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Journal Articles

Long-Term Outcome of a Prospective Randomized Trial Comparing Continuous Lenalidomide/Dexamethasone with Lenalidomide/Dexamethasone Induction, MEL140 with Autologous Blood Stem Cell Transplantation and Single Agent Lenalidomide Maintenance in Patients of Age 60-75 Years with Newly Diagnosed Multiple Myeloma

Christian Straka, Kerstin Schaefer-Eckart, Bernd Hertenstein, Florian Bassermann, Hans Salwender, Christian Langer, Jan Krönke, Miriam Kull, Georgia Schilling, Aneta Schieferdecker, Monika Engelhardt, Stefan Knop, Julia Reusch, Wolf Roesler, Bernd Metzner, Holger Hebart, Albrecht Reichle, Matthias Grube, Norbert Frickhofen, Christian Gerecke, Stephan Fuhrmann, Wolfram Jung, Martin Gramatzki, Thomas Decker, Tobias Dechow, Jochen Greiner, Tim H. Brümmendorf, Juliana Ababei, Ivana von Metzler, Ralph Naumann, Elisabeth Fritz, Marcus Hentrich, Peter Bojko, Thomas Kubin, Christian Schmidt, Martin Kaufmann, Burkhard Schmidt, Axel Hinke, Hermann Einsele
Journal: Blood
Blood (2022) 140 (Supplement 1): 287–288.
https://doi.org/10.1182/blood-2022-159357
Published: 2022
Journal Articles

Characterization of Rare Germline Variants in Familial Multiple Myeloma

Calogerina Catalano, PhD, Joanna Blocka, MD, Stefanie Huhn, PhD, Nagarajan Paramasivam, PhD, Matthias Schlesner, PhD, Niels Weinhold, PhD, Rolf Sijmons, MD, Christian Langer, MD, Klaus Preuss, PhD, Brian G.M. Durie, MD, Björn Nilsson, MD PhD, Hartmut Goldschmidt, MD, Obul Reddy Bandapalli, PhD, Kari Hemminki, MD PhD, Asta Försti, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 45–46.
https://doi.org/10.1182/blood-2020-142253
Published: 2020
Journal Articles

Patterns of Renal Recovery and Toxicity with Novel Agent-Based Induction Triplets in Newly Diagnosed Multiple Myeloma - an Analysis of Two Prospective Studies By the German DSMM Myeloma Study Group

Friederike Bachmann, MD, Swantje Held, Monika Engelhardt, MD, Christian Langer, MD, Denise Wolleschak, Janik Fleissner, Lars-Olof Mügge, MD, Heinz Duerk, MD PhD, Martin Schreder, MD, Kerstin Schaefer-Eckart, MD, Igor-Wolfgang Blau, MD PhD, Martin Gramatzki, MD, Peter Liebisch, MD, Albrecht Reichle, MD, Ivana Metzler, MD, Florian Bassermann, MD PhD, Bernd Metzner, MD PhD, Christoph Röllig, MD MSC, Bernd Hertenstein, Tobias Dechow, Wolfram Jung, MD, Helmut Ostermann, MD, Holger Hebart, Georg Maschmeyer, MD, Hans Jürgen Salwender, MD, Marie von Lilienfeld-Toal, MD, Kai-Uwe Eckardt, MD, Christian Straka, MD PhD, Hermann Einsele, MD, Stefan Knop
Journal: Blood
Blood (2019) 134 (Supplement_1): 1840.
https://doi.org/10.1182/blood-2019-125235
Published: 2019
Journal Articles

Exome Sequencing of Relapsed Multiple Myeloma Combined with Pooled CRISPR/Cas9 Screens Identifies Gene Mutations Associated with Drug-Specific Resistance

Stephan Bohl, Laura K. Schmalbrock, MD, Imke Bauhuf, Anna Dolnik, Tamara J. Blätte, MSc, Stefanie Lindner, Dr., Tatjana Meyer, MSc, BSc, Sarah Knödler, Denise Miller, Miriam Kull, Christian Langer, MD, Hartmut Döhner, MD, Dirk Heckl, PhD, Lars Bullinger, Jan Krönke, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 809.
https://doi.org/10.1182/blood-2019-131245
Published: 2019
Journal Articles

Treatment with AMG 420, an Anti-B-Cell Maturation Antigen (BCMA) Bispecific T-Cell Engager (BiTE ® ) Antibody Construct, Induces Minimal Residual Disease (MRD) Negative Complete Responses in Relapsed and/or Refractory (R/R) Multiple Myeloma (MM) Patients: Results of a First-in-Human (FIH) Phase I Dose Escalation Study

