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Journal Articles

Osteoclasts Promote Immune Suppressive Microenvironment in Multiple Myeloma: Therapeutic Implication

Gang An, MD PhD, Chirag Acharya, Xiaoyan Feng, MD, Kenneth Wen, Mike Zhong, BS, Li Zhang, Nikhil C Munshi, MD, Lugui Qiu, MD, Yu-Tzu Tai, PhD, Kenneth C. Anderson, MD

Blood (2016) 128 (22): 3303.

https://doi.org/10.1182/blood.V128.22.3303.3303

Published: 2016

Journal Articles

Targeting CD38 Suppresses Induction and Function of T Regulatory Cells to Reverse Immunosuppression in Multiple Myeloma

Xiaoyan Feng, Chirag Acharya, MD, Gang An, MD PhD, Kenneth Wen, Li Zhang, Alireza Kalbasi, Lugui Qiu, MD, Nikhil C Munshi, MD, Yu-Tzu Tai, PhD, Kenneth C. Anderson, MD

Blood (2016) 128 (22): 2106.

https://doi.org/10.1182/blood.V128.22.2106.2106

Published: 2016

Journal Articles

Osteoclasts promote immune suppressive microenvironment in multiple myeloma: therapeutic implication

Gang An, Chirag Acharya, Xiaoyan Feng, Kenneth Wen, Mike Zhong, Li Zhang, Nikhil C. Munshi, Lugui Qiu, Yu-Tzu Tai, Kenneth C. Anderson

Blood (2016) 128 (12): 1590–1603.

https://doi.org/10.1182/blood-2016-03-707547

Published: 2016

Includes: Supplemental data

Journal Articles

APRIL and BCMA promote human multiple myeloma growth and immunosuppression in the bone marrow microenvironment

Yu-Tzu Tai, Chirag Acharya, Gang An, Michele Moschetta, Mike Y. Zhong, Xiaoyan Feng, Michele Cea, Antonia Cagnetta, Kenneth Wen, Hans van Eenennaam, Andrea van Elsas, Lugui Qiu, Paul Richardson, Nikhil Munshi, Kenneth C. Anderson

Blood (2016) 127 (25): 3225–3236.

https://doi.org/10.1182/blood-2016-01-691162

Published: 2016

Includes: Supplemental data

Journal Articles

Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells

Blood (2016) 127 (9): 1138–1150.

https://doi.org/10.1182/blood-2015-06-649970

Published: 2016

Includes: Supplemental data

Journal Articles

Activation of Lysosomal Function and Reactive Oxygen Species Play Crucial Roles in SAR650984-Induced Direct Killing of Human Multiple Myeloma Cells with Mutated p53, Which Is Further Augmented By Pomalidomide

Hua Jiang, MDPhD, Chirag Acharya, MD, Gang An Gang An, MDPhD, Xiaoyan Feng, MD, Zhili Song, Guang Yang, PhD, Francisco Adrian, Lugui Qiu, MD, Paul Richardson, MD, Nikhil C. Munshi, MD, Yu-Tzu Tai, PhD, Kenneth C Anderson, MD

Blood (2015) 126 (23): 4253.

https://doi.org/10.1182/blood.V126.23.4253.4253

Published: 2015

Journal Articles

APRIL/B Cell Maturation Antigen (BCMA) Signaling Cascades Promote Human Multiple Myeloma Growth and Mediate Immunosuppression in the Bone Marrow Microenvironment Via IL-10, TGF-b, and PD-L1

Yu-Tzu Tai, PhD, Chirag Acharya, MD, Gang An, MDPhD, Michele Moschetta, MD, Mike Zhong, BS, Xiaoyan Feng, MD, Hans van Eenennaam, PhD, Andrea van Elsas, PhD, Lugui Qiu, MD PhD, Nikhil C. Munshi, MD, Kenneth C Anderson, MD

Blood (2015) 126 (23): 1810.

