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Journal Articles

Targeting Glycolysis and MAPK Pathway: A Combined Pre-Clinical Approach on Acute Myeloid Leukemia

Simone Mirabilii, PhD, Maria Rosaria Ricciardi, PhD, Roberto Licchetta, M.Sc., Maria Paola Bianchi, MD, Monica Piedimonte, MD, Agostino Tafuri, MD

Blood (2016) 128 (22): 2751.

https://doi.org/10.1182/blood.V128.22.2751.2751

Published: 2016

Journal Articles

Targeting the leukemia cell metabolism by the CPT1a inhibition: functional preclinical effects in leukemias

Maria Rosaria Ricciardi, Simone Mirabilii, Matteo Allegretti, Roberto Licchetta, Anna Calarco, Maria Rosaria Torrisi, Robin Foà, Raffaella Nicolai, Gianfranco Peluso, Agostino Tafuri

Blood (2015) 126 (16): 1925–1929.

https://doi.org/10.1182/blood-2014-12-617498

Published: 2015

Includes: Supplemental data

Journal Articles

Modulation Of The Glycolytic Metabolism In Acute Myeloid Leukemia Cells

Simone Mirabilii, Maria Rosaria Ricciardi, Matteo Allegretti, Roberto Licchetta, Martina Vincenzi, Raffaella Nicolai, Robin Foà, Agostino Tafuri

Blood (2013) 122 (21): 5045.

https://doi.org/10.1182/blood.V122.21.5045.5045

Published: 2013

Journal Articles

The Phosphatidylinositol-3-Kinase Inhibitor BKM120 Impairs Proliferation and Induces Pro-Apoptotic Effects In Acute Myeloid Leukemia

Matteo Allegretti, Maria Rosaria Ricciardi, Martina Vincenzi, Roberto Licchetta, Simone Mirabilii, Sergio Amadori, Robin Foà, Agostino Tafuri

Blood (2013) 122 (21): 4222.

https://doi.org/10.1182/blood.V122.21.4222.4222

Published: 2013

Journal Articles

Proteomic Profile Of CD34+ Cells From Chronic Myeloid Leukemia Patients and From Normal Donors

Maria Rosaria Ricciardi, Valentina Salvestrini, Mattia Forcato, Roberto Licchetta, Simone Mirabilii, Lara Rossi, Matteo Allegretti, Martina Vincenzi, Simona Salati, Phd, Fausto Castagnetti, Gianantonio Rosti, Giuliana Alimena, Rossella Manfredini, PhD, Silvio Bicciato, PhD, Roberto Lemoli, Agostino Tafuri

Blood (2013) 122 (21): 2712.

https://doi.org/10.1182/blood.V122.21.2712.2712

Published: 2013

Journal Articles

Targeting Metabolic Pathways for Leukemia Treatment

Simone Mirabilii, Maria Rosaria Ricciardi, Matteo Allegretti, Roberto Licchetta, Stefano Iacovelli, Paola Bergamo, Maria Teresa Petrucci, Raffaella Nicolai, Gianfranco Peluso, Robin Foà, MD, Giuliana Alimena, Agostino Tafuri

Blood (2012) 120 (21): 1371.

https://doi.org/10.1182/blood.V120.21.1371.1371

Published: 2012

Journal Articles

Proteomic Signature of CD34+ Cells From Chronic Myeloid Leukemia Patients

Maria Rosaria Ricciardi, Valentina Salvestrini, Roberto Licchetta, Simone Mirabilii, Maria Teresa Petrucci, Lara Rossi, Matteo Allegretti, Simona Salati, Fausto Castagnetti, Gianantonio Rosti, prof, Giuliana Alimena, Rossella Manfredini, Roberto M. Lemoli, Agostino Tafuri

Blood (2012) 120 (21): 3733.

https://doi.org/10.1182/blood.V120.21.3733.3733

Published: 2012

Journal Articles

Purinergic signaling inhibits human acute myeloblastic leukemia cell proliferation, migration, and engraftment in immunodeficient mice

Valentina Salvestrini, Roberta Zini, Lara Rossi, Sara Gulinelli, Rossella Manfredini, Elisa Bianchi, Wanda Piacibello, Luisa Caione, Giorgia Migliardi, Maria Rosaria Ricciardi, Agostino Tafuri, Marco Romano, Simona Salati, Francesco Di Virgilio, Sergio Ferrari, Michele Baccarani, Davide Ferrari, Roberto M. Lemoli

Blood (2012) 119 (1): 217–226.

https://doi.org/10.1182/blood-2011-07-370775

Published: 2012

Includes: Supplemental data

Journal Articles

Pre Clinical mTOR-Inhibition of Acute Lymphoblastic Leukemia Cells Synergizes with Pro-Apoptotic Target Therapy Through Mcl-1 Down-Regulation,

Stefano Iacovelli, Maria Rosaria Ricciardi, PhD, Paola Bergamo, Cinzia Rinaldo, PhD, Roberto Licchetta, Antonella Vitale, Anna Testi, MD, Maria Teresa Petrucci, MD, Marina Konopleva, MD, PhD, Michele Milella, MD, Robin Foà, Agostino Tafuri

