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Journal Articles

A Blastic Plasmacytoid Dendritic Cell Neoplasm-like Phenotype Identifies a Subgroup of NPM1-Mutated AML Patients with Worse Prognosis While Has Not Predictive Value in NPM1-Wt AML

Fabio Guolo, MD, Paola Minetto, MD, Annalisa Kunkl, MD, Elisabetta Tedone, Marino Clavio, MD, Maurizio Miglino, PhD, Fabrizio Caviglia, Nicoletta Colombo, PhD, Antonia Cagnetta, MD, Michele Cea, MD, Filippo Ballerini, MD, Jean Louis Ravetti, MD, Marco Gobbi, MD, Roberto Massimo Lemoli, MD

Blood (2018) 132 (Supplement 1): 5243.

https://doi.org/10.1182/blood-2018-99-118984

Published: 2018

Journal Articles

Erwinia Chrysantemi-Derived L-Asparaginase Strongly Enhances Proteasome Inhibitors Activity By Deregulating Cell Metabolic Programs

Paola Minetto, MD, Debora Soncini, PhD, Fabio Guolo, MD, Samantha Ruberti, BSc, PhD, Veronica Retali, Paola Contini, Nadia Bisso, MD, Nikki Di Felice, MD, Giulia Rivoli, MD, Antonia Cagnetta, MD, Marco Gobbi, MD, Roberto Massimo Lemoli, MD, Michele Cea, MD

Blood (2018) 132 (Supplement 1): 3221.

https://doi.org/10.1182/blood-2018-99-119622

Published: 2018

Journal Articles

Activation of the Non-Canonical Estrogen Receptor Gper As a Novel Therapeutic Strategy Against WaldenstrÃ¶m Macroglobulinemia

Nicola Amodio, PhD, Giada Juli, PhD, Eugenio Morelli, MD, Maria Angelica Stamato, PhD, Maria Eugenia Gallo Cantafio, PhD, Cinzia Federico, PhD, Katia Todoerti, PhD, Emanuela Altomare, Katia Grillone, PhD, Marco Rossi, MD, Michele Cea, MD, Antonino Neri, MD, Mariateresa Fulciniti, PhD, Nikhil Munshi, MD, Pierosandro Tagliaferri, Pierfrancesco Tassone, MD

Blood (2018) 132 (Supplement 1): 1585.

https://doi.org/10.1182/blood-2018-99-110928

Published: 2018

Journal Articles

SIRT6 Inhibition As a Novel Approach for Treating Acute Myeloid Leukemia

Michele Cea, MD, Antonia Cagnetta, MD, Debora Soncini, PhD, Paola Minetto, MD, Davide Lovera, MD, Fabio Guolo, MD, Nicoletta Colombo, PhD, Filippo Ballerini, MD, Marino Clavio, MD, Maurizio Miglino, PhD, Marco Gobbi, MD, Roberto M Lemoli, MD

Blood (2016) 128 (22): 5222.

https://doi.org/10.1182/blood.V128.22.5222.5222

Published: 2016

Journal Articles

CD38 Deregulation As Strategy to Make Multiple Myeloma Cells More Sensitive to NAD+ Depleting Agents

Michele Cea, MD, Antonia Cagnetta, MD, Debora Soncini, PhD, Paola Minetto, MD, Micaela Bergamaschi, MD, Giulia Rivoli, MD, Letizia Canepa, MD, Marco Gobbi, MD, Roberto M Lemoli, MD

Blood (2016) 128 (22): 5671.

https://doi.org/10.1182/blood.V128.22.5671.5671

Published: 2016

Journal Articles

A Novel Synthetic Lethal Approach Targeting SIRT6 in Acute Myeloid Leukemia

Michele Cea, MD, Antonia Cagnetta, MD, Davide Lovera, MD, Raffaella Grasso, PhD, Nicoletta Colombo, PhD, Micaela Bergamaschi, MD, Sara Aquino, MD, Fabio Guolo, MD, Paola Minetto, MD, Filippo Ballerini, MD, Letizia Canepa, MD, Sophia Adamia, PhD, Alessio Nencioni, Ivana Pierri, MD, Marino Clavio, Maurizio Miglino, PhD, Marco Gobbi, MD, Roberto Massimo Lemoli, MD

