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Journal Articles

Subclonal Complexity in Myeloid Malignancies and Mechanism of Selection and Resistance

Margaret Goodell, PhD

Blood (2020) 136 (Supplement 1): SCI5.

https://doi.org/10.1182/blood-2020-133074

Published: 2020

Journal Articles

Tet2 Deficiency Rejuvenates Hematopoietic Stem and Progenitor Cells during Ageing

Tingting Hong, Shengli Li, PhD, Shaohai Fang, MS, Anna Guzman, Wei Han, MS, Yubin Zhou, PhD, Leng Han, PhD, Margaret Goodell, PhD, Yun Huang, PhD

Blood (2020) 136 (Supplement 1): 37.

https://doi.org/10.1182/blood-2020-141705

Published: 2020

Journal Articles

A Combination Strategy Targeting Enhancer Plasticity Exerts Synergistic Lethality Against Beti-Resistant Leukemia Cells

Lei Guo, PhD, Jia Li, PhD, Hongxiang Zeng, PhD, Anna Guzman, Tingting Li, MD, Minjung Lee, MS, Yubin Zhou, PhD, Clifford Stephan, Peter J.A Davies, Margaret Goodell, PhD, Deqiang Sun, PhD, Mark A. Dawson, PhD MBBS, Yun Huang, PhD

Blood (2019) 134 (Supplement_1): 5053.

https://doi.org/10.1182/blood-2019-130586

Published: 2019

Journal Articles

Targeting Activated Signaling Pathways for the Treatment of IKZF1 -Deleted B Lymphoblastic Leukemia

Rohit Gupta, BA, Jason H. Rogers, MS, Xin Long, PhD, Geraldo Medrano, BS, Jaime M. Reyes, BS, Michele Redell, MD PhD, Zachary T Ball, PhD, Margaret Goodell, PhD, Rachel E. Rau, MD

Blood (2019) 134 (Supplement_1): 3789.

https://doi.org/10.1182/blood-2019-127209

Published: 2019

Journal Articles

A Novel Short Latency, High Penetrance Model of KRAS Mutation-Driven T-Cell Acute Lymphoblastic Leukemia

Jacob J. Junco, PhD, Vincent Ulysses Gant, PhD, Maci S. Terrell, BS, Matthew Benjamin Miller, MD, Chun Shik Park, PhD, Taylor J Chen, BS, H. Daniel Lacorazza, PhD, Margaret Goodell, PhD, Rachel E. Rau, MD, Karen R. Rabin, MD PhD

Blood (2019) 134 (Supplement_1): 3792.

https://doi.org/10.1182/blood-2019-126858

Published: 2019

Journal Articles

Single Cell Profiling of DNMT3A-Mutant Progenitors Reveals LY86 As a Novel Pre-Leukemia Marker and Potential Therapeutic Target

Mira Jeong, PhD, Sangbae Kim, PhD, Yumei Li, PhD, Rui Chen, PhD, Premal Lulla, MBBS, Margaret Goodell, PhD

Blood (2019) 134 (Supplement_1): 2724.

https://doi.org/10.1182/blood-2019-123597

Published: 2019

Journal Articles

Mosaic DNMT3A Germline Mutation As a Model for Mutant DNMT3A Competitive Advantage in the Blood Lineage

Ayala Tovy, PhD, Hyun Jung Park, PhD, Jaime M. Reyes, BS, Anna Guzman, Rachel E. Rau, MD, Aaron Jeffries, PhD, Mill Jonnathan, PhD, Emma Baple, PhD, Andrew Crosby, MD, Mia Petljak, Henry Lee-Six, PhD, Heng Wang, MD PhD, Xin Baozhong, MD PhD, Mathijs A. Sanders, PhD, Peter J. Campbell, PhD, Michael Stratton, Wei Li, Margaret Goodell, PhD

Blood (2018) 132 (Supplement 1): 173.

https://doi.org/10.1182/blood-2018-173

Published: 2018

Journal Articles

A Gene Depleted DNA Methylation Canyon Maintains Hematopoietic Stem Cell Self-Renewal and NPM1c+ Leukemia By Regulating the Gene Expression of HOXA Cluster

Xiaotian Zhang, PhDBS, Margaret Goodell, PhD, Mira Jeong, PhD, Haley Gore, Wanding Zhou

