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Journal Articles

TP53 Abnormalities Correlate with Immune Infiltration and Associate with Response to Flotetuzumab Immunotherapy in Acute Myeloid Leukemia

Blood (2020) 136 (Supplement 1): 3–4.

https://doi.org/10.1182/blood-2020-136919

Published: 2020

Journal Articles

Archived Bone Marrow Smears Are an Excellent Source for NGS-Based Mutation Detection in Acute Myeloid Leukemia

Adil S.A. Al Hinai, MSc, Francois G. Kavelaars, Melissa Rijken, Tim Grob, MD, Kirsten Gussinklo, Annelieke Zeilemaker, Claudia Erpelinck-Verschueren, B.Sc., Mathijs A. Sanders, PhD, Kirsten van Lom, Peter J.M. Valk, PhD

Blood (2018) 132 (Supplement 1): 2783.

https://doi.org/10.1182/blood-2018-99-118066

Published: 2018

Journal Articles

Prospective Molecular MRD Detection By NGS: A Powerful Independent Predictor for Relapse and Survival in Adults with Newly Diagnosed AML

Blood (2017) 130 (Supplement 1): LBA-5.

https://doi.org/10.1182/blood.V130.Suppl_1.LBA-5.LBA-5

Published: 2017

Journal Articles

Genetically-Defined AML Subgroups Represent Diverse Epigenetic Heterogeneity Landscape

Sheng Li, PhD, Xiaowen Chen, PhD, Jihui Wang, MS, Cem Meydan, PhD, Jacob L Glass, MDPhD, Alan H. Shih, MD PhD, Peter J.M. Valk, PhD, Ruud Delwel, PhD, Ross L. Levine, MD, Christopher Mason, PhD, Ari Melnick, MD

Blood (2017) 130 (Supplement 1): 243.

https://doi.org/10.1182/blood.V130.Suppl_1.243.243

Published: 2017

Journal Articles

C-Terminal BRE Overexpression in 11q23-Rearranged and t(8;16) Acute Myeloid Leukemia Is Caused By Intragenic Transcription Initiation

Blood (2017) 130 (Supplement 1): 3810.

https://doi.org/10.1182/blood.V130.Suppl_1.3810.3810

Published: 2017

Journal Articles

Lineage Deconvolution Using Chromatin Accessibility and DNA Methylation Shows a Spectrum of Lineage Characteristics and Differentiation States across Acute Leukemias

Jacob L Glass, MDPhD, Alyson J Palia, Francine E. Garrett-Bakelman, MDPhD, Richard Koche, PhD, Ross L. Levine, MD, Martin S. Tallman, MD, Richard James Dillon, MA, PhD MRCP, FRCPath, David Grimwade, Adolfo A. Ferrando, MD PhD, Peter J.M. Valk, PhD, Ruud Delwel, PhD, Maria E. Figueroa, MD, Ari Melnick, MD, Olivier Elemento, PhD

Blood (2017) 130 (Supplement 1): 1208.

https://doi.org/10.1182/blood.V130.Suppl_1.1208.1208

Published: 2017

Journal Articles

Whole Transcriptome Sequencing (RNAseq) As a Comprehensive, Cost-Efficient Diagnostic Tool for Acute Myeloid Leukemia

Marieke Griffioen, PhD, Wibowo Arindrarto, MSc, Daniel Borràs, MSc, Saskia A.M.E. van Diessen, BSc, Edith D. van der Meijden, M. Willy Honders, Mariam Alloul, PhD, Inge Jedema, PhD, Wilma G.M. Kroes, PhD, Peter J.M. Valk, PhD, Bart Janssen, PhD, Cornelis A.M. van Bergen, PhD, Szymon M. Kiełbasa, PhD, Jeroen F.J. Laros, PhD, Peter A.C. 't Hoen, PhD, Hendrik Veelken, MD PhD

Blood (2016) 128 (22): 1701.

