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Journal Articles

Hemoglobin Bart’s hydrops fetalis: charting the past and envisioning the future

Ali Amid, Siyu Liu, Christian Babbs, Douglas R. Higgs

Blood (2024) 144 (8): 822–833.

https://doi.org/10.1182/blood.2023023692

Published: 2024

Journal Articles

An Ancient Transcriptional Hub Couples Developmentally Regulated Gene Expression with Metabolism during Erythropoiesis

Alexandra E. Preston, Joe N. Frost, Mohsin Badat, Andrew E. Armitage, Sarah Wideman, Megan Teh, Ruggiero Norfo, Noémi Roy, James O.J. Davies, Robert Beagrie, Douglas R. Higgs, Hal Drakesmith

Blood (2022) 140 (Supplement 1): 4–5.

https://doi.org/10.1182/blood-2022-166534

Published: 2022

Journal Articles

Base Editing Repairs the HbE Mutation Restoring the Production of Normal Globin Chains in Severe HbE/β-Thalassemia Patient Hematopoietic Stem Cells and Erythroid Cells

Mohsin Badat, Peng Hua, Sachith Mettananda, Christopher Fisher, Noemi Roy, Siobhan Rice, Anindita Roy, Douglas R. Higgs, James Davies

Blood (2021) 138 (Supplement 1): 2935.

https://doi.org/10.1182/blood-2021-153283

Published: 2021

Journal Articles

A remarkable case of HbH disease illustrates the relative contributions of the α-globin enhancers to gene expression

Mohsin Badat, James O. J. Davies, Christopher A. Fisher, Damien J. Downes, Anna Rose, Andreas B. Glenthøj, Eduard J. van Beers, Cornelis L. Harteveld, Douglas R. Higgs

Blood (2021) 137 (4): 572–575.

https://doi.org/10.1182/blood.2020006680

Published: 2021

Includes: Supplemental data

Journal Articles

An evolutionarily ancient mechanism for regulation of hemoglobin expression in vertebrate red cells

Masato Miyata, Nynke Gillemans, Dorit Hockman, Jeroen A. A. Demmers, Jan-Fang Cheng, Jun Hou, Matti Salminen, Christopher A. Fisher, Stephen Taylor, Richard J. Gibbons, Jared J. Ganis, Leonard I. Zon, Frank Grosveld, Eskeatnaf Mulugeta, Tatjana Sauka-Spengler, Douglas R. Higgs, Sjaak Philipsen

Blood (2020) 136 (3): 269–278.

https://doi.org/10.1182/blood.2020004826

Published: 2020

Includes: Multimedia, Supplemental data

Journal Articles

Expression of the Human Alpha-Globin Cluster in the Absence of the Major Regulatory Element Mcs-R2

Mohsin Badat, MBBChir, James O.J. Davies, PhD, Eduard J. van Beers, MD PhD, Cornelis Harteveld, PhD, Damien Downes, PhD, Douglas R. Higgs, FRS

Blood (2018) 132 (Supplement 1): 3632.

https://doi.org/10.1182/blood-2018-99-116209

Published: 2018

Journal Articles

An international registry of survivors with Hb Bart's hydrops fetalis syndrome

Duantida Songdej, Christian Babbs, Douglas R. Higgs

Blood (2017) 129 (10): 1251–1259.

https://doi.org/10.1182/blood-2016-08-697110

Published: 2017

Includes: Supplemental data

Journal Articles

Krüppeling erythropoiesis: an unexpected broad spectrum of human red blood cell disorders due to KLF1 variants

Andrew Perkins, Xiangmin Xu, Douglas R. Higgs, George P. Patrinos, Lionel Arnaud, James J. Bieker, Sjaak Philipsen, the KLF1 Consensus Workgroup

Blood (2016) 127 (15): 1856–1862.

https://doi.org/10.1182/blood-2016-01-694331

Published: 2016

Includes: Supplemental data

Journal Articles

Characterisation of Three Unique Head-to-Tail Alpha Globin Cluster Duplications Contributing to Beta Thalassemia Intermedia in 3 Families

Blood (2015) 126 (23): 3375.

https://doi.org/10.1182/blood.V126.23.3375.3375

Published: 2015

Journal Articles

The LRF/ZBTB7A Transcription Factor Is a BCL11A-Independent Repressor of Fetal Hemoglobin

Blood (2015) 126 (23): 2.

https://doi.org/10.1182/blood.V126.23.2.2

Published: 2015

Journal Articles

α-Globin as a molecular target in the treatment of β-thalassemia

Sachith Mettananda, Richard J. Gibbons, Douglas R. Higgs

Blood (2015) 125 (24): 3694–3701.

https://doi.org/10.1182/blood-2015-03-633594

Published: 2015

Journal Articles

Mutations in Krüppel-like factor 1 cause transfusion-dependent hemolytic anemia and persistence of embryonic globin gene expression

Vip Viprakasit, Supachai Ekwattanakit, Suchada Riolueang, Nipon Chalaow, Chris Fisher, Karen Lower, Hitoshi Kanno, Kalaya Tachavanich, Sasithorn Bejrachandra, Jariya Saipin, Monthana Juntharaniyom, Kleebsabai Sanpakit, Voravarn S. Tanphaichitr, Duantida Songdej, Christian Babbs, Richard J. Gibbons, Sjaak Philipsen, Douglas R. Higgs

