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Journal Articles

Hydroxyurea Dose Optimization Is Safe and Improves Outcomes for Children with Sickle Cell Anemia Living in Sub-Saharan Africa: The Reach Experience

Banu Aygun, Adam C. Lane, Luke R. Smart, Leon Tshilolo, Thomas N. Williams, Peter Olupot-Olupot, Brigida Santos, Susan E. Stuber, George A. Tomlinson, Teresa S. Latham, Russell E. Ware
Journal: Blood
Blood (2023) 142 (Supplement 1): 6.
https://doi.org/10.1182/blood-2023-172919
Published: 2023
Journal Articles

Hydroxyurea treatment is associated with lower malaria incidence in children with sickle cell anemia in sub-Saharan Africa

Clinical Trials & Observations
Peter Olupot-Olupot, George Tomlinson, Thomas N. Williams, Léon Tshilolo, Brígida Santos, Luke R. Smart, Kathryn McElhinney, Thad A. Howard, Banu Aygun, Susan E. Stuber, Adam Lane, Teresa S. Latham, Russell E. Ware
Journal: Blood
Blood (2023) 141 (12): 1402–1410.
https://doi.org/10.1182/blood.2022017051
Published: 2023
Includes: Supplemental data
Journal Articles

Decreased Red Blood Cell Deformability Contributes to Loss of Splenic Filtration Function and Variations in Spleen Size in Children with Sickle Cell Anaemia

Amina Nardo-Marino, Andreas Glenthøj, John N. Brewin, Jesper Petersen, Thomas H. Braunstein, Jørgen A.L. Kurtzhals, Thomas N. Williams, David C. Rees
Journal: Blood
Blood (2022) 140 (Supplement 1): 1639–1640.
https://doi.org/10.1182/blood-2022-165460
Published: 2022
Journal Articles

Hydroxyurea Reduces the Transfusion Burden in Children with Sickle Cell Anemia: The Reach Experience

Alexandra Power-Hays, George A. Tomlinson, Leon Tshilolo, Brigida Santos, Thomas N. Williams, Peter Olupot-Olupot, Patrick T. McGann, Banu Aygun, Adam Lane, Susan E. Stuber, Teresa Latham, Russell E. Ware
Journal: Blood
Blood (2021) 138 (Supplement 1): 11.
https://doi.org/10.1182/blood-2021-146632
Published: 2021
Journal Articles

Immature Platelet Fraction Does Not Correlate with Treatment Response in Immune Thrombocytopenia

Emily M. Harris, Michele P. Lambert, Jenny M. Despotovic, Susan E Kirk, Abinaya Arulselvan, Matthew Basara, Brenna Cannon, Sam King, David N Williams, Rachael F. Grace
Journal: Blood
Blood (2021) 138 (Supplement 1): 1024.
https://doi.org/10.1182/blood-2021-151681
Published: 2021
Journal Articles

Duplex Sequencing with Patient-Specific Hybrid Capture Panels Reveals Ultra-Low Frequency Measurable Residual Disease in Pediatric Acute Myeloid Leukemia

Jacob Higgins, PhD, Fang Yin Lo, PhD, Michael J. Hipp, MS, Charles C. Valentine, MS, Lindsey N. Williams, PhD, Amanda R. Leonti, MS, Rhonda E. Ries, MA, Jerald P. Radich, MD, Soheil Meshinchi, MDPhD, Benjamin J. Huang, MD, Jesse J. Salk, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 31–32.
https://doi.org/10.1182/blood-2020-143062
Published: 2020
Journal Articles

Novel Genetic Loci That Influence Fetal Hemoglobin Expression in Children with Sickle Cell Anemia

Anu Marahatta, PhD, Thad A. Howard, MS, Susan E. Stuber, MA, Kathryn L McElhinney, BS, Leon Tshilolo, MDPhD, Thomas N. Williams, MDPhD, Peter Olupot-Olupot, MDPhD, Brigida Santos, MD, Chandy C. John, MD MS, Robert Opoka, MMED, Rosa M. Nieves, MD, Rafael Mena, MD, Jasmine Baker, PhD, Teresa Latham, MA, Jonathan M. Flanagan, PhD, Russell E. Ware, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 33–34.
https://doi.org/10.1182/blood-2020-143025
Published: 2020
Journal Articles

