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Journal Articles

Therapy-Related Myeloid Neoplasms in 108 Patients Following Radiation Therapy Only

Anand Ashwin Patel, MD, Alexandra E Rojek, MD, Howard Weiner, Michael W. Drazer, MD, Lucy A. Godley, Michelle M. Le Beau, PhD, Richard A. Larson, MD

Blood (2020) 136 (Supplement 1): 25–26.

https://doi.org/10.1182/blood-2020-134433

Published: 2020

Journal Articles

Creating a Variant Database for the American Society of Hematalogy By Consensus Variant Classification of Common Genes Associated with Hematologic Malignancies

Niroshan Nadarajah, Alex Wagner, PhD, Rafael Bejar, MD PhD, Mark Ewalt, MD, Annette S. Kim, MD, Michelle M. Le Beau, PhD, Xiaotu Ma, PhD, Manja Meggendorfer, PhD, Jamile M. Shammo, MD, Gabriella Ryan, Alexa J. Siddon, MD, David P. Steensma, MD, Matthew J. Walter, MD, Ahmet Zehir, PhD, Jinghui Zhang, PhD, Torsten Haferlach, MD

Blood (2020) 136 (Supplement 1): 4–5.

https://doi.org/10.1182/blood-2020-141204

Published: 2020

Journal Articles

RNA:m 5 c/Methyltransferases Mediate Chromatin Organization and 5-Azacytidine Response/Resistance in Leukemia

Jason Cheng, MD PhD, Li Chen, PhD MD, Yuan Li, MD, Ming Yue, PhD, Adam Cloe, MD, PhD, Jamile M. Shammo, MD FASCP, FACP, Richard A. Larson, MD, Chuan He, PhD, Michelle M. Le Beau, PhD, James W. Vardiman, MD

Blood (2017) 130 (Supplement 1): 2471.

https://doi.org/10.1182/blood.V130.Suppl_1.2471.2471

Published: 2017

Journal Articles

Inhibition of Canonical WNT Signaling in the Bone Marrow Niche Prevents the Development of Disease in a Mouse MDS Model with Apc Haploinsufficiency

Angela Stoddart, PhD, Jianghong Wang, MD, Chunmei Hu, MD, Anthony A. Fernald, BS, Elizabeth M. Davis, BS, Jason X. Cheng, MDPhD, Michelle M. Le Beau, PhD

Blood (2016) 128 (22): 1129.

https://doi.org/10.1182/blood.V128.22.1129.1129

Published: 2016

Journal Articles

Bromodomain and Extra-Terminal Motif Proteins (BETs) Mediate 5-Azacitidine Resistance in Myeloid Leukemia through Recruitment of an Active RNA Polymerase II Complex

Li Chen, MD PhD, Yuan Li, MD, Ming Yue, PhD, Adam Cloe, MD PhD, Michelle M. Le Beau, PhD, Chuan He, PhD, Richard A. Larson, MD, James W. Vardiman, MD, Jason X. Cheng, MD PhD

Blood (2016) 128 (22): 746.

https://doi.org/10.1182/blood.V128.22.746.746

Published: 2016

Journal Articles

Cytotoxic Exposure to Both Hematopoietic Stem and Progenitor Cells and the Bone Marrow Niche Cooperate to Promote Leukemogenesis in a Mouse Model of Therapy-Related Myeloid Neoplasms with a Del(5q)

Angela Stoddart, PhD, Jianghong Wang, MD, Chunmei Hu, MD, Anthony A. Fernald, BS, Elizabeth M. Davis, BS, Jason X. Cheng, MDPhD, Michelle M. Le Beau, PhD

Blood (2015) 126 (23): 357.

https://doi.org/10.1182/blood.V126.23.357.357

Published: 2015

Journal Articles

Targeted Treatment of FLT3 -Overexpressing Acute Myeloid Leukemia with MiR-150 Nanoparticles Guided By Conjugated FLT3 Ligand Peptides

Blood (2015) 126 (23): 3784.

https://doi.org/10.1182/blood.V126.23.3784.3784

Published: 2015

Journal Articles

Brca1 Deficiency Causes Bone Marrow Failure and Spontaneous Hematologic Malignancies in Mice

Aparna Vasanthakumar, BSc, MSc, PhD, Stephen Arnovitz, Rafael Marquez, Janet Lepore, George Rafidi, Elizabeth M. Davis, BS, Anase Asom, Madison Weatherly, Barbara Neistadt, Robert Duszynski, James W. Vardiman, MD, Michelle M. Le Beau, PhD, Lucy A. Godley, MD PhD, Jane E. Churpek, MD

Blood (2015) 126 (23): 295.

https://doi.org/10.1182/blood.V126.23.295.295

Published: 2015

Journal Articles

Identification of TET1⊣miR-22⊣CREB-MYC Signaling Reveals Potent Tumor-Suppressor Role of Mir-22 in Acute Myeloid Leukemia

Blood (2014) 124 (21): 886.

