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Journal Articles

Nutrient-Sensitising Drug Repurposing Screen Identifies Lomerizine As a Mitochondrial Metabolism Inhibitor in Chronic Myeloid Leukaemia

Ahmed Khalaf, Lucie de Beauchamp, Eric Kalkman, Kevin Rattigan, Ekaterini Himonas, Joe Jones, Daniel James, Engy Shokry Abd Shokry, Mary Scott, Karen Dunn, Saverio Tardito, Mhairi Copland, David Sumpton, Emma Shanks, Vignir Helgason

Blood (2023) 142 (Supplement 1): 862.

https://doi.org/10.1182/blood-2023-186405

Published: 2023

Journal Articles

Novel Role of Mitochondrial Folate Metabolism in Cell Fate Decisions and Leukaemogenesis

Martha M. Zarou, Kevin Rattigan, Daniele Sarnello, Amy Dawson, Karen Dunn, Mhairi Copland, David Sumpton, Alexei Vazquez, G. Vignir Helgason

Blood (2023) 142 (Supplement 1): 1369.

https://doi.org/10.1182/blood-2023-185915

Published: 2023

Journal Articles

Metabolic profiling of myeloproliferative neoplasms reveals subtype specific metabolic traits

Kristina Kirschner, Kevin Rattigan, Vignir Helgason, Fei Yan

Blood (2022) 140 (Supplement 1): 12180.

https://doi.org/10.1182/blood-2022-166992

Published: 2022

Journal Articles

Inhibition of Folate Metabolism Drives Autophagy-Dependent Differentiation and Reduces Survival of Therapy-Resistant Leukaemic Stem Cells

Martha M. Zarou, Kevin Rattigan, Zuzana Brabcova, Amy Dawson, David Sumpton, Alexei Vazquez, Vignir Helgason

Blood (2021) 138 (Supplement 1): 2543.

https://doi.org/10.1182/blood-2021-149664

Published: 2021

Journal Articles

Mannose Metabolism Is a Metabolic Vulnerability Unveiled By Standard and Novel Therapies in Acute Myeloid Leukemia

Keith Woodley, Laura S Dillingh, George Giotopoulos, Pedro Madrigal, Konstantinos Tzelepis, Celine Philippe, Kevin Rattigan, Ryan Asby, Vilma Dembitz, Aoife S.M. Magee, Gudmundur Helgason, Kevin Rouault-Pierre, George S. Vassiliou, Brian J.P Huntly, Paolo Gallipoli

Blood (2021) 138 (Supplement 1): 508.

https://doi.org/10.1182/blood-2021-148489

Published: 2021