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Journal Articles

Fetal Hemoglobin Induction in Baboons (P. Anubis) Following Admistration of a Novel Decitabine Dinucleotide (S110) Compound.

Donald Lavelle, PhD, Kestis Vaitkus, B.S., Virryan Banzon, M.S., Maria Hankewych, B.S., Pasit Phiasivongsva, Ph.D., Sanjeev Redkar, Ph.D., Sarath Kanekal, Ph.D., David Bearss, Ph.D., Chongtie Shi, Ph.D., Roger Inloes, Ph.D., Joseph DeSimone, Ph.D.

Blood (2007) 110 (11): 571.

https://doi.org/10.1182/blood.V110.11.571.571

Published: 2007

Journal Articles

Expression of γ-Globin Is Reactivated by a Novel Mechanism in Baboon CD34+ Erythroid Progenitor Cell Cultures.

Donald Lavelle, PhD, Janet Chin, M.D., Mahipal Singh, Ph.D., Kestis Vaitkus, B.S., Virryan Banzon, M.S., Tatiana Kousnetzova, M.S., Maria Hankewych, B.S., Joseph DeSimone, Ph.D.

Blood (2007) 110 (11): 1768.

https://doi.org/10.1182/blood.V110.11.1768.1768

Published: 2007

Journal Articles

RNAi Targeting MBD2 Increases γ-Globin Expression in a CID-Dependent Human β-YAC Murine Fetal Bone Marrow Cell Line.

Virryan Banzon, MS, Tatiana Kousnetzova, M.S., Maria Hankewych, B.S., Kenneth Peterson, Ph.D., Joseph DeSimone, Ph.D., Donald Lavelle, Ph.D.

Blood (2007) 110 (11): 1769.

https://doi.org/10.1182/blood.V110.11.1769.1769

Published: 2007

Journal Articles

Exportin 4, a Potential Amplifier of TGF-β Signaling, Is Increased in Primary Baboon Bone Marrow Erythroblasts Following Decitabine Treatment.

Donald Lavelle, PhD, Tatiana Kouznetsova, M.S., Kestis Vaitkus, Peter Larsen, M.S., Maria Hankewych, B.S., Joseph DeSimone, Ph.D.

Blood (2006) 108 (11): 1582.

https://doi.org/10.1182/blood.V108.11.1582.1582

Published: 2006

Journal Articles

Differences in the Pattern of Histone H3 (K4) and (K27) Methylation throughout the β-Globin Gene Locus in Baboon Fetal Liver and Adult Bone Marrow Erythroblasts Pre- and Post-Decitabine Treatment.

Janet Chin, MD, Donald Lavelle, PhD, Kestis Vaitkus, Maria Hankewych, B.S., Joseph DeSimone, Ph.D.

Blood (2006) 108 (11): 1584.

https://doi.org/10.1182/blood.V108.11.1584.1584

Published: 2006

Journal Articles

Recapitulation of the Fetal Pattern of Expression of the Iγ and Vγ-Globin Genes in Cultured Baboon CD34+ Bone Marrow Cells.

Donald Lavelle, PhD, Kestis Vaitkus, Mahipal Singh, Ph.D., Maria Hankewych, B.S., Joseph DeSimone, Ph.D.

Blood (2006) 108 (11): 1590.

https://doi.org/10.1182/blood.V108.11.1590.1590

Published: 2006

Journal Articles

Oral Administration of Dacogen Mesylate Increases HbF and Decreases DNA Methylation of the ε- and γ-Globin Genes in Anemic Baboons ( Papio anubis ).

Donald Lavelle, PhD, Kestis Vaitkus, DVM, Janet Chin, MD, Sanjeev Redkar, PhD, Pasit Phiasivongsa, PhD, Maria Hankewych, BS, Joseph DeSimone, PhD

Blood (2005) 106 (11): 3645.

https://doi.org/10.1182/blood.V106.11.3645.3645

Published: 2005

Journal Articles

Epigenetic Changes in the γ-Globin Gene Promoter in Hematopoietic Progenitor Cells at Different Stages of Differentiation.

Mahipal Singh, PhD, Kestas Vaitkus, DVM, Maria Hankewych, BS, Donald Lavelle, PhD, Nadim Mahmud, MD, PhD, Joseph DeSimone, PhD

Blood (2005) 106 (11): 1742.

https://doi.org/10.1182/blood.V106.11.1742.1742

Published: 2005

Journal Articles

Subdomains of the Baboon ( P. anubis ) β-Globin Gene Cluster Are Differentially Sensitive to Dacogen Treatment.