https://doi.org/10.1182/blood.V124.21.886.886

Published: 2014

Journal Articles

Loss of Wild-Type Kras is Associated with Enhanced Fitness and Increased Mitogen-Activated Protein Kinase Pathway Addiction in K-Ras G12D Acute Myeloid Leukemia

Michael R. Burgess, MD PhD, Eugene Hwang, BA, Anica M. Wandler, PhD, Saurabh Asthana, PhD, Elizabeth M. Davis, BS, Michelle M. Le Beau, PhD, Barry Taylor, PhD, Kevin Shannon, MD

Blood (2014) 124 (21): 907.

https://doi.org/10.1182/blood.V124.21.907.907

Published: 2014

Journal Articles

Cellular Reprogramming Erases Aberrant DNA Methylation and the Malignant Phenotype in Chronic Myeloid Leukemia

Giovanni Amabile, PhD, Annalisa Di Ruscio, MDPhD, Fabian Muller, PhD, Robert S Welner, PhD, Henry Yang, PhD, Alexander K Ebralidze, PhD, Hong Zhang, PhD, Lihua Qi, PhD, Giovanni Martinelli, MD, Thijn Brummelkamp, PhD, Michelle M. Le Beau, PhD, Maria E Figueroa, MD, Christoph Bock, PhD, Daniel G Tenen, MD

Blood (2014) 124 (21): 4524.

https://doi.org/10.1182/blood.V124.21.4524.4524

Published: 2014

Journal Articles

Retroviral Insertional Mutagenesis In Egr1 +/- mice, Haploinsufficient For a Human Del(5q) Myeloid Leukemia Gene, Develop Myeloid Neoplasms With Proviral Insertions In Genes Syntenic To Human 5q

Angela Stoddart, PhD, Anthony Fernald, Rachel Joy Bergerson, PhD, Jianghong Wang, M.D., Megan E. McNerney, MD, PhD, Theodore Karrison, Ph.D., John Anastasi, MD, Elizabeth Bartom, Ph.D., Aaron G. Sarver, Ph.D., Zhijian Qian, PhD, Linda Wolff, PhD, David A. Largaespada, PhD, Michelle M. le Beau, PhD

Blood (2013) 122 (21): 1275.

https://doi.org/10.1182/blood.V122.21.1275.1275

Published: 2013

Journal Articles

Increased γH2AX Foci in Old Hematopoietic Stem Cells Are Independent of the DNA Damage Response and Linked to Inefficient DNA Replication/Transcription

Johanna Flach, Sietske Bakker, PhD, Pauline Conroy, Damien Reynaud, PhD, Michelle M. Le Beau, PhD, Ciaran Morrison, PhD, Emmanuelle Passegué, PhD

Blood (2012) 120 (21): 1207.

https://doi.org/10.1182/blood.V120.21.1207.1207

Published: 2012

Journal Articles

Blockade of Mir-150 Maturation by MLL -Fusion/MYC/Lin-28 Is Required for MLL -Associated Leukemia

Blood (2012) 120 (21): 3499.

https://doi.org/10.1182/blood.V120.21.3499.3499

Published: 2012

Journal Articles

A Phase II Prospective Feasibility Study of Clofarabine Cytoreduction Prior to Allogeneic Hematopoietic Cell Transplantation (HCT) for Patients with Relapsed or Refractory Acute Leukemias and Advanced Myelodysplastic Syndromes

Rajiv Agarwal, BA, Frederick L Locke, MD, Rangesh Kunnavakkam, MS, Koen van Besien, MD, Richard A. Larson, MD, Olatoyosi Odenike, MD, Lucy Godley, MD, PhD, Hongtao Liu, MD, PhD, Michelle M. Le Beau, PhD, Sandeep Gurbuxani, MBBS, PhD, Michael J Thirman, MD, Dorothy A. Sipkins, M.D., Ph.D., Carol White, APN, Andrew Artz, MD, MS, Wendy Stock, MD

Blood (2011) 118 (21): 496.

https://doi.org/10.1182/blood.V118.21.496.496

Published: 2011

Journal Articles

Activation of a Mir-181-Targeting HOXA-PBX3 Homeobox Gene Signature Is Associated with Adverse Prognosis of Cytogenetically Abnormal Acute Myeloid Leukemia

Blood (2011) 118 (21): 236.

https://doi.org/10.1182/blood.V118.21.236.236

Published: 2011

Journal Articles

Therapy-Related Myeloid Neoplasms (t-MN) in 71 Patients Following Radiation Therapy (RT) Only,

Richard J Lin, M.D., Smita Joshi, M.D., Michelle M. Le Beau, PhD, Howard Weiner, Peggy Green, RN, Theodore Karrison, Ph.D., Richard A. Larson, MD

Blood (2011) 118 (21): 3522.

https://doi.org/10.1182/blood.V118.21.3522.3522

Published: 2011

Journal Articles

Prognostic Impact of Monosomy 7 as a Single Anomaly In Primary MDS – Reclassification From Poor to Intermediate Prognosis

