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Journal Articles

Hnrnpk Overexpression Drives Nucleolar Aberrancies Causing Ribosomopathies

Pedro Aguilar-Garrido, Maria Velasco-Estevez, Miguel Ángel Navarro-Aguadero, María Hernández-Sánchez, Marta Ibáñez-Navarro, Prerna Malaney, Marisa Aitken, Xiaorui Zhang, Adrián Fernández, Alejandra Ortiz-Ruiz, Álvaro Otero-Sobrino, Diego Megías, Manuel Pérez, Jesús Gómez, Gadea Mata, Orlando Domínguez, Osvaldo Graña, Pilar Ximénez, Marta Isasa, Paloma Jimena-de Andrés, Sandra Rodríguez, Raúl Torres, Miguel Lafarga, Oleksandra Sirozh, Vanesa Lafarga, Joaquin Martinez-Lopez, Sean M. Post, Miguel Gallardo
Journal: Blood
Blood (2023) 142 (Supplement 1): 5659.
https://doi.org/10.1182/blood-2023-178022
Published: 2023
Journal Articles

TRAF3 Alterations Identify a Subgroup of Patients with Adverse Clinical Outcome and Induce Metabolic Reprogramming in Chronic Lymphocytic Leukemia

Claudia Pérez Carretero, Miguel Quijada Álamo, Mariana Tannoury, Léa Dehgane, David J. Sanz, Teresa González, Rocio Benito, Elise Chapiro, Maria Hernandez-Sanchez, Ana E. Rodriguez, Florence Nguyen Khac, Santos A. Susin, Jesús María Hernández-Rivas
Journal: Blood
Blood (2022) 140 (Supplement 1): 4105–4106.
https://doi.org/10.1182/blood-2022-168861
Published: 2022
Journal Articles

Survival Analysis According to the Standardized Phase Angle Measured By Bioimpedanciometry to Estimate Body Composition in Patients with Hematological Malignancies during Nutritional Screening at Hospital Admission

Agustín María Hernández Sanchez, Lara Dalla Rovere, Rahinatu Awol, Rocio Fernández-Jiménez, Antonio González - Fernández, Raul Cordoba
Journal: Blood
Blood (2022) 140 (Supplement 1): 13262–13263.
https://doi.org/10.1182/blood-2022-163121
Published: 2022
Journal Articles

Different Prognostic Impact of Recurrent Gene Mutations in IGHV-Mutated and IGHV-Unmutated Chronic Lymphocytic Leukemia: A Retrospective, Multi-Center Cohort Study By Eric, the European Research Initiative on CLL, in Harmony

Larry Mansouri, Birna Thorvaldsdottir, Lesley-Ann Sutton, Manja Meggendorfer, Ferran Nadeu, Christian Brieghel, Helen Parker, Stamatia Laidou, Riccardo Moia, Davide Rossi, Mark Catherwood, Jana Kotaskova, Julio Delgado, Ana E Rodríguez-Vicente, Rocio Benito, Gian Matteo Rigolin, Silvia Bonfiglio, Lydia Scarfo, Mattias Mattsson, Zadie Davis, Ajay Gogia, Lata Rani, Panagiotis Baliakas, Cecilia Jylhä, Aron Skaftason, Inmaculada Rapado, Fatima Miras, Joaquin Martinez-Lopez, Javier de la Serna, Jesús M Hernández Rivas, Patrick Thornton, Maria Jose Larrayoz, María José Calasanz, Zoltán Mátrai, Csaba Bodor, Karin E. Smedby, Blanca Espinet, Anna Puiggros, Ritu Gupta, Lars Bullinger, Francesc Bosch, Bárbara Tazón, Fanny Baran-Marszak, David Oscier, Florence Nguyen-Khac, Thorsten Zenz, María José Terol, Antonio Cuneo, María Hernández-Sánchez, Sarka Pospisilova, Ken I Mills, Gianluca Gaidano, Carsten Utoft Niemann, Elías Campo, Jonathan C Strefford, Paolo Ghia, Kostas Stamatopoulos, Richard Rosenquist
Journal: Blood
Blood (2021) 138 (Supplement 1): 2617.
https://doi.org/10.1182/blood-2021-150648
Published: 2021
Journal Articles

