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Krzysztof Mrózek
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Journal Articles

Adverse Prognostic Impact of GAS6 Expression in De Novo Cytogenetically Normal Acute Myeloid Leukemia (CN-AML) (CALGB 8461, 9665, 20202; Alliance)

Susan Whitman, PhD, Jessica Kohlschmidt, PhD, Kati Maharry, MAS, Deedra Nicolet, MS, Sebastian Schwind, MD, Heiko Becker, MD, Klaus H. Metzeler, MD, Krzysztof Mrózek, MD, PhD, Jason H. Mendler, MD, PhD, Ann-Kathrin Eisfeld, MD, Stefano Volinia, PhD, Bayard L. Powell, MD, Thomas H. Carter, MD, PhD, Jonathan E. Kolitz, MD, Richard M. Stone, MD, Il-Kyoo Park, Michael A. Caligiuri, M.D., Guido Marcucci, MD, Clara D. Bloomfield, MD
Journal: Blood
Blood (2012) 120 (21): 1293.
https://doi.org/10.1182/blood.V120.21.1293.1293
Published: 2012
Journal Articles

SPARC contributes to Leukemia Growth and Aggressive Disease in Acute Myeloid Leukemia (AML)

Houda Alachkar, PharmD, Kati Maharry, MAS, Ramasamy Santhanam, Ph.D, Paolo Neviani, Ph.D, Stefano Volinia, PhD, Jessica Kohlschmidt, PhD, Klaus H. Metzeler, MD, Adrienne M Dorrance, Ph.D, Sebastian Schwind, MD, Heiko Becker, MD, Jason H. Mendler, MD, PhD, Ann-Kathrin Eisfeld, MD, Susan Whitman, PhD, Krzysztof Mrózek, MD, PhD, Ramiro Garzon, MD, Danilo Perrotti, MD, Ph.D, Michael A. Caligiuri, M.D., Richard M. Stone, MD, Guido Marcucci, MD, Clara D. Bloomfield, MD
Journal: Blood
Blood (2012) 120 (21): 773.
https://doi.org/10.1182/blood.V120.21.773.773
Published: 2012
Journal Articles

The Clinical Role of Micrornas (miRs) in Cytogenetically Normal (CN) Acute Myeloid Leukemia (AML): miR-155 Upregulation Independently Identifies High-Risk Patients (Pts)

Guido Marcucci, MD, Kati Maharry, MAS, Klaus H. Metzeler, MD, Stefano Volinia, PhD, Yue-Zhong Wu, MS, Krzysztof Mrózek, MD, PhD, Deedra Nicolet, MS, Jessica Kohlschimdt, Susan Whitman, PhD, Jason H. Mendler, MD, PhD, Sebastian Schwind, MD, Heiko Becker, MD, Ann-Kathrin Eisfeld, MD, Andrew J. Carroll, PhD, Bayard L. Powell, MD, Jonathan E. Kolitz, MD, Ramiro Garzon, MD, Michael A. Caligiuri, M.D., Richard M. Stone, MD, Clara D Bloomfield
Journal: Blood
Blood (2012) 120 (21): 1387.
https://doi.org/10.1182/blood.V120.21.1387.1387
Published: 2012
Journal Articles

Prognostic Significance of Karyotype in Octogenarian Patients (Pts) with Acute Myeloid Leukemia (AML)–An International Study

Meir Wetzler, MD, Jessica Kohlschmidt, PhD, Krzysztof Mrózek, MD, PhD, Herve Dombret, Hartmut Döhner, Prof. Dr. med., Sylvain Pilorge, Utz Krug, MD, Richard A. Larson, MD, Guido Marcucci, MD, Wolfgang Hiddemann, MD, Thomas Buchner, MD, Clara D. Bloomfield, MD
Journal: Blood
Blood (2011) 118 (21): 2521.
https://doi.org/10.1182/blood.V118.21.2521.2521
Published: 2011
Journal Articles