Blood (2015) 126 (23): 1375.

https://doi.org/10.1182/blood.V126.23.1375.1375

Published: 2015

Journal Articles

The KDM3A-KLF2-IRF4 Axis Maintains Myeloma Cell Survival

Hiroto Ohguchi, MD PhD, Teru Hideshima, MDPhD, Manoj Bhasin, PhD, Gullu Gorgun, PhD, Loredana Santo, MD, Michele Cea, MD, Naoya Mimura, MD PhD, Rikio Suzuki, MDPhD, Yu-Tzu Tai, PhD, Ruben D. Carrasco, MD PhD, Noopur S. Raje, MD, Paul G. Richardson, MD, Hideo Harigae, MD PhD, Takaomi Sanda, MD PhD, Kenneth C. Anderson, MD

Blood (2015) 126 (23): 3633.

https://doi.org/10.1182/blood.V126.23.3633.3633

Published: 2015

Journal Articles

A Novel Anti-a Proliferation-Inducing Ligand Hapril.01A Monoclonal Antibody Targets Multiple Myeloma Cells in the Bone Marrow Microenvironment

Yu-Tzu Tai, PhD, Chirag Acharya, MD, Gang An, MD PhD, Mike Y Zhong, Michele Cea, MD, Antonia Cagnetta, MD, Hua Jiang, MDPhD, Hans van Eenennaam, PhD, Andrea van Elsas, PhD, Nikhil C. Munshi, MD, Kenneth C. Anderson

Blood (2014) 124 (21): 2098.

https://doi.org/10.1182/blood.V124.21.2098.2098

Published: 2014

Journal Articles

NFκB Signaling and Mcl-1 Are Critical in B Cell Maturation Antigen-Promoted Multiple Myeloma Cell Growth and Survival

Chirag Acharya, MD, Gang An, MD PhD, Mike Y Zhong, Michele Cea, MD, Antonia Cagnetta, MD, Hua Jiang, MDPhD, Yu-Tzu Tai, PhD, Kenneth C. Anderson, MD

Blood (2014) 124 (21): 3384.

https://doi.org/10.1182/blood.V124.21.3384.3384

Published: 2014

Journal Articles

Identification Of Novel Alternative Splice Variants Of Sirtuins In Multiple Myeloma: Therapeutic Implications

Antonia Cagnetta, MD, Michele Cea, MD, Sophia Adamia, PhD, Yu-Tzu Tai, PhD, Teru Hideshima, MD, PhD, Marco Gobbi, MD, Nikhil C. Munshi, MD, Dharminder Chauhan, PhD, Kenneth C. Anderson, MD

Blood (2013) 122 (21): 3121.

https://doi.org/10.1182/blood.V122.21.3121.3121

Published: 2013

Journal Articles

Role Of Sirtuin-6 In Maintenance Of Genomic Instability In Multiple Myeloma Cells

Michele Cea, MD, Antonia Cagnetta, MD, Mariateresa Fulciniti, PhD, Yu-Tzu Tai, PhD, Chirag Acharya, Mike Zhong, Teru Hideshima, MD, PhD, Marco Gobbi, MD, Nikhil Munshi, MD, Dharminder Chauhan, PhD, Kenneth C. Anderson, MD

Blood (2013) 122 (21): 276.

https://doi.org/10.1182/blood.V122.21.276.276

Published: 2013

Journal Articles

Non Homologous End Joining, a Marker Of Genomic Instability Is Elevated In Multiple Myeloma: A New Prognostic Factor

Teresa Calimeri, MD, Mehmet Kemal Samur, PhD, Nicola Amodio, PhD, Michele Cea, MD, Antonia Cagnetta, MD, Mariateresa Fulciniti, PhD, Sophia Adamia, PhD, Marco Rossi, MD, Yu-Tzu Tai, PhD, Fortunato Morabito, MD, Abdel Kareem Azab, BPharm, PhD, Stephane Minvielle, PhD, Herve Avet-Loiseau, MD, Cheng Li, PhD, Jean-Bernard Lazaro, PhD, Kenneth C. Anderson, Masood A. Shammas, Pierfrancesco Tassone, MD, Nikhil C. Munshi, MD

