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Journal Articles

Early-life infection depletes preleukemic cells in a mouse model of hyperdiploid B-cell acute lymphoblastic leukemia

Ali Farrokhi, Tanmaya Atre, Samuel Salitra, Maryam Aletaha, Ana Citlali Márquez, Matthew Gynn, Mario Fidanza, Sumin Jo, Nina Rolf, Karen Simmons, Jesus Duque-Afonso, Michael L. Cleary, Alix E. Seif, Tobias Kollmann, Soren Gantt, Gregor S. D. Reid

Blood (2024) 144 (8): 809–821.

https://doi.org/10.1182/blood.2024025038

Published: 2024

Includes: Supplemental data

Journal Articles

Identification of a Novel Chromosomal Translocation t(11;16)(q23;q22) Fusing MLL to Enhancer of mRNA Decapping (EDC)-4 in Smoldering Acute Myeloid Leukemia

Heiko Becker, MD, Keisuke Kataoka, MD PhD, Gabriele Greve, Jesús Duque Afonso, MD, Tobias Ma, Sabine Bleul, Milena Pantic, PhD, Julia Schüler, DVM, PhD, Justus Duyster, MD, Michael L Cleary, MD, Seishi Ogawa, MD PhD, Michael Lübbert, MD

Blood (2016) 128 (22): 1696.

https://doi.org/10.1182/blood.V128.22.1696.1696

Published: 2016

Journal Articles

Oncogenic Role for the Lck/ZAP70/PLCG2 Signaling Pathway in Pre-B-ALL Pathogenesis

Jesus Duque-Afonso, MD, Michael C. Wei, MD PhD, Chiou-Hong Lin, PhD, Jue Feng, PhD, Corina Buechele, MD, Stephen Hon-Kit Wong, PhD, Michael C Bassik, PhD, Michael L. Cleary, MD

Blood (2015) 126 (23): 810.

https://doi.org/10.1182/blood.V126.23.810.810

Published: 2015

Journal Articles

MLL leukemia induction by genome editing of human CD34 + hematopoietic cells

Corina Buechele, Erin H. Breese, Dominik Schneidawind, Chiou-Hong Lin, Johan Jeong, Jesus Duque-Afonso, Stephen H. K. Wong, Kevin S. Smith, Robert S. Negrin, Matthew Porteus, Michael L. Cleary

Blood (2015) 126 (14): 1683–1694.

https://doi.org/10.1182/blood-2015-05-646398

Published: 2015

Includes: Supplemental data

Journal Articles

Comparative Studies of B Cell Precursor ALL Pathogenesis and Translational Biology Using a Conditional E2a-PBX1 Transgenic Mouse Model

Jesus Duque-Afonso, MD, Jue Feng, PhD, Florian Scherer, MD, Zhong Wang, PhD, Michael L. Cleary, MD

Blood (2014) 124 (21): 283.

https://doi.org/10.1182/blood.V124.21.283.283

Published: 2014

Journal Articles

Genome Engineering to Prospectively Investigate the Pathogenesis of MLL-AF9 Acute Leukemia

Corina Buechele, MD, Erin H. Breese, MDPhD, Dominik Schneidawind, MD, Matthew H. Porteus, MD PhD, Michael L. Cleary, MD

Blood (2014) 124 (21): 883.

https://doi.org/10.1182/blood.V124.21.883.883

Published: 2014

Journal Articles

Using Genome Engineering To Prospectively Investigate The Pathogenesis Of MLL Translocations In Infant Acute Lymphoblastic Leukemia

Erin H. Breese, MD, PhD, Catherine Dawson, Corina Buechele, MD, Marcus R. Breese, PhD, Michael L. Cleary, MD, Matthew H. Porteus, MD, PhD

Blood (2013) 122 (21): 3722.

https://doi.org/10.1182/blood.V122.21.3722.3722

Published: 2013

Journal Articles

Next-Generation NAMPT Inhibitors For ALL Identified By Sequential High-Throughput Phenotypic Chemical and Functional Genomic Screens

Michael C. Wei, MD, PhD, Christina J. Matheny, PhD, Michael C. Bassik, PhD, Alicia J. Donnelly, PhD, Martin Kampmann, PhD, Masayuki Iwasaki, PhD, MSC, Obdulio Piloto, PhD, David E. Solow-Cordero, PhD, Donna Bouley, DVM, PhD, Rachel E. Rau, MD, Patrick Brown, MD, Michael T. McManus, PhD, Jonathan S. Weissman, PhD, Michael L. Cleary, MD

Blood (2013) 122 (21): 171.

https://doi.org/10.1182/blood.V122.21.171.171

Published: 2013

Journal Articles

Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6

Michaela Liedtke, Paul M. Ayton, Tim C. P. Somervaille, Kevin S. Smith, Michael L. Cleary

Blood (2010) 116 (1): 63–70.

https://doi.org/10.1182/blood-2009-09-243386

Published: 2010

Includes: Supplemental data

Journal Articles

Counterpoint: In Some AMLs, Stem Cells are More Mature and Present at High Frequency.

Michael L. Cleary, MD

Blood (2009) 114 (22): SCI-35.

https://doi.org/10.1182/blood.V114.22.SCI-35.SCI-35

Published: 2009

Journal Articles

The Roles of MLL Holocomplex in Embryogenesis, Hematopoiesis and Tumor Suppression.

Akihiko Yokoyama, PhD, Francesca Ficara, PhD, Issay Kitabayashi, PhD, Michael L. Cleary, MD

Blood (2009) 114 (22): 2969.

https://doi.org/10.1182/blood.V114.22.2969.2969

Published: 2009

Journal Articles

Therapeutic targeting of MLL

Michaela Liedtke, Michael L. Cleary

Blood (2009) 113 (24): 6061–6068.

https://doi.org/10.1182/blood-2008-12-197061

Published: 2009

Journal Articles

Pbx1 Regulates the Self-Renewal of Long-Term Hematopoietic Stem Cells by Maintaining Their Quiescence.