Dissecting Richter's Syndrome in a Multiplexed CRISPR-Based Mouse Model Reveals Key Changes in MYC, Interferon and BCR Signaling Underlying Transformation

Elisa Ten Hacken, Shanye Yin, Tomasz Sewastianik, Livius Penter, Neil Ruthen, Michaela Gruber, Erin Michelle Parry, Romain Guieze, Robert A. Redd, Mohamed Uduman, Shuqiang Li, Jackson Southard, Maria Hernandez-Sanchez, Salma Parvin, Fen Zhu, Gabriela Brunsting Hoffmann, Elizabeth Witten, Kenneth J. Livak, Matthew S. Davids, Anthony G. Letai, Donna S. Neuberg, Ruben D. Carrasco, Catherine J. Wu
Journal: Blood
Blood (2021) 138 (Supplement 1): 251.
https://doi.org/10.1182/blood-2021-148614
Published: 2021
Journal Articles

RPS15 and TP53 Co-Mutation Drives B Cell Malignancy through Altered Translation and MYC Activation in a Murine Model

Catherine Gutierrez, Tamara Ouspenskaia, PhD, Doris Fu, Peyton Waddicor, B.S., Anat Biran, PhD, Aviv Liani, Gregory Lazarian, PharmD, Elisa Ten Hacken, PhD, Elizabeth Witten, Fara Faye Regis, BS, Heather Joyal, Leah Billington, BA, Fabienne Lucas, MDPhD, Mei Zheng, Blake Tye, PhD, Maria Hernandez-Sanchez, PhD, Miguel Quijada Álamo, MSc, Shuqiang Li, PhD, Binyamin A. Knisbacher, PhD, Ziao Lin, BS, Aziz Al'Khafaji, PhD, Lili Wang, MDPhD, Kenneth J. Livak, PhD, Donna S. Neuberg, ScD, Florence Cymbalista, MD PhD, Gad Getz, PhD, Stirling Churchman, PhD, Ruben D. Carrasco, MD PhD, Sichen Shao, PhD, Aviv Regev, PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 28–29.
https://doi.org/10.1182/blood-2020-138900
Published: 2020
Journal Articles

Biological Impact of Monoallelic and Biallelic BIRC3 Loss in Del(11q) Chronic Lymphocytic Leukemia Progression

Miguel Quijada Álamo, MSc, Maria Hernandez-Sanchez, PhD, Ana E. Rodriguez, PhD, Claudia Pérez Carretero, MSc, BSc, Marta Martín Izquierdo, MSc, Verónica Alonso Pérez, PhD, Ignacio García-Tuñón, PhD, Jose Maria Bastida, MDPhD, Maria Jesus Vidal, MD, Josefina Galende DEL Canto, MD, Carlos Aguilar, MD, José Antonio Queizán, MD, Isabel González-Gascón Y Marín, MD PhD, Jose-Angel Hernandez, MD PhD, Rocio Benito, PhD, José Luis Ordóñez, PhD, Jesus Maria Hernández-Rivas, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 4.
https://doi.org/10.1182/blood-2020-142658
Published: 2020
Journal Articles

Multiplexed CRISPR In Vivo Editing of CLL Loss-of-Function Lesions Models Transformation of Chronic Lymphocytic Leukemia into Richter's Syndrome