Blood (2013) 122 (21): 124.

https://doi.org/10.1182/blood.V122.21.124.124

Published: 2013

Journal Articles

Novel Fc-Engineered Anti-B Cell Maturation Antigen-Monomethyl Auristatin F Antibody-Drug Conjugate (GSK2857916) Induces Potent and Selective Anti-Multiple Myeloma Activity Via Enhanced Effector Function and Direct Tumor Cell Killing

Yu-Tzu Tai, PhD, Chirag Acharya, Mike Y Zhong, Michele Cea, MD, Antonia Cagnetta, MD, Patrick A Mayes, PhD, Jenny L Craigen, PhD, Louise Gliddon, James Smothers, Amanda L Christie, B.S., Andrew L. Kung, MD, PhD, Paul G. Richardson, MD, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD

Blood (2013) 122 (21): 877.

https://doi.org/10.1182/blood.V122.21.877.877

Published: 2013

Journal Articles

Constitutive B-Cell Maturation Antigen (BCMA) Activation In Human Multiple Myeloma Cells Promotes Myeloma Cell Growth and Survival In The Bone Marrow Microenvironment Via Upregulated MCL-1 and NFκB Signaling

Yu-Tzu Tai, PhD, Chirag Acharya, MD, Mike Y Zhong, Michele Cea, MD, Antonia Cagnetta, MD, Paul G. Richardson, MD, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD

Blood (2013) 122 (21): 681.

https://doi.org/10.1182/blood.V122.21.681.681

Published: 2013

Journal Articles

Intracellular NAD + Depletion Enhances Bortezomib-Induced Myeloma Cytotoxicity

Antonia Cagnetta, MD, Michele Cea, MD, Chirag Acharya, MD, Teresa Calimeri, MD, Yu-Tzu Tai, PhD, Teru Hideshima, MD, PhD, Dharminder Chauhan, PhD, Franco Patrone, Marco Gobbi, MD, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD

Blood (2012) 120 (21): 330.

https://doi.org/10.1182/blood.V120.21.330.330

Published: 2012

Journal Articles

CRM1 Blockade by Novel Inhibitors of Nuclear Export (SINEs) Inhibits Multiple Myeloma Cell Growth, Osteoclastogenesis, and Myeloma-Induced Osteolysis

Blood (2012) 120 (21): 326.

https://doi.org/10.1182/blood.V120.21.326.326

Published: 2012

Journal Articles

Aberrant Non-Homologous End Joining in Multiple Myeloma: A Role in Genomic Instability and As Potential Prognostic Marker.

Blood (2012) 120 (21): 2932.

https://doi.org/10.1182/blood.V120.21.2932.2932

Published: 2012

Journal Articles

Compromised Nuclear Sirtuins Activity Sensitizes BRCA-Proficient multiple Myeloma Cells to DNA Damage Agents

Michele Cea, MD, Antonia Cagnetta, MD, Aditya Munshi, Yu-Tzu Tai, PhD, Teru Hideshima, MD, PhD, Dharminder Chauhan, PhD, Franco Patrone, Marco Gobbi, MD, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD

Blood (2012) 120 (21): 723.

https://doi.org/10.1182/blood.V120.21.723.723

Published: 2012

Journal Articles

Targeting Brouton's Tyrosine Kinase with PCI-32765 Blocks Growth and Survival of Multiple Myeloma and Waldenström Macroglobulinemia Via Potent Inhibition of Osteoclastogenesis, Cytokines/Chemokine Secretion, and Myeloma Stem-Like Cells in the Bone Marrow Microenvironment

Blood (2011) 118 (21): 883.

https://doi.org/10.1182/blood.V118.21.883.883

Published: 2011

Journal Articles

Blockade of Nuclear Export Protein CRM1 (chromosomal region maintenance 1, XPO1) by a Novel, Potent and Selective CRM1 Inhibitor KPT-185 Induces Significant Antitumor Activity Against Human Multiple Myeloma

