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Michaela Gruber
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Journal Articles

Dissecting Richter's Syndrome in a Multiplexed CRISPR-Based Mouse Model Reveals Key Changes in MYC, Interferon and BCR Signaling Underlying Transformation

Elisa Ten Hacken, Shanye Yin, Tomasz Sewastianik, Livius Penter, Neil Ruthen, Michaela Gruber, Erin Michelle Parry, Romain Guieze, Robert A. Redd, Mohamed Uduman, Shuqiang Li, Jackson Southard, Maria Hernandez-Sanchez, Salma Parvin, Fen Zhu, Gabriela Brunsting Hoffmann, Elizabeth Witten, Kenneth J. Livak, Matthew S. Davids, Anthony G. Letai, Donna S. Neuberg, Ruben D. Carrasco, Catherine J. Wu
Journal: Blood
Blood (2021) 138 (Supplement 1): 251.
https://doi.org/10.1182/blood-2021-148614
Published: 2021
Journal Articles

Multiplexed CRISPR In Vivo Editing of CLL Loss-of-Function Lesions Models Transformation of Chronic Lymphocytic Leukemia into Richter's Syndrome

Elisa Ten Hacken, PhD, Tomasz Sewastianik, PhD, Robert A. Redd, MS, Geoffrey Fell, MS, Mohamed Uduman, PhD, Michaela Gruber, MD PhD, Shanye Yin, PhD, Kendell Clement, PhD, Erin Michelle Parry, MD PhD, Shuqiang Li, PhD, Maria Hernandez-Sanchez, PhD, Leah Billington, BA, Elizabeth Witten, Kaitlyn J Baranowski, Lili Wang, MDPhD, Luca Pinello, PhD, Kenneth J. Livak, PhD, Donna S. Neuberg, ScD, Ruben D. Carrasco, MD PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 2–3.
https://doi.org/10.1182/blood-2020-137130
Published: 2020
Journal Articles

Interrogation of Individual CLL Loss-of-Function Lesions By CRISPR In Vivo Editing Reveals Common and Unique Pathway Alterations

Elisa Ten Hacken, PhD, Shanye Yin, PhD, Kendell Clement, PhD, Robert A. Redd, MS, Maria Hernandez-Sanchez, PhD, Shuqiang Li, PhD, Michaela Gruber, MD PhD, Heather Joyal, Geoffrey Fell, MS, Shu Wang, Jose Jacob, James Flynn, David Ruff, Keith W. Jones, Lili Wang, MD PhD, Donna S Neuberg, ScD, Luca Pinello, PhD, Kenneth J. Livak, PhD, Ruben D. Carrasco, MD PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 684.
https://doi.org/10.1182/blood-2019-127673
Published: 2019
Journal Articles

CRISPR/Cas9-Generated Models Uncover Therapeutic Vulnerabilities of Del(11q) Chronic Lymphocytic Leukemia Cells to Dual BCR and PARP Inhibition

Miguel Quijada Álamo, BSc, MSc, María Hernández-Sánchez, PhD, José Luis Ordóñez, PhD, Verónica Alonso Pérez, PhD, Ana E. Rodriguez, PhD, Ignacio García-Tuñón, PhD, Ana B Herrero, PhD, Laura San-Segundo, Michaela Gruber, MD PhD, Juan Luis García, PhD, Rocio Benito, PhD, Catherine J. Wu, MD, Jesús-María Hernández-Rivas, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 948.
https://doi.org/10.1182/blood-2018-99-116080
Published: 2018
Journal Articles

Splicing Modulation Perturbs Key Survival Pathways and Sensitizes Chronic Lymphocytic Leukemia to Venetoclax Treatment

Elisa Ten Hacken, PhD, Rebecca Valentin, MD, Jing Sun, PhD, Jing Deng, PhD, Angela Brooks, PhD, Lillian Werner, MS, Fara Faye Regis, BS, Michaela Gruber, MD PhD, Jessica Wong, BS, Zachary Cartun, BS, Michael Seiler, PhD, Peter Smith, PhD, Michael Thomas, PhD, Silvia Buonamici, PhD, Emanuela M. Ghia, PhD, Ekaterina Kim, PhD, Laura Z. Rassenti, PhD, Jan A. Burger, MD PhD, Thomas J. Kipps, MD, Matthew Meyerson, MDPhD, Donna S. Neuberg, ScD, Ruben D. Carrasco, MD PhD, Lili Wang, MD PhD, Matthew S. Davids, MD, Anthony Letai, MD PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 264.
https://doi.org/10.1182/blood.V130.Suppl_1.264.264
Published: 2017
Journal Articles

Integrated ATAC-Seq and Chemosensitivity Profiling Identifies Rational Drug Combinations in Ibrutinib-Treated CLL Patients

