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Journal Articles

miR-15a/16-1 deletion in activated B cells promotes plasma cell and mature B-cell neoplasms

Blood (2021) 137 (14): 1905–1919.

https://doi.org/10.1182/blood.2020009088

Published: 2021

Includes: Supplemental data

Journal Articles

Dysregulated Translational Control Is a Central Feature of MM Mediated By 14-3-3ε Interactome Promoting Multiple Myeloma Cell Growth and Viability

Blood (2018) 132 (Supplement 1): 3176.

https://doi.org/10.1182/blood-2018-99-118994

Published: 2018

Journal Articles

A Single Gene-Mediated Perturbation of the Human Genome Leads to Malignant Transformation in a Murine Transgenic Model

Jianhong Lin, MD MSc, Chun Yang, MD PhD, Li Xue, MD PhD, Zhenkui Wang, MD PhD, Yan Xu, MD, Mehmet Kemal Samur, PhD, Jianjun Zhao, MD, Ariel Kwart, BS, Masood A. Shammas, PhD, Xiaofeng Jiang, MD PhD, Wong Kwok-Kin, MD PhD, Ruben D. Carrasco, MD PhD, Kenneth C Anderson, MD, Nikhil Munshi, MD

Blood (2017) 130 (Supplement 1): 4410.

https://doi.org/10.1182/blood.V130.Suppl_1.4410.4410

Published: 2017

Journal Articles

Ywhae Located on Chromosome 17p13 Promotes Myeloma Cells Proliferation Via Induction of Anti-Apoptosis and Survival Signaling Pathways

Blood (2017) 130 (Supplement 1): 1755.

https://doi.org/10.1182/blood.V130.Suppl_1.1755.1755

Published: 2017

Journal Articles

Germinal Center-Derived Lymphomas and Plasmacytomas in Mice with Targeted Deletion of MiR-15a/16-1 in Activated B Cells

Tomasz Sewastianik, PhD, Jianjun Zhao, MD PhD, Meng Jiang, MD, Jianli Wang, MD PhD, Vinodh Pillai, MD PhD, Peter S. Dennis, BS, Jianhong Lin, MD M.Sc, Daniel Brooks, Mary Bouxsein, PhD, Geraldine S Pinkus, MD, Petr Jarolim, MD PhD, Davide Robbiani, Irene M. Ghobrial, MD, Kenneth C. Anderson, MD, Ruben D. Carrasco, MD PhD

Blood (2016) 128 (22): 743.

https://doi.org/10.1182/blood.V128.22.743.743

Published: 2016

Journal Articles

A clinically relevant in vivo zebrafish model of human multiple myeloma to study preclinical therapeutic efficacy

Jianhong Lin, Weihong Zhang, Jian-Jun Zhao, Ariel H. Kwart, Chun Yang, Dongdong Ma, Xiubao Ren, Yu-Tzu Tai, Kenneth C. Anderson, Robert I. Handin, Nikhil C. Munshi

Blood (2016) 128 (2): 249–252.

https://doi.org/10.1182/blood-2016-03-704460

Published: 2016

Journal Articles

Nuclease Activity Is Associated with Genomic Instability As Well As Survival in Myeloma; Underlying Mechanisms and Significance

Masood A Shammas, PhD, Leutz Buon, Jianhong Lin, MD M.Sc, Mehmet K Samur, PhD, Jaymin M. Patel, MD, Ankit Vahia, Purushothama Nanjappa, Subodh Kumar, PhD, Ahsun Bajwa, Humza Ahmad, David Alagpulinsa, BPham, Giovanni Parmigiani, PhD, Florence Magrangeas, Stephane Minvielle, Herve Avet-Loiseau, Nikhil C. Munshi, MD

Blood (2015) 126 (23): 2420.

https://doi.org/10.1182/blood.V126.23.2420.2420

Published: 2015

Journal Articles

Blocking Specific CD44 Splicing Variant Isoform Inhibits the Differentiation of Th-2 Cells through Interfering with IL-4/IL-4R Signaling Pathway

Chun Yang, MD PhD, Jianhong Lin, MD M.Sc, Hongyan Liang, MD PhD, Ariel Kwart, B.S., Meng Jiang, MD, Jianjun Zhao, MD PhD, Xiaofeng Jiang, MD PhD, Nikhil C. Munshi, MD

Blood (2015) 126 (23): 285.

https://doi.org/10.1182/blood.V126.23.285.285

Published: 2015

Journal Articles

Apurinic/Apyrimidinic Endonuclease 1 Induced Genomic Instability Causes T-Cell Acute Lymphoblastic Leukemia in Zebrafish

