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Journal Articles

Frequency and Stimulation of NPM1-Specific Immune Responses By Anti-PD1 Antibodies in NPM1-Mutated AML

Jochen Greiner, MD, Vanessa Schneider, Dr. rer. nat., Hubert Schrezenmeier, Markus Wiesneth, MD, Susanne Hofmann, MD, Marlies Götz

Blood (2020) 136 (Supplement 1): 15.

https://doi.org/10.1182/blood-2020-134876

Published: 2020

Journal Articles

Results of a Prospective, Multicenter, Phase I/II Clinical Study in Pediatric and Adult Patients Using TCR Alpha/Beta and CD19 Depleted Haploidentical Hematopoietic Stem Cell Grafts Following Reduced-Intensity Conditioning

Blood (2018) 132 (Supplement 1): 604.

https://doi.org/10.1182/blood-2018-99-110124

Published: 2018

Journal Articles

Expression of PD-L1 in Leukemic Progenitor Cells Defines NPM1 Mutated AML As a Potential Subgroup for PD1/PD-L1 Directed Immunotherapy

Jochen Greiner, Vanessa Schneider, Dr. rer. nat., Hubert Schrezenmeier, MD, Markus Wiesneth, MD, Lars Bullinger, MD, Hartmut Döhner, MD, Susanne Hofmann, MD, Marlies Götz

Blood (2018) 132 (Supplement 1): 2734.

https://doi.org/10.1182/blood-2018-99-111458

Published: 2018

Journal Articles

Treg Downregulation Was Associated with Augmentation of T Cell Responses Against Immunogenic Antigens and Clinical Responses in Patients with Hematological Malignancies after Donor Lymphocyte Infusion (DLI)

Jochen Greiner, Marlies Götz, Michael Schmitt, MD PhD, Hartmut Döhner, MD, Markus Wiesneth, MD, Donald Bunjes, MD, Susanne Hofmann, MD

Blood (2018) 132 (Supplement 1): 3423.

https://doi.org/10.1182/blood-2018-99-111783

Published: 2018

Journal Articles

First Results of a Prospective Multicenter Phase I/II Clinical Trial in Adult Patients Using Tcralpha/Beta and CD19 Depleted Haploidentical Stem Cell Transplantation Following Reduced Intensity Conditioning

Wolfgang Bethge, MD, Stephan Mielke, MD, Dietger Niederwieser, MD, Roland Meisel, MD, Donald w. Bunjes, MD, Arne Brecht, MD, Jurgen Kuball, MD, Sandra Karitzky, PhD, Silke Holtkamp, Christiane Siewert, PhD, Stefanie Pflitsch, Michael Schumm, DVM, Matthias K. Eyrich, MD, Vladan Vucinic, Markus Wiesneth, MD, Kasper Westinga, Rupert Handgretinger, MD PhD

Blood (2017) 130 (Supplement 1): 213.

https://doi.org/10.1182/blood.V130.Suppl_1.213.213

Published: 2017

Journal Articles

Safety and Efficacy of Tcralpha/Beta and CD19 Depleted Haploidentical Stem Cell Transplantation Following Reduced Intensity Conditioning in Children: Results of a Prospective Multicenter Phase I/II Clinical Trial

Peter J. Lang, MD, Paul G. Schlegel, MD, Roland Meisel, MD, Ansgar S. Schulz, MD, Johann Greil, MD, Peter Bader, MD PhD, Sandra Karitzky, PhD, Silke Holtkamp, Christiane Siewert, PhD, Stefanie Pflitsch, Michael Schumm, DVM, Matthias K. Eyrich, MD, Markus Wiesneth, MD, Halvard Bonig, MD MA, Rupert Handgretinger, MD PhD

Blood (2017) 130 (Supplement 1): 214.

https://doi.org/10.1182/blood.V130.Suppl_1.214.214

Published: 2017

Journal Articles

Specific Immune Responses for Leukemia-Associated Antigens Against Myeloid Leukemic Cells Are Increased By Immune Checkpoint Inhibition