https://doi.org/10.1182/blood.V126.23.1810.1810

Published: 2015

Journal Articles

A Novel Anti-a Proliferation-Inducing Ligand Hapril.01A Monoclonal Antibody Targets Multiple Myeloma Cells in the Bone Marrow Microenvironment

Yu-Tzu Tai, PhD, Chirag Acharya, MD, Gang An, MD PhD, Mike Y Zhong, Michele Cea, MD, Antonia Cagnetta, MD, Hua Jiang, MDPhD, Hans van Eenennaam, PhD, Andrea van Elsas, PhD, Nikhil C. Munshi, MD, Kenneth C. Anderson

Blood (2014) 124 (21): 2098.

https://doi.org/10.1182/blood.V124.21.2098.2098

Published: 2014

Journal Articles

NFκB Signaling and Mcl-1 Are Critical in B Cell Maturation Antigen-Promoted Multiple Myeloma Cell Growth and Survival

Chirag Acharya, MD, Gang An, MD PhD, Mike Y Zhong, Michele Cea, MD, Antonia Cagnetta, MD, Hua Jiang, MDPhD, Yu-Tzu Tai, PhD, Kenneth C. Anderson, MD

Blood (2014) 124 (21): 3384.

https://doi.org/10.1182/blood.V124.21.3384.3384

Published: 2014

Journal Articles

SAR 650984, a Therapeutic Anti-CD38 Monoclonal Antibody, Blocks CD38-CD31 Interaction in Multiple Myeloma

Gang An, MD PhD, Hua Jiang, MDPhD, Chirag Acharya, MD, Mike Y Zhong, BS, Ti Cai, PhD, Guang Yang, Zhili Song, Joachim Theilhaber, PhD, Francisco Adrian, PhD, Yu-Tzu Tai, PhD, Kenneth C. Anderson, MD

Blood (2014) 124 (21): 4729.

https://doi.org/10.1182/blood.V124.21.4729.4729

Published: 2014

Journal Articles

SAR650984 (SAR) Directly Promotes Homotypic Adhesion-Related Multiple Myeloma (MM) Cell Death and SAR-Induced Anti-MM Activities Are Enhanced By Pomalidomide, More Potently Than Lenalidomide

Hua Jiang, MDPhD, Gang An, MD PhD, Chirag Acharya, MD, Mike Y Zhong, BS, Ti Cai, PhD, Zhili Song, Guang Yang, Francisco Adrian, PhD, Nikhil C. Munshi, MD, Yu-Tzu Tai, PhD, Kenneth C. Anderson

Blood (2014) 124 (21): 2124.

https://doi.org/10.1182/blood.V124.21.2124.2124

Published: 2014

Journal Articles

Novel anti–B-cell maturation antigen antibody-drug conjugate (GSK2857916) selectively induces killing of multiple myeloma

Yu-Tzu Tai, Patrick A. Mayes, Chirag Acharya, Mike Y. Zhong, Michele Cea, Antonia Cagnetta, Jenny Craigen, John Yates, Louise Gliddon, William Fieles, Bao Hoang, James Tunstead, Amanda L. Christie, Andrew L. Kung, Paul Richardson, Nikhil C. Munshi, Kenneth C. Anderson

Blood (2014) 123 (20): 3128–3138.

https://doi.org/10.1182/blood-2013-10-535088

Published: 2014

Includes: Supplemental data

Journal Articles

Role Of Sirtuin-6 In Maintenance Of Genomic Instability In Multiple Myeloma Cells

Michele Cea, MD, Antonia Cagnetta, MD, Mariateresa Fulciniti, PhD, Yu-Tzu Tai, PhD, Chirag Acharya, Mike Zhong, Teru Hideshima, MD, PhD, Marco Gobbi, MD, Nikhil Munshi, MD, Dharminder Chauhan, PhD, Kenneth C. Anderson, MD