Gregory Ian Vladimer, PhD, Christian Schmidl, PhD, Andre Renderio, MS, Susanne Schnabl, MS, Tea Pemovska, PhD, Berend Snijder, PhD, Thomas Krausgruber, PhD, Nikolaus Krall, PhD, Mohammad Araghi, Rainer Hubmann, Anna Ringler, Dita Demirtas, Oscar Lopez de la Fuente, BSc, Martin Hilgrath, Cathrin Skrabs, MD, Edit Anna Porpaczy, MD, Michaela Gruber, MD PhD, Gregor Hoermann, MD, Stefan Kubicek, PhD, Philipp Bernhard Staber, MD PhD, Medhat M. Shehata, MD, Giulio Superti-Furga, PhD, Christoph Bock, PhD, Ulrich Jaeger, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 800.
https://doi.org/10.1182/blood.V130.Suppl_1.800.800
Published: 2017
Journal Articles

Comparative Analysis of Japanese and European Typical CLL Patients

Jun Takizawa, MD PhD, Michaela Gruber, MD PhD, Ritsuro Suzuki, MD PhD, Naoya Nakamura, Gregor Hoermann, Leonhard Muellauer, MD, Sadao Aoki, MD PhD, Junji Suzumiya, MD PhD, Ulrich Jaeger, MD
Journal: Blood
Blood (2016) 128 (22): 5564.
https://doi.org/10.1182/blood.V128.22.5564.5564
Published: 2016
Journal Articles

Overexpression of uridine diphospho glucuronosyltransferase 2B17 in high-risk chronic lymphocytic leukemia

Clinical Trials & Observations
Michaela Gruber, Judith Bellemare, Gregor Hoermann, Andreas Gleiss, Edit Porpaczy, Martin Bilban, Trang Le, Sonja Zehetmayer, Christine Mannhalter, Alexander Gaiger, Medhat Shehata, Karin Fleiss, Cathrin Skrabs, Éric Lévesque, Katrina Vanura, Chantal Guillemette, Ulrich Jaeger
Journal: Blood
Blood (2013) 121 (7): 1175–1183.
https://doi.org/10.1182/blood-2012-08-447359
Published: 2013
Includes: Supplemental data
Journal Articles

Cannabinoid Receptor 1 in Chronic Lymphocytic Leukemia: Strong Prognostic Marker with Limited Therapeutic Use

Patricia Weiss, Edit Anna Porpaczy, MD, Trang Le, Cathrin Skrabs, Michaela Gruber, Clemens Pausz, Ulrich Jäger, Katrina Vanura
Journal: Blood
Blood (2012) 120 (21): 4565.
https://doi.org/10.1182/blood.V120.21.4565.4565
Published: 2012
Journal Articles

Induction Therapy with Novel Agents Improves Relapse-Free Survival After Autologous Stem-Cell Transplantation in Multiple Myeloma

Sandra Eder, Wolfgang Lamm, Michaela Gruber, Beatrice Schauer, Jutta Ackermann, Heinz Gisslinger, Johannes Drach
Journal: Blood
Blood (2011) 118 (21): 4494.
https://doi.org/10.1182/blood.V118.21.4494.4494
Published: 2011
Journal Articles

Expression of Lipoprotein Lipase In Chronic Lymphocytic Leukemia Cells: Is There a Biological Function?

Edit anna Porpaczy, MD, Stefanie Tauber, Martin Bilban, Gerhard Kostner, Michaela Gruber, Trang Le, Karin Fleiss, Cathrine Skrabs, Christine Einberger, Medhat Shehata, Ulrich Jaeger, Katrina Vanura
Journal: Blood
Blood (2010) 116 (21): 3580.
https://doi.org/10.1182/blood.V116.21.3580.3580
Published: 2010
Journal Articles

UDP Glucuronosyltransferase 2B17 Double Deletion Genotype Is An Independent Marker for Poor Prognosis In Multiple Myeloma

Michaela Gruber, Sandra Eder, Trang Le, Jutta Ackermann, Katrina Vanura, Ulrich Jaeger, Johannes Drach
Journal: Blood
Blood (2010) 116 (21): 2955.
https://doi.org/10.1182/blood.V116.21.2955.2955
Published: 2010
Journal Articles

Gene Expression Signature of B-Cell Chronic Lymphocytic Leukemia with Trisomy 12.

Edit Porpaczy, Martin Bilban, Elisabeth Kroemer, Georg Heinze, Michaela Gruber, Katrina Vanura, Daniel Heintel, Martin Hilgarth, Bernadette Hilgarth, Trang Le, Rainer Hubmann, Susanne Schnabl, Andreas Chott, Ilse Schwarzinger, Alexander Hauswirth, Cathrin Scrabs, Stephan Stilgenbauer, Oswald Wagner, Christa Fonatsch, Ulrich Jaeger, Medhat Shehata, Alexander Gaiger
Journal: Blood
Blood (2007) 110 (11): 2079.
https://doi.org/10.1182/blood.V110.11.2079.2079
Published: 2007