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Journal Articles

FLT3L-based conjugate targets chemoresistant leukemia stem cells via cell cycle re-entry in Acute Myeloid Leukemia

Dengyang Zhang, Yao Guo, Zhiyong Peng, Yan Xiao, Zhiguang Chang, Liuting Yu, Yuming Zhao, Qi Zhang, Lingling Ma, Shuping Li, Chi Kong Li, Kam Tong Leung, Zhizhuang Zhao, Chun Chen, Yun Chen

Blood (2025) 146 (Supplement 1): 319.

https://doi.org/10.1182/blood-2025-319

Published: 2025

Journal Articles

PTPN11 copy number gain drives leukemogenesis via mutant SHP2 in juvenile myelomonocytic leukemia

Zhiguang Chang, Zhiyong Peng, Lingling Ma, Yan Xiao, Yao Guo, Dengyang Zhang, Yuming Zhao, Liuting Yu, Junbin Huang, Hongman Xue, Chi Kong Li, Chun Chen, Zhizhuang Zhao, Yun Chen

Blood (2025) 146 (Supplement 1): 3234.

https://doi.org/10.1182/blood-2025-3234

Published: 2025

Journal Articles

Long-acting GM-CSF-based drug conjugate effectively targets leukemia stem cells in Acute Myeloid Leukemia with limited toxicity

Yan Xiao, Yao Guo, Dengyang Zhang, Zhiyong Peng, Yuming Zhao, Zhiguang Chang, Liuting Yu, Lingling Ma, Chi Kong Li, Zhizhuang Zhao, Chun Chen, Yun Chen

Blood (2025) 146 (Supplement 1): 752.

https://doi.org/10.1182/blood-2025-752

Published: 2025

Journal Articles

PI3Kδ inhibition enhances trametinib efficacy by suppressing feedback-activated PI3K/AKT signaling in PTPN11-mutant JMML

Yuming Zhao, Yao Guo, Zhiyong Peng, Tianqi Liang, Zhiguang Chang, Yan Xiao, Dengyang Zhang, Liuting Yu, Lingling Ma, Chi Kong Li, Zhizhuang Zhao, Chun Chen, Yun Chen

Blood (2025) 146 (Supplement 1): 5010.

https://doi.org/10.1182/blood-2025-5010

Published: 2025