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Journal Articles

A Phase 1 Study to Evaluate the Pharmacokinetics of Single High Doses of Iptacopan

Free
Robert Schmouder, Noemi Kaetterer, Kenneth Kulmatycki, Prasanna Kumar Nidamarthy
Journal: Blood
Blood (2023) 142 (Supplement 1): 2723.
https://doi.org/10.1182/blood-2023-179012
Published: 2023
Journal Articles

A First-in-Human, Phase 1 Study to Assess the Pharmacodynamic Properties of Single-Dose Iptacopan (CLNP023X2101)

Free
Robert Schmouder, Guido Junge, Prasanna Kumar Nidamarthy, Kenneth Kulmatycki
Journal: Blood
Blood (2023) 142 (Supplement 1): 4096.
https://doi.org/10.1182/blood-2023-179655
Published: 2023
Journal Articles

Hypoimmune, Allogeneic CD22-Directed CAR T Cells That Evade Innate and Adaptive Immune Rejection for the Treatment of Large B Cell Lymphoma Patients That Are Relapsed/Refractory to CD19-Directed CAR T Cell Therapy

Free
Adam Johnson, Hallee Wright, Xiaomeng Hu, Jeremy Kinder, Neal van Hoeven, Ouwen Liang, Brian Granger, Tori Duback, Chris Baldeviano, Sundeep Chandra, Trevor McGill, Boris Gorovits, Shannon Joyce, Sam Crocker, Anna Liang, Carrie Rocca, Jenny Migliaccio, Prasanna Kumar, Vasily Vagin, Kerrie Enger, Chi Young, Andrew McAlister, Sonja Schrepfer, Terry J. Fry
Journal: Blood
Blood (2023) 142 (Supplement 1): 3437.
https://doi.org/10.1182/blood-2023-187096
Published: 2023
Journal Articles

A Phase 1 Study to Assess the Effect of Supratherapeutic Doses of Iptacopan on Cardiac Conduction Parameters and Safety

Free
Robert Schmouder, Noemi Kaetterer, Kenneth Kulmatycki, Prasanna Kumar Nidamarthy
Journal: Blood
Blood (2023) 142 (Supplement 1): 5644.
https://doi.org/10.1182/blood-2023-179648
Published: 2023
Journal Articles

Single-Cell Proteomics Identifies Leukemia Landscape Associated with Clinical Outcomes in R/R AML Treated with MDM2i (Milademetan) and FLT3i (Quizartinib): Putative Role of CD68 and Diversity Index

Free
Muharrem Muftuoglu, Li Li, Mahesh Basyal, Shaoheng Liang, Carissa J. Ball, Ken Chen, Prasanna Kumar, Arnaud Lesegretain, Naval Daver, Michael Andreeff
Journal: Blood
Blood (2021) 138 (Supplement 1): 3443.
https://doi.org/10.1182/blood-2021-154376
Published: 2021
Journal Articles

Clonal Expansion of Mutant p53 Clones By MDM2 Inhibition in Acute Myeloid Leukemias

Free
Yuki Nishida, MDPhD, Rafael Heinz Montoya, BS, Kiyomi Morita, MDPhD, Tomoyuki Tanaka, MDPhD, Feng Wang, PhD, Koichi Takahashi, MD PhD, Jo Ishizawa, MDPhD, Prasanna Kumar, PhD, Parul Patel, PhD, Cedric E. Dos Santos, PhD, Courtney D. DiNardo, MD MSCE, Michael Andreeff, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 27–28.
https://doi.org/10.1182/blood-2020-142794
Published: 2020
Journal Articles

A Phase 1 Dose Escalation Study of Milademetan in Combination with 5-Azacitidine (AZA) in Patients with Acute Myeloid Leukemia (AML) or High-Risk Myelodysplastic Syndrome (MDS)

Free
Courtney D. DiNardo, MDMSc, Rebecca Olin, MDMS, Jo Ishizawa, MD PhD, Hiroyuki Sumi, PhD, Jingdong Xie, PhD, Kazunobu Kato, MD PhD, Prasanna Kumar, PhD, Michael Andreeff, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3932.
https://doi.org/10.1182/blood-2019-122241
Published: 2019
Journal Articles

A Phase 1 Study of Milademetan in Combination with Quizartinib in Patients with Newly Diagnosed (ND) or Relapsed/Refractory (R/R) FLT3 -ITD Acute Myeloid Leukemia (AML)