Max S. Topp, Johannes Duell, MD, Gerhard Zugmaier, Michel Attal, Philippe Moreau, Christian Langer, Jan Kroenke, MD, Thierry Facon, Hermann Einsele, Gerd Munzert, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1010.
https://doi.org/10.1182/blood-2018-99-109769
Published: 2018
Journal Articles

Lenalidomide, Adriamycin and Dexamethasone (RAD) Versus Bortezomib, Lenalidomide and Dexamethasone (VRD) in Newly Diagnosed Multiple Myeloma (MM) - Post-Induction Response and MRD Results By Flow Cytometry and NGS from a Phase 3 Randomized Controlled Clinical Trial (RCT)

Thomas Stübig, MD, Christian Langer, MD, Monika Engelhardt, MD, Lars-Olof Mügge, MD, Florian Bassermann, MD PhD, Martin Schreder, MD, Kerstin Schäfer-Eckart, MD, Igor Wolfgang Blau, Denise Wolleschak, Albrecht Reichle, MD, Ivana Metzler, MD, Bernd Metzner, MDPhD, Christoph Rollig, MD MSC, Bernd Hertenstein, MD, Heinz Dürk, Harald Biersack, MD, Helge Menzel, MD, Tobias Dechow, Jan Schleicher, Martin Gramatzki, MD, Tim H. Brümmendorf, MD, Stephan Fuhrmann, Max Bittrich, MD, Franziska Appelt, Martina Müller, Jan Krönke, MD, Julia Reusch, Christian Schmidt, MD, Monika Brüggemann, MD, Swantje Held, Stefan Knop, Hermann Einsele, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1979.
https://doi.org/10.1182/blood-2018-99-116067
Published: 2018
Journal Articles

Ixazomib significantly prolongs progression-free survival in high-risk relapsed/refractory myeloma patients

Clinical Trials & Observations
Hervé Avet-Loiseau, Nizar J. Bahlis, Wee-Joo Chng, Tamas Masszi, Luisa Viterbo, Ludek Pour, Peter Ganly, Antonio Palumbo, Michele Cavo, Christian Langer, Andrzej Pluta, Arnon Nagler, Shaji Kumar, Dina Ben-Yehuda, S. Vincent Rajkumar, Jesus San-Miguel, Deborah Berg, Jianchang Lin, Helgi van de Velde, Dixie-Lee Esseltine, Alessandra di Bacco, Philippe Moreau, Paul G. Richardson
Journal: Blood
Blood (2017) 130 (24): 2610–2618.
https://doi.org/10.1182/blood-2017-06-791228
Published: 2017
Includes: Supplemental data
Journal Articles

Whole Exome Sequencing Reveals High Genetic Diversity in Relapsed Multiple Myeloma

Laura K. Schmalbrock, MD, Stephan Bohl, MD, Anna Dolnik, PhD, Tamara J. Blätte, MSc, Maria-Veronica Teleanu, Miriam Kull, MD, Denise Miller, Lars Bullinger, MD, Christian Langer, MD, Jan Kronke
Journal: Blood
Blood (2017) 130 (Supplement 1): 4363.
https://doi.org/10.1182/blood.V130.Suppl_1.4363.4363
Published: 2017
Journal Articles

Age Related Distribution of Cytogenetic Abnormalities in Multiple Myeloma

Sonia Jaramillo, MD MSc, Miriam Kull, MD, Jan Kroenke, MD, Phyllis Schwarzwaelder, MD, Stefan Schoensteiner, MD, Stefan Knop, MD, Christian Straka, MD PhD, Hermann Einsele, Christian Langer, MD, Maria-Veronica Teleanu
Journal: Blood
Blood (2017) 130 (Supplement 1): 4381.
https://doi.org/10.1182/blood.V130.Suppl_1.4381.4381
Published: 2017
Journal Articles

Functional Geriatric Assessment (F-GA) in Multiple Myeloma Patients: Results from a Prospective Multicenter Study Group (DSMM) Trial and Changes from Baseline to Follow-up Assessment

Sophia Scheubeck, Sandra Maria Dold, M. Sc., Gabriele Ihorst, PhD, Alexander Zober, MD, Stefan J. Müller, Dipl.-Pharm., Christian Langer, MD, Wolfram Pönisch, Lars-Olof Mügge, MD, Stefan Knop, MD, Justus Duyster, MD, Martin Schumacher, PhD, Ralph M. Waesch, MD, Monika Engelhardt, MD
Journal: Blood
Blood (2016) 128 (22): 5627.
https://doi.org/10.1182/blood.V128.22.5627.5627
Published: 2016
Journal Articles

Higher c-MYC Expression Is Associated with Ixazomib-Lenalidomide-Dexamethasone (IRd) Progression-Free Survival (PFS) Benefit Versus Placebo-Rd: Biomarker Analysis of the Phase 3 Tourmaline-MM1 Study in Relapsed/Refractory Multiple Myeloma (RRMM)