Jianhong Lin, MD M.Sc, Chun Yang, MD PhD, Ariel Kwart, B.S., Jianjun Zhao, MD PhD, Mehmet K Samur, PhD, Weihong Zhang, MD, Purushothama Nanjappa, M.S., Teresa Calimeri, MD PhD, Xiubao Ren, MD, Dongdong Ma, MD PhD, Xiaofeng Jiang, MD PhD, Yi Zhou, PhD, Masood Shammas, PhD, Kenneth C. Anderson, MD, Jon C. Aster, MD PhD, Leonard I. Zon, MD, Robert I. Handin, MD, Nikhil C. Munshi, MD

Blood (2015) 126 (23): 1431.

https://doi.org/10.1182/blood.V126.23.1431.1431

Published: 2015

Journal Articles

Functional and Genomic Signatures of Homologous Recombination (HR) Predict for Clinical Outcome in Multiple Myeloma (MM)

Masood A Shammas, PhD, Subodh Kumar, PhD, Purushothama Nanjappa, Mehmet K Samur, PhD, Srikanth Talluri, PhD, Jianhong Lin, MD M.Sc, Florence Magrangeas, Stephane Minvielle, Hervé Avet-Loiseau, MD, Nikhil C. Munshi, MD

Blood (2015) 126 (23): 3626.

https://doi.org/10.1182/blood.V126.23.3626.3626

Published: 2015

Journal Articles

Telomerase Contributes To Repair Of DNA Breaks In Myeloma Cells By Incorporating “TTAGGG” Sequences Within Genome: Biological and Translational Significance

Jagannath Pal, PhD, Jie Ding, PhD, Subodh Kumar, PhD, Zachary Hunter, Teresa Calimeri, MD, Jianhong Lin, Maria Gkotzamanidou, MD, Giovanni Parmigiani, PhD, Steven Treon, Masood Shammas, PhD, Nikhil Munshi, MD

Blood (2013) 122 (21): 1249.

https://doi.org/10.1182/blood.V122.21.1249.1249

Published: 2013

Journal Articles

Differences in the Angiogenic Response and Subsequent Growth of Plasma Cells From Myeloma and MGUS Patients Xenografted Into Zebrafish Embryos.

Dongdong Ma, PhD, Aravind Ramachandran, Yali Chang, MD, Jianhong Lin, MD, Weihong Zhang, PhD, Yu-Tzu Tai, PhD, Nikhil C. Munshi, MD, Robert I Handin, MD

Blood (2012) 120 (21): 2912.

https://doi.org/10.1182/blood.V120.21.2912.2912

Published: 2012

Journal Articles

Aberrant Non-Homologous End Joining in Multiple Myeloma: A Role in Genomic Instability and As Potential Prognostic Marker.

Blood (2012) 120 (21): 2932.

https://doi.org/10.1182/blood.V120.21.2932.2932

Published: 2012

Journal Articles

A Clinically Relevant Zebrafish in Vivo Model of Human Multiple Myeloma (MM) to Study Disease Biology and Preclinical Therapeutic Efficacy

Weihong Zhang, MD, Jianhong Lin, MD, Dongdong Ma, MD, PhD, Ariel H Kwart, BA, Aravind Ramachandran, Shirley He, Sharma Swagata, Yu-Tzu Tai, PhD, Kenneth C. Anderson, MD, Robert I Handin, MD, Nikhil C Munshi, MD

Blood (2012) 120 (21): 4078.

https://doi.org/10.1182/blood.V120.21.4078.4078

Published: 2012

Journal Articles

Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma

Blood (2012) 120 (9): 1877–1887.

https://doi.org/10.1182/blood-2011-12-396853

Published: 2012

Includes: Supplemental data

Journal Articles

Targeting Brouton's Tyrosine Kinase with PCI-32765 Blocks Growth and Survival of Multiple Myeloma and Waldenström Macroglobulinemia Via Potent Inhibition of Osteoclastogenesis, Cytokines/Chemokine Secretion, and Myeloma Stem-Like Cells in the Bone Marrow Microenvironment

Blood (2011) 118 (21): 883.

https://doi.org/10.1182/blood.V118.21.883.883

Published: 2011

Journal Articles

Investigational Agent MLN9708 Target Tumor Suppressor MicroRNA-33b in Multiple Myeloma Cells

Ze Tian, Jian-Jun Zhao, Jianhong Lin, PhD, Dharminder Chauhan, PhD, Kenneth C. Anderson, MD

Blood (2011) 118 (21): 136.

https://doi.org/10.1182/blood.V118.21.136.136

Published: 2011

Journal Articles

Mir-222-221 Induce Dexamethasone Resistance by Targeting BBC3/PUMA in Human Multiple Myeloma