Free
Naval G. Daver, MD, Weiguo Zhang, MD PhD, Richard Graydon, MD PhD, Vikas K Dawra, MBA, PhD, Jingdong Xie, PhD, Prasanna Kumar, PhD, Michael Andreeff, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1389.
https://doi.org/10.1182/blood-2019-122585
Published: 2019
Journal Articles

Synergistic Anti-Leukemic Activity with Combination of FLT3 Inhibitor Quizartinib and MDM2 Inhibitor Milademetan in FLT3-ITD Mutant/p53 Wild-Type Acute Myeloid Leukemia Models

Free
Michael Andreeff, MD PhD, Weiguo Zhang, MD PhD, Prasanna Kumar, PhD, Oleg Zernovak, MD, Naval G. Daver, MD, Takeshi Isoyama, PhD, Kouichi Iwanaga, D.V.M, PhD, Noriko Togashi, Takahiko Seki, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2720.
https://doi.org/10.1182/blood-2018-99-115183
Published: 2018
Journal Articles

Phase 1 Dose Escalation Study of MDM2 Inhibitor DS-3032b in Patients with Hematological Malignancies - Preliminary Results

Free
Courtney D DiNardo, MD, Joseph Rosenthal, MD MS, Michael Andreeff, MD PhD, Oleg Zernovak, MD, Prasanna Kumar, PhD, Roohi Gajee, PhD, Shuquan Chen, PhD, Michael Rosen, PhD, Saeheum Song, PhD, Jarema Kochan, PhD, Tharin Limsakun, PhD, Rebecca Olin, MD
Journal: Blood
Blood (2016) 128 (22): 593.
https://doi.org/10.1182/blood.V128.22.593.593
Published: 2016
Journal Articles

Efficacy and Safety of Dose-Optimized Nilotinib (NIL) in Patients (Pts) with Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase (CML-CP): ENESTxtnd Interim Analysis

Free
Timothy P. Hughes, MD, Eduardo Ciliao Munhoz, MD, Alaa Elhaddad, MD PhD, Ong Tee Chuan, MD, Kudrat Abdulkadyrov, MD, Jake Shortt, MD, Hang Quach, MD FRACP, FRCPA, MBBS, Carolina Pavlovsky, MD, Vernon J. Louw, MBChB, M.MD FCP(SA), PhDHPE), Luis Meillon, MD, Lee-Yung Shih, MD Professor, Anna G. Turkina, MD PhD, Jonathan Hwang, PharmD, MBA, Prasanna Kumar Nidamarthy, Darshan Dalal, MD PhD MPH, Jeffrey H. Lipton, PhD MD
Journal: Blood
Blood (2014) 124 (21): 4542.
https://doi.org/10.1182/blood.V124.21.4542.4542
Published: 2014
Journal Articles

Evaluating Biomarkers Of Iron Deficiency Anemia In Anemia Of Inflammation

Free
Sherwin DeSouza, MBBS, Anita Shet, MD, Prasanna Kumar Kapavarapu, MBBS, DCH, Arun S. Shet, MD
Journal: Blood
Blood (2013) 122 (21): 948.
https://doi.org/10.1182/blood.V122.21.948.948
Published: 2013
Journal Articles

Switching To Nilotinib In Patients (pts) With Chronic Myeloid Leukemia In Chronic Phase (CML-CP) With Suboptimal Cytogenetic Response (CyR) On Imatinib: First Results Of The LASOR Trial

Free
Jorge E. Cortes, MD, Carmino Antonio De Souza, PhD, Jose Luis Lopez, MD, Manuel Ayala, MD, Eduardo Bullorsky, Xiaojun Huang, Sandip Shah, K. Govind Babu, Tomasz Sacha, MD, Israel Bendit, Zhizhou Liang, Tina Owugah, Prasanna Kumar Nidamarthy, Tomasz Szczudlo, Carmen Piccolo, MD, Philipp D. le Coutre, MD
Journal: Blood
Blood (2013) 122 (21): 95.
https://doi.org/10.1182/blood.V122.21.95.95
Published: 2013
Journal Articles

Zinc Protoporphyrin/Heme: A Low-Cost Biomarker of Iron Deficiency Among HIV-Infected Children in a Resource Limited Setting,

Free
Prasanna Kumar Kapavarapu, MBBS, DCH, Anita Shet, MD, Faye Marlene Pais, MBBS, Karthika Kumar, Shubha K, Anish Sharda, MBBS, Arun S. Shet, MD
Journal: Blood
Blood (2011) 118 (21): 3174.
https://doi.org/10.1182/blood.V118.21.3174.3174
Published: 2011