Alessandra Di Bacco, PhD, Nizar J. Bahlis, MD, Nikhil C Munshi, MD, Hervé Avet-Loiseau, MD PhD, Tamás Masszi, MD, Luísa Viterbo, MD, Ludek Pour, MD PhD, Peter Ganly, BMBCh, PhD, Michele Cavo, MD, Christian Langer, MD, Shaji Kumar, MD, S. Vincent Rajkumar, MD, Deborah Berg, RN, MSN, Jianchang Lin, PhD, Bin Li, Sunita Badola, Lei Shen, Jacob Zhang, Ling Wang, PhD, Dixie-Lee Esseltine, MD, Katarina Luptakova, Helgi van de Velde, MD PhD, Paul G. Richardson, MD, Philippe Moreau
Journal: Blood
Blood (2016) 128 (22): 243.
https://doi.org/10.1182/blood.V128.22.243.243
Published: 2016
Journal Articles

Bortezomib Consolidation Following Autologous Transplant Equalizes the Outcome for Older Patients with Less Intensive Pretreatment Compared to Younger Patients with Newly Diagnosed Multiple Myeloma

Christian Straka, MD, Stefan Knop, MD, Martin Vogel, MD PhD, Jurgen Müller, Dipl. Stat., Martin Kropff, MD, Bernd Metzner, MD, Christian Langer, MD, Herbert Sayer, MD, Wolfram Jung, MD, Heinz Dürk, MD PhD, Hans-Juergen Salwender, MD, Hannes Wandt, MD, PhD, Florian Bassermann, MD, Martin Gramatzki, MD, Wolf Rösler, MD, Hans-Heinrich Wolf, MD, Wolfram Brugger, MD PhD, Monika Engelhardt, MD, Thomas Fischer, MD, Peter Liebisch, MD, Hermann Einsele, MD
Journal: Blood
Blood (2016) 128 (22): 516.
https://doi.org/10.1182/blood.V128.22.516.516
Published: 2016
Journal Articles

Targeted Genomic Mutation Panel (M 3 P) Results from 504 Multiple Myeloma (MM) Patients

K Martin Kortuem, Esteban Braggio, Pieter Sonneveld, MD PhD, Laura Ann Bruins, Santiago Barrio, Davine Hofste op Bruinink, Mark vanDuin, Elias Karl Mai, MD, Nur Hanafiah, Hartmut Goldschmidt, MD, Sanchin Pathangey, Yanira Ruiz Heredia, Inmaculada Rapado, Beatriz Sanchez-Vega, Stefan Knop, Leo Rasche, Christian Langer, Miriam Kull, Lars Bullinger, Monika Engelhardt, Joaquin Martinez-Lopez, Hermann Einsele, Marc S. Raab, A. Keith Stewart
Journal: Blood
Blood (2015) 126 (23): 1795.
https://doi.org/10.1182/blood.V126.23.1795.1795
Published: 2015
Journal Articles

Impact of Comorbidities and Prospective Functional Geriatric Assessment Tools (CF-GA) As an Aide to Understand Outcome, Therapy Tolerance, Side Effects and Clinical Trial Eligibility in Multiple Myeloma (MM) Patients (pts)

Alexander Zober, MD, Mandy Möller, Sandra-Maria Dold, Gabriele Ihorst, PhD, Stefanie Hieke, PhD, Jochen Knaus, Milena Pantic, PhD, Barbara Deschler-Baier, MD, Stefan Knop, Hermann Einsele, Christian Langer, Lars-Olof Muegge, MD, Wolfram Poenisch, MD, Justus Duyster, MD PhD, Martin Schumacher, PhD, Ralph M. Waesch, MD PhD, Monika Engelhardt, MD PhD
Journal: Blood
Blood (2015) 126 (23): 5616.
https://doi.org/10.1182/blood.V126.23.5616.5616
Published: 2015
Journal Articles

Autologous Followed By Allogeneic Versus Tandem-Autologous Stem Cell Transplant in Newly Diagnosed FISH-del13q Myeloma

Stefan Knop, MD, Peter Liebisch, MD, Holger Hebart, MD, Ernst Holler, MD, Monika Engelhardt, MD, Bernd Metzner, MD, Dietrich Peest, MD, Walter Aulitzky, MD, Donald W. Bunjes, MD, Christian Straka, MD, Thomas Fischer, MD, Hannes Wandt, MD, Orhan Sezer, MD, Markus Hentrich, MD, Helmut Ostermann, MD, Christian Peschel, MD, Georg Hess, MD, Bernd Hertenstein, MD, Mathias Freund, MD, Martin H Kropff, MD, Hans-Heinrich Wolf, MD, Wolfram E Jung, MD, Norbert Frickhofen, MD, Ralf C. Bargou, Georg Maschmeyer, MD, Else Heidemann, MD, Christian Langer, MD, Lothar Kanz, MD, Christoph Meisner, PhD, Hermann Einsele, MD
Journal: Blood
Blood (2014) 124 (21): 43.
https://doi.org/10.1182/blood.V124.21.43.43
Published: 2014
Journal Articles