Jian-Jun Zhao, M.D., Ph.D., Zhangbo Chu, M.D., Jianhong Lin, PhD, Yu-Tzu Tai, PhD, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD, Ruben Carrasco, MD, PhD

Blood (2011) 118 (21): 1419.

https://doi.org/10.1182/blood.V118.21.1419.1419

Published: 2011

Journal Articles

Follicular dendritic cell–dependent drug resistance of non-Hodgkin lymphoma involves cell adhesion–mediated Bim down-regulation through induction of microRNA-181a

Tint Lwin, Jianhong Lin, Yong Sung Choi, Xinwei Zhang, Lynn C. Moscinski, Kenneth L. Wright, Eduardo M. Sotomayor, William S. Dalton, Jianguo Tao

Blood (2010) 116 (24): 5228–5236.

https://doi.org/10.1182/blood-2010-03-275925

Published: 2010

Includes: Supplemental data

Journal Articles

Bone Marrow Niche Down-Regulates Mir-30 In Multiple Myeloma Cells to Promote Cancer Progression and Cancer Initiation by Targeting BCL9/Wnt Pathway.

Jian-Jun Zhao, M.D., Ph.D., Jianhong Lin, M.D., Zhangbo Chu, M.D., Qi Wang, Ph.D., Kohichi Takada, M.D., Ph.D., Mala Mani, Ph.D., Bryan Ciccarelli, Teru Hideshima, M.D., Ph.D., Tai Yu-Tzu, Ph.D., Jianguo Tao, MD, PhD, Steven P. Treon, MD, PhD, Nikhil C. Munshi, M.D., Kenneth C. Anderson, M.D., Ruben Carrasco, MD, PhD

Blood (2010) 116 (21): 1569.

https://doi.org/10.1182/blood.V116.21.1569.1569

Published: 2010

NARROW

miR-15a/16-1 deletion in activated B cells promotes plasma cell and mature B-cell neoplasms

Dysregulated Translational Control Is a Central Feature of MM Mediated By 14-3-3ε Interactome Promoting Multiple Myeloma Cell Growth and Viability

A Single Gene-Mediated Perturbation of the Human Genome Leads to Malignant Transformation in a Murine Transgenic Model

Ywhae Located on Chromosome 17p13 Promotes Myeloma Cells Proliferation Via Induction of Anti-Apoptosis and Survival Signaling Pathways

Germinal Center-Derived Lymphomas and Plasmacytomas in Mice with Targeted Deletion of MiR-15a/16-1 in Activated B Cells

A clinically relevant in vivo zebrafish model of human multiple myeloma to study preclinical therapeutic efficacy

Nuclease Activity Is Associated with Genomic Instability As Well As Survival in Myeloma; Underlying Mechanisms and Significance

Blocking Specific CD44 Splicing Variant Isoform Inhibits the Differentiation of Th-2 Cells through Interfering with IL-4/IL-4R Signaling Pathway

Apurinic/Apyrimidinic Endonuclease 1 Induced Genomic Instability Causes T-Cell Acute Lymphoblastic Leukemia in Zebrafish

Functional and Genomic Signatures of Homologous Recombination (HR) Predict for Clinical Outcome in Multiple Myeloma (MM)

Telomerase Contributes To Repair Of DNA Breaks In Myeloma Cells By Incorporating “TTAGGG” Sequences Within Genome: Biological and Translational Significance

Differences in the Angiogenic Response and Subsequent Growth of Plasma Cells From Myeloma and MGUS Patients Xenografted Into Zebrafish Embryos.

Aberrant Non-Homologous End Joining in Multiple Myeloma: A Role in Genomic Instability and As Potential Prognostic Marker.

A Clinically Relevant Zebrafish in Vivo Model of Human Multiple Myeloma (MM) to Study Disease Biology and Preclinical Therapeutic Efficacy

Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma

Targeting Brouton's Tyrosine Kinase with PCI-32765 Blocks Growth and Survival of Multiple Myeloma and Waldenström Macroglobulinemia Via Potent Inhibition of Osteoclastogenesis, Cytokines/Chemokine Secretion, and Myeloma Stem-Like Cells in the Bone Marrow Microenvironment

Investigational Agent MLN9708 Target Tumor Suppressor MicroRNA-33b in Multiple Myeloma Cells

Mir-222-221 Induce Dexamethasone Resistance by Targeting BBC3/PUMA in Human Multiple Myeloma

Follicular dendritic cell–dependent drug resistance of non-Hodgkin lymphoma involves cell adhesion–mediated Bim down-regulation through induction of microRNA-181a

Bone Marrow Niche Down-Regulates Mir-30 In Multiple Myeloma Cells to Promote Cancer Progression and Cancer Initiation by Targeting BCL9/Wnt Pathway.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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