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Journal Articles

An evolutionarily ancient mechanism for regulation of hemoglobin expression in vertebrate red cells

Masato Miyata, Nynke Gillemans, Dorit Hockman, Jeroen A. A. Demmers, Jan-Fang Cheng, Jun Hou, Matti Salminen, Christopher A. Fisher, Stephen Taylor, Richard J. Gibbons, Jared J. Ganis, Leonard I. Zon, Frank Grosveld, Eskeatnaf Mulugeta, Tatjana Sauka-Spengler, Douglas R. Higgs, Sjaak Philipsen

Blood (2020) 136 (3): 269–278.

https://doi.org/10.1182/blood.2020004826

Published: 2020

Includes: Multimedia, Supplemental data

Journal Articles

α-Globin as a molecular target in the treatment of β-thalassemia

Sachith Mettananda, Richard J. Gibbons, Douglas R. Higgs

Blood (2015) 125 (24): 3694–3701.

https://doi.org/10.1182/blood-2015-03-633594

Published: 2015

Journal Articles

Mutations in Krüppel-like factor 1 cause transfusion-dependent hemolytic anemia and persistence of embryonic globin gene expression

Vip Viprakasit, Supachai Ekwattanakit, Suchada Riolueang, Nipon Chalaow, Chris Fisher, Karen Lower, Hitoshi Kanno, Kalaya Tachavanich, Sasithorn Bejrachandra, Jariya Saipin, Monthana Juntharaniyom, Kleebsabai Sanpakit, Voravarn S. Tanphaichitr, Duantida Songdej, Christian Babbs, Richard J. Gibbons, Sjaak Philipsen, Douglas R. Higgs

Blood (2014) 123 (10): 1586–1595.

https://doi.org/10.1182/blood-2013-09-526087

Published: 2014

Includes: Supplemental data

Journal Articles

Discovering Regulatory SNPs by Genome-Wide Analysis of Differential Scl/TAL-1 Occupancy in Human Primary Erythroid Cells,

Marco De Gobbi, Jim R. Hughes, Karen M. Lower, Chris J. Derry, Emanuele Marchi, Jacqueline Sloane-Stanley, BSc, Nigel Roberts, BSc, Stephen Taylor, Catherine Porcher, Richard J. Gibbons, Douglas R. Higgs, DSc

Blood (2011) 118 (21): 3381.

https://doi.org/10.1182/blood.V118.21.3381.3381

Published: 2011

Journal Articles

Analysis of DNA Methylation at the Human Alpha Globin Cluster during Hematopoiesis.

Supachai Ekwattanakit, Helena Ayyub, Kevin Clark, Fatima Marques-Kranc, Sue Butler, Jackie Sloane-Stanley, Jacqueline A Sharpe, Stefano Colella, Jiannis Ragoussis, Vip Viprakasit, Richard J Gibbons, Douglas R Higgs

Blood (2008) 112 (11): 1861.

https://doi.org/10.1182/blood.V112.11.1861.1861

Published: 2008

Journal Articles

Tissue-specific histone modification and transcription factor binding in α globin gene expression

Marco De Gobbi, Eduardo Anguita, Jim Hughes, Jacqueline A. Sloane-Stanley, Jacqueline A. Sharpe, Christoph M. Koch, Ian Dunham, Richard J. Gibbons, William G. Wood, Douglas R. Higgs

Blood (2007) 110 (13): 4503–4510.

https://doi.org/10.1182/blood-2007-06-097964

Published: 2007

Includes: Supplemental data

Journal Articles

Acquired α-thalassemia in association with myelodysplastic syndrome and other hematologic malignancies

David P. Steensma, Richard J. Gibbons, Douglas R. Higgs

Blood (2005) 105 (2): 443–452.

https://doi.org/10.1182/blood-2004-07-2792

Published: 2005

Journal Articles

A Novel Splicing Mutation in the Gene Encoding the Chromatin-Associated Factor ATRX Associated with Acquired Hemoglobin H Disease in Myelodysplastic Syndrome (ATMDS).

David P. Steensma, MD, Steven L. Allen, MD, Richard J. Gibbons, MA DPhil FRCP, Chris A. Fisher, DPhil, Douglas R. Higgs, DSc(Med) FRCP

Blood (2004) 104 (11): 3606.

https://doi.org/10.1182/blood.V104.11.3606.3606

Published: 2004

Journal Articles

Somatic Point Mutations in RUNX1/CBFA2/AML1 Are Common in High-Risk Myelodysplastic Syndrome, but Not in Myelofibrosis with Myeloid Metaplasia.

David P. Steensma, MD, Richard J. Gibbons, MA DPhil FRCP, Ruben A. Mesa, MD, Ayalew Tefferi, MD, Douglas R. Higgs, DSc(Med) FRCP

Blood (2004) 104 (11): 2438.

https://doi.org/10.1182/blood.V104.11.2438.2438

Published: 2004

Journal Articles

Acquired somatic ATRX mutations in myelodysplastic syndrome associated with α thalassemia (ATMDS) convey a more severe hematologic phenotype than germline ATRX mutations

David P. Steensma, Douglas R. Higgs, Chris A. Fisher, Richard J. Gibbons

Blood (2004) 103 (6): 2019–2026.

https://doi.org/10.1182/blood-2003-09-3360

Published: 2004

Journal Articles

Deletion of the α-globin gene cluster as a cause of acquired α-thalassemia in myelodysplastic syndrome

David P. Steensma, Vip Viprakasit, Alex Hendrick, David K. Goff, Joanne Leach, Richard J. Gibbons, Douglas R. Higgs

Blood (2004) 103 (4): 1518–1520.

https://doi.org/10.1182/blood-2003-09-3222

Published: 2004

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An evolutionarily ancient mechanism for regulation of hemoglobin expression in vertebrate red cells

α-Globin as a molecular target in the treatment of β-thalassemia

Mutations in Krüppel-like factor 1 cause transfusion-dependent hemolytic anemia and persistence of embryonic globin gene expression

Discovering Regulatory SNPs by Genome-Wide Analysis of Differential Scl/TAL-1 Occupancy in Human Primary Erythroid Cells,

Analysis of DNA Methylation at the Human Alpha Globin Cluster during Hematopoiesis.

Tissue-specific histone modification and transcription factor binding in α globin gene expression

Acquired α-thalassemia in association with myelodysplastic syndrome and other hematologic malignancies

A Novel Splicing Mutation in the Gene Encoding the Chromatin-Associated Factor ATRX Associated with Acquired Hemoglobin H Disease in Myelodysplastic Syndrome (ATMDS).

Somatic Point Mutations in RUNX1/CBFA2/AML1 Are Common in High-Risk Myelodysplastic Syndrome, but Not in Myelofibrosis with Myeloid Metaplasia.

Acquired somatic ATRX mutations in myelodysplastic syndrome associated with α thalassemia (ATMDS) convey a more severe hematologic phenotype than germline ATRX mutations

Deletion of the α-globin gene cluster as a cause of acquired α-thalassemia in myelodysplastic syndrome

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