Cytogenetic, Molecular and Clinical Features Associated with Rare CBFB-MYH11 Fusion Transcripts in Patients (Pts) with Acute Myeloid Leukemia (AML) and inv(16)/t(16;16)

Colin G Edwards, PhD, Kati Maharry, MAS, Krzysztof Mrózek, MD, PhD, Sebastian Schwind, MD, Peter Paschka, MD, Deedra Nicolet, MS, Jessica Kohlschmidt, PhD, Thomas W Prior, PhD, Yue-Zhong Wu, MS, Jonathan E. Kolitz, MD, William Blum, MD, Mark J. Pettenati, PhD, Paola Dal Cin, PhD, Andrew J. Carroll, PhD, Michael A Caligiuri, MD, Richard A. Larson, MD, Guido Marcucci, MD, Clara D. Bloomfield, MD
Journal: Blood
Blood (2011) 118 (21): 2514.
https://doi.org/10.1182/blood.V118.21.2514.2514
Published: 2011
Journal Articles

Poor Outcome of RUNX1 -Mutated ( RUNX1 -mut) Patients (Pts) with Primary, Cytogenetically Normal Acute Myeloid Leukemia (CN-AML) and Associated Gene- and MicroRNA (miR) Expression Signatures,

Jason H. Mendler, MD, PhD, Kati Maharry, MAS, Michael D. Radmacher, PhD, Krzysztof Mrózek, MD, PhD, Jessica Kohlschmidt, PhD, Deedra Nicolet, MS, Heiko Becker, MD, Klaus H. Metzeler, MD, Sebastian Schwind, MD, Susan P. Whitman, PhD, William Blum, MD, Bayard L. Powell, MD, Jonathan E. Kolitz, MD, Thomas H. Carter, MD, PhD, Meir Wetzler, MD, Joseph O. Moore, MD, Andrew J. Carroll, PhD, Maria R. Baer, MD, Richard A. Larson, MD, Michael A Caligiuri, MD, Guido Marcucci, MD, Clara D. Bloomfield, MD
Journal: Blood
Blood (2011) 118 (21): 3454.
https://doi.org/10.1182/blood.V118.21.3454.3454
Published: 2011
Journal Articles

ASXL1 Mutations Identify a High-Risk Subgroup of Older Patients with Primary Cytogenetically Normal Acute Myeloid Leukemia within the European LeukemiaNet ‘Favorable' Genetic Category

Klaus H. Metzeler, MD, Heiko Becker, MD, Kati Maharry, MAS, Michael D. Radmacher, PhD, Jessica Kohlschmidt, PhD, Krzysztof Mrózek, MD, PhD, Deedra Nicolet, MS, Susan P. Whitman, PhD, Yue-Zhong Wu, MS, Sebastian Schwind, MD, Bayard L. Powell, MD, Thomas H. Carter, MD, PhD, Meir Wetzler, MD, Joseph O. Moore, MD, Jonathan E. Kolitz, MD, Maria R. Baer, MD, Andrew J. Carroll, PhD, Richard A. Larson, MD, Michael A Caligiuri, MD, Guido Marcucci, MD, Clara D. Bloomfield, MD
Journal: Blood
Blood (2011) 118 (21): 417.
https://doi.org/10.1182/blood.V118.21.417.417
Published: 2011
Journal Articles

Prognostic Utility of the European LeukemiaNet (ELN) Genetic-Risk Classification in Adults with De Novo Acute Myeloid Leukemia (AML): A Study of 1,550 Patients (Pts)

Krzysztof Mrózek, MD, PhD, Guido Marcucci, MD, Kati Maharry, MAS, Deedra Nicolet, MS, Heiko Becker, MD, Susan P. Whitman, PhD, Klaus H. Metzeler, MD, Sebastian Schwind, MD, Yue-Zhong Wu, MS, Jessica Kohlschmidt, PhD, Mark J. Pettenati, PhD, Prasad R. K. Koduru, PhD, Nyla A. Heerema, PhD, Annemarie W. Block, PhD, Shivanand R. Patil, PhD, Maria R. Baer, MD, Jonathan E. Kolitz, MD, Joseph O. Moore, MD, Andrew J. Carroll, PhD, Richard A. Larson, MD, Clara D. Bloomfield, MD
Journal: Blood
Blood (2011) 118 (21): 414.
https://doi.org/10.1182/blood.V118.21.414.414
Published: 2011
Journal Articles