Elisa Ten Hacken, PhD, Tomasz Sewastianik, PhD, Robert A. Redd, MS, Geoffrey Fell, MS, Mohamed Uduman, PhD, Michaela Gruber, MD PhD, Shanye Yin, PhD, Kendell Clement, PhD, Erin Michelle Parry, MD PhD, Shuqiang Li, PhD, Maria Hernandez-Sanchez, PhD, Leah Billington, BA, Elizabeth Witten, Kaitlyn J Baranowski, Lili Wang, MDPhD, Luca Pinello, PhD, Kenneth J. Livak, PhD, Donna S. Neuberg, ScD, Ruben D. Carrasco, MD PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 2–3.
https://doi.org/10.1182/blood-2020-137130
Published: 2020
Journal Articles

Clinical and Biological Impact of TP53 Alterations in Del(11q) Chronic Lymphocytic Leukemia

Claudia Pérez Carretero, MSc, BSc, Miguel Quijada Álamo, MSc, Maria Hernandez-Sanchez, PhD, Ana E. Rodriguez, PhD, Ana B Herrero, PhD, Jesus M Hernández-Sánchez, PhD, Marta Martín Izquierdo, MSc, Teresa González, PhD, Sandra Santos-Mínguez, Cristina Miguel-García, Araceli Rubio-Martínez, Alfonso García de Coca, MD PhD, Julio Dávila, Jose-Angel Hernandez, MD PhD, Rocio Benito, PhD, José Luis Ordóñez, PhD, Jesus Maria Hernández-Rivas, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 6–7.
https://doi.org/10.1182/blood-2020-141015
Published: 2020
Journal Articles

Interrogation of Individual CLL Loss-of-Function Lesions By CRISPR In Vivo Editing Reveals Common and Unique Pathway Alterations

Elisa Ten Hacken, PhD, Shanye Yin, PhD, Kendell Clement, PhD, Robert A. Redd, MS, Maria Hernandez-Sanchez, PhD, Shuqiang Li, PhD, Michaela Gruber, MD PhD, Heather Joyal, Geoffrey Fell, MS, Shu Wang, Jose Jacob, James Flynn, David Ruff, Keith W. Jones, Lili Wang, MD PhD, Donna S Neuberg, ScD, Luca Pinello, PhD, Kenneth J. Livak, PhD, Ruben D. Carrasco, MD PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 684.
https://doi.org/10.1182/blood-2019-127673
Published: 2019
Journal Articles

MCL-1 and PKA/AMPK Axis Fuel Venetoclax Resistance in Lymphoid Cancers

Vivian M. Liu, MD, Romain Guièze, MD, Daniel Rosebrock, Alexis A Jourdain, PhD, María Hernández-Sánchez, PhD, Aina Zurita Martinez, Elisa Ten Hacken, PhD, Philip A. Thompson, MBBS, Julian Bryan Iorgulescu, MD PhD, Shuqiang Li, PhD, Matthew S. Davids, MD, Jennifer R. Brown, MD PhD, Ana Lako, Zoe B. Ciantra, Matthew A. Lawlor, William G. Wierda, MD PhD, Anthony G. Letai, MD PhD, Donna S Neuberg, ScD, Christopher J. Ott, PhD, Ignaty Leshchiner, PhD, Vamsi Mootha, MD, Gad Getz, PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1284.
https://doi.org/10.1182/blood-2019-131336
Published: 2019
Journal Articles

Chronic Lymphocytic Leukemia Patients with IGH Rearrangements Are Characterized By a Distinct Genetic Landscape with Prognostic Implications

Claudia Pérez Carretero, MSc, BSc, Maria Hernandez-Sanchez, Teresa Gonzalez, Miguel Quijada Álamo, BSc, MSc, Marta Martín Izquierdo, MSc, Jesus M Hernández-Sánchez, MSc, Sandra Santos-Mínguez, María-Jesús Vidal, Alfonso García de Coca, MD PhD, Carlos Aguilar, Manuel Vargas-Pabón, Sara Alonso, MD, Magdalena Sierra, Araceli Rubio-Martínez, Julio Dávila, José R Díaz-Valdés, Jose Antonio Queizan, Jose Angel Hernandez-Rivas, MD, Maria-Victoria Mateos, MD PhD, Rocio Benito, PhD, Ana E. Rodriguez, PhD, Jesús-María Hernández-Rivas, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3129.
https://doi.org/10.1182/blood-2018-99-115959
Published: 2018
Journal Articles