https://doi.org/10.1182/blood.V128.22.1701.1701

Published: 2016

Journal Articles

DNMT3A Mutations Enhance CpG Mutagenesis through Deregulation of the Active DNA Demethylation Pathway

Mathijs A. Sanders, PhD, Annelieke Zeilemaker, Adil al Hinai, Remco Hoogenboezem, François G. Kavelaars, BSc, Melissa Rijken, Eric M.J. Bindels, PhD, Bob Löwenberg, MD PhD, Peter J.M. Valk, PhD

Blood (2016) 128 (22): 1076.

https://doi.org/10.1182/blood.V128.22.1076.1076

Published: 2016

Journal Articles

Changes of the Mutational Landscape in Relapsed Acute Myeloid Leukemia

Blood (2016) 128 (22): 599.

https://doi.org/10.1182/blood.V128.22.599.599

Published: 2016

Journal Articles

Extensive RAG-Mediated Rearrangements and Mutations in BCR-ABL1 and BCR - ABL1 -like Adult Acute Lymphoblastic Leukemia

Mathijs A. Sanders, PhD, Anikó Szabó, MD, Carla Exalto, Remco Hoogenboezem, Annelieke Zeilemaker, Jasper E. Koenders, Peter van Geel, Anita Schelen, H. Berna Beverloo, PhD, Jan J. Cornelissen, MD PhD, Anita W. Rijneveld, MD PhD, Peter J.M. Valk, PhD

Blood (2016) 128 (22): 4067.

https://doi.org/10.1182/blood.V128.22.4067.4067

Published: 2016

Journal Articles

Integrative Analysis of Lincrna Expression and Clinical Annotations Reveals a Signature of 17 Genes with Prognostic Significance in Acute Myeloid Leukemia (AML)

Dominik Beck, PhD, Cintia Palu, MSc, Anushi Shah, PhD, Tobias Herold, MD, Jake Olivier, PhD, Peter J.M. Valk, PhD, Ruud Delwel, PhD, Stefan K Bohlander, MD, Jason W Wong, DPhil, John E Pimanda, MD PhD

Blood (2014) 124 (21): 483.

https://doi.org/10.1182/blood.V124.21.483.483

Published: 2014

Journal Articles

The Comparative Value of Hematopoietic Stem Cell Transplantation and Chemotherapy in Cytogenetically Normal AML Subclassified By NPM1 Mutation Status and FLT3 -ITD Allelic Ratio

Blood (2014) 124 (21): 323.

https://doi.org/10.1182/blood.V124.21.323.323

Published: 2014

Journal Articles

Conditional Expression of a Leukemogenic Fusion Oncogene in Murine Hematopoietic Stem Cells Results in Highly Invasive AML with Origin-Related Genetic Signatures of Prognostic Significance for the Human Disease

Vaia Stavropoulou, PhD, Susanne Kaspar, Laurent Brault, PhD, Sabine Juge, Alexander Tzankov, MD PhD, Mathijs A. Sanders, MSc, Michael Kyba, PhD, Peter J.M. Valk, PhD, Antoine H.F.M. Peters, PhD, Juerg Schwaller, MD

Blood (2014) 124 (21): 779.

https://doi.org/10.1182/blood.V124.21.779.779

Published: 2014

Journal Articles

Defects in the RAS/RTK Signaling Pathways Predominate the Mutational Spectrum of EVI1/GATA2 Rearranged Myeloid Malignancies with Inv(3)/t(3;3)

Mathijs A. Sanders, MSc, Stefan Gröschel, Remco M. Hoogenboezem, Annelieke Zeilemaker, Marije Havermans, Claudia Erpelinck, Eric M. J. Bindels, PhD, Berna Beverloo, PhD, Hartmut Döhner, MD, Bob Löwenberg, MD PhD, Konstanze Döhner, MD, Ruud Delwel, PhD, Peter J.M. Valk, PhD

Blood (2014) 124 (21): 701.