MiR-3151 , a Novel MicroRNA Embedded in BAALC , Is Only Weakly Co-Expressed with Its Host Gene and Independently Impacts on the Clinical Outcome of Older Patients (Pts) with De Novo Cytogenetically Normal Acute Myeloid Leukemia (CN-AML)

Ann-Kathrin Eisfeld, MD, Guido Marcucci, MD, Kati Maharry, MAS, Sebastian Schwind, MD, Michael D. Radmacher, PhD, Deedra Nicolet, MS, Heiko Becker, MD, Susan P. Whitman, PhD, Klaus H. Metzeler, MD, Krzysztof Mrózek, MD, PhD, Yue-Zhong Wu, MS, Maria R. Baer, MD, Bayard L. Powell, MD, Thomas H. Carter, MD, PhD, Joseph O. Moore, MD, Jonathan E. Kolitz, MD, Meir Wetzler, MD, Michael A Caligiuri, MD, Richard A. Larson, MD, Stephan M. Tanner, PhD, Albert de la Chapelle, MD, PhD, Clara D. Bloomfield, MD
Journal: Blood
Blood (2011) 118 (21): 1462.
https://doi.org/10.1182/blood.V118.21.1462.1462
Published: 2011
Journal Articles

Sole Trisomy 8 In Patients (pts) with De Novo Acute Myeloid Leukemia (AML) Is Associated with Age-Independent Poor Outcome That Is Modified by Molecular Markers and with Unique Gene- and Microrna (miR)-Signatures: a Cancer and Leukemia Group B (CALGB) Study

Heiko Becker, MD, Kati Maharry, MAS, Michael D. Radmacher, PhD, Dean Margeson, MAS, Krzysztof Mrózek, MD, PhD, Susan P. Whitman, PhD, Yue-Zhong Wu, MS, Klaus H. Metzeler, MD, Sebastian Schwind, MD, Kelsi B. Holland, MS, Jonathan E. Kolitz, MD, Andrew J. Carroll, PhD, Michael A. Caligiuri, MD, Maria R. Baer, MD, Richard A. Larson, MD, Guido Marcucci, MD, Clara D. Bloomfield, MD
Journal: Blood
Blood (2010) 116 (21): 577.
https://doi.org/10.1182/blood.V116.21.577.577
Published: 2010
Journal Articles

Mutations In the Tet Oncogene Family Member 2 ( TET2 ) Gene Refine the New European LeukemiaNet Risk Classification of Primary, Cytogenetically Normal Acute Myeloid Leukemia (CN-AML) In Adults: A Cancer and Leukemia Group B (CALGB) Study

Klaus H. Metzeler, MD, Kati Maharry, MAS, Michael D. Radmacher, PhD, Krzysztof Mrózek, MD, PhD, Dean Margeson, MAS, Heiko Becker, MD, John Curfman, Kelsi B. Holland, MS, Sebastian Schwind, MD, Susan P. Whitman, PhD, Yue-Zhong Wu, MS, William Blum, MD, Bayard L. Powell, MD, Thomas H. Carter, MD, PhD, Meir Wetzler, MD, Joseph O. Moore, MD, Jonathan E. Kolitz, MD, Maria R. Baer, MD, Andrew J. Carroll, PhD, Richard A. Larson, MD, Michael A. Caligiuri, MD, Guido Marcucci, MD, Clara D. Bloomfield, MD
Journal: Blood
Blood (2010) 116 (21): 98.
https://doi.org/10.1182/blood.V116.21.98.98
Published: 2010
Journal Articles

Increased Expression of Macrophage Migration Inhibitory Factor (MIF) Receptor CD74 Is Associated with Inferior Outcome in Younger Patients (Pts) with Cytogenetically Normal Acute Myeloid Leukemia (CN-AML): a Cancer and Leukemia Group B (CALGB) Study.