Blood (2011) 118 (21): 3581.

https://doi.org/10.1182/blood.V118.21.3581.3581

Published: 2011

Journal Articles

Bcl-2 and mTOR as Effective Targets for Molecular Therapy of Acute Lymphoblastic Leukemia

Stefano Iacovelli, Maria Rosaria Ricciardi, PhD, Andrea Miele, Paola Bergamo, Roberto Licchetta, Antonella Vitale, MD, Anna Testi, MD, Maria Teresa Petrucci, MD, Michele Milella, MD, Robin Foà, MD, Agostino Tafuri, MD

Blood (2010) 116 (21): 3228.

https://doi.org/10.1182/blood.V116.21.3228.3228

Published: 2010

Journal Articles

Novel Histone Deacetilase (HDAC) Inhibitors: In Vitro Effects on Leukemic Cells

Maria Rosaria Ricciardi, PhD, Roberto Licchetta, Paola Bergamo, Stefano Iacovelli, Andrea Miele, Maria Teresa Petrucci, MD, Michele Milella, MD, Claudio Pisano, PhD, Agostino Tafuri, MD

Blood (2010) 116 (21): 4946.

https://doi.org/10.1182/blood.V116.21.4946.4946

Published: 2010

Journal Articles

Preclinical Approach to Sensitize Multiple Myeloma Cells: Combination of the MEK Inhibitor PD0325901 with ABT-737 or Mevinolin.

Maria Rosaria Ricciardi, Elisabetta Calabrese, Michele Milella, Paola Bergamo, Samantha Decandia, Cinzia De Benedictis, Robin Foà, Agostino Tafuri, Maria Teresa Petrucci

Blood (2009) 114 (22): 1842.

https://doi.org/10.1182/blood.V114.22.1842.1842

Published: 2009

Journal Articles

Preclinical Study to Sensitize Acute Lymphoblastic Leukemia Primary Cells by Combined mTOR and BCL-2 Inhibition with CCI-779 and ABT-737.

Maria Rosaria Ricciardi, Samantha Decandia, Paola Bergamo, Cinzia De Benedictis, Antonella Vitale, Anna Maria Testi, Joanna Fei, Maria Teresa Petrucci, Michele Milella, Robin Foà, Agostino Tafuri

Blood (2009) 114 (22): 985.

https://doi.org/10.1182/blood.V114.22.985.985

Published: 2009

Journal Articles

Simultaneous Targeting of Bcl-2/Bcl-Xl and MEK/ERK Results in Highly Synergistic Induction of Apoptosis in Human AML, Both in Vitro and In Vivo.

Marina Konopleva, MD, PhD, Michele Milella, MD, Julie C Watts, PhD, Maria Rosaria Ricciardi, PhD, Borys Korchin, PhD, Twee Tsao, PhD, Paola Bergamo, MS, Duncan H. Mak, PhD, Samantha Decandia, PhD, James McCubrey, PhD, Agostino Tafuri, MD, Michael Andreeff, MD, PhD

Blood (2009) 114 (22): 2757.

https://doi.org/10.1182/blood.V114.22.2757.2757

Published: 2009

Journal Articles

Parallel Signaling through PI3K/AKT/mTOR Mediates Resistance to MEK Inhibition in Preclinical Models of Acute Myeloid Leukemia (AML): Synergistic Effects of Combined MEK and mTOR Inhibition.

Maria Rosaria Ricciardi, PhD, Twee Tsao, PhD, Stephen Lee Abrams, PhD, Paola Bergamo, MS, Linda S Steelman, BS., MS, Samantha Decandia, PhD, Lara Felicioni, PhD, Ludovica Ciuffreda, PhD, Cristina Di Sanza, PhD, Antonio Marchetti, MD, PhD, Francesco Cognetti, MD, James McCubrey, PhD, Marina Konopleva, MD, PhD, Michael Andreeff, MD, PhD, Agostino Tafuri, MD, Michele Milella, MD

Blood (2009) 114 (22): 594.

https://doi.org/10.1182/blood.V114.22.594.594

Published: 2009

Journal Articles

ATM-ATR–dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype

Alessandra Soriani, Alessandra Zingoni, Cristina Cerboni, Maria Luisa Iannitto, Maria Rosaria Ricciardi, Valentina Di Gialleonardo, Marco Cippitelli, Cinzia Fionda, Maria Teresa Petrucci, Anna Guarini, Robin Foà, Angela Santoni

Blood (2009) 113 (15): 3503–3511.

https://doi.org/10.1182/blood-2008-08-173914

Published: 2009

Includes: Supplemental data

Journal Articles

BCL-2/BCL-XL Inhibition in Smoldering Multiple Myeloma CD138+ Cells: Functional Effects and Protein Expression Levels

Francesco Libotte, Maria Rosaria Ricciardi, Elisabetta Calabrese, Cinzia De Benedictis, Sara Santinelli, Paola Bergamo, Samantha Decandia, Anna Levi, Ali Fathi Mohamad, Vincenzo Federico, Michele Milella, Robert Foà, Agostino Tafuri, Maria Teresa Petrucci

