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Phaik Har Lim
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Journal Articles

BRAF-V600E in Peripheral Mononuclear Cells and Microglia-like Brain Cells Suggest Hematopoietic Origin of Langerhans Cell Histiocytosis-Associated Neurodegeneration

Free
Daniel Zinn, MD, Jennifer Picarsic, Rikhia Chakraborty, PhD BSc, MSc, Howard Lin, Harshal Abhyankar, MS, Brooks Scull, Albert Shih, Karen Phaik Har Lim, Olive S. Eckstein, MD, Tricia L. Peters, MD, Walter Olea, Thomas Burke, Nabil Ahmed, MD, John Hicks, Brandon Tran, Jeremy Jones, Robert Dauser, Michael R. Jeng, MD, Robert A Baiocchi, MD PhD, Deborah E. Schiff, MD, Stanton Goldman, MD, Kenneth Matthew Heym, MD, Harry Wilson, Benjamin Carcamo, Ashish Kumar, MBBS, Carlos Rodriguez-Galindo, MD, Nicholas Whipple, Patrick Campbell, MD PhD, Geoffrey Murdoch, Simon Heales, Marian Malone, Randy Woltjer, Joseph Quinn, Paul Orchard, MD, Michael Kruer, Ronald Jaffe, Markus G Manz, MD, Sergio Lira, Donald Will Parsons, MD PhD, Miriam Merad, MD, Tsz-kwong Man, Kenneth L. McClain, MD PhD, Carl E. Allen, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2930.
https://doi.org/10.1182/blood.V130.Suppl_1.2930.2930
Published: 2017
Journal Articles

Transcriptional Profiles, Lineage Tracing with BRAF-V600E and HLA-DQB2 Expression Support a Model of Blood CD1c+ Cells As Precursors to LCH Lesion CD207+ Cells

Free
Karen Phaik Har Lim, Paul Milne, PhD BSc, Michael Poidinger, PhD, Kaibo Duan, PhD, Howard Lin, Harshal Abhyankar, MS, Daniel Zinn, MD, Olive S. Eckstein, MD, Rikhia Chakraborty, PhD BSc, MSc, Evan Newell, PhD, Miriam Merad, MD, Kenneth L. McClain, MD PhD, Chris Tsz-Kwong Man, PhD, Florent Ginhoux, PhD, Matthew P. Collin, MD PhD, Carl E. Allen, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4218.
https://doi.org/10.1182/blood.V130.Suppl_1.4218.4218
Published: 2017
Journal Articles

Alternative genetic mechanisms of BRAF activation in Langerhans cell histiocytosis

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Clinical Trials & Observations Brief Report
Rikhia Chakraborty, Thomas M. Burke, Oliver A. Hampton, Daniel J. Zinn, Karen Phaik Har Lim, Harshal Abhyankar, Brooks Scull, Vijetha Kumar, Nipun Kakkar, David A. Wheeler, Angshumoy Roy, Poulikos I. Poulikakos, Miriam Merad, Kenneth L. McClain, D. Williams Parsons, Carl E. Allen
Journal: Blood
Blood (2016) 128 (21): 2533–2537.
https://doi.org/10.1182/blood-2016-08-733790
Published: 2016
Includes: Supplemental data
Journal Articles

A Genome-Wide Assessment of Inherited Genetic Variants and the Risk of Langerhans Cell Histiocytosis

Free
Erin Peckham, PhD, Philip J Lupo, PhD MPH, Michael E Scheurer, PhD MPH, Rikhia Chakraborty, PhD BSc, MSc, John Belmont, MDPhD, Spiridon Tsavachidis, MS, Albert Shih, BS, Harshal Abhyankar, MS, Karen Phaik Har Lim, MS, Brooks Scull, MS, Kenneth L. McClain, MD PhD, Carl Allen, MD PhD
Journal: Blood
Blood (2015) 126 (23): 4059.
https://doi.org/10.1182/blood.V126.23.4059.4059
Published: 2015
Journal Articles

Inflammatory Plasma Proteins Predict Disease Severity and Response to Therapy in Patients with LCH

Free
Daniel Zinn, MD, Howard Lin, Albert Shih, BS, Brooks Scull, MS, Miguel Dario Cantu, Harshal Abhyankar, MS, Rikhia Chakraborty, PhD BSc, MSc, Karen Phaik Har Lim, Tricia L. Peters, MD, Sergio Lira, MD PhD, Chris Tsz-Kwong, PhD, Kenneth McClain, MD PhD, Miriam Merad, MD PhD, Carl Allen, MD PhD
Journal: Blood
Blood (2015) 126 (23): 4072.
https://doi.org/10.1182/blood.V126.23.4072.4072
Published: 2015
Journal Articles

Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis

Free
Rikhia Chakraborty, Oliver A. Hampton, Xiaoyun Shen, Stephen J. Simko, Albert Shih, Harshal Abhyankar, Karen Phaik Har Lim, Kyle R. Covington, Lisa Trevino, Ninad Dewal, Donna M. Muzny, Harshavardhan Doddapaneni, Jianhong Hu, Linghua Wang, Philip J. Lupo, M. John Hicks, Diana L. Bonilla, Karen C. Dwyer, Marie-Luise Berres, Poulikos I. Poulikakos, Miriam Merad, Kenneth L. McClain, David A. Wheeler, Carl E. Allen, D. Williams Parsons
Journal: Blood
Blood (2014) 124 (19): 3007–3015.
https://doi.org/10.1182/blood-2014-05-577825
Published: 2014
Includes: Supplemental data
Journal Articles

Hematopoietic Stem Cells and Circulating Myelomonocytic Precursors With BRAF-V600E Are Identified In High-Risk Patients and Define LCH As a Myeloid Neoplasia

Free
Karen Phaik-Har Lim, MS, Tricia L Peters, MD, MS, Marie-Luise Berres, MD, Jeremy Price, Hitoshi Takizawa, PhD, Philip Lupo, PhD, M. John Hicks, MD, PhD, DDS, Albert Shih, Stephen James Simko, III, MD, Kenneth Matthew Heym, MD, Venetia Bigley, MD, PhD, Matthew P. Collin, MD, PhD, Markus G. Manz, MD, Kenneth McClain, MD, PhD, Miriam Merad, MD, PhD, Carl E. Allen, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 103.
https://doi.org/10.1182/blood.V122.21.103.103
Published: 2013
Journal Articles

Plasma Biomarker Profiling In Langerhans Cell Histiocytosis: Risk-Stratifying The Inflammatory Storm

Free
Miguel Dario Cantu, Tricia L Peters, MD, MS, Karen Phaik-Har Lim, MS, Albert Shih, Rikhia Chakraborty, PhD, Harshal Abhyankar, MS, Maria Angelica Cantu, MD, Kenneth McClain, MD, PhD, Tsz-Kwong Chris Man, PhD, Carl E. Allen, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 2854.
https://doi.org/10.1182/blood.V122.21.2854.2854
Published: 2013
Journal Articles

Frequent BRAF V600E Mutations Are Identified in CD207+ Cells in LCH Lesions, but BRAF Status does not Correlate with Clinical Presentation of Patients or Transcriptional Profiles of CD207+ Cells

Free
Tricia L Peters, MD, MS, Tsz-Kwong Chris Man, PhD, Jeremy Price, Renelle George, Phaik Har Lim, MS, Kenneth Matthew Heym, MD, Miriam Merad, MD, PhD, Kenneth L. McClain, MD, PhD, Carl E Allen, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 1372.
https://doi.org/10.1182/blood.V118.21.1372.1372
Published: 2011