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Journal Articles

BRAF V600E vs cell of origin: what governs LCH?

Kenneth L. McClain, Rikhia Chakraborty

Blood (2021) 138 (14): 1203–1204.

https://doi.org/10.1182/blood.2021012907

Published: 2021

Journal Articles

Overcoming T-cell exhaustion in LCH: PD-1 blockade and targeted MAPK inhibition are synergistic in a mouse model of LCH

Amel Sengal, Jessica Velazquez, Meryl Hahne, Thomas M. Burke, Harshal Abhyankar, Robert Reyes, Walter Olea, Brooks Scull, Olive S. Eckstein, Camille Bigenwald, Catherine M. Bollard, Wendong Yu, Miriam Merad, Kenneth L. McClain, Carl E. Allen, Rikhia Chakraborty

Blood (2021) 137 (13): 1777–1791.

https://doi.org/10.1182/blood.2020005867

Published: 2021

Includes: Supplemental data

Journal Articles

Comprehensive Cell Specific Transcriptome Profiling of a Pediatric Hodgkin Lymphoma Cohort

Jennifer Agrusa, MD, Elmoataz A Abdel Fattah, MBBCh, Howard Lin, BS, Rikhia Chakraborty, PhD, Brooks Scull, MS, Harshal Abhyankar, MS, Nmazuo Wudo Ozuah, MBBS, Olive S. Eckstein, MD, Terzah M Horton, MD PhD, Kala Kamdar, MD, Kenneth L. McClain, MD PhD, Chris Tsz-Kwong Man, PhD, Carl E. Allen, MD PhD

Blood (2019) 134 (Supplement_1): 2773.

https://doi.org/10.1182/blood-2019-125982

Published: 2019

Journal Articles

Creating and Testing a CD207+ Langerhans Cell Histiocytosis-like Cell Line

Jessica Velazquez, BS, Amel Sengal, BS, Carl E. Allen, MD PhD, Rikhia Chakraborty, PhD

Blood (2019) 134 (Supplement_1): 5399.

https://doi.org/10.1182/blood-2019-130588

Published: 2019

Journal Articles

TCR Repertoire Clonality Analysis and Transcriptome Analyses of Immune Infiltrates in Patients with Langerhans Cell Histiocytosis Can Define Prognostic Biomarkers for Future Therapeutic Development

Rikhia Chakraborty, PhD, Jessica Velasquez, Amel Sengal, BS, Ankita Das, Vasumathi Kode, Nitin Mandloi, Miriam Merad, MD, Carl E. Allen, MD PhD

Blood (2019) 134 (Supplement_1): 3601.

https://doi.org/10.1182/blood-2019-129013

Published: 2019

Journal Articles

Blocking MAPK Activation and Immune Checkpoints Reverse Immune Dysfunction and Reduce Disease in a Mouse Model of LCH

Amel Sengal, BS, Meryl Hahne, Jessica Velasquez, Harshal Abhyankar, MS, Thomas Burke, BS, Walter Olea, Robert Reyes, Brooks Scull, MS, Camille Bigenwald, Catherine M. Bollard, MD, Wendong Yu, Miriam Merad, MD, Kenneth L. McClain, MD PhD, Carl E. Allen, MD PhD, Rikhia Chakraborty, PhD

Blood (2019) 134 (Supplement_1): 3602.

https://doi.org/10.1182/blood-2019-128253

Published: 2019

Journal Articles

The ''Gatekeeper'' Mutation T315I in BCR/ABL Confers Additional Oncogenic Activities to Philadelphia Chromosome Positive Leukemia

Usva Zafar, BSc, Mohammed Yusuf, PhD, Rikhia Chakraborty, PhD, El-Nasir M A Lalani, BSc MBChB FRCPath PhDFHEA, Afsar Ali Mian, BSc, MPhil, PhD

Blood (2019) 134 (Supplement_1): 5196.

https://doi.org/10.1182/blood-2019-131694

Published: 2019

Journal Articles

Inherited Genetic Risk Factors and Langerhans Cell Histiocytosis Relapse Events

Erin Peckham-Gregory, PhD, Michael Scheurer, MPH, PhD, Rikhia Chakraborty, PhD, Harshal Abhyankar, MS, Kenneth L. McClain, MD PhD, Carl E. Allen, MD PhD, Philip J Lupo, PhD

Blood (2018) 132 (Supplement 1): 4278.

https://doi.org/10.1182/blood-2018-99-118743

Published: 2018

Journal Articles

Whole Exome Analysis Reveals Key Genomic Differences between Sporadic and Endemic Pediatric Burkitt Lymphoma

