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David Sumpton
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Journal Articles

NADPH controls a cell state vulnerability towards ferroptosis in acute lymphoblastic leukaemia

Free
Nikolai Gajic, Rhona Christie, Jordan Martin, Jonathan Josephs-Spaulding, Shirley Lam, Tobias Ackermann, Karen Dunn, Engy Shokry, Alejandro Huerta Uribe, Julie Irving, Frederick van Delft, Freya de Muyer, Panagiotis Ntziachristos, Johan Vande Voorde, David Sumpton, Saverio Tardito, Andrew Brown, Stephen Tait, Chris Halsey
Journal: Blood
Blood (2025) 146 (Supplement 1): 144.
https://doi.org/10.1182/blood-2025-144
Published: 2025
Journal Articles

Selenocysteine dependency renders central nervous system leukaemia therapeutically sensitive to ferroptosis

Free
Nikolai Gajic, Rhona Christie, Shirley Lam, Tobias Ackermann, Ekaterini Himonas, Jonathan Josephs-Spaulding, Anand Manoharan, Victoria Assmann, Jordan Martin, Alexander Collings, Karen Dunn, Engy Shokry, Alejandro Huerta Uribe, Sharon Burns, David O'Connor, Marc Mansour, David Sumpton, G. Vignir Helgason, Johan Vande Voorde, Saverio Tardito, Stephen Tait, Chris Halsey
Journal: Blood
Blood (2025) 146 (Supplement 1): 1526.
https://doi.org/10.1182/blood-2025-1526
Published: 2025
Journal Articles

Metabolic signatures mirror divergent modalities of leukemia immune evasion and relapse after transplantation

Free
Annalisa Tameni, Emanuele Rondelli, Angela Gentile, Vittorio Niccolucci, Maria Chiara Di Bonito, Fatemeh Kordevani, Francesca Tortorelli, Simone Cardaci, Raffaella Di Micco, Dejan Lazarevic, Giovanni Tonon, David Sumpton, Alejandro Huerta Uribe, Marco Punta, Cristina Toffalori, Fabio Ciceri, Luca Vago
Journal: Blood
Blood (2025) 146 (Supplement 1): 590.
https://doi.org/10.1182/blood-2025-590
Published: 2025
Journal Articles

Serine/glycine starvation induces metabolic rewiring to uncover ATF4-driven therapeutic vulnerabilities in infant ALL

Free
Victoria Assmann, Jonathan Josephs-Spaulding, Lynn McGarry, Federico Bernuzzi, David Sumpton, Johan Vande Voorde, Leo Carlin, Oliver Maddocks, Katrin Ottersbach, Chris Halsey
Journal: Blood
Blood (2025) 146 (Supplement 1): 5084.
https://doi.org/10.1182/blood-2025-5084
Published: 2025
Journal Articles

Nutrient-Sensitising Drug Repurposing Screen Identifies Lomerizine As a Mitochondrial Metabolism Inhibitor in Chronic Myeloid Leukaemia

Free
Ahmed Khalaf, Lucie de Beauchamp, Eric Kalkman, Kevin Rattigan, Ekaterini Himonas, Joe Jones, Daniel James, Engy Shokry Abd Shokry, Mary Scott, Karen Dunn, Saverio Tardito, Mhairi Copland, David Sumpton, Emma Shanks, Vignir Helgason
Journal: Blood
Blood (2023) 142 (Supplement 1): 862.
https://doi.org/10.1182/blood-2023-186405
Published: 2023
Journal Articles

Novel Role of Mitochondrial Folate Metabolism in Cell Fate Decisions and Leukaemogenesis

Free
Martha M. Zarou, Kevin Rattigan, Daniele Sarnello, Amy Dawson, Karen Dunn, Mhairi Copland, David Sumpton, Alexei Vazquez, G. Vignir Helgason
Journal: Blood
Blood (2023) 142 (Supplement 1): 1369.
https://doi.org/10.1182/blood-2023-185915
Published: 2023
Journal Articles

Inhibition of Folate Metabolism Drives Autophagy-Dependent Differentiation and Reduces Survival of Therapy-Resistant Leukaemic Stem Cells

Free
Martha M. Zarou, Kevin Rattigan, Zuzana Brabcova, Amy Dawson, David Sumpton, Alexei Vazquez, Vignir Helgason
Journal: Blood
Blood (2021) 138 (Supplement 1): 2543.
https://doi.org/10.1182/blood-2021-149664
Published: 2021