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Neal Van Hoeven
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Journal Articles

Relieving Restriction in Resting CD8+ T Cells Increases Gene Transfer and Improves Tumor Killing after Transduction with CD8-Targeted CD19CAR Fusosome

Free
Mariliis Ott, Hadega Aamer, Daryl Humes, Reuben Burch, Christina Proano, Brian Dolinski, Diana Vedenova, Ashley Benson, Ryan White, Semih Tareen, Jesse Green, Kutlu G Elpek, Neal van Hoeven, Terry J Fry
Journal: Blood
Blood (2024) 144 (Supplement 1): 2196.
https://doi.org/10.1182/blood-2024-208368
Published: 2024
Journal Articles

In Vitro and In Vivo Specificity and Biodistribution of a Novel CD8-Targeted Fusosome

Free
Hemantkumar Chavan, Shirisha Amatya, Valeria Berlfein, Patricia Cruite, Vandana Chaturvedi, Vasily Vagin, Neal van Hoeven, Jagesh Shah, Terry J. Fry, Boris Gorovits, Sundeep Chandra
Journal: Blood
Blood (2023) 142 (Supplement 1): 3630.
https://doi.org/10.1182/blood-2023-190158
Published: 2023
Journal Articles

Identification of Healthy Donor Phenotypic and Functional Signatures That Predict Allogeneic, Hypoimmune CD19-Directed CAR T Cell Potency

Free
Darin Salloum, Kavita Tundwal, Kwang Bom Choi, Ashley Ranere, Jaclyn Lock, Ben Lam, Jasmin Kristianto, John Yu, Jessica Li, John Lam, Pascal Beauchesne, Allison O'Rourke, Ouwen Liang, Aaron Lampano, Neal van Hoeven, Hosein Kouros-Mehr, Dave Shivak, Weidong Zhang, Tiffany Wan, Lisa Arjes, Christina Chaivorapol, Athena Wong, Adam Johnson, Paul Brunetta, Terry Fry
Journal: Blood
Blood (2023) 142 (Supplement 1): 6810.
https://doi.org/10.1182/blood-2023-188264
Published: 2023
Journal Articles

Development of a Novel, Allogeneic GPRC5D-Directed CAR for Treatment of Multiple Myeloma Patients

Free
Jeremy Kinder, Chanel Athena Estrada, Brian Granger, Allison O'Rourke, Ouwen Liang, Aaron Lampano, Garrett Zipp, Vandana Chaturvedi, Xiaomeng Hu, Chi Young, Neal van Hoeven, Sonja Schrepfer, Terry J. Fry
Journal: Blood
Blood (2023) 142 (Supplement 1): 3290.
https://doi.org/10.1182/blood-2023-189665
Published: 2023
Journal Articles

Hypoimmune, Allogeneic CD22-Directed CAR T Cells That Evade Innate and Adaptive Immune Rejection for the Treatment of Large B Cell Lymphoma Patients That Are Relapsed/Refractory to CD19-Directed CAR T Cell Therapy

Free
Adam Johnson, Hallee Wright, Xiaomeng Hu, Jeremy Kinder, Neal van Hoeven, Ouwen Liang, Brian Granger, Tori Duback, Chris Baldeviano, Sundeep Chandra, Trevor McGill, Boris Gorovits, Shannon Joyce, Sam Crocker, Anna Liang, Carrie Rocca, Jenny Migliaccio, Prasanna Kumar, Vasily Vagin, Kerrie Enger, Chi Young, Andrew McAlister, Sonja Schrepfer, Terry J. Fry
Journal: Blood
Blood (2023) 142 (Supplement 1): 3437.
https://doi.org/10.1182/blood-2023-187096
Published: 2023
Journal Articles

Preclinical Efficacy of a Novel CD8-Targeted Fusosome for In Vivo CAR T Cell Therapy

Free
Vandana Chaturvedi, Jesse Green, Garrett Zipp, Aaron Lampano, Ouwen Liang, Allison O'Rourke, Brian Granger, Kutlu G Elpek, Neal van Hoeven, Terry Fry
Journal: Blood
Blood (2023) 142 (Supplement 1): 7121.
https://doi.org/10.1182/blood-2023-189669
Published: 2023
Journal Articles

CD8-Targeted, Integrating Viral Vectors Transduce Resting T Cells and Enable Extracorporeal Delivery (ECD) for Rapid CAR T Cell Therapies

Free
Jesse Green, Adam Johnson, Brian Granger, Ouwen Liang, Jesus Moreno, Andrew Tucker, Hallee Wright, Brian Dolinski, Hanane Ennajdaoui, Semih Tareen, Neal van Hoeven, PhD, Jagesh Shah, Kutlu Elpek, Aaron Foster, Terry J. Fry
Journal: Blood
Blood (2022) 140 (Supplement 1): 7768–7769.
https://doi.org/10.1182/blood-2022-162705
Published: 2022
Journal Articles

A Dual-Antigen Targeting, Hypoimmune Allogeneic CAR T to Evade Innate and Adaptive Immune Rejection and Overcome Antigen Escape

Free
Adam Johnson, Hallee Wright, Xiaomeng Hu, Neal van Hoeven, PhD, Brian Granger, Ouwen Liang, Jesus Moreno, Meghan Lamba, Chi Young, Andrew McAlister, Terry J. Fry, Sonja Schrepfer, Aaron Foster
Journal: Blood
Blood (2022) 140 (Supplement 1): 4552–4553.
https://doi.org/10.1182/blood-2022-168251
Published: 2022
Journal Articles

BCMA-Targeted, Hypoimmune Allogeneic CAR T Cells Exhibit Potent Anti-Tumor Activity Together with the Ability to Evade Innate and Adaptive Immune Rejection in Pre-Clinical Tumor Models

Free
Jeremy M. Kinder, Chanel Athena-Estrada, Danyal Malik, Xiaomeng Hu, Meghan Lamba, Chi Young, Neal Van Hoeven, Brian Granger, Vandana Chaturvedi, Ouwen Liang, Jesus Moreno, Aaron Lampano, Garrett Zipp, Adam Johnson, Terry Fry, Sonja Schrepfer, Aaron Foster
Journal: Blood
Blood (2022) 140 (Supplement 1): 7120–7121.
https://doi.org/10.1182/blood-2022-166845
Published: 2022
Journal Articles

Functional T Cell Assays Are Predictive of Pre-Clinical Potency to Generate Allogeneic, Hypoimmune CD19 CAR T Cells

Free
Darin Salloum, PhD, Kavita Tundwal, Divy Kangeyan, PhD, Adam Johnson, Neal van Hoeven, PhD, Brian Granger, Jesus Moreno, Ouwen Liang, Pascal Beauchesne, Terry J. Fry, Aaron Foster
Journal: Blood
Blood (2022) 140 (Supplement 1): 4524–4525.
https://doi.org/10.1182/blood-2022-168372
Published: 2022