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Laura Ann Bruins
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Journal Articles

Newly Diagnosed, Untreated, Multiple Myeloma (MM) Patient Samples Already Harbor Cereblon (CRBN) Exon 10 Deletions Associated with Drug Resistance

Yuan Xiao Zhu, Gregory J Ahmann, Laura Ann Bruins, Mariano Arribas, Xianfeng Chen, Marta Chesi, P. Leif Bergsagel, Rafael Fonseca, Lisa M. Rimsza
Journal: Blood
Blood (2022) 140 (Supplement 1): 4187–4188.
https://doi.org/10.1182/blood-2022-157316
Published: 2022
Journal Articles

Chronic Lymphocytic Leukemia in African Ancestry Population Is Characterized By Increased Telomere Erosion

Cecilia Bonolo De Campos, Chantal McCabe, Laura Ann Bruins, Daniel R. O'Brien, Sochilt Brown, Cristine Allmer, Yuan Xiao Zhu, Kari G Rabe, Sameer A. Parikh, Neil E. Kay, James R. Cerhan, Laura Z Rassenti, Richard R. Furman, J. Brice Weinberg, Danielle Brander, Marta Chesi, Susan L. Slager, Esteban Braggio
Journal: Blood
Blood (2022) 140 (Supplement 1): 4135–4136.
https://doi.org/10.1182/blood-2022-170944
Published: 2022
Journal Articles

Identifying Mechanisms Associated with Venetoclax Resistance in Multiple Myeloma (MM)

Yuan Xiao Zhu, Laura Ann Bruins, Joseph Ahmann, Cecilia Bonolo De Campos, Esteban Braggio, Xianfeng Chen, Mariano Arribas, Susie Darvish, Gregory J Ahmann, Rafael Fonseca
Journal: Blood
Blood (2021) 138 (Supplement 1): 2668.
https://doi.org/10.1182/blood-2021-153747
Published: 2021
Journal Articles

Integrative Analysis of FISH, Transcriptomics and Mutational Status Predicts Responsiveness to Novel Agents in Multiple Myeloma

Cecilia Bonolo De Campos, PhD, Caleb K Stein, PhD, Nathalie Meurice, PhD, Laura Ann Bruins, BS, Joachim L Petit, PhD, Alysia N Polito, BS, Gregory J Ahmann, BS, Shulan Tian, MS, PhD, P. Leif Bergsagel, MD, Esteban Braggio, PhD, A. Keith Stewart, MB, ChB
Journal: Blood
Blood (2019) 134 (Supplement_1): 574.
https://doi.org/10.1182/blood-2019-130977
Published: 2019
Journal Articles

The Contribution of Proteasome Subunits to Myeloma Cell Viability and Proteasome Inhibitor Sensitivity

Chang-Xin Shi, PhD, Yuan Xiao Zhu, PhD, Laura Ann Bruins, BS, Cecilia Bonolo De Campos, PhD, William Stewart, Esteban Braggio, PhD, A Keith Stewart, M.B. Ch.B.
Journal: Blood
Blood (2019) 134 (Supplement_1): 4337.
https://doi.org/10.1182/blood-2019-127149
Published: 2019
Journal Articles

Lenalidomide, Pomalidomide and CC-220 Resistant Multiple Myeloma: Confirmation of Role of CRBN/IRF4 Axis and Identification of Multiple Disruption Mechanisms

Yuan Xiao Zhu, PhD, Chang-Xin Shi, PhD, Laura Ann Bruins, BS, Xuewei Wang, PhD, Daniel Riggs, PhD, Brooke Porter, Jonathan Ahmann, BS, Esteban Braggio, PhD, P. Leif Bergsagel, MD, A. Keith Stewart, MBChB, MBA
Journal: Blood
Blood (2017) 130 (Supplement 1): 4369.
https://doi.org/10.1182/blood.V130.Suppl_1.4369.4369
Published: 2017
Journal Articles

Targeted Deep Sequencing in Untreated Progressive CLL Helps to Better Dissect the Genomic Landscape and Shows Novel Associations between Mutations, Prognostic and Clinical Parameters: Data from E1912, a Randomized Phase III Study of the ECOG-ACRIN Cancer Research Group

Esteban Braggio, PhD, Victoria Wang, Laura Ann Bruins, BS, Santiago Barrio, PhD, Connie Lesnick, Jacqueline C. Barrientos, MD, Susan M. O'Brien, MD, Martin S. Tallman, MD, Mark R. Litzow, MD, Rafael Fonseca, MD, Neil E. Kay, MD, Tait D Shanafelt, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4288.
https://doi.org/10.1182/blood.V130.Suppl_1.4288.4288
Published: 2017
Journal Articles

PIKfyve Inhibitors for the Treatment of Multiple Myeloma

Cecilia Bonolo De Campos, PhD, Yuan Xiao Zhu, PhD, Chang-Xin Shi, PhD, Laura Ann Bruins, BS, Joachim L Petit, PhD, Alysia N Polito, BS, Meaghen E Sharik, BS, Caleb K Stein, MS, Gregory J Ahmann, BS, Ilsel D Lopez Armenta, BS, Nikolai Sepetov, PhD, Sergei Romanov, PhD, P. Leif Bergsagel, MD, Marta Chesi, PhD, Nathalie Meurice, PhD, A. Keith Stewart, MBChB, MBA
Journal: Blood
Blood (2017) 130 (Supplement 1): 4423.
https://doi.org/10.1182/blood.V130.Suppl_1.4423.4423
Published: 2017
Journal Articles