Response to Lenalidomide, Doxorubicin and Dexamethasone (RAD) in Newly Diagnosed Multiple Myeloma Is Independent of Cytogenetic Risk and Retained after Double Stem Cell Transplant

Stefan Knop, MD, Christian Langer, MD, Monika Engelhardt, MD, Lars-Olof Mügge, MD, Albrecht Reichle, Wolf Rösler, MD, Florian Bassermann, MD, Bernd Hertenstein, MD, Isrid Sturm, MD, Christoph Röllig, MD, Helmut Ostermann, MD, Kerstin Schäfer-Eckart, MD, Mark Ringhoffer, MD, Andreas Günther, Christian Junghanss, MD, Harald Biersack, MD, Susanne Strifler, MD, Andreas Bachinger, Hermann Einsele, MD, Ralf C. Bargou
Journal: Blood
Blood (2014) 124 (21): 177.
https://doi.org/10.1182/blood.V124.21.177.177
Published: 2014
Journal Articles

Survival Analysis in Patients with Multiple Myeloma after Allogeneic Hematopoietic Stem Cell Transplantation, a Single Center Study (1994-2013)

Susanne Hofmann, MD, Lisa Müller, Stephanie Harsdorf, MD, Christian Langer, MD, Peter Liebisch, MD, Jochen Greiner, MD, Hartmut Döhner, MD, Donald Bunjes, MD
Journal: Blood
Blood (2014) 124 (21): 1233.
https://doi.org/10.1182/blood.V124.21.1233.1233
Published: 2014
Journal Articles

Lenalidomide with Low-Dose Dexamethasone (Rd) Continuously Versus Rd Induction, Tandem MEL140 with Autologous Transplantation and Lenalidomide Maintenance: Planned Interim Analysis of a Prospective Randomized Trial in Patients 60-75 Years of Age with Multiple Myeloma

Christian Straka, MD, Kerstin Schaefer-Eckart, MD, Florian Bassermann, MD, Hansen Timon, MD, Bernd Hertenstein, MD, Christian Langer, MD, Hans Salwender, MD, Stefan Knop, MD, Monika Engelhardt, MD, Martin Kropff, MD, Wolf Roesler, MD, Thomas Decker, MD, Holger Hebart, MD, Norbert Frickhofen, MD, Albrecht Reichle, Christian Gerecke, MD, Bernd Metzner, Else Heidemann, MD, Tim H Brummendorf, MD, Juliane Ababei, MD, Wolfram E Jung, MD, Martin Gramatzki, MD, Marcus Hentrich, MD, Peter Bojko, MD, Ivana von Metzler, MD, Martin Kaufmann, MD, Ralph Naumann, MD, Thomas Kubin, MD, Burkhard Schmidt, MD, Jochem Walther, MD, Tobias Dechow, MD, Hannes Wandt, MD, Brigitte Schnabel, Axel Hinke, PhD, Hermann Einsele
Journal: Blood
Blood (2014) 124 (21): 3969.
https://doi.org/10.1182/blood.V124.21.3969.3969
Published: 2014
Journal Articles

Outcome and Prognostic Factors of 17p Deleted Multiple Myeloma Patients

Miriam Kull, MD, Veronica Teleanu, MD, Daniela Hayde, Katrin Wildbihler, Stephanie Harsdorf, MD, Donald Bunjes, MD, Peter Liebisch, MD, Christian Langer, MD
Journal: Blood
Blood (2014) 124 (21): 3994.
https://doi.org/10.1182/blood.V124.21.3994.3994
Published: 2014
Journal Articles

Inherited genetic susceptibility to monoclonal gammopathy of unknown significance

CME Brief Report
Niels Weinhold, David C. Johnson, Andrew C. Rawstron, Asta Försti, Chi Doughty, Jayaram Vijayakrishnan, Peter Broderick, Nasrin B. Dahir, Dil B. Begum, Fay J. Hosking, Kwee Yong, Brian A. Walker, Per Hoffmann, Thomas W. Mühleisen, Christian Langer, Elisabeth Dörner, Karl-Heinz Jöckel, Lewin Eisele, Markus M. Nöthen, Dirk Hose, Faith E. Davies, Hartmut Goldschmidt, Gareth J. Morgan, Kari Hemminki, Richard S. Houlston
Journal: Blood
Blood (2014) 123 (16): 2513–2517.
https://doi.org/10.1182/blood-2013-10-532283
Published: 2014
Includes: Supplemental data