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Kyoko Miyamoto
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Journal Articles

Docirbrutinib (AS-1763), a novel non-COVALENT BTK inhibitor, demonstrates efficacy in BTK inhibitor-resistant mutant cells

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Tokiko Asami, Hitomi Fujiwara, Hiroko Endo, Natalia Timofeeva, Mariko Hatakeyama, Fumio Nakajima, Kyoko Miyamoto, Akinori Arimura, Yu Nishioka, Nitin Jain, Varsha Gandhi, Masaaki Sawa
Journal: Blood
Blood (2025) 146 (Supplement 1): 5077.
https://doi.org/10.1182/blood-2025-5077
Published: 2025
Journal Articles

Docirbrutinib (AS-1763), a novel non-COVALENT pan-mutant BTK inhibitor, demonstrates durable clinical responses in patients with previously treated B-cell malignancies: Data from an ongoing Phase 1b study

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Nitin Jain, Catherine Coombs, James D'Olimpio, Nirav Shah, Jacqueline Barrientos, Seung Tae Lee, Danielle Brander, John Nemunaitis, Andrew Gillis-Smith, Shuo Ma, Shirou Kirita, Koji Yoshida, Masaaki Sawa, Kyoko Miyamoto, Akinori Arimura, William Wierda, Varsha Gandhi, Javier Pinilla-Ibarz
Journal: Blood
Blood (2025) 146 (Supplement 1): 3892.
https://doi.org/10.1182/blood-2025-3892
Published: 2025
Journal Articles

Impact of Docirbrutinib (AS-1763) Treatment in CLL: Preclinical Data and Early Clinical Biomarkers

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Natalia Timofeeva, Breana Herrera, Shady I. Tantawy, Hitomi Fujiwara, Lizbeth Loza, Mariko Hatakeyama, Tokiko Asami, Hiroshi Ohmoto, Kyoko Miyamoto, Yu Nishioka, Akinori Arimura, Masaaki Sawa, Nitin Jain, Varsha Gandhi
Journal: Blood
Blood (2024) 144 (Supplement 1): 1850.
https://doi.org/10.1182/blood-2024-210788
Published: 2024
Journal Articles

Preliminary Results from a Phase 1b Study of Non-Covalent Pan-Mutant BTK Inhibitor Docirbrutinib (AS-1763) in Patients with Previously Treated B-Cell Malignancies

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Nitin Jain, Catherine C. Coombs, James D'Olimpio, Nirav N. Shah, Jacqueline C. Barrientos, Seung Tae Lee, Andrew Gillis-Smith, Shuo Ma, Shirou Kirita, Masaaki Sawa, Kyoko Miyamoto, Akinori Arimura, William G. Wierda, Varsha Gandhi, Javier Pinilla-Ibarz
Journal: Blood
Blood (2024) 144 (Supplement 1): 1866.
https://doi.org/10.1182/blood-2024-208549
Published: 2024
Journal Articles

Trial in Progress: A Phase 1b Study of AS-1763, an Oral, Potent and Selective Noncovalent BTK Inhibitor, in Patients with Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma or Non-Hodgkin Lymphoma

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Nitin Jain, James D'Olimpio, Andew gillis-Smith, Seung Tae Lee, Nirav N. Shah, Javier Pinilla-Ibarz, Catherine C. Coombs, Jacqueline C. Barrientos, Shuo Ma, Masaaki Sawa, Kyoko Miyamoto, Akinori Arimura, Varsha Gandhi, William G. Wierda
Journal: Blood
Blood (2023) 142 (Supplement 1): 3288.
https://doi.org/10.1182/blood-2023-182568
Published: 2023
Journal Articles

Characterization and Preclinical Evaluation of AS-1763, an Oral, Potent and Selective Noncovalent BTK Inhibitor, in Chronic Lymphocytic Leukemia

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Shady I. Tantawy, Natalia Timofeeva, Hitomi Fujiwara, Mariko Hatakeyama, Breana Herrera, Lizbeth Loza, Tokiko Asami, Hiroshi Ohmoto, Kyoko Miyamoto, Yu Nishioka, Akinori Arimura, Masaaki Sawa, Nitin Jain, Varsha Gandhi
Journal: Blood
Blood (2023) 142 (Supplement 1): 1453.
https://doi.org/10.1182/blood-2023-189659
Published: 2023