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Journal Articles

Differential Expression and Functions of NOTCH Family Members and Involvement of NR4A1 in the Regulation of Apoptosis in CLL

Rainer Hubmann, Martin Hilgarth, Susanne Schnabl, Elena Ponath, Dita Demirtas, Marlies Reiter, Ulrich Jäger, Medhat Shehata

Blood (2012) 120 (21): 3919.

https://doi.org/10.1182/blood.V120.21.3919.3919

Published: 2012

Journal Articles

Green Tea Extract EGCG Induces Apoptosis in CLL Cells and Overcomes the Supportive Effect of Primary Bone Marrow Stromal Cells Through the Regulation of PI3K/Akt Cascade and Proteasome Activity

Elena Ponath, Susanne Schnabl, Martin Hilgarth, Dita Demirtas, Marlies Reiter, Eva Fuchs, Rainer Hubmann, Ulrich Jäger, Medhat Shehata

Blood (2012) 120 (21): 3916.

https://doi.org/10.1182/blood.V120.21.3916.3916

Published: 2012

Journal Articles

Inhibition of NOTCH Activity by GLIOTOXIN Induces Apoptosis in CLL Cells and Overcomes the Supportive Effect of Primary Bone Marrow Stromal Cells

Rainer Hubmann, Martin Hilgarth, Susanne Schnabl, Elena Ponath, Dita Demirtas, Marlies Reiter, Christoph Zielinski, Ulrich Jäger, Medhat Shehata

Blood (2011) 118 (21): 4609.

https://doi.org/10.1182/blood.V118.21.4609.4609

Published: 2011

Journal Articles

Partial Characterization and In Vitro Expansion of Putative CLL Precursor/Stem Cells Which Are Dependent on Bone Marrow Microenvironment for Survival

Medhat Shehata, Rainer Hubmann, Martin Hilgarth, Susanne Schnabl, Dita Demirtas, Elina Ponath, Ekaterina Brynzak, Sabine Strommer, Volker Wachek, Alexander Hauswirth, Berthold Streubel, M.D., Katrina Vanura, Josef Schwarzmeier, Alexander Gaiger, MD, Christoph Zielinski, Peter Valent, Ulrich Jaeger

Blood (2010) 116 (21): 2433.

https://doi.org/10.1182/blood.V116.21.2433.2433

Published: 2010

Journal Articles

Reconstitution of PTEN activity by CK2 inhibitors and interference with the PI3-K/Akt cascade counteract the antiapoptotic effect of human stromal cells in chronic lymphocytic leukemia

Medhat Shehata, Susanne Schnabl, Dita Demirtas, Martin Hilgarth, Rainer Hubmann, Elena Ponath, Sigrun Badrnya, Claudia Lehner, Andrea Hoelbl, Markus Duechler, Alexander Gaiger, Christoph Zielinski, Josef D. Schwarzmeier, Ulrich Jaeger

Blood (2010) 116 (14): 2513–2521.

https://doi.org/10.1182/blood-2009-10-248054

Published: 2010

Includes: Supplemental data

Journal Articles

Lumiliximab Triggers Apoptosis Mechanisms in CLL Cells through the Inhibition of PI3-K/Akt Pathway.

Medhat Shehata, Susanne Schnabl, Elena Ponath, Stefanie Tauber, Dita Demirtas, Martin Hilgarth, Martin Bilban, Sigrun Badrnya, Karin Fleiss, Josef D. Schwarzmeier, Alexander Gaiger, Rainer Hubmann, Christoph C Zielinski, Steve Hughes, Ann Maclaren, Ulrich Jaeger

Blood (2009) 114 (22): 2371.

https://doi.org/10.1182/blood.V114.22.2371.2371

Published: 2009

Journal Articles

Effective Targeting of the PI3-K Pathway in CLL with NVP-BEZ235, a Novel Orally Available Dual PI3K/mTOR Inhibitor

Medhat Shehata, Susanne Schnabl, Dita Demirtas, Stefanie Tauber, Martin Hilgarth, Martin Bilban, Katrina Vanura, Edit Porpaczy, Christa Fonatsch, Stephan Stilgenbauer, MD, PhD, Josef D. Schwarzmeier, Rainer Hubmann, Alexander Gaiger, Christoph Zielinski, MD, Sauveur-Michel Maira, Carlos Garcia-Echeverria, Wolfgang Hackl, Ulrich Jaeger

Blood (2008) 112 (11): 3166.

https://doi.org/10.1182/blood.V112.11.3166.3166

Published: 2008

Journal Articles

Identification of Genes Associated with Resistance and Response in Vivo to Therapy with Rituximab, Fludarabine and Cyclophosphamide in Patients with Chronic Lymphocytic Leukemia.

Blood (2008) 112 (11): 1622.

https://doi.org/10.1182/blood.V112.11.1622.1622

Published: 2008

Journal Articles

Gene Expression Signature of B-Cell Chronic Lymphocytic Leukemia with Trisomy 12.

Blood (2007) 110 (11): 2079.

https://doi.org/10.1182/blood.V110.11.2079.2079

Published: 2007

Journal Articles

Regulation and Function of NOTCH2 in B-CLL Cells.