Building Capacity and Assessing Stroke Risk with Transcranial Doppler Ultrasonography in Sub-Saharan Africa: The Reach Experience

Brigida Santos, MD, Maria Nakafeero, Adam Lane, PhD, Leon Tshilolo, MDPhD, Thomas N. Williams, MDPhD, Peter Olupot-Olupot, MDPhD, Janet Adams, Banu Aygun, MD, Susan E. Stuber, MA, George A. Tomlinson, PhD BSc, MSc, Teresa Latham, MA, Patrick T. McGann, MD MS, Russell E. Ware, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 17–18.
https://doi.org/10.1182/blood-2020-142318
Published: 2020
Journal Articles

Optimizing Hydroxyurea Therapy with Reduced Laboratory Monitoring for Children with Sickle Cell Anemia in Sub-Saharan Africa: The Reach Experience

Banu Aygun, MD, George A. Tomlinson, PhD BSc, MSc, Patrick T. McGann, MD MS, Leon Tshilolo, MDPhD, Thomas N. Williams, MDPhD, Peter Olupot-Olupot, MDPhD, Brigida Santos, MD, Susan E. Stuber, MA, Adam Lane, PhD, Teresa Latham, MA, Russell E. Ware, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 17.
https://doi.org/10.1182/blood-2020-134180
Published: 2020
Journal Articles

Genetic Variants That Influence Fetal Hemoglobin Expression from Hydroxyurea Treatment

Anu Marahatta, PhD, Jonathan M. Flanagan, PhD, Thad A. Howard, MS, Nicole Mortier, MHS, PA-C, William Schultz, MHS, PA, Kathryn L McElhinney, BS, Leon Tshilolo, MDPhD, Thomas N. Williams, MDPhD, Peter Olupot-Olupot, MDPhD, Brigida Santos, MD, Chandy C. John, MD MS, Robert Opoka, MMED, Rosa M. Nieves, MD, Rafael Mena, MD, Marvin E Reid, MB, BS, PhD, Angela Rankine-Mullings, MBBS, Jasmine Baker, PhD, Patrick T. McGann, MD MS, Banu Aygun, MD, Adam Lane, PhD, George A. Tomlinson, PhD BSc, MSc, Teresa Latham, MA, Susan E. Stuber, MA, Russell E. Ware, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 8–9.
https://doi.org/10.1182/blood-2020-143139
Published: 2020
Journal Articles

Effects of Hydroxyurea Treatment on Malaria Infections in Sub-Saharan Africa

Peter Olupot-Olupot, George A. Tomlinson, PhD BSc, MSc, Teresa S. Latham, MA, Patrick T. McGann, MD, Brigida Santos, Banu Aygun, MD, Susan Stuber, MA, Leon Tshilolo, MD PhD, Adam Lane, PhD, Thomas N. Williams, Russell E. Ware, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 522.
https://doi.org/10.1182/blood-2019-129251
Published: 2019
Journal Articles

Redefining "Gold Standard": Ultra-Sensitive Characterization of Commercial DNA Standards with Duplex Sequencing

Jacob Higgins, PhD, Gabriel Pratt, PhD, Charles C. Valentine, MS, Lindsey N. Williams, PhD, Jesse J. Salk, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2093.
https://doi.org/10.1182/blood-2019-131428
Published: 2019
Journal Articles

Ultra-Accurate Assessment of Pretreatment ABL1 Kinase Domain (KD) Mutations in Patients (pts) with Newly Diagnosed Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (Ph+ ALL) Using Duplex Sequencing (DS)

Nicholas J. Short, MD, Hagop M. Kantarjian, MD, Rashmi Kanagal-Shamanna, MD, Koji Sasaki, MD, Farhad Ravandi, MD, Jorge E. Cortes, MD, Marina Y Konopleva, MD PhD, Ghayas C. Issa, MD, Steven M. Kornblau, MD, Guillermo Garcia-Manero, MD, Victor Rivera, PhD, Rebecca Garris, MSc, Jacob Higgins, PhD, Gabriel Pratt, PhD, Lindsey N. Williams, PhD, Charles C. Valentine, MS, Jesse J. Salk, MD PhD, Justin Prichard, PhD, Jerald P. Radich, MD, Elias Jabbour, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2578.
https://doi.org/10.1182/blood-2019-125131
Published: 2019
Journal Articles

