC Mimetic Birinapant-Induced Cell Death in AML

Apoptosis Repressor with Caspase Recruitment Domain (ARC) Increases AML Cell Migration and Adhesion in Vitro and in Vivo by Regulating Leukemia-Stroma Interactions.

Survivin is highly expressed in CD34 + 38 − leukemic stem/progenitor cells and predicts poor clinical outcomes in AML

MRx102, a Novel Triptolide Analogue, Has Low Nanomolar Activity Against AML Stem/Progenitor Cells in Vitro and in a Murine Model of AML

Survivin Is Highly Expressed in AML Stem Cells and Predicts Poor Clinical Outcome

Antagonizing IAPs by SMAC Mimetic TL32711 Induces Apoptosis in AML Cells Including AML Stem/Progenitor Cells Alone and in Combination with Chemotherapy

Expression of ARC (apoptosis repressor with caspase recruitment domain), an antiapoptotic protein, is strongly prognostic in AML

Preclinical Development of Triptolide Derivative MRx102 as a Therapeutic Agent for Acute Myeloid Leukemia

Targeting XIAP and ARC (apoptosis repressor with caspase recruitment domain) Overcomes Imatinib Resitance In Blast Crisis CML Cells.

MDM2 Inhibitor Nutlin-3a Triggers Autophagic Cell Death In Addition to Apoptosis In Leukemia Cell Lines with Wild-Type p53

SMAC-Mimetic BV-6 Sensitizes Therapeutic Agents-Induced Apoptosis In AML Cells

Simultaneous activation of p53 and inhibition of XIAP enhance the activation of apoptosis signaling pathways in AML

Expression of Apoptosis Repressor with Caspase Recruitment Domain (ARC), An Antiapoptotic Protein, Is Strongly Prognostic in Acute Myeloid Leukemia (AML).

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American Society of Hematology

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American Society of Hematology

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