Sun-Young Kong, MD, PhD, Yosef Landesman, PhD, Jana Jakubikova, PhD, Michael A. Sellitto, Antonia Cagnetta, MD, Michele Cea, MD, Michelle C. Chen, Francesca Cottini, MD, Douglas W. McMillin, PhD, Chirag Acharya, MD, William Senapedis, PhD, Sharon Shacham, PhD, MBA, Michael Kauffman, MD, PhD, Dilara McCauley, PhD, Jean-Richard Saint-Martin, BS, Nikhil C. Munshi, MD, Paul G. Richardson, MD, Kenneth C. Anderson, MD, Yu-Tzu Tai, PhD

Blood (2011) 118 (21): 2913.

https://doi.org/10.1182/blood.V118.21.2913.2913

Published: 2011

NARROW

A Blastic Plasmacytoid Dendritic Cell Neoplasm-like Phenotype Identifies a Subgroup of NPM1-Mutated AML Patients with Worse Prognosis While Has Not Predictive Value in NPM1-Wt AML

Erwinia Chrysantemi-Derived L-Asparaginase Strongly Enhances Proteasome Inhibitors Activity By Deregulating Cell Metabolic Programs

Activation of the Non-Canonical Estrogen Receptor Gper As a Novel Therapeutic Strategy Against WaldenstrÃ¶m Macroglobulinemia

SIRT6 Inhibition As a Novel Approach for Treating Acute Myeloid Leukemia

CD38 Deregulation As Strategy to Make Multiple Myeloma Cells More Sensitive to NAD+ Depleting Agents

A Novel Synthetic Lethal Approach Targeting SIRT6 in Acute Myeloid Leukemia

The KDM3A-KLF2-IRF4 Axis Maintains Myeloma Cell Survival

A Novel Anti-a Proliferation-Inducing Ligand Hapril.01A Monoclonal Antibody Targets Multiple Myeloma Cells in the Bone Marrow Microenvironment

NFκB Signaling and Mcl-1 Are Critical in B Cell Maturation Antigen-Promoted Multiple Myeloma Cell Growth and Survival

Identification Of Novel Alternative Splice Variants Of Sirtuins In Multiple Myeloma: Therapeutic Implications

Role Of Sirtuin-6 In Maintenance Of Genomic Instability In Multiple Myeloma Cells

Non Homologous End Joining, a Marker Of Genomic Instability Is Elevated In Multiple Myeloma: A New Prognostic Factor

Novel Fc-Engineered Anti-B Cell Maturation Antigen-Monomethyl Auristatin F Antibody-Drug Conjugate (GSK2857916) Induces Potent and Selective Anti-Multiple Myeloma Activity Via Enhanced Effector Function and Direct Tumor Cell Killing

Constitutive B-Cell Maturation Antigen (BCMA) Activation In Human Multiple Myeloma Cells Promotes Myeloma Cell Growth and Survival In The Bone Marrow Microenvironment Via Upregulated MCL-1 and NFκB Signaling

Intracellular NAD + Depletion Enhances Bortezomib-Induced Myeloma Cytotoxicity

CRM1 Blockade by Novel Inhibitors of Nuclear Export (SINEs) Inhibits Multiple Myeloma Cell Growth, Osteoclastogenesis, and Myeloma-Induced Osteolysis

Aberrant Non-Homologous End Joining in Multiple Myeloma: A Role in Genomic Instability and As Potential Prognostic Marker.

Compromised Nuclear Sirtuins Activity Sensitizes BRCA-Proficient multiple Myeloma Cells to DNA Damage Agents

Targeting Brouton's Tyrosine Kinase with PCI-32765 Blocks Growth and Survival of Multiple Myeloma and Waldenström Macroglobulinemia Via Potent Inhibition of Osteoclastogenesis, Cytokines/Chemokine Secretion, and Myeloma Stem-Like Cells in the Bone Marrow Microenvironment

Blockade of Nuclear Export Protein CRM1 (chromosomal region maintenance 1, XPO1) by a Novel, Potent and Selective CRM1 Inhibitor KPT-185 Induces Significant Antitumor Activity Against Human Multiple Myeloma

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American Society of Hematology

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ASH Publications

American Society of Hematology

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