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Mike Y Zhong
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Journal Articles

APRIL and BCMA promote human multiple myeloma growth and immunosuppression in the bone marrow microenvironment

Yu-Tzu Tai, Chirag Acharya, Gang An, Michele Moschetta, Mike Y. Zhong, Xiaoyan Feng, Michele Cea, Antonia Cagnetta, Kenneth Wen, Hans van Eenennaam, Andrea van Elsas, Lugui Qiu, Paul Richardson, Nikhil Munshi, Kenneth C. Anderson
Journal: Blood
Blood (2016) 127 (25): 3225–3236.
https://doi.org/10.1182/blood-2016-01-691162
Published: 2016
Includes: Supplemental data
Journal Articles

A Novel Anti-a Proliferation-Inducing Ligand Hapril.01A Monoclonal Antibody Targets Multiple Myeloma Cells in the Bone Marrow Microenvironment

Yu-Tzu Tai, PhD, Chirag Acharya, MD, Gang An, MD PhD, Mike Y Zhong, Michele Cea, MD, Antonia Cagnetta, MD, Hua Jiang, MDPhD, Hans van Eenennaam, PhD, Andrea van Elsas, PhD, Nikhil C. Munshi, MD, Kenneth C. Anderson
Journal: Blood
Blood (2014) 124 (21): 2098.
https://doi.org/10.1182/blood.V124.21.2098.2098
Published: 2014
Journal Articles

NFκB Signaling and Mcl-1 Are Critical in B Cell Maturation Antigen-Promoted Multiple Myeloma Cell Growth and Survival

Chirag Acharya, MD, Gang An, MD PhD, Mike Y Zhong, Michele Cea, MD, Antonia Cagnetta, MD, Hua Jiang, MDPhD, Yu-Tzu Tai, PhD, Kenneth C. Anderson, MD
Journal: Blood
Blood (2014) 124 (21): 3384.
https://doi.org/10.1182/blood.V124.21.3384.3384
Published: 2014
Journal Articles

SAR 650984, a Therapeutic Anti-CD38 Monoclonal Antibody, Blocks CD38-CD31 Interaction in Multiple Myeloma

Gang An, MD PhD, Hua Jiang, MDPhD, Chirag Acharya, MD, Mike Y Zhong, BS, Ti Cai, PhD, Guang Yang, Zhili Song, Joachim Theilhaber, PhD, Francisco Adrian, PhD, Yu-Tzu Tai, PhD, Kenneth C. Anderson, MD
Journal: Blood
Blood (2014) 124 (21): 4729.
https://doi.org/10.1182/blood.V124.21.4729.4729
Published: 2014
Journal Articles

SAR650984 (SAR) Directly Promotes Homotypic Adhesion-Related Multiple Myeloma (MM) Cell Death and SAR-Induced Anti-MM Activities Are Enhanced By Pomalidomide, More Potently Than Lenalidomide

Hua Jiang, MDPhD, Gang An, MD PhD, Chirag Acharya, MD, Mike Y Zhong, BS, Ti Cai, PhD, Zhili Song, Guang Yang, Francisco Adrian, PhD, Nikhil C. Munshi, MD, Yu-Tzu Tai, PhD, Kenneth C. Anderson
Journal: Blood
Blood (2014) 124 (21): 2124.
https://doi.org/10.1182/blood.V124.21.2124.2124
Published: 2014
Journal Articles

Novel anti–B-cell maturation antigen antibody-drug conjugate (GSK2857916) selectively induces killing of multiple myeloma

Yu-Tzu Tai, Patrick A. Mayes, Chirag Acharya, Mike Y. Zhong, Michele Cea, Antonia Cagnetta, Jenny Craigen, John Yates, Louise Gliddon, William Fieles, Bao Hoang, James Tunstead, Amanda L. Christie, Andrew L. Kung, Paul Richardson, Nikhil C. Munshi, Kenneth C. Anderson
Journal: Blood
Blood (2014) 123 (20): 3128–3138.
https://doi.org/10.1182/blood-2013-10-535088
Published: 2014
Includes: Supplemental data
Journal Articles

Novel Fc-Engineered Anti-B Cell Maturation Antigen-Monomethyl Auristatin F Antibody-Drug Conjugate (GSK2857916) Induces Potent and Selective Anti-Multiple Myeloma Activity Via Enhanced Effector Function and Direct Tumor Cell Killing

Yu-Tzu Tai, PhD, Chirag Acharya, Mike Y Zhong, Michele Cea, MD, Antonia Cagnetta, MD, Patrick A Mayes, PhD, Jenny L Craigen, PhD, Louise Gliddon, James Smothers, Amanda L Christie, B.S., Andrew L. Kung, MD, PhD, Paul G. Richardson, MD, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD
Journal: Blood
Blood (2013) 122 (21): 877.
https://doi.org/10.1182/blood.V122.21.877.877
Published: 2013
Journal Articles