Jochen Greiner, Marlies Götz, Vanessa Schneider, Hubert Schrezenmeier, Markus Wiesneth, Lars Bullinger, Hartmut Döhner, MD, Susanne Hofmann

Blood (2016) 128 (22): 4054.

https://doi.org/10.1182/blood.V128.22.4054.4054

Published: 2016

Journal Articles

TCR-Alpha/Beta and CD19 Depleted Haploidentical Stem Cell Transplantation Following Reduced Intensity Conditioning in Children: First Results of a Prospective Multicenter Phase I/II Clinical Trial

Peter J. Lang, MD, Paul G. Schlegel, MD, Roland Meisel, MD, Ansgar S. Schulz, MD, Johann Greil, MD, Peter Bader, MD, Sandra Karitzky, PhD, Silke Holtkamp, PhD, Christiane Siewert, PhD, Michael Schumm, VMD, Matthias K. Eyrich, MD, Markus Wiesneth, Halvard Bönig, MD, Rupert Handgretinger, MD

Blood (2016) 128 (22): 389.

https://doi.org/10.1182/blood.V128.22.389.389

Published: 2016

Journal Articles

Decentralized Manufacture of TCR-Alpha/Beta and CD19 Depleted Haploidentical Stem Cell Grafts for Children within a Multicenter Phase I/II Clinical Trial

Michael Schumm, VMD, Matthias K. Eyrich, MD, Markus Wiesneth, Halvard Bönig, MD, Peter J. Lang, MD, Paul G. Schlegel, MD, Roland Meisel, MD, Ansgar S. Schulz, MD, Johann Greil, MD, Peter Bader, MD, Murat Aktas, Philipp Dresing, PhD, Sandra Karitzky, PhD, Silke Holtkamp, PhD, Rupert Handgretinger, MD

Blood (2016) 128 (22): 2172.

https://doi.org/10.1182/blood.V128.22.2172.2172

Published: 2016

Journal Articles

Peptide Vaccination Against Cytomegalovirus (CMV) Elicits Immunological and Clinical Responses after Allogeneic Stem Cell Transplantation Even from a CMV Seronegative Donor

Blood (2016) 128 (22): 2519.

https://doi.org/10.1182/blood.V128.22.2519.2519

Published: 2016

Journal Articles

Cytotoxic T-Cell Responses (CTL) Against Several Leukemia-Associated-Antigens (LAA) Related to the Detected Cytokine Profile in the Course of Allogeneic Hematopoietic Stem Cell Transplantation (allo-HSCT) and Donor Lymphocyte Infusion (DLI) in Patients with Different Hematological Diseases

Susanne Hofmann, MD, Marlies Götz, Cornelia Herbst, Vanessa Schneider, Markus Wiesneth, MD, Donald Bunjes, MD, Hartmut Döhner, MD, Jochen Greiner, MD

Blood (2014) 124 (21): 2442.

https://doi.org/10.1182/blood.V124.21.2442.2442

Published: 2014

Journal Articles

Analysis Of Leukemic Stem Cell Population Comparing NPM1 wt and NPM1 mut AML Patients and Potential Therapeutic Targets

Vanessa Schneider, Lars Bullinger, MD, PhD, Lu Zhang, Markus Rojewski, Markus Wiesneth, Susanne Hofmann, Marlies Goetz, Hubert Schrezenmeier, MD, Ulla Botzenhardt, Thomas F.E. Barth, Konstanze Doehner, MD, Hartmut Doehner, MD, Jochen Greiner, MD

Blood (2013) 122 (21): 2624.

https://doi.org/10.1182/blood.V122.21.2624.2624

Published: 2013

Journal Articles

Immune responses against the mutated region of cytoplasmatic NPM1 might contribute to the favorable clinical outcome of AML patients with NPM1 mutations ( NPM1 mut )

Jochen Greiner, Vanessa Schneider, Michael Schmitt, Marlies Götz, Konstanze Döhner, Markus Wiesneth, Hartmut Döhner, Susanne Hofmann

Blood (2013) 122 (6): 1087–1088.