Francesca Ficara, PhD, Mark J. Murphy, Ph.D., Min Lin, Ph.D, Michael L. Cleary, M.D.

Blood (2007) 110 (11): 94.

https://doi.org/10.1182/blood.V110.11.94.94

Published: 2007

Journal Articles

B-cell development fails in the absence of the Pbx1 proto-oncogene

Mrinmoy Sanyal, James W. Tung, Holger Karsunky, Hong Zeng, Licia Selleri, Irving L. Weissman, Leonore A. Herzenberg, Michael L. Cleary

Blood (2007) 109 (10): 4191–4199.

https://doi.org/10.1182/blood-2006-10-054213

Published: 2007

Includes: Supplemental data

Journal Articles

Identification of an Oncogenic MLL Fusion Complex with Histone Methylation and Acetylation Activities.

Ngai Cheung, PhD, Judy Yam, Ph.D, Li Chong Chan, Ph.D, Michael L. Cleary, M.D, Chi Wai Eric So, Ph.D

Blood (2006) 108 (11): 732.

https://doi.org/10.1182/blood.V108.11.732.732

Published: 2006

Journal Articles

Leukemia Stem Cells in Murine MLL−AF9 AML Are Downstream Myeloid Lineage Cells That Have Acquired Stem−Like Biological and Genetic Properties.

Tim C.P. Somervaille, MD, PhD, Michael L. Cleary, MD

Blood (2006) 108 (11): 771.

https://doi.org/10.1182/blood.V108.11.771.771

Published: 2006

Journal Articles

The Menin Tumor Suppressor Protein Is an Essential Oncogenic Cofactor for MLL-Associated Leukemogenesis.

Akihiko Yokoyama, PhD, Tim Somervaille, MD, PhD, Michael L. Cleary, MD

Blood (2005) 106 (11): 665.

https://doi.org/10.1182/blood.V106.11.665.665

Published: 2005

Journal Articles

Self-Association Contributes to E2a-Pbx1-Mediated Oncogenesis.

Zhong Wang, PhD, Michael L. Cleary, MD

Blood (2005) 106 (11): 2611.

https://doi.org/10.1182/blood.V106.11.2611.2611

Published: 2005

Journal Articles

MLL Translocation Partners AF4, AF5q31, and ENL Associate in a Higher Order Protein Complex with CDK9 and Cyclin T1.

Min Lin, PhD, Michael L. Cleary, MD

Blood (2005) 106 (11): 99.

https://doi.org/10.1182/blood.V106.11.99.99

Published: 2005

Journal Articles

Leukemia Proto-Oncoprotein MLL Forms a SET1 like Complex with Menin to Regulate Hox Gene Expression.

Akihiko Yokoyama, Ph.D, Zhong Wang, Ph.D, Joanna Wysocka, Ph.D, Mrinmoy Sanyal, Ph.D, Deborah J. Aufiero, Issay Kitabayashi, Ph.D, Winship Herr, Ph.D, Michael L. Cleary, M.D

Blood (2004) 104 (11): 2550.

https://doi.org/10.1182/blood.V104.11.2550.2550

Published: 2004

NARROW

Early-life infection depletes preleukemic cells in a mouse model of hyperdiploid B-cell acute lymphoblastic leukemia

Identification of a Novel Chromosomal Translocation t(11;16)(q23;q22) Fusing MLL to Enhancer of mRNA Decapping (EDC)-4 in Smoldering Acute Myeloid Leukemia

Oncogenic Role for the Lck/ZAP70/PLCG2 Signaling Pathway in Pre-B-ALL Pathogenesis

MLL leukemia induction by genome editing of human CD34 + hematopoietic cells

Comparative Studies of B Cell Precursor ALL Pathogenesis and Translational Biology Using a Conditional E2a-PBX1 Transgenic Mouse Model

Genome Engineering to Prospectively Investigate the Pathogenesis of MLL-AF9 Acute Leukemia

Using Genome Engineering To Prospectively Investigate The Pathogenesis Of MLL Translocations In Infant Acute Lymphoblastic Leukemia

Next-Generation NAMPT Inhibitors For ALL Identified By Sequential High-Throughput Phenotypic Chemical and Functional Genomic Screens

Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6

Counterpoint: In Some AMLs, Stem Cells are More Mature and Present at High Frequency.

The Roles of MLL Holocomplex in Embryogenesis, Hematopoiesis and Tumor Suppression.

Therapeutic targeting of MLL

Pbx1 Regulates the Self-Renewal of Long-Term Hematopoietic Stem Cells by Maintaining Their Quiescence.

B-cell development fails in the absence of the Pbx1 proto-oncogene

Identification of an Oncogenic MLL Fusion Complex with Histone Methylation and Acetylation Activities.

Leukemia Stem Cells in Murine MLL−AF9 AML Are Downstream Myeloid Lineage Cells That Have Acquired Stem−Like Biological and Genetic Properties.

The Menin Tumor Suppressor Protein Is an Essential Oncogenic Cofactor for MLL-Associated Leukemogenesis.

Self-Association Contributes to E2a-Pbx1-Mediated Oncogenesis.

MLL Translocation Partners AF4, AF5q31, and ENL Associate in a Higher Order Protein Complex with CDK9 and Cyclin T1.

Leukemia Proto-Oncoprotein MLL Forms a SET1 like Complex with Menin to Regulate Hox Gene Expression.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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