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Laura Mazzera
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Journal Articles

The Pharmacological Blockade of Phosphodiesterase IV Potentiates the Anti-Tumor Effects of Arsenic Trioxide (ATO) in Acute Myelogenous Leukemia Cells through Multiple Signaling Pathways

Laura Mazzera, PhD, Manuela Abeltino, PhD, Antonio Bonati, MD, Paolo Lunghi, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2520.
https://doi.org/10.1182/blood.V130.Suppl_1.2520.2520
Published: 2017
Journal Articles

Aurora and IKK kinases cooperatively interact to protect multiple myeloma cells from Apo2L/TRAIL

Laura Mazzera, Guerino Lombardi, Manuela Abeltino, Micaela Ricca, Gaetano Donofrio, Nicola Giuliani, Anna Maria Cantoni, Attilio Corradi, Antonio Bonati, Paolo Lunghi
Journal: Blood
Blood (2013) 122 (15): 2641–2653.
https://doi.org/10.1182/blood-2013-02-482356
Published: 2013
Includes: Supplemental data
Journal Articles

Pan-Aurora Kinases and TRAIL Combination Therapy Has Potent Antitumor Activity In Vivo Against Drug-Resistant Human Multiple Myeloma Xenograft Model

Paolo Lunghi, PhD, Laura Mazzera, Guerino Lombardi, Micaela Ricca, Manuela Abeltino, Davide Arienti, Anna Maria Cantoni, Attilio Corradi, Antonio Bonati, MD
Journal: Blood
Blood (2011) 118 (21): 1846.
https://doi.org/10.1182/blood.V118.21.1846.1846
Published: 2011
Journal Articles

Blockade of Aurora Kinase Activity Enhances Apo2L/TRAIL Sensitivity In Multiple Myeloma

Paolo Lunghi, PhD, Laura Mazzera, Manuela Abeltino, Nicola Giuliani, Antonio Bonati, MD
Journal: Blood
Blood (2010) 116 (21): 4059.
https://doi.org/10.1182/blood.V116.21.4059.4059
Published: 2010
Journal Articles

Pan-Aurora Kinase Inhibitor Mk-0457 Synergistically Potentiates Apo2L/Trail Cytotoxicity in Multiple Mieloma Cells Sensitive and Resistant to Bortezomib.

Paolo Lunghi, Laura Mazzera, Antonio Costanzo, Nicola Giuliani, Vittorio Rizzoli, Massimo Levrero, Antonio Bonati
Journal: Blood
Blood (2009) 114 (22): 1837.
https://doi.org/10.1182/blood.V114.22.1837.1837
Published: 2009
Journal Articles

Arsenic Trioxide (ATO) Interacts Synergistically with MEK Inhibitors to Induce Apoptosis in STI571-Resistant Bcr-Abl Mutants.

Paolo Lunghi, Laura Mazzera, Attilio Corradi, Anna Maria Cantoni, Stefano Jottini, Guerino Lombardi, Micaela Ricca, Davide Arienti, Vittorio Rizzoli, Michael WN Deininger, MD, Antonio Bonati, MD
Journal: Blood
Blood (2009) 114 (22): 2177.
https://doi.org/10.1182/blood.V114.22.2177.2177
Published: 2009
Journal Articles

Combined Treatment with the Mek Inhibitor PD0325901 and Arsenic Trioxide Has Potent Antitumor Activity in Vivo against Human Multiple Myeloma Xenograft Model.

Paolo Lunghi, Laura Mazzera, Guerino Lombardi, Micaela Ricca, Attilio Corradi, Anna Maria Cantoni, Nicola Giuliani, Luigi Salvatore, Roberta Riccioni, Antonio Costanzo, Ugo Testa, Massimo Levrero, Vittorio Rizzoli, Antonio Bonati
Journal: Blood
Blood (2008) 112 (11): 1712.
https://doi.org/10.1182/blood.V112.11.1712.1712
Published: 2008
Journal Articles

Targeting MEK/MAPK signal transduction module potentiates ATO-induced apoptosis in multiple myeloma cells through multiple signaling pathways

Paolo Lunghi, Nicola Giuliani, Laura Mazzera, Guerino Lombardi, Micaela Ricca, Attilio Corradi, Anna Maria Cantoni, Luigi Salvatore, Roberta Riccioni, Antonio Costanzo, Ugo Testa, Massimo Levrero, Vittorio Rizzoli, Antonio Bonati
Journal: Blood
Blood (2008) 112 (6): 2450–2462.
https://doi.org/10.1182/blood-2007-10-114348
Published: 2008
Includes: Supplemental data
Journal Articles

The new tumor-suppressor gene inhibitor of growth family member 4 (ING4) regulates the production of proangiogenic molecules by myeloma cells and suppresses hypoxia-inducible factor-1 α (HIF-1α) activity: involvement in myeloma-induced angiogenesis

Simona Colla, Sara Tagliaferri, Francesca Morandi, Paolo Lunghi, Gaetano Donofrio, Davide Martorana, Cristina Mancini, Mirca Lazzaretti, Laura Mazzera, Lara Ravanetti, Sabrina Bonomini, Luca Ferrari, Claudia Miranda, Marco Ladetto, Tauro Maria Neri, Antonino Neri, Angela Greco, Marcellina Mangoni, Antonio Bonati, Vittorio Rizzoli, Nicola Giuliani
Journal: Blood
Blood (2007) 110 (13): 4464–4475.
https://doi.org/10.1182/blood-2007-02-074617
Published: 2007
Journal Articles

Targeting MEK/MAPK Signal Transduction Module Potentiates Arsenic Trioxide (ATO)-Induced Apoptosis in Multiple Myeloma Cells through Multiple Signaling Pathways.

Paolo Lunghi, Nicola Giuliani, Laura Mazzera, Francesca Morandi, Luigi Salvatore, Marcellina Mangoni, Vittorio Rizzoli, Antonio Bonati
Journal: Blood
Blood (2007) 110 (11): 1517.
https://doi.org/10.1182/blood.V110.11.1517.1517
Published: 2007
Journal Articles

MEK1 Blockade Sensitizes Multiple Myeloma Tumor Cells to Arsenic Trioxide (ATO)-Induced Apoptosis: A Functional and Molecular Study.

Paolo Lunghi, PhD, Nicola Giuliani, MD, Laura Mazzera, PhD, Francesca Morandi, PhD, Vittorio Rizzoli, MD, Antonio Bonati, MD
Journal: Blood
Blood (2006) 108 (11): 1372.
https://doi.org/10.1182/blood.V108.11.1372.1372
Published: 2006
Journal Articles

Mdm2 Inhibitor Nutlin-3 Enhances the Cytotoxic Synergism Induced by the Combination of MEK1 Inhibitor and Arsenic Trioxide (ATO) in AML Cells.

Paolo Lunghi, PhD, Laura Mazzera, PhD, Vittorio Rizzoli, MD, Antonio Bonati, MD
Journal: Blood
Blood (2006) 108 (11): 1364.
https://doi.org/10.1182/blood.V108.11.1364.1364
Published: 2006
Journal Articles

MEK1 inhibition sensitizes primary acute myelogenous leukemia to arsenic trioxide–induced apoptosis

Paolo Lunghi, Antonio Costanzo, Luigi Salvatore, Nelida Noguera, Laura Mazzera, Antonio Tabilio, Francesco Lo-Coco, Massimo Levrero, Antonio Bonati
Journal: Blood
Blood (2006) 107 (11): 4549–4553.
https://doi.org/10.1182/blood-2005-07-2829
Published: 2006