Constitutive B-Cell Maturation Antigen (BCMA) Activation In Human Multiple Myeloma Cells Promotes Myeloma Cell Growth and Survival In The Bone Marrow Microenvironment Via Upregulated MCL-1 and NFκB Signaling

Yu-Tzu Tai, PhD, Chirag Acharya, MD, Mike Y Zhong, Michele Cea, MD, Antonia Cagnetta, MD, Paul G. Richardson, MD, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD
Journal: Blood
Blood (2013) 122 (21): 681.
https://doi.org/10.1182/blood.V122.21.681.681
Published: 2013
Journal Articles

Intracellular NAD + depletion enhances bortezomib-induced anti-myeloma activity

Antonia Cagnetta, Michele Cea, Teresa Calimeri, Chirag Acharya, Mariateresa Fulciniti, Yu-Tzu Tai, Teru Hideshima, Dharminder Chauhan, Mike Y. Zhong, Franco Patrone, Alessio Nencioni, Marco Gobbi, Paul Richardson, Nikhil Munshi, Kenneth C. Anderson
Journal: Blood
Blood (2013) 122 (7): 1243–1255.
https://doi.org/10.1182/blood-2013-02-483511
Published: 2013
Includes: Supplemental data
Journal Articles

CRM1 Blockade by Novel Inhibitors of Nuclear Export (SINEs) Inhibits Multiple Myeloma Cell Growth, Osteoclastogenesis, and Myeloma-Induced Osteolysis

Yu-Tzu Tai, PhD, Yosef Landesman, PhD, Chirag Acharya, M.D., Mike Y Zhong, B.S., Yolanda Calle, PhD, Michele Cea, MD, Yiguo Hu, PhD, Antonia Cagnetta, MD, Daniel Tannenbaum, B.S., Michelle Chen, Aditya Munshi, William Senapedis, PhD, Jean-Richard Saint-Martin, BS, Trinayan Kashyap, Haoqiang Ying, Dilara McCauley, PhD, Sharon Shacham, PhD MBA, Michael Kauffman, MD, PhD, Yumei Gu, Ph.D., Lizi Wu, PhD, Stephen Schey, MD, Andrew L. Kung, MD, PhD, Nikhil C. Munshi, MD, Paul G. Richardson, MD, Kenneth C. Anderson, MD
Journal: Blood
Blood (2012) 120 (21): 326.
https://doi.org/10.1182/blood.V120.21.326.326
Published: 2012
Journal Articles

CRM1 Inhibition Abrogates Osteoclast Formation and Bone Resorption Via Inhibition of RANKL-Induced NFκB While Sparing Osteoblastogenesis: Further Therapeutic Implication in Multiple Myeloma

Chirag Acharya, MD, Mike Y Zhong, B.S., Yolanda Calle, PhD, Stephen Schey, MD, Michelle Chen, Daniel Tannenbaum, B.S., Michaela R Reagan, PhD, Irene M. Ghobrial, MD, Yosef Landesman, PhD, Sharon Shacham, PhD MBA, Michael Kauffman, MD, PhD, Kenneth C. Anderson, MD, Yu-Tzu Tai, PhD
Journal: Blood
Blood (2012) 120 (21): 1835.
https://doi.org/10.1182/blood.V120.21.1835.1835
Published: 2012
Journal Articles

Targeting Aminopeptidases by Tosedostat (TST) (CHR2797), Alone and with LBH589, Induces Significant Cytotoxicity Against Human Multiple Myeloma (MM) Cells

Chirag Acharya, Mike Y Zhong, B.S., Daniel Tannenbaum, B.S., Michelle Chen, Matt Ma, Jack Singer, MD, Kenneth C. Anderson, MD, Paul G. Richardson, MD, Yu-Tzu Tai, PhD
Journal: Blood
Blood (2012) 120 (21): 1847.
https://doi.org/10.1182/blood.V120.21.1847.1847
Published: 2012
Journal Articles

Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma

Yu-Tzu Tai, Betty Y. Chang, Sun-Young Kong, Mariateresa Fulciniti, Guang Yang, Yolanda Calle, Yiguo Hu, Jianhong Lin, Jian-Jun Zhao, Antonia Cagnetta, Michele Cea, Michael A. Sellitto, Mike Y. Zhong, Qiuju Wang, Chirag Acharya, Daniel R. Carrasco, Joseph J. Buggy, Laurence Elias, Steven P. Treon, William Matsui, Paul Richardson, Nikhil C. Munshi, Kenneth C. Anderson
Journal: Blood
Blood (2012) 120 (9): 1877–1887.
https://doi.org/10.1182/blood-2011-12-396853
Published: 2012
Includes: Supplemental data