https://doi.org/10.1182/blood.V124.21.701.701

Published: 2014

Journal Articles

Extensive Molecular Analysis Strongly Improves the Distinction Between AML and ALL in Adult Acute Leukemias of Ambiguous Lineage

Aniko Szabo, MD, Mathijs A. Sanders, MSc, Carla Exalto, Jasper E. Koenders, Patricia G. Hoogeveen, Anita M. Schelen, Willemijn van den Ancker, MD MSc, PhD, Arjan A. van de Loosdrecht, MD PhD, Bob Lowenberg, MD PhD, Vincent H.J. van der Velden, PhD, Jan J. Cornelissen, MD PhD, Peter J.M. Valk, PhD, Anita W. Rijneveld, MD PhD

Blood (2014) 124 (21): 1067.

https://doi.org/10.1182/blood.V124.21.1067.1067

Published: 2014

Journal Articles

A 16-Gene Signature Associated with High Levels of Wilms Tumor-1 ( WT1 ) Expression Is an Adverse Prognostic Factor in Acute Myeloid Leukemia

Ahmadreza Niavarani, MD PhD, Tobias Herold, MD, Yasmin Reyal, MD PhD, Erin Currie, MSc, Stuart Horswell, PhD, Arash Jalali, PhD, Maria Cristina Sauerland, MSc, Thomas Buchner, MD, Wolfgang Hiddemann, MD, Stefan K Bohlander, PhD, Reza Malekzadeh, MD AGAF, Peter J.M. Valk, PhD, Dominique Bonnet, PhD

Blood (2014) 124 (21): 1021.

https://doi.org/10.1182/blood.V124.21.1021.1021

Published: 2014

Journal Articles

High Prognostic Impact of Flowcytometric Minimal Residual Disease Detection In Acute Myeloid Leukemia: Prospective Data From the HOVON/SAKK 42a Study

Monique Terwijn, Angèle Kelder, Wim L.J. van Putten, Alexander N. Snel, Vincent H.J. van der elden, PhD, Rik A. Brooimans, PhD, Nancy Boeckx, MD, PhD, Frank W.M.B. Preijers, PhD, Bob Löwenberg, MD, PhD, Angelika M. Dräger, PhD, Peter C. Huijgens, MD, PhD, Peter J.M Valk, PhD, Johan Maertens, MD, Thomas Pabst, MD, PhD, Gert J. Ossenkoppele, MD, PhD, Gerrit J. Schuurhuis, PhD

Blood (2010) 116 (21): 760.

https://doi.org/10.1182/blood.V116.21.760.760

Published: 2010

Journal Articles

High INDO (Indoleamine 2,3-Dioxygenase) mRNA Level in Blasts of Acute Myeloid Leukemic Patients Predicts Poor Clinical Outcome.

Martine E.D. Chamuleau, MD, Arjan A. Van de Loosdrecht, MD, PhD, Corine J. Hess, MD, Jeroen J.W.M. Janssen, MD, Adri Zevenbergen, Ruud Delwel, PhD, Peter J.M. Valk, PhD, Bob Lowenberg, MD, PhD, Gert J. Ossenkoppele, MD, PhD

Blood (2007) 110 (11): 4297.

https://doi.org/10.1182/blood.V110.11.4297.4297

Published: 2007

Journal Articles

Identification of a Subgroup of Biphenotypic Myeloid/T-Cell Acute Leukemias with a CEBPA-Mutant Gene Expression Profile, Frequent CEBPA Promoter Hypermethylation and NOTCH1 Mutations.

Bas J. Wouters, MD, Irene Louwers, Claudia A.J. Erpelinck-Verschueren, Peter J.M. Valk, PhD, Dennis Tielemans, Anton W. Langerak, PhD, Daniel G. Tenen, MD PhD, Warren S. Pear, MD PhD, Bob Lowenberg, MD PhD, Ruud Delwel, PhD

Blood (2006) 108 (11): 2237.

https://doi.org/10.1182/blood.V108.11.2237.2237

Published: 2006

Journal Articles

A Novel Subgroup of Poor Prognostic AML with Low CEBPA Expression, CEBPA Promoter Hypermethylation and DNMT3b Overexpression.