Eyal C. Attar, MD, Kati Maharry, MAS, Krzysztof Mrózek, MD, PhD, Michael D. Radmacher, PhD, Susan P. Whitman, PhD, Peter Paschka, MD, Christian Langer, MD, Kelsi B. Holland, MS, Bayard L. Powell, MD, Jonathan E. Kolitz, MD, Andrew J. Carroll, PhD, Richard A. Larson, MD, Guido Marcucci, MD, Clara D. Bloomfield, MD
Journal: Blood
Blood (2009) 114 (22): 1616.
https://doi.org/10.1182/blood.V114.22.1616.1616
Published: 2009
Journal Articles

Adverse Prognostic Impact of FLT3 Internal Tandem Duplication (ITD) Is Age-Associated in Older [≥60 Years (Y)] De Novo cytogenetically Normal Acute Myeloid Leukemia (CN-AML) Patients (Pts): a Cancer and Leukemia Group B (CALGB) Study.

Susan P. Whitman, PhD, Kati Maharry, MAS, Michael D. Radmacher, PhD, Krzysztof Mrózek, MD, PhD, Dean Margeson, MAS, Kelsi B. Holland, MS, Heiko Becker, MD, Yue-Zong Wu, MS, Sebastian Schwind, MD, Maria R Baer, MD, Bayard L. Powell, MD, Richard M Stone, MD, Andrew J. Carroll, PhD, Richard A. Larson, MD, Michael A. Caligiuri, MD, Guido Marcucci, MD, Clara D. Bloomfield, MD
Journal: Blood
Blood (2009) 114 (22): 1579.
https://doi.org/10.1182/blood.V114.22.1579.1579
Published: 2009
Journal Articles

Aberrant Gene Expression of BAALC and ERG in Older [≥60 Years (y)] De Novo Cytogenetically Normal Acute Myeloid Leukemia (CN-AML): A Cancer and Leukemia Group B (CALGB) Study.

Sebastian Schwind, MD, Guido Marcucci, MD, Kati Maharry, MAS, Krzysztof Mrózek, MD, PhD, Michael D. Radmacher, PhD, Kelsi B. Holland, MS, Heiko Becker, MD, Susan P. Whitman, PhD, Yue-Zhong Wu, MS, Maria R Baer, MD, Bayard L. Powell, MD, Andrew J. Carroll, PhD, Michael A. Caligiuri, MD, Richard A. Larson, MD, Clara D. Bloomfield, MD
Journal: Blood
Blood (2009) 114 (22): 214.
https://doi.org/10.1182/blood.V114.22.214.214
Published: 2009
Journal Articles

Comparison of Clinical and Biologic Significance of WT1 Mutations in Populations of Older (≥60 years[y]) and Younger (<60 y) Adult Patients (Pts) with Cytogenetically Normal (CN) De Novo Acute Myeloid Leukemia (AML): a Cancer and Leukemia Group B (CALGB) Study.

Heiko Becker, MD, Guido Marcucci, MD, Kati Maharry, MAS, Michael D. Radmacher, PhD, Krzysztof Mrózek, MD, PhD, Susan P. Whitman, PhD, Peter Paschka, MD, Dean Margeson, MAS, Yue-Zhong Wu, MS, Sebastian Schwind, MD, Christian Langer, MD, Maria R. Baer, MD, Andrew J. Carroll, PhD, Michael A. Caligiuri, MD, Jonathan E. Kolitz, MD, Richard A. Larson, MD, Clara D. Bloomfield, MD
Journal: Blood
Blood (2009) 114 (22): 326.
https://doi.org/10.1182/blood.V114.22.326.326
Published: 2009
Journal Articles

Prognostic Significance of Unbalanced Chromosome Abnormalities Used by 2008 World Health Organization (WHO) Classification to Define “Acute Myeloid Leukemia (AML) with Myelodysplasia-Related Changes” in Adults: a Cancer and Leukemia Group B (CALGB) Study.