Denice Mae Palmos, BS, Rikhia Chakraborty, PhD, Harshal Abhyankar, MS, Joy C. Jayaseelan, MS, Maria F. Cardenas, BS, Joyce Kambugu, MBChB, Jeff Otiti, MBChB, Fadhil Geriga, MBChB, Pietro Pala, MD, John Sekabira, MBChB, MMed, Peter Wasswa, MBChB, Joseph Ssenyondwa, MBChB, Jackson Orem, MBChB, MMed, PhD, David A. Wheeler, PhD, Joseph Lubega, MBChB, MPH, Carl E. Allen, MD PhD, Donald Williams Parsons, MD PhD

Blood (2018) 132 (Supplement 1): 4117.

https://doi.org/10.1182/blood-2018-99-110762

Published: 2018

Journal Articles

Immune Checkpoint Inhibitors Restore Function of Lesion Infiltrating T Lymphocytes in Langerhans Cell Histiocytosis

Rikhia Chakraborty, PhD BSc, MSc, Carl E. Allen, MD PhD, Amel Sengal, BS, Amos S. Gaikwad, PhD, Harshal Abhyankar, MS, Brooks Scull, Olive S. Eckstein, MD, Miriam Merad, MD, Kenneth L. McClain, MD PhD

Blood (2017) 130 (Supplement 1): 2280.

https://doi.org/10.1182/blood.V130.Suppl_1.2280.2280

Published: 2017

Journal Articles

Plasma Inflammatory Protein Profiles Distinguish Hemophagocytic Lymphohistiocytosis from Sepsis and SIRS

Harshal Abhyankar, MS, Carl E. Allen, MD PhD, Howard Lin, Baruch Goldberg, Brooks Scull, Kenneth L. McClain, MD PhD, Jordana Goldman, Trung Nguyen, Michael B. Jordan, MD, Tsz-kwong Man, Olive S. Eckstein, MD, Joseph Lubega, Dalia Bashir, Rikhia Chakraborty, PhD BSc, MSc, Hector Wong, Eyal Muscal, Daniel Zinn, MD

Blood (2017) 130 (Supplement 1): 1011.

https://doi.org/10.1182/blood.V130.Suppl_1.1011.1011

Published: 2017

Journal Articles

Transcriptional Profiles, Lineage Tracing with BRAF-V600E and HLA-DQB2 Expression Support a Model of Blood CD1c+ Cells As Precursors to LCH Lesion CD207+ Cells

Karen Phaik Har Lim, Paul Milne, PhD BSc, Michael Poidinger, PhD, Kaibo Duan, PhD, Howard Lin, Harshal Abhyankar, MS, Daniel Zinn, MD, Olive S. Eckstein, MD, Rikhia Chakraborty, PhD BSc, MSc, Evan Newell, PhD, Miriam Merad, MD, Kenneth L. McClain, MD PhD, Chris Tsz-Kwong Man, PhD, Florent Ginhoux, PhD, Matthew P. Collin, MD PhD, Carl E. Allen, MD PhD

Blood (2017) 130 (Supplement 1): 4218.

https://doi.org/10.1182/blood.V130.Suppl_1.4218.4218

Published: 2017

Journal Articles

BRAF-V600E in Peripheral Mononuclear Cells and Microglia-like Brain Cells Suggest Hematopoietic Origin of Langerhans Cell Histiocytosis-Associated Neurodegeneration

Blood (2017) 130 (Supplement 1): 2930.

https://doi.org/10.1182/blood.V130.Suppl_1.2930.2930

Published: 2017

Journal Articles

A genome-wide association study of LCH identifies a variant in SMAD6 associated with susceptibility

Erin C. Peckham-Gregory, Rikhia Chakraborty, Michael E. Scheurer, John W. Belmont, Harshal Abhyankar, Amel G. Sengal, Brooks P. Scull, Olive Eckstein, Daniel J. Zinn, Louisa Mayer, Albert Shih, Miriam Merad, D. Williams Parsons, Kenneth L. McClain, Philip J. Lupo, Carl E. Allen

Blood (2017) 130 (20): 2229–2232.

https://doi.org/10.1182/blood-2017-08-800565

Published: 2017

Includes: Supplemental data

Journal Articles

Clonal, Exhausted and Activated Infiltrating T Lymphocytes in Langerhans Cell Histiocytosis Lesions

Rikhia Chakraborty, PhD, Amel G Sengal, MS, Meryl Hahne, BS, Amos S. Gaikwad, PhD, Brooks Scull, MS, Harshal Abhyankar, MS, Miriam Merad, MD PhD, Kenneth McClain, MD PhD, Carl E. Allen, MD PhD

Blood (2016) 128 (22): 3708.

https://doi.org/10.1182/blood.V128.22.3708.3708

Published: 2016

Journal Articles

Alternative genetic mechanisms of BRAF activation in Langerhans cell histiocytosis