https://doi.org/10.1182/blood-2013-04-496844

Published: 2013

Journal Articles

Mutated Nucleophosmin 1 (NPM1) Is an Immunogenic Target and Patients with NPM1 mut Acute Myeloid Leukemia (AML) Showed High Expression of Different Leukemia-Associated Antigens (LAAs)

Susanne Hofmann, Vanessa Schneider, Lars Bullinger, Yoko Ono, Anita Schmitt, Lu Zhang, Marlies Götz, Konstanze Döhner, MD, Ph.D, Joannis Mytilineos, Markus Wiesneth, Hartmut Döhner, MD, Michael Schmitt, Jochen Greiner, MD

Blood (2012) 120 (21): 3592.

https://doi.org/10.1182/blood.V120.21.3592.3592

Published: 2012

Journal Articles

The Mutated Region of Cytoplasmatic Nucleophosmine 1 (NPM1) Elicits Both CD4+ and CD8+ T Cell Responses

Jochen Greiner, MD, Yoko Ono, Susanne Hofmann, Vanessa Schneider, Anita Schmitt, Lu Zhang, Elmar Mehring, Marlies Götz, Konstanze Döhner, Joannis Mytilineos, Markus Wiesneth, Hartmut Döhner, MD, Michael Schmitt, MD, PhD

Blood (2011) 118 (21): 2569.

https://doi.org/10.1182/blood.V118.21.2569.2569

Published: 2011

Journal Articles

Preemptive Donor Lymphocyte Infusion Induces Polyspecific T-Cell Responses in a Patient with AML with NPM1 Mutation

Susanne Hofmann, Marlies Götz, Cornelia Herbst, Vanessa Schneider, Lu Zhang, Donald Bunjes, MD, Hartmut Döhner, MD, Markus Wiesneth, Jochen Greiner, MD

Blood (2011) 118 (21): 4311.

https://doi.org/10.1182/blood.V118.21.4311.4311

Published: 2011

Journal Articles

Efficiency of Leukemic Stem Cell Separation From Patients with Acute Myeloid Leukemia

Lu Zhang, Susanne Hofmann, Lars Bullinger, Marlies Goetz, Markus Wiesneth, Markus Rojewski, Hartmut Dohner, MD, Jochen Greiner, MD, Vanessa Schneider

Blood (2011) 118 (21): 4997.

https://doi.org/10.1182/blood.V118.21.4997.4997

Published: 2011

Journal Articles

Adoptive Transfer and Consequential Selective Reconstitution of Streptamer-Selected Cytomegalovirus-Specific CD8+ T Cells Leads to Enduring Virus Clearance in Patients after Allogeneic Stem Cell Transplantation

Anita Schmitt, Torsten Tonn, Dirk Busch, Götz Grigoleit, Hermann Einsele, Marcus Odendahl, Lothar Germeroth, Mark Ringhoffer, Simone Ringhoffer, Markus Wiesneth, Detlef Michel, Thomas Mertens, Markus Rojewski, Martin Marx, Stephanie Harsdorf, Hartmut Döhner, Erhard Seifried, Donald Bunjes, Michael Schmitt

Blood (2008) 112 (11): 1181.

https://doi.org/10.1182/blood.V112.11.1181.1181

Published: 2008

Journal Articles

Peptide Vaccine Preparation and Validation with a Bio-Assay

Anita Schmitt, Clemens Bechter, Junxia Yao, Marlies Goetz, Birgit Maccari, Peter Schauwecker, Markus Wiesneth, Michael Schmitt

Blood (2008) 112 (11): 5444.

https://doi.org/10.1182/blood.V112.11.5444.5444

Published: 2008

Journal Articles

Streptamer Technology for the Assessment of CMVpp65 Specific CD8+ T Cell Frequencies and for the Adoptive T Cell Transfer to Post-Transplant Patients.