Genetic Determinants of Venetoclax Resistance in Lymphoid Malignancies

Romain Guieze, MD, Vivian M Liu, Daniel Rosebrock, Alexis Jourdain, PhD, María Hernández-Sánchez, PhD, Aina zurita Martinez, Sun Jing, PhD, Kaitlyn J Baranowski, Philip A. Thompson, MBBS, Heo Jin-Mi, PhD, Zacchary Cartun, Ozan Aygun, PhD, Giulia Notarangelo, Dimitri Livitz, BS, Shuqiang Li, PhD, Matthew S. Davids, MD, Jennifer R. Brown, MD PhD, William G. Wierda, MD PhD, Anthony Letai, MD PhD, Donna S Neuberg, ScD, Wade Harper, PhD, Steven A. Carr, PhD, Federica Piccioni, PhD, Christopher J. Ott, PhD, Ignaty Leshchiner, PhD, Cory Johannessen, PhD, John G Doench, PhD, Vamsi Mootha, MD PhD, Gad Getz, PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 893.
https://doi.org/10.1182/blood-2018-99-118604
Published: 2018
Journal Articles

CRISPR/Cas9-Generated Models Uncover Therapeutic Vulnerabilities of Del(11q) Chronic Lymphocytic Leukemia Cells to Dual BCR and PARP Inhibition

Miguel Quijada Álamo, BSc, MSc, María Hernández-Sánchez, PhD, José Luis Ordóñez, PhD, Verónica Alonso Pérez, PhD, Ana E. Rodriguez, PhD, Ignacio García-Tuñón, PhD, Ana B Herrero, PhD, Laura San-Segundo, Michaela Gruber, MD PhD, Juan Luis García, PhD, Rocio Benito, PhD, Catherine J. Wu, MD, Jesús-María Hernández-Rivas, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 948.
https://doi.org/10.1182/blood-2018-99-116080
Published: 2018
Journal Articles

Patterns of Clonal Evolution Assessed By Whole Exome Sequencing during Progression from MDS to AML Are Related to Therapy

María Abáigar, PhD, Jesús M Hernández-Sánchez, David Tamborero, PhD, Marta Martín-Izquierdo, María Díez-Campelo, MD, María Hernández-Sánchez, Fernando Ramos, MD, Marta Megido, Carlos Aguilar, Eva Lumbreras, Isabel Recio, Carmen Olivier, Cristina Robledo, Rocío Benito, PhD, Nuria Lopez-Bigas, Consuelo Del Cañizo, MD PhD, Jesús María Hernández-Rivas, MD
Journal: Blood
Blood (2016) 128 (22): 4309.
https://doi.org/10.1182/blood.V128.22.4309.4309
Published: 2016
Journal Articles

Analysis of Clonal Evolution in Chronic Lymphocytic Leukemia from Inactive to Symptomatic Disease Prior Treatment Using Whole-Exome Sequencing

María Hernández-Sánchez, Lenka Radova, PhD, Jana Kotaskova, David Tamborero, PhD, Ana E Rodriguez, PhD, Karla Plevova, PhD, María Abáigar, PhD, Vasileios Bikos, Rocío Benito, PhD, Sylvia Takacova, PhD, Miguel Quijada, Ana África Martín, MD, Miguel Alcoceba, BSc, PhD, Alfonso García de Coca, Michael Doubek, Marcos González, MD PhD, Nuria Lopez-Bigas, PhD, Sarka Pospisilova, Jesús María Hernández-Rivas, MD
Journal: Blood
Blood (2016) 128 (22): 3206.
https://doi.org/10.1182/blood.V128.22.3206.3206
Published: 2016