Rikhia Chakraborty, Thomas M. Burke, Oliver A. Hampton, Daniel J. Zinn, Karen Phaik Har Lim, Harshal Abhyankar, Brooks Scull, Vijetha Kumar, Nipun Kakkar, David A. Wheeler, Angshumoy Roy, Poulikos I. Poulikakos, Miriam Merad, Kenneth L. McClain, D. Williams Parsons, Carl E. Allen

Blood (2016) 128 (21): 2533–2537.

https://doi.org/10.1182/blood-2016-08-733790

Published: 2016

Includes: Supplemental data

Journal Articles

A Genome-Wide Assessment of Inherited Genetic Variants and the Risk of Langerhans Cell Histiocytosis

Erin Peckham, PhD, Philip J Lupo, PhD MPH, Michael E Scheurer, PhD MPH, Rikhia Chakraborty, PhD BSc, MSc, John Belmont, MDPhD, Spiridon Tsavachidis, MS, Albert Shih, BS, Harshal Abhyankar, MS, Karen Phaik Har Lim, MS, Brooks Scull, MS, Kenneth L. McClain, MD PhD, Carl Allen, MD PhD

Blood (2015) 126 (23): 4059.

https://doi.org/10.1182/blood.V126.23.4059.4059

Published: 2015

Journal Articles

Inflammatory Plasma Proteins Predict Disease Severity and Response to Therapy in Patients with LCH

Daniel Zinn, MD, Howard Lin, Albert Shih, BS, Brooks Scull, MS, Miguel Dario Cantu, Harshal Abhyankar, MS, Rikhia Chakraborty, PhD BSc, MSc, Karen Phaik Har Lim, Tricia L. Peters, MD, Sergio Lira, MD PhD, Chris Tsz-Kwong, PhD, Kenneth McClain, MD PhD, Miriam Merad, MD PhD, Carl Allen, MD PhD

Blood (2015) 126 (23): 4072.

https://doi.org/10.1182/blood.V126.23.4072.4072

Published: 2015

Journal Articles

Mutually Exclusive Recurrent Somatic Mutations in MAP2K1 and BRAF Support a Central Role for ERK Activation in LCH Pathogenesis

Rikhia Chakraborty, PhD

Blood (2014) 124 (21): 5587.

https://doi.org/10.1182/blood.V124.21.5587.5587

Published: 2014

Journal Articles

Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis

Blood (2014) 124 (19): 3007–3015.

https://doi.org/10.1182/blood-2014-05-577825

Published: 2014

Includes: Supplemental data

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BRAF V600E vs cell of origin: what governs LCH?

Overcoming T-cell exhaustion in LCH: PD-1 blockade and targeted MAPK inhibition are synergistic in a mouse model of LCH

Comprehensive Cell Specific Transcriptome Profiling of a Pediatric Hodgkin Lymphoma Cohort

Creating and Testing a CD207+ Langerhans Cell Histiocytosis-like Cell Line

TCR Repertoire Clonality Analysis and Transcriptome Analyses of Immune Infiltrates in Patients with Langerhans Cell Histiocytosis Can Define Prognostic Biomarkers for Future Therapeutic Development

Blocking MAPK Activation and Immune Checkpoints Reverse Immune Dysfunction and Reduce Disease in a Mouse Model of LCH

The ''Gatekeeper'' Mutation T315I in BCR/ABL Confers Additional Oncogenic Activities to Philadelphia Chromosome Positive Leukemia

Inherited Genetic Risk Factors and Langerhans Cell Histiocytosis Relapse Events

Whole Exome Analysis Reveals Key Genomic Differences between Sporadic and Endemic Pediatric Burkitt Lymphoma

Immune Checkpoint Inhibitors Restore Function of Lesion Infiltrating T Lymphocytes in Langerhans Cell Histiocytosis

Plasma Inflammatory Protein Profiles Distinguish Hemophagocytic Lymphohistiocytosis from Sepsis and SIRS

Transcriptional Profiles, Lineage Tracing with BRAF-V600E and HLA-DQB2 Expression Support a Model of Blood CD1c+ Cells As Precursors to LCH Lesion CD207+ Cells

BRAF-V600E in Peripheral Mononuclear Cells and Microglia-like Brain Cells Suggest Hematopoietic Origin of Langerhans Cell Histiocytosis-Associated Neurodegeneration

A genome-wide association study of LCH identifies a variant in SMAD6 associated with susceptibility

Clonal, Exhausted and Activated Infiltrating T Lymphocytes in Langerhans Cell Histiocytosis Lesions

Alternative genetic mechanisms of BRAF activation in Langerhans cell histiocytosis

A Genome-Wide Assessment of Inherited Genetic Variants and the Risk of Langerhans Cell Histiocytosis

Inflammatory Plasma Proteins Predict Disease Severity and Response to Therapy in Patients with LCH

Mutually Exclusive Recurrent Somatic Mutations in MAP2K1 and BRAF Support a Central Role for ERK Activation in LCH Pathogenesis

Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis

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