Krzysztof Mrózek, MD, PhD, Kelsi B. Holland, MS, Mark J. Pettenati, PhD, Kati Maharry, MAS, Guido Marcucci, MD, Maria R. Baer, MD, Jonathan E. Kolitz, MD, Dean Margeson, MAS, Colin G. Edwards, PhD, Andrew J. Carroll, PhD, Richard A. Larson, MD, Clara D. Bloomfield, MD
Journal: Blood
Blood (2009) 114 (22): 2602.
https://doi.org/10.1182/blood.V114.22.2602.2602
Published: 2009
Journal Articles

Wilms Tumor 1 (WT1) Gene Mutations Predict Poor Outcome in Adults with Cytogenetically Normal (CN) Acute Myeloid Leukemia (AML): A Cancer and Leukemia Group B (CALGB) Study.

Peter Paschka, Guido Marcucci, Amy S. Ruppert, Krzysztof Mrózek, Susan P. Whitman, Kati Maharry, Christian Langer, Claudia D. Baldus, Bayard L. Powell, Maria R. Baer, Andrew J. Carroll, Michael A. Caligiuri, Jonathan E. Kolitz, Richard A. Larson, Clara D. Bloomfield
Journal: Blood
Blood (2007) 110 (11): 362.
https://doi.org/10.1182/blood.V110.11.362.362
Published: 2007
Journal Articles

Acute Myeloid Leukemia (AML) with 9q Aberrations Occuring within a Non-Complex Karyotype Is Highly Associated with CEBPA and NPM1 Mutations - A Joint Analysis of the German-Austrian AML Study Group (AMLSG) and Cancer and Leukemia Group B (CALGB).

Andrea Corbacioglu, PhD, Stefan Fröhling, MD, Peter Paschka, MD, Guido Marcucci, MD, Andreas Anhalt, Katja Urlbauer, Jürgen Krauter, MD, Richard Larson, MD, Krzysztof Mrózek, MD, Amy S. Ruppert, MD, Arnold Ganser, MD, Michael A. Caligiuri, MD, Hartmut Döhner, MD, Richard F. Schlenk, MD, Clara D. Bloomfield, MD, Konstanze Döhner, MD
Journal: Blood
Blood (2007) 110 (11): 762.
https://doi.org/10.1182/blood.V110.11.762.762
Published: 2007
Journal Articles

Gene and microRNA (miRNA) Expression Signatures and Prognostic Significance of CEBPA Mutations in Cytogenetically Normal (CN) Acute Myeloid Leukemia (AML) with High-Risk Molecular Features: A Cancer and Leukemia Group B (CALGB) Study.

Guido Marcucci, MD, Kati Maharry, MAS, Michael D. Radmacher, PhD, Krzysztof Mrózek, MD, PhD, Tamara Vukosavljevic, MAS, Peter Paschka, PhD, Susan P. Whitman, PhD, Christian Langer, MD, Claudia D. Baldus, MD, Amy S. Ruppert, MAS, Bayard L. Powell, MD, Andrew J. Carroll, PhD, Michael A. Caligiuri, MD, Jonathan E. Kolitz, MD, Richard A. Larson, MD, Clara D. Bloomfield, MD
Journal: Blood
Blood (2007) 110 (11): 104.
https://doi.org/10.1182/blood.V110.11.104.104
Published: 2007
Journal Articles

Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification?

Krzysztof Mrózek, Guido Marcucci, Peter Paschka, Susan P. Whitman, Clara D. Bloomfield
Journal: Blood
Blood (2006) 109 (2): 431–448.
https://doi.org/10.1182/blood-2006-06-001149
Published: 2006