Hendrik Rudolpf Delwel, PhD, Claudia Erpelinck, Roel Verhaak, MSc, Ivo P. Touw, PhD, Bob Lowenberg, MD, PhD, Peter J.M. Valk, PhD

Blood (2004) 104 (11): 418.

https://doi.org/10.1182/blood.V104.11.418.418

Published: 2004

NARROW

TP53 Abnormalities Correlate with Immune Infiltration and Associate with Response to Flotetuzumab Immunotherapy in Acute Myeloid Leukemia

Archived Bone Marrow Smears Are an Excellent Source for NGS-Based Mutation Detection in Acute Myeloid Leukemia

Prospective Molecular MRD Detection By NGS: A Powerful Independent Predictor for Relapse and Survival in Adults with Newly Diagnosed AML

Genetically-Defined AML Subgroups Represent Diverse Epigenetic Heterogeneity Landscape

C-Terminal BRE Overexpression in 11q23-Rearranged and t(8;16) Acute Myeloid Leukemia Is Caused By Intragenic Transcription Initiation

Lineage Deconvolution Using Chromatin Accessibility and DNA Methylation Shows a Spectrum of Lineage Characteristics and Differentiation States across Acute Leukemias

Whole Transcriptome Sequencing (RNAseq) As a Comprehensive, Cost-Efficient Diagnostic Tool for Acute Myeloid Leukemia

DNMT3A Mutations Enhance CpG Mutagenesis through Deregulation of the Active DNA Demethylation Pathway

Changes of the Mutational Landscape in Relapsed Acute Myeloid Leukemia

Extensive RAG-Mediated Rearrangements and Mutations in BCR-ABL1 and BCR - ABL1 -like Adult Acute Lymphoblastic Leukemia

Integrative Analysis of Lincrna Expression and Clinical Annotations Reveals a Signature of 17 Genes with Prognostic Significance in Acute Myeloid Leukemia (AML)

The Comparative Value of Hematopoietic Stem Cell Transplantation and Chemotherapy in Cytogenetically Normal AML Subclassified By NPM1 Mutation Status and FLT3 -ITD Allelic Ratio

Conditional Expression of a Leukemogenic Fusion Oncogene in Murine Hematopoietic Stem Cells Results in Highly Invasive AML with Origin-Related Genetic Signatures of Prognostic Significance for the Human Disease

Defects in the RAS/RTK Signaling Pathways Predominate the Mutational Spectrum of EVI1/GATA2 Rearranged Myeloid Malignancies with Inv(3)/t(3;3)

Extensive Molecular Analysis Strongly Improves the Distinction Between AML and ALL in Adult Acute Leukemias of Ambiguous Lineage

A 16-Gene Signature Associated with High Levels of Wilms Tumor-1 ( WT1 ) Expression Is an Adverse Prognostic Factor in Acute Myeloid Leukemia

High Prognostic Impact of Flowcytometric Minimal Residual Disease Detection In Acute Myeloid Leukemia: Prospective Data From the HOVON/SAKK 42a Study

High INDO (Indoleamine 2,3-Dioxygenase) mRNA Level in Blasts of Acute Myeloid Leukemic Patients Predicts Poor Clinical Outcome.

Identification of a Subgroup of Biphenotypic Myeloid/T-Cell Acute Leukemias with a CEBPA-Mutant Gene Expression Profile, Frequent CEBPA Promoter Hypermethylation and NOTCH1 Mutations.

A Novel Subgroup of Poor Prognostic AML with Low CEBPA Expression, CEBPA Promoter Hypermethylation and DNMT3b Overexpression.

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American Society of Hematology

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American Society of Hematology

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