Blood (2018) 132 (Supplement 1): 649.

https://doi.org/10.1182/blood-2018-99-112962

Published: 2018

Journal Articles

High Prevalence of PPM1D Mutations in Therapy-Related AML/MDS Is Due to Context-Specific Clonal Hematopoiesis

Joanne Hsu, BS, Tajhal Dayaram, Ayala Tovy, PhD, Etienne De Braekeleer, PhD MSc, Mira Jeong, PhD, Jason H. Rogers, MS, Feng Wang, PhD, Jianhua Zhang, PhD, Guillermo Garcia-Manero, MD, Hagop M. Kantarjian, MD, George S. Vassiliou, Andrew Futreal, PhD, Lawrence Donehower, Koichi Takahashi, MD, Margaret Goodell, PhD

Blood (2018) 132 (Supplement 1): 746.

https://doi.org/10.1182/blood-2018-99-115007

Published: 2018

Journal Articles

Loss of De Novo DNA Methyltransferase DNMT3A Impacts Alternative Splicing in Hematopoietic Stem Cells

Raghav Ramabadran, BS, Jarey Wang, Anna Guzman, Sean Michael Cullen, MD PhD, Lorenzo Brunetti, MD, Michael Gundry, Sunny Chan, PhD, Michael Kyba, PhD, Thomas Westbrook, PhD, Margaret Goodell, PhD

Blood (2017) 130 (Supplement 1): 1.

https://doi.org/10.1182/blood.V130.Suppl_1.1.1

Published: 2017

Journal Articles

Novel Roles of Separase in Hematopoiesis

Samridhdi Paudyal, PhD, Praveen Kumar, PhD, Nakamura Lanelle, MDPhD, Mira Jeong, PhD, Jessica Tao Li, PhD, Nenggang Zhang, PhD, Margaret Goodell, PhD, Debananda Pati, PhD

Blood (2017) 130 (Supplement 1): 3768.

https://doi.org/10.1182/blood.V130.Suppl_1.3768.3768

Published: 2017

Journal Articles

Acute Myeloid Leukemia with Mutated NPM1 Is Dependent on the Cytoplasmic Localization of NPM1c

Lorenzo Brunetti, MD, Michael Gundry, Anna Guzman, Ilaria Gionfriddo, PhD, Federica Mezzasoma, PhD, Francesca Milano, PhD, Maria Paola Martelli, MD PhD, Brunangelo Falini, MD, Margaret Goodell, PhD

Blood (2017) 130 (Supplement 1): 877.

https://doi.org/10.1182/blood.V130.Suppl_1.877.877

Published: 2017

Journal Articles

High Order Chromatin Structure Regulates Gene Expression in Hematopoietic Stem Cell Self-Renewal and Erythroid Differentiation

Xiaotian Zhang, BS, Mira Jeong, PhD, Ivan Bochkov, Muhammad Saad Shamim, Erez Lieberman Aiden, Margaret Goodell, PhD

Blood (2016) 128 (22): 1033.

https://doi.org/10.1182/blood.V128.22.1033.1033

Published: 2016

Journal Articles

Two-Pronged Cell Therapy for B-Cell Malignancies: Engineering NK Cells to Target CD22 and Redirect Bystander T Cells to CD19

Mireya Paulina Velasquez, MD, Arpad Szoor, MD PhD, Challice L. Bonifant, MD PhD, Abishek Vaidya, Lorenzo Brunetti, MD, Michael C Gundry, BS, Robin Parihar, MD PhD, Margaret Goodell, PhD, Stephen Gottschalk, MD

Blood (2016) 128 (22): 4560.

https://doi.org/10.1182/blood.V128.22.4560.4560

Published: 2016

Journal Articles

Fast and Efficient Gene Editing in Human Hematopoietic Cells

Michael C Gundry, BS, Lorenzo Brunetti, MD, Dimitrios Laurin Wagner, Joanne Hsu, BS, Mireya Paulina Velasquez, MD, Stephen Gottschalk, MD, Cliona M. Rooney, PhD, Margaret Goodell, PhD

Blood (2016) 128 (22): 4704.

https://doi.org/10.1182/blood.V128.22.4704.4704

Published: 2016

Journal Articles

Overexpression of the TGF-Beta Modulator . Bambi Promotes Hematopoetic Stem Cell Proliferation.