Blood (2013) 122 (21): 276.

https://doi.org/10.1182/blood.V122.21.276.276

Published: 2013

Journal Articles

Novel Fc-Engineered Anti-B Cell Maturation Antigen-Monomethyl Auristatin F Antibody-Drug Conjugate (GSK2857916) Induces Potent and Selective Anti-Multiple Myeloma Activity Via Enhanced Effector Function and Direct Tumor Cell Killing

Yu-Tzu Tai, PhD, Chirag Acharya, Mike Y Zhong, Michele Cea, MD, Antonia Cagnetta, MD, Patrick A Mayes, PhD, Jenny L Craigen, PhD, Louise Gliddon, James Smothers, Amanda L Christie, B.S., Andrew L. Kung, MD, PhD, Paul G. Richardson, MD, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD

Blood (2013) 122 (21): 877.

https://doi.org/10.1182/blood.V122.21.877.877

Published: 2013

Journal Articles

Constitutive B-Cell Maturation Antigen (BCMA) Activation In Human Multiple Myeloma Cells Promotes Myeloma Cell Growth and Survival In The Bone Marrow Microenvironment Via Upregulated MCL-1 and NFκB Signaling

Yu-Tzu Tai, PhD, Chirag Acharya, MD, Mike Y Zhong, Michele Cea, MD, Antonia Cagnetta, MD, Paul G. Richardson, MD, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD

Blood (2013) 122 (21): 681.

https://doi.org/10.1182/blood.V122.21.681.681

Published: 2013

Journal Articles

Intracellular NAD + depletion enhances bortezomib-induced anti-myeloma activity

Antonia Cagnetta, Michele Cea, Teresa Calimeri, Chirag Acharya, Mariateresa Fulciniti, Yu-Tzu Tai, Teru Hideshima, Dharminder Chauhan, Mike Y. Zhong, Franco Patrone, Alessio Nencioni, Marco Gobbi, Paul Richardson, Nikhil Munshi, Kenneth C. Anderson

Blood (2013) 122 (7): 1243–1255.

https://doi.org/10.1182/blood-2013-02-483511

Published: 2013

Includes: Supplemental data

Journal Articles

Intracellular NAD + Depletion Enhances Bortezomib-Induced Myeloma Cytotoxicity

Antonia Cagnetta, MD, Michele Cea, MD, Chirag Acharya, MD, Teresa Calimeri, MD, Yu-Tzu Tai, PhD, Teru Hideshima, MD, PhD, Dharminder Chauhan, PhD, Franco Patrone, Marco Gobbi, MD, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD

Blood (2012) 120 (21): 330.

https://doi.org/10.1182/blood.V120.21.330.330

Published: 2012

Journal Articles

CRM1 Blockade by Novel Inhibitors of Nuclear Export (SINEs) Inhibits Multiple Myeloma Cell Growth, Osteoclastogenesis, and Myeloma-Induced Osteolysis

Blood (2012) 120 (21): 326.

https://doi.org/10.1182/blood.V120.21.326.326

Published: 2012

Journal Articles

CRM1 Inhibition Abrogates Osteoclast Formation and Bone Resorption Via Inhibition of RANKL-Induced NFκB While Sparing Osteoblastogenesis: Further Therapeutic Implication in Multiple Myeloma

Chirag Acharya, MD, Mike Y Zhong, B.S., Yolanda Calle, PhD, Stephen Schey, MD, Michelle Chen, Daniel Tannenbaum, B.S., Michaela R Reagan, PhD, Irene M. Ghobrial, MD, Yosef Landesman, PhD, Sharon Shacham, PhD MBA, Michael Kauffman, MD, PhD, Kenneth C. Anderson, MD, Yu-Tzu Tai, PhD

Blood (2012) 120 (21): 1835.