Blood (2008) 112 (11): 5159.

https://doi.org/10.1182/blood.V112.11.5159.5159

Published: 2008

Journal Articles

Synergistic Induction of Apoptosis in Multiple Myeloma Cells by Simultaneous Inhibition of the Raf/MEK/ERK and BCL-2 Pathways

Maria Rosaria Ricciardi, Michele Milella, Francesco Libotte, Elisabetta Calabrese, Paola Bergamo, Sara Santinelli, Samantha Decandia, Cinzia De Benedictis, Anna Levi, Robert Foà, Agostino Tafuri, Maria Teresa Petrucci

Blood (2008) 112 (11): 5161.

https://doi.org/10.1182/blood.V112.11.5161.5161

Published: 2008

Journal Articles

Multiple Strategies Based on MEK, mTOR and BCL-2 Signal Transduction Inhibition in Acute Lymphoblastic Leukemia (ALL)

Maria Rosaria Ricciardi, PhD, Samantha Decandia, Sara Santinelli, Chiara Gregorj, Fabiana De Cave, Maria Cristina Scerpa, PhD, Paola Bergamo, MS, Francesco Libotte, Cinzia De Benedictis, Antonella Vitale, Maria Teresa Petrucci, MD, Marina Konopleva, MD, PhD, Michael Andreeff, MD, PhD, Michele Milella, Robert Foa, Agostino Tafuri

Blood (2008) 112 (11): 5034.

https://doi.org/10.1182/blood.V112.11.5034.5034

Published: 2008

Journal Articles

Development of Mek inhibition (MEK-I)-Based Therapeutic Strategies in Acute Myeloid Leukemia (AML)

Michele Milella, MD, Maria Rosaria Ricciardi, Paola Bergamo, MS, Maria Cristina Scerpa, PhD, Jacopo Gervasoni, MS, Maria Teresa Petrucci, MD, Sabina Chiaretti, MD, Simona Tavolaro, MS, Ludovica Ciuffreda, PhD, Samantha Decandia, Francesco Libotte, Stephen Lee Abrams, Linda S Steelman, BS., MS, Marina Konopleva, MD, PhD, Francesco Cognetti, MD, Robert Foa, Michael Andreeff, MD, PhD, James McCubrey, PhD, Agostino Tafuri

Blood (2008) 112 (11): 860.

https://doi.org/10.1182/blood.V112.11.860.860

Published: 2008

NARROW

Targeting Glycolysis and MAPK Pathway: A Combined Pre-Clinical Approach on Acute Myeloid Leukemia

Targeting the leukemia cell metabolism by the CPT1a inhibition: functional preclinical effects in leukemias

Modulation Of The Glycolytic Metabolism In Acute Myeloid Leukemia Cells

The Phosphatidylinositol-3-Kinase Inhibitor BKM120 Impairs Proliferation and Induces Pro-Apoptotic Effects In Acute Myeloid Leukemia

Proteomic Profile Of CD34+ Cells From Chronic Myeloid Leukemia Patients and From Normal Donors

Targeting Metabolic Pathways for Leukemia Treatment

Proteomic Signature of CD34+ Cells From Chronic Myeloid Leukemia Patients

Purinergic signaling inhibits human acute myeloblastic leukemia cell proliferation, migration, and engraftment in immunodeficient mice

Pre Clinical mTOR-Inhibition of Acute Lymphoblastic Leukemia Cells Synergizes with Pro-Apoptotic Target Therapy Through Mcl-1 Down-Regulation,

Bcl-2 and mTOR as Effective Targets for Molecular Therapy of Acute Lymphoblastic Leukemia

Novel Histone Deacetilase (HDAC) Inhibitors: In Vitro Effects on Leukemic Cells

Preclinical Approach to Sensitize Multiple Myeloma Cells: Combination of the MEK Inhibitor PD0325901 with ABT-737 or Mevinolin.

Preclinical Study to Sensitize Acute Lymphoblastic Leukemia Primary Cells by Combined mTOR and BCL-2 Inhibition with CCI-779 and ABT-737.

Simultaneous Targeting of Bcl-2/Bcl-Xl and MEK/ERK Results in Highly Synergistic Induction of Apoptosis in Human AML, Both in Vitro and In Vivo.

Parallel Signaling through PI3K/AKT/mTOR Mediates Resistance to MEK Inhibition in Preclinical Models of Acute Myeloid Leukemia (AML): Synergistic Effects of Combined MEK and mTOR Inhibition.

ATM-ATR–dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype

BCL-2/BCL-XL Inhibition in Smoldering Multiple Myeloma CD138+ Cells: Functional Effects and Protein Expression Levels

Synergistic Induction of Apoptosis in Multiple Myeloma Cells by Simultaneous Inhibition of the Raf/MEK/ERK and BCL-2 Pathways

Multiple Strategies Based on MEK, mTOR and BCL-2 Signal Transduction Inhibition in Acute Lymphoblastic Leukemia (ALL)

Development of Mek inhibition (MEK-I)-Based Therapeutic Strategies in Acute Myeloid Leukemia (AML)

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American Society of Hematology

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American Society of Hematology

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