Rainer Hubmann, PhD, Martin Hilgarth, Susanne Schnabl, Dita Demirtas, MD, Josef D. Schwarzmeier, MD, Ulrich Jaeger, MD, Medhat Shehata, MD

Blood (2007) 110 (11): 1138.

https://doi.org/10.1182/blood.V110.11.1138.1138

Published: 2007

Journal Articles

Regulation of NOTCH2 Signaling in B-CLL: Involvement of PKC-δ.

Rainer Hubmann, PhD, Markus Duechler, PhD, Martin Hilgarth, Susanne Schnabl, Dita Demirtas, MD, Josef D. Schwarzmeier, MD, Ulrich Jaeger, MD, Medhat Shehata, MD

Blood (2006) 108 (11): 1440.

https://doi.org/10.1182/blood.V108.11.1440.1440

Published: 2006

Journal Articles

Lymphoid Microenvironment Inhibits Apoptosis in B-CLL Cells: Involvement of PI3-K/AKT Pathway and PTEN.

Medhat Shehata, MD, Susanne Schnabl, Dita Demirtas, MD, Josef D. Schwarzmeier, MD, Martin Hilgarth, Markus Duechler, PhD, Alexander Gaiger, MD, Rainer Hubmann, PhD, Ulrich Jaeger, MD

Blood (2006) 108 (11): 1443.

https://doi.org/10.1182/blood.V108.11.1443.1443

Published: 2006

Journal Articles

Involvement of PKC-δ in the Regulation of Notch2 in B-CLL.

Rainer Hubmann, PhD, Markus Duechler, PhD, Martin Hilgarth, Susanne Schnabl, Josef D. Schwarzmeier, MD, Ulrich Jaeger, MD, Medhat Shehata, MD

Blood (2005) 106 (11): 4990.

https://doi.org/10.1182/blood.V106.11.4990.4990

Published: 2005

Journal Articles

Interaction between B-CLL Cells and Lymphoid Microenvironment Leads to Activation of PI3-K/Akt Pathway and Inhibition of Apoptosis.

Medhat Shehata, MD, Susanne Schnabl, Dita Demirtas, MD, Josef D. Schwarzmeier, Martin Hilgarth, Markus Duechler, PhD, Rainer Hubmann, PhD, Ulrich Jaeger

Blood (2005) 106 (11): 2102.

https://doi.org/10.1182/blood.V106.11.2102.2102

Published: 2005

Journal Articles

Notch2 is involved in the overexpression of CD23 in B-cell chronic lymphocytic leukemia

Rainer Hubmann, Josef D. Schwarzmeier, Medhat Shehata, Martin Hilgarth, Markus Duechler, Markus Dettke, Rudolf Berger

Blood (2002) 99 (10): 3742–3747.

https://doi.org/10.1182/blood.V99.10.3742

Published: 2002

Journal Articles

Basic Fibroblast Growth Factor Is Expressed by CD19/CD11c-Positive Cells in Hairy Cell Leukemia

Gerhard Gruber, Josef D. Schwarzmeier, Medhat Shehata, Martin Hilgarth, Rudolf Berger

Blood (1999) 94 (3): 1077–1085.

https://doi.org/10.1182/blood.V94.3.1077.415k06_1077_1085

Published: 1999

NARROW

Differential Expression and Functions of NOTCH Family Members and Involvement of NR4A1 in the Regulation of Apoptosis in CLL

Green Tea Extract EGCG Induces Apoptosis in CLL Cells and Overcomes the Supportive Effect of Primary Bone Marrow Stromal Cells Through the Regulation of PI3K/Akt Cascade and Proteasome Activity

Inhibition of NOTCH Activity by GLIOTOXIN Induces Apoptosis in CLL Cells and Overcomes the Supportive Effect of Primary Bone Marrow Stromal Cells

Partial Characterization and In Vitro Expansion of Putative CLL Precursor/Stem Cells Which Are Dependent on Bone Marrow Microenvironment for Survival

Reconstitution of PTEN activity by CK2 inhibitors and interference with the PI3-K/Akt cascade counteract the antiapoptotic effect of human stromal cells in chronic lymphocytic leukemia

Lumiliximab Triggers Apoptosis Mechanisms in CLL Cells through the Inhibition of PI3-K/Akt Pathway.

Effective Targeting of the PI3-K Pathway in CLL with NVP-BEZ235, a Novel Orally Available Dual PI3K/mTOR Inhibitor

Identification of Genes Associated with Resistance and Response in Vivo to Therapy with Rituximab, Fludarabine and Cyclophosphamide in Patients with Chronic Lymphocytic Leukemia.

Gene Expression Signature of B-Cell Chronic Lymphocytic Leukemia with Trisomy 12.

Regulation and Function of NOTCH2 in B-CLL Cells.

Regulation of NOTCH2 Signaling in B-CLL: Involvement of PKC-δ.

Lymphoid Microenvironment Inhibits Apoptosis in B-CLL Cells: Involvement of PI3-K/AKT Pathway and PTEN.

Involvement of PKC-δ in the Regulation of Notch2 in B-CLL.

Interaction between B-CLL Cells and Lymphoid Microenvironment Leads to Activation of PI3-K/Akt Pathway and Inhibition of Apoptosis.

Notch2 is involved in the overexpression of CD23 in B-cell chronic lymphocytic leukemia

Basic Fibroblast Growth Factor Is Expressed by CD19/CD11c-Positive Cells in Hairy Cell Leukemia

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American Society of Hematology

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American Society of Hematology

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