https://doi.org/10.1182/blood.V120.21.1835.1835

Published: 2012

Journal Articles

Targeting Aminopeptidases by Tosedostat (TST) (CHR2797), Alone and with LBH589, Induces Significant Cytotoxicity Against Human Multiple Myeloma (MM) Cells

Chirag Acharya, Mike Y Zhong, B.S., Daniel Tannenbaum, B.S., Michelle Chen, Matt Ma, Jack Singer, MD, Kenneth C. Anderson, MD, Paul G. Richardson, MD, Yu-Tzu Tai, PhD

Blood (2012) 120 (21): 1847.

https://doi.org/10.1182/blood.V120.21.1847.1847

Published: 2012

NARROW

Osteoclasts Promote Immune Suppressive Microenvironment in Multiple Myeloma: Therapeutic Implication

Targeting CD38 Suppresses Induction and Function of T Regulatory Cells to Reverse Immunosuppression in Multiple Myeloma

Osteoclasts promote immune suppressive microenvironment in multiple myeloma: therapeutic implication

APRIL and BCMA promote human multiple myeloma growth and immunosuppression in the bone marrow microenvironment

Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells

Activation of Lysosomal Function and Reactive Oxygen Species Play Crucial Roles in SAR650984-Induced Direct Killing of Human Multiple Myeloma Cells with Mutated p53, Which Is Further Augmented By Pomalidomide

APRIL/B Cell Maturation Antigen (BCMA) Signaling Cascades Promote Human Multiple Myeloma Growth and Mediate Immunosuppression in the Bone Marrow Microenvironment Via IL-10, TGF-b, and PD-L1

A Novel Anti-a Proliferation-Inducing Ligand Hapril.01A Monoclonal Antibody Targets Multiple Myeloma Cells in the Bone Marrow Microenvironment

NFκB Signaling and Mcl-1 Are Critical in B Cell Maturation Antigen-Promoted Multiple Myeloma Cell Growth and Survival

SAR 650984, a Therapeutic Anti-CD38 Monoclonal Antibody, Blocks CD38-CD31 Interaction in Multiple Myeloma

SAR650984 (SAR) Directly Promotes Homotypic Adhesion-Related Multiple Myeloma (MM) Cell Death and SAR-Induced Anti-MM Activities Are Enhanced By Pomalidomide, More Potently Than Lenalidomide

Novel anti–B-cell maturation antigen antibody-drug conjugate (GSK2857916) selectively induces killing of multiple myeloma

Role Of Sirtuin-6 In Maintenance Of Genomic Instability In Multiple Myeloma Cells

Novel Fc-Engineered Anti-B Cell Maturation Antigen-Monomethyl Auristatin F Antibody-Drug Conjugate (GSK2857916) Induces Potent and Selective Anti-Multiple Myeloma Activity Via Enhanced Effector Function and Direct Tumor Cell Killing

Constitutive B-Cell Maturation Antigen (BCMA) Activation In Human Multiple Myeloma Cells Promotes Myeloma Cell Growth and Survival In The Bone Marrow Microenvironment Via Upregulated MCL-1 and NFκB Signaling

Intracellular NAD + depletion enhances bortezomib-induced anti-myeloma activity

Intracellular NAD + Depletion Enhances Bortezomib-Induced Myeloma Cytotoxicity

CRM1 Blockade by Novel Inhibitors of Nuclear Export (SINEs) Inhibits Multiple Myeloma Cell Growth, Osteoclastogenesis, and Myeloma-Induced Osteolysis

CRM1 Inhibition Abrogates Osteoclast Formation and Bone Resorption Via Inhibition of RANKL-Induced NFκB While Sparing Osteoblastogenesis: Further Therapeutic Implication in Multiple Myeloma

Targeting Aminopeptidases by Tosedostat (TST) (CHR2797), Alone and with LBH589, Induces Significant Cytotoxicity Against Human Multiple Myeloma (MM) Cells

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American Society of Hematology

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ASH Publications

American Society of Hematology

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