Janet Chin, MD, Donald Lavelle, PhD, Bryan Roxas, BS, Kestis Vaitkus, DVM, Maria Hankewych, BS, Joseph DeSimone, PhD

Blood (2005) 106 (11): 525.

https://doi.org/10.1182/blood.V106.11.525.525

Published: 2005

Journal Articles

Changes in Globin Gene Methylation and Covalent Histone Modifications of Chromatin Associated with the ε-, γ-, and β-Globin Promoters of the Baboon (P. Anubis) during Development.

Donald Lavelle, Ph.D., Kestas Vaitkus, D.V.M., Maria Hankewych, B.S., Mahipal Singh, Ph.D., Joseph DeSimone, Ph.D.

Blood (2004) 104 (11): 1206.

https://doi.org/10.1182/blood.V104.11.1206.1206

Published: 2004

Journal Articles

The Effect of Decitabine on Covalent Histone Modifications of Chromatin Associated with the ε-,γ -, and β-Globin Gene Promoters in the Baboon (P. anubis).

Donald Lavelle, Ph.D., Kestas Vaitkus, D.V.M., Maria Hankewych, B.S., Mahipal Singh, Ph.D., Joseph DeSimone, Ph.D.

Blood (2004) 104 (11): 378.

https://doi.org/10.1182/blood.V104.11.378.378

Published: 2004

Journal Articles

Polymorphic Pvu II Sites in the Stage-Selector Elements of the Baboon (P. anubis) γ-Globin Gene Promoter May Determine HbF Levels by Reducing DNA Methylation Density.

Donald Lavelle, Ph.D., Mahipal Singh, Ph.D., Kestas Vaitkus, D.V.M., Maria Hankewych, B.S., Lauren Wilson, Joseph DeSimone, Ph.D.

Blood (2004) 104 (11): 1211.

https://doi.org/10.1182/blood.V104.11.1211.1211

Published: 2004

Journal Articles

Growth Inhibition of a Human Myeloma Cell Line by All -trans Retinoic Acid Is Not Mediated Through Downregulation of Interleukin-6 Receptors but Through Upregulation of p21 WAF1

Yi-Hsiang Chen, Donald Lavelle, Joseph DeSimone, Shahab Uddin, Leonidas C. Platanias, Maria Hankewych

Blood (1999) 94 (1): 251–259.

https://doi.org/10.1182/blood.V94.1.251.413k42_251_259

Published: 1999

NARROW

Fetal Hemoglobin Induction in Baboons (P. Anubis) Following Admistration of a Novel Decitabine Dinucleotide (S110) Compound.

Expression of γ-Globin Is Reactivated by a Novel Mechanism in Baboon CD34+ Erythroid Progenitor Cell Cultures.

RNAi Targeting MBD2 Increases γ-Globin Expression in a CID-Dependent Human β-YAC Murine Fetal Bone Marrow Cell Line.

Exportin 4, a Potential Amplifier of TGF-β Signaling, Is Increased in Primary Baboon Bone Marrow Erythroblasts Following Decitabine Treatment.

Differences in the Pattern of Histone H3 (K4) and (K27) Methylation throughout the β-Globin Gene Locus in Baboon Fetal Liver and Adult Bone Marrow Erythroblasts Pre- and Post-Decitabine Treatment.

Recapitulation of the Fetal Pattern of Expression of the Iγ and Vγ-Globin Genes in Cultured Baboon CD34+ Bone Marrow Cells.

Oral Administration of Dacogen Mesylate Increases HbF and Decreases DNA Methylation of the ε- and γ-Globin Genes in Anemic Baboons ( Papio anubis ).

Epigenetic Changes in the γ-Globin Gene Promoter in Hematopoietic Progenitor Cells at Different Stages of Differentiation.

Subdomains of the Baboon ( P. anubis ) β-Globin Gene Cluster Are Differentially Sensitive to Dacogen Treatment.

Changes in Globin Gene Methylation and Covalent Histone Modifications of Chromatin Associated with the ε-, γ-, and β-Globin Promoters of the Baboon (P. Anubis) during Development.

The Effect of Decitabine on Covalent Histone Modifications of Chromatin Associated with the ε-,γ -, and β-Globin Gene Promoters in the Baboon (P. anubis).

Polymorphic Pvu II Sites in the Stage-Selector Elements of the Baboon (P. anubis) γ-Globin Gene Promoter May Determine HbF Levels by Reducing DNA Methylation Density.

Growth Inhibition of a Human Myeloma Cell Line by All -trans Retinoic Acid Is Not Mediated Through Downregulation of Interleukin-6 Receptors but Through Upregulation of p21 WAF1

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American Society of Hematology

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American Society of Hematology

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