Rui Mao, Olga Sirin, BS/MS, Margaret Goodell, PhD

Blood (2009) 114 (22): 1446.

https://doi.org/10.1182/blood.V114.22.1446.1446

Published: 2009

Journal Articles

TIMP-1 Deficiency Subverts Cell Cycle Dynamics in Long-Term HSCs.

Lara Rossi, PhD, Margaret Goodell, PhD

Blood (2009) 114 (22): 2514.

https://doi.org/10.1182/blood.V114.22.2514.2514

Published: 2009

Journal Articles

Lyl1 and Scl Regulate Bcl2 Expression and Control Apoptosis at Different Stages of Hematopoietic Development.

George Souroullas, PhD, Candidate, Margaret Goodell, PhD

Blood (2009) 114 (22): 569.

https://doi.org/10.1182/blood.V114.22.569.569

Published: 2009

Journal Articles

Lyl1 and Scl Dosage Is Critical for Adult Hematopoietic Stem Cell Function and Survival

George Souroullas, Jessica Salmon, David J. Curtis, MD, PhD, Margaret Goodell, PhD

Blood (2008) 112 (11): 281.

https://doi.org/10.1182/blood.V112.11.281.281

Published: 2008

Journal Articles

Immune Responses Are Induced Against Side-Population B-CLL “Stem Cells ” by Patient Vaccination with hCD40L/IL2 Gene Modified Tumor Cells.

Aaron E. Foster, PhD, Gianpietro Dotti, MD, An Lu, Michael Andreeff, MD, Margaret Goodell, PhD, Cliona M. Rooney, PhD, Malcolm K. Brenner, MD

Blood (2006) 108 (11): 2552.

https://doi.org/10.1182/blood.V108.11.2552.2552

Published: 2006

NARROW

Subclonal Complexity in Myeloid Malignancies and Mechanism of Selection and Resistance

Tet2 Deficiency Rejuvenates Hematopoietic Stem and Progenitor Cells during Ageing

A Combination Strategy Targeting Enhancer Plasticity Exerts Synergistic Lethality Against Beti-Resistant Leukemia Cells

Targeting Activated Signaling Pathways for the Treatment of IKZF1 -Deleted B Lymphoblastic Leukemia

A Novel Short Latency, High Penetrance Model of KRAS Mutation-Driven T-Cell Acute Lymphoblastic Leukemia

Single Cell Profiling of DNMT3A-Mutant Progenitors Reveals LY86 As a Novel Pre-Leukemia Marker and Potential Therapeutic Target

Mosaic DNMT3A Germline Mutation As a Model for Mutant DNMT3A Competitive Advantage in the Blood Lineage

A Gene Depleted DNA Methylation Canyon Maintains Hematopoietic Stem Cell Self-Renewal and NPM1c+ Leukemia By Regulating the Gene Expression of HOXA Cluster

High Prevalence of PPM1D Mutations in Therapy-Related AML/MDS Is Due to Context-Specific Clonal Hematopoiesis

Loss of De Novo DNA Methyltransferase DNMT3A Impacts Alternative Splicing in Hematopoietic Stem Cells

Novel Roles of Separase in Hematopoiesis

Acute Myeloid Leukemia with Mutated NPM1 Is Dependent on the Cytoplasmic Localization of NPM1c

High Order Chromatin Structure Regulates Gene Expression in Hematopoietic Stem Cell Self-Renewal and Erythroid Differentiation

Two-Pronged Cell Therapy for B-Cell Malignancies: Engineering NK Cells to Target CD22 and Redirect Bystander T Cells to CD19

Fast and Efficient Gene Editing in Human Hematopoietic Cells

Overexpression of the TGF-Beta Modulator . Bambi Promotes Hematopoetic Stem Cell Proliferation.

TIMP-1 Deficiency Subverts Cell Cycle Dynamics in Long-Term HSCs.

Lyl1 and Scl Regulate Bcl2 Expression and Control Apoptosis at Different Stages of Hematopoietic Development.

Lyl1 and Scl Dosage Is Critical for Adult Hematopoietic Stem Cell Function and Survival

Immune Responses Are Induced Against Side-Population B-CLL “Stem Cells ” by Patient Vaccination with hCD40L/IL2 Gene Modified Tumor Cells.

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ASH Publications

American Society of Hematology

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ASH Publications

American Society of Hematology

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