Julie Schanz, MD, Heinz Tüchler, Francesc Sole, Mar Mallo, Barbara Hildebrandt, Christian Steidl, MD, Christa Fonatsch, Michael Pfeilstöcker, MD, Thomas Nösslinger, MD, Peter Valent, Aristoteles Giagounidis, Michael Lübbert, MD, Reinhard Stauder, Otto Krieger, M.D., Michelle M. Le Beau, PhD, John M. Bennett, MD, Peter L. Greenberg, MD, Ulrich Germing, Detlef Haase

Blood (2010) 116 (21): 1861.

https://doi.org/10.1182/blood.V116.21.1861.1861

Published: 2010

Journal Articles

Combination of a MEK Inhibitor, AZD6244, and Dual PI3K/mTOR Inhibitor, NVP-BEZ235: An Effective Therapeutic Strategy for Acute Myeloid Leukemia

Hongtao Liu, MD, PhD, Ernesto Diaz-Flores, PhD, Xavier Poiré, MD, Olatoyosi Odenike, MD, Greg Koval, MS, Greg Malnassy, MS, Pamela Ihonor, MS, Yanming Zhang, MD, Michelle M. Le Beau, PhD, Kevin Shannon, MD, Wendy Stock, MD

Blood (2010) 116 (21): 3978.

https://doi.org/10.1182/blood.V116.21.3978.3978

Published: 2010

Journal Articles

Loss of the Y Chromosome in MDS - Age-Related Phenomenon or Clonal Abnormality?

Blood (2010) 116 (21): 4008.

https://doi.org/10.1182/blood.V116.21.4008.4008

Published: 2010

NARROW

Therapy-Related Myeloid Neoplasms in 108 Patients Following Radiation Therapy Only

Creating a Variant Database for the American Society of Hematalogy By Consensus Variant Classification of Common Genes Associated with Hematologic Malignancies

RNA:m 5 c/Methyltransferases Mediate Chromatin Organization and 5-Azacytidine Response/Resistance in Leukemia

Inhibition of Canonical WNT Signaling in the Bone Marrow Niche Prevents the Development of Disease in a Mouse MDS Model with Apc Haploinsufficiency

Bromodomain and Extra-Terminal Motif Proteins (BETs) Mediate 5-Azacitidine Resistance in Myeloid Leukemia through Recruitment of an Active RNA Polymerase II Complex

Cytotoxic Exposure to Both Hematopoietic Stem and Progenitor Cells and the Bone Marrow Niche Cooperate to Promote Leukemogenesis in a Mouse Model of Therapy-Related Myeloid Neoplasms with a Del(5q)

Targeted Treatment of FLT3 -Overexpressing Acute Myeloid Leukemia with MiR-150 Nanoparticles Guided By Conjugated FLT3 Ligand Peptides

Brca1 Deficiency Causes Bone Marrow Failure and Spontaneous Hematologic Malignancies in Mice

Identification of TET1⊣miR-22⊣CREB-MYC Signaling Reveals Potent Tumor-Suppressor Role of Mir-22 in Acute Myeloid Leukemia

Loss of Wild-Type Kras is Associated with Enhanced Fitness and Increased Mitogen-Activated Protein Kinase Pathway Addiction in K-Ras G12D Acute Myeloid Leukemia

Cellular Reprogramming Erases Aberrant DNA Methylation and the Malignant Phenotype in Chronic Myeloid Leukemia

Retroviral Insertional Mutagenesis In Egr1 +/- mice, Haploinsufficient For a Human Del(5q) Myeloid Leukemia Gene, Develop Myeloid Neoplasms With Proviral Insertions In Genes Syntenic To Human 5q

Increased γH2AX Foci in Old Hematopoietic Stem Cells Are Independent of the DNA Damage Response and Linked to Inefficient DNA Replication/Transcription

Blockade of Mir-150 Maturation by MLL -Fusion/MYC/Lin-28 Is Required for MLL -Associated Leukemia

A Phase II Prospective Feasibility Study of Clofarabine Cytoreduction Prior to Allogeneic Hematopoietic Cell Transplantation (HCT) for Patients with Relapsed or Refractory Acute Leukemias and Advanced Myelodysplastic Syndromes

Activation of a Mir-181-Targeting HOXA-PBX3 Homeobox Gene Signature Is Associated with Adverse Prognosis of Cytogenetically Abnormal Acute Myeloid Leukemia

Therapy-Related Myeloid Neoplasms (t-MN) in 71 Patients Following Radiation Therapy (RT) Only,

Prognostic Impact of Monosomy 7 as a Single Anomaly In Primary MDS – Reclassification From Poor to Intermediate Prognosis

Combination of a MEK Inhibitor, AZD6244, and Dual PI3K/mTOR Inhibitor, NVP-BEZ235: An Effective Therapeutic Strategy for Acute Myeloid Leukemia

Loss of the Y Chromosome in MDS - Age-Related Phenomenon or Clonal Abnormality?

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American Society of Hematology

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American Society of Hematology

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