Red Blood Cell Deformability Demonstrated with the Oxygenscan: Exploring the Association with Hydroxyurea Treatment, Co-Inherited α-Thalassemia, and Frequency of Pain in Children with Sickle Cell Anemia

Amina Nardo-Marino, Jesper Petersen, Andreas Glenthoej, MD PhD, John N. Brewin, Joergen Kurtzhals, Thomas N. Williams, David C. Rees, Henrik Birgens
Journal: Blood
Blood (2019) 134 (Supplement_1): 4834.
https://doi.org/10.1182/blood-2019-129836
Published: 2019
Journal Articles

Splenomegaly in Children with Sickle Cell Anemia Receiving Hydroxyurea in Sub-Saharan Africa

Leon Tshilolo, MD PhD, George A. Tomlinson, PhD BSc, MSc, Patrick T. McGann, MD, Teresa S. Latham, MA, Peter Olupot-Olupot, Brigida Santos, Banu Aygun, MD, Susan Stuber, MA, Adam Lane, PhD, Thomas N. Williams, Russell E. Ware, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 993.
https://doi.org/10.1182/blood-2019-129937
Published: 2019
Journal Articles

Characterization of Clonal Dynamics after Hematopoietic Cell Transplantation Using Ultra-Sensitive Duplex Sequencing

Jacob Higgins, PhD, Gabriel Pratt, PhD, Charles C. Valentine, MS, Lindsey N. Williams, PhD, Masumi Ueda, MD, Rainer Storb, MD, Jerald P. Radich, MD, Jesse J. Salk, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2483.
https://doi.org/10.1182/blood-2019-122490
Published: 2019
Journal Articles

Duplex Sequencing Accurately Detects Variants below 1/100,000 in Genes Recurrently Mutated in Acute Myeloid Leukemia

Jacob E. Higgins, PhD, Lindsey N. Williams, PhD, Sarah A Buckley, MD, Christopher S. Hourigan, DPhil FACP FRCP, Jerald P. Radich, MD, Jesse J. Salk, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2769.
https://doi.org/10.1182/blood-2018-99-115071
Published: 2018
Journal Articles

Health Related Quality of Life and Fatigue in Patients with Pyruvate Kinase Deficiency

Eduard J. Van Beers, MD PhD, Kevin H. M. Kuo, MD MSc, FRCPC, D. Holmes Morton, MD, Wilma Barcellini, MD, Stefan W. Eber, MD, Bertil Glader, MD, Hassan M. Yaish, MD, Satheesh Chonat, MD, Nina Kollmar, MD, Jenny M. Despotovic, DO, MS, Dagmar Pospisilova, Prof. MD PhD, Christine M. Knoll, MD, Janet L. Kwiatkowski, MD, Yves D. Pastore, MD, Alexis A. Thompson, MD MPH, Winfred Wang, MD, Marcin W. Wlodarski, MD PhD, Peter E. Newburger, MD, Yaddanapudi Ravindranath, MBBS, Jennifer A. Rothman, MD, Heng Wang, MD PhD, Suzanne Holzhauer, MD MSc, Vicky R. Breakey, BSc, MD FRCPC, Madeleine M Verhovsek, MD FRCPC, Joachim B. Kunz, MD, Sujit Sheth, MD, Mukta Sharma, MD MPH, Melissa J. Rose, DO, Heather A. Bradeen, MD, Melissa A. McNaull, MD, Kathryn Addonizio, BA, David N Williams, Rachael F. Grace, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4807.
https://doi.org/10.1182/blood-2018-99-113206
Published: 2018
Journal Articles

Realizing Effectiveness across Continents with Hydroxyurea (REACH): A Prospective Multi-National Trial of Hydroxyurea for Sickle Cell Anemia in Sub-Saharan Africa

Leon Tshilolo, MDPhD, George Tomlinson, Thomas N. Williams, Brigida Santos, Peter Olupot-Olupot, Adam Lane, PhD, Banu Aygun, MD, Susan Stuber, MA, Teresa Latham, MA, Patrick T. McGann, MD, Russell E. Ware, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3.
https://doi.org/10.1182/blood-2018-99-113818
Published: 2018
Journal Articles

Subphenotypes of sickle cell disease in Africa

Frédéric B. Piel, Thomas N. Williams
Journal: Blood
Blood (2017) 130 (20): 2157–2158.
https://doi.org/10.1182/blood-2017-10-808550
Published: 2017