Anita Schmitt, MD, Junxia Yao, MD, Hermann Einsele, PhD, MD, Ulrich Grigoleit, MD, Dirk Busch, PhD, MD, Manuel Odendahl, MD, Lothar Germeroth, PhD, Torsten Tonn, PhD, MD, Markus Wiesneth, MD, Markus Rojewski, MD, Clemens Bechter, Stefanie von Harsdorf, MD, Hartmut Dohner, PhD, MD, Donald Bunjes, PhD, MD, Michael Schmitt, PhD, MD

Blood (2007) 110 (11): 1964.

https://doi.org/10.1182/blood.V110.11.1964.1964

Published: 2007

NARROW

Frequency and Stimulation of NPM1-Specific Immune Responses By Anti-PD1 Antibodies in NPM1-Mutated AML

Results of a Prospective, Multicenter, Phase I/II Clinical Study in Pediatric and Adult Patients Using TCR Alpha/Beta and CD19 Depleted Haploidentical Hematopoietic Stem Cell Grafts Following Reduced-Intensity Conditioning

Expression of PD-L1 in Leukemic Progenitor Cells Defines NPM1 Mutated AML As a Potential Subgroup for PD1/PD-L1 Directed Immunotherapy

Treg Downregulation Was Associated with Augmentation of T Cell Responses Against Immunogenic Antigens and Clinical Responses in Patients with Hematological Malignancies after Donor Lymphocyte Infusion (DLI)

First Results of a Prospective Multicenter Phase I/II Clinical Trial in Adult Patients Using Tcralpha/Beta and CD19 Depleted Haploidentical Stem Cell Transplantation Following Reduced Intensity Conditioning

Safety and Efficacy of Tcralpha/Beta and CD19 Depleted Haploidentical Stem Cell Transplantation Following Reduced Intensity Conditioning in Children: Results of a Prospective Multicenter Phase I/II Clinical Trial

Specific Immune Responses for Leukemia-Associated Antigens Against Myeloid Leukemic Cells Are Increased By Immune Checkpoint Inhibition

TCR-Alpha/Beta and CD19 Depleted Haploidentical Stem Cell Transplantation Following Reduced Intensity Conditioning in Children: First Results of a Prospective Multicenter Phase I/II Clinical Trial

Decentralized Manufacture of TCR-Alpha/Beta and CD19 Depleted Haploidentical Stem Cell Grafts for Children within a Multicenter Phase I/II Clinical Trial

Peptide Vaccination Against Cytomegalovirus (CMV) Elicits Immunological and Clinical Responses after Allogeneic Stem Cell Transplantation Even from a CMV Seronegative Donor

Cytotoxic T-Cell Responses (CTL) Against Several Leukemia-Associated-Antigens (LAA) Related to the Detected Cytokine Profile in the Course of Allogeneic Hematopoietic Stem Cell Transplantation (allo-HSCT) and Donor Lymphocyte Infusion (DLI) in Patients with Different Hematological Diseases

Analysis Of Leukemic Stem Cell Population Comparing NPM1 wt and NPM1 mut AML Patients and Potential Therapeutic Targets

Immune responses against the mutated region of cytoplasmatic NPM1 might contribute to the favorable clinical outcome of AML patients with NPM1 mutations ( NPM1 mut )

Mutated Nucleophosmin 1 (NPM1) Is an Immunogenic Target and Patients with NPM1 mut Acute Myeloid Leukemia (AML) Showed High Expression of Different Leukemia-Associated Antigens (LAAs)

The Mutated Region of Cytoplasmatic Nucleophosmine 1 (NPM1) Elicits Both CD4+ and CD8+ T Cell Responses

Preemptive Donor Lymphocyte Infusion Induces Polyspecific T-Cell Responses in a Patient with AML with NPM1 Mutation

Efficiency of Leukemic Stem Cell Separation From Patients with Acute Myeloid Leukemia

Adoptive Transfer and Consequential Selective Reconstitution of Streptamer-Selected Cytomegalovirus-Specific CD8+ T Cells Leads to Enduring Virus Clearance in Patients after Allogeneic Stem Cell Transplantation

Peptide Vaccine Preparation and Validation with a Bio-Assay

Streptamer Technology for the Assessment of CMVpp65 Specific CD8+ T Cell Frequencies and for the Adoptive T Cell Transfer to Post-Transplant Patients.

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American Society of Hematology

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American Society of Hematology

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