"Direct to Drug" Screening As a Route to Individualized Therapy in Multiple Myeloma

Nathalie Meurice, PhD, Joachim L Petit, PhD, Cecilia Bonolo De Campos, PhD, Alysia N Polito, BS, Ilsel D Lopez Armenta, BS, Gregory J Ahmann, BS, Laura Ann Bruins, BS, Joseph R Mikhael, MD FRCPC, MD, Craig B. Reeder, MD, Angela A Mayo, MS, PA-C, P. Leif Bergsagel, MD, Rafael Fonseca, MD, Nikolai Sepetov, PhD, Sergei Romanov, PhD, A. Keith Stewart, MBChB, MBA
Journal: Blood
Blood (2017) 130 (Supplement 1): 3080.
https://doi.org/10.1182/blood.V130.Suppl_1.3080.3080
Published: 2017
Journal Articles

Novel Associations Between Mutations, Prognostic and Clinical Parameters in Untreated Progressive CLL: Data from E1912, a Randomized Phase III Study of the ECOG-ACRIN Cancer Research Group

Esteban Braggio, PhD, Victoria X Wang, Santiago Garcia, PhD, Laura Ann Bruins, Connie Lesnick, Jacqueline C. Barrientos, MD, Susan M. O'Brien, MD, Martin S. Tallman, MD, Rafael Fonseca, MD, Neil E. Kay, MD, Tait D. Shanafelt, MD
Journal: Blood
Blood (2016) 128 (22): 4373.
https://doi.org/10.1182/blood.V128.22.4373.4373
Published: 2016
Journal Articles

Crispr Sgrnas Genome-Wide Screen Identifies the Proteasome Regulatory Subunit PSMC6 As a Bortezomib Resistance Gene in Human Multiple Myeloma Cells

Chang-Xin Shi, PhD, Klaus M Kortum, MD, Yuan Xiao Zhu, PhD, Patrick Jedlowski, Esteban Braggio, PhD, Laura Ann Bruins, Patrick G. Votruba, M.S., Moulun Luo, PhD, Robert A. Stewart, Jonathan M. Ahmann, A. Keith Stewart
Journal: Blood
Blood (2015) 126 (23): 450.
https://doi.org/10.1182/blood.V126.23.450.450
Published: 2015
Journal Articles

Targeted Sequencing of Relapsed/Refractory Myeloma Patients Identifies an Enrichment of Mutations in Cereblon and MAPK Pathways

Elias Karl Mai, MD, K. Martin Kortuem, MD, Nur Hanafiah, Santiago Barrio, Laura Ann Bruins, Maximilian Merz, MD, Jing Xu, Koenuel Pashayeva, MD, Yuan-Xiao Zhu, Chang-Xin Shi, PhD, R. Alexander Stewart, Patrick Jedlowski, Mindaugas Andrulis, MD, Anna Jauch, Prof., Jens Hillengass, MD, Hartmut Goldschmidt, MD, P. Leif Bergsagel, MD PhD, Esteban Braggio, PhD, A. Keith Stewart, MD, Marc Steffen Raab, MD PhD
Journal: Blood
Blood (2015) 126 (23): 723.
https://doi.org/10.1182/blood.V126.23.723.723
Published: 2015
Journal Articles

Identification of FAM46C As a Multiple Myeloma Repressor

Yuan Xiao Zhu, PhD, Chang-Xin Shi, PhD, Patrick Jedlowski, Klaus Martin Kortum, Laura Ann Bruins, Jonathan Ahmann, Esteban Braggio, PhD, Xuewei Wang, A. Keith Stewart
Journal: Blood
Blood (2015) 126 (23): 836.
https://doi.org/10.1182/blood.V126.23.836.836
Published: 2015
Journal Articles

Targeted Genomic Mutation Panel (M 3 P) Results from 504 Multiple Myeloma (MM) Patients

K Martin Kortuem, Esteban Braggio, Pieter Sonneveld, MD PhD, Laura Ann Bruins, Santiago Barrio, Davine Hofste op Bruinink, Mark vanDuin, Elias Karl Mai, MD, Nur Hanafiah, Hartmut Goldschmidt, MD, Sanchin Pathangey, Yanira Ruiz Heredia, Inmaculada Rapado, Beatriz Sanchez-Vega, Stefan Knop, Leo Rasche, Christian Langer, Miriam Kull, Lars Bullinger, Monika Engelhardt, Joaquin Martinez-Lopez, Hermann Einsele, Marc S. Raab, A. Keith Stewart
Journal: Blood
Blood (2015) 126 (23): 1795.
https://doi.org/10.1182/blood.V126.23.1795.1795
Published: 2015
Journal Articles

Development and Results of a Multiple Myeloma Specific Custom 77-Gene Mutation Panel for Clinical Targeted Sequencing

K. Martin Kortuem, MD, A. Keith Stewart, MD, Laura Ann Bruins, Gregory Ahmann, BS, George Vasmatzis, PhD, S. Vincent Rajkumar, MD, Shaji Kumar, MD, Angela Dispenzieri, MD, Martha Q Lacy, MD, Morie A Gertz, MD, Rafael Fonseca, MD, Mia Champion, PhD, P. Leif Bergsagel, MD, Esteban Braggio, PhD
Journal: Blood
Blood (2014) 124 (21): 169.
https://doi.org/10.1182/blood.V124.21.169.169
Published: 2014