Blood (2014) 123 (10): 1586–1595.

https://doi.org/10.1182/blood-2013-09-526087

Published: 2014

Includes: Supplemental data

Journal Articles

Discovering Regulatory SNPs by Genome-Wide Analysis of Differential Scl/TAL-1 Occupancy in Human Primary Erythroid Cells,

Marco De Gobbi, Jim R. Hughes, Karen M. Lower, Chris J. Derry, Emanuele Marchi, Jacqueline Sloane-Stanley, BSc, Nigel Roberts, BSc, Stephen Taylor, Catherine Porcher, Richard J. Gibbons, Douglas R. Higgs, DSc

Blood (2011) 118 (21): 3381.

https://doi.org/10.1182/blood.V118.21.3381.3381

Published: 2011

Journal Articles

Codanin-1 mutations in congenital dyserythropoietic anemia type 1 affect HP1α localization in erythroblasts

Raffaele Renella, Nigel A. Roberts, Jill M. Brown, Marco De Gobbi, Louise E. Bird, Tasneem Hassanali, Jacqueline A. Sharpe, Jacqueline Sloane-Stanley, David J. P. Ferguson, Jacqueline Cordell, Veronica J. Buckle, Douglas R. Higgs, William G. Wood

Blood (2011) 117 (25): 6928–6938.

https://doi.org/10.1182/blood-2010-09-308478

Published: 2011

Includes: Supplemental data

Journal Articles

Global gene expression analysis of human erythroid progenitors

Alison T. Merryweather-Clarke, Ann Atzberger, Shamit Soneji, Nicki Gray, Kevin Clark, Craig Waugh, Simon J. McGowan, Stephen Taylor, Asoke K. Nandi, William G. Wood, David J. Roberts, Douglas R. Higgs, Veronica J. Buckle, Kathryn J. H. Robson

Blood (2011) 117 (13): e96–e108.

https://doi.org/10.1182/blood-2010-07-290825

Published: 2011

Includes: Supplemental data

Journal Articles

Codanin-1 Mutations In Congenital Dyserythropoietic Anemia Type 1 Affect HP1α Localization In Erythroblasts

Raffaele Renella, MD, PhD, Nigel Roberts, BSc, Jill M Brown, MSc, Marco De Gobbi, MD, PhD, Louise Bird, PhD, Tasneem Hassanali, BSc, Jacqueline Sloane-Stanley, BSc, Jacqueline A Sharpe, PhD, Jacqueline Loelia Cordell, BSc, David J.P. Ferguson, MD, PhD, Veronica Buckle, PhD, Douglas R. Higgs, DSc, William G Wood, PhD

Blood (2010) 116 (21): 1003.

https://doi.org/10.1182/blood.V116.21.1003.1003

Published: 2010

Journal Articles

Does Transcription of Remote α- Globin Regulatory Elements Affect Their Function?.

Monika S Kowalczyk, MD, Jim R Hughes, DPhil, Jacqueline A Sharpe, PhD, Jill M Brown, BSc, Veronica J Buckle, PhD, William G Wood, PhD, Douglas R Higgs, FRS

Blood (2009) 114 (22): 4060.

https://doi.org/10.1182/blood.V114.22.4060.4060

Published: 2009

Journal Articles

Chromosome looping at the human α-globin locus is mediated via the major upstream regulatory element (HS −40)

Douglas Vernimmen, Fatima Marques-Kranc, Jacqueline A. Sharpe, Jacqueline A. Sloane-Stanley, William G. Wood, Helen A. C. Wallace, Andrew J. H. Smith, Douglas R. Higgs

Blood (2009) 114 (19): 4253–4260.

https://doi.org/10.1182/blood-2009-03-213439

Published: 2009

Includes: Supplemental data

Journal Articles

Switching Genes On and Off During Hematopoiesis.

Douglas R. Higgs, DSc

Blood (2008) 112 (11): sci-17.

https://doi.org/10.1182/blood.V112.11.sci-17.sci-17

Published: 2008

Journal Articles

A Transgenic Mouse Model for Congenital Dyserythropoietic Anemia Type I

Raffaele Renella, MD, Nigel A Roberts, BSc, Jacqueline A Sharpe, PhD, Pik-Shan Li, BSc, Jill M Brown, BSc, Christian Babbs, PhD, Cristina Fugazza, PhD, Nicolas Goardon, PhD, Douglas R Higgs, DSc, William G Wood, PhD

Blood (2008) 112 (11): 3455.

https://doi.org/10.1182/blood.V112.11.3455.3455

Published: 2008

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Hemoglobin Bart’s hydrops fetalis: charting the past and envisioning the future

An Ancient Transcriptional Hub Couples Developmentally Regulated Gene Expression with Metabolism during Erythropoiesis

Base Editing Repairs the HbE Mutation Restoring the Production of Normal Globin Chains in Severe HbE/β-Thalassemia Patient Hematopoietic Stem Cells and Erythroid Cells

A remarkable case of HbH disease illustrates the relative contributions of the α-globin enhancers to gene expression

An evolutionarily ancient mechanism for regulation of hemoglobin expression in vertebrate red cells

Expression of the Human Alpha-Globin Cluster in the Absence of the Major Regulatory Element Mcs-R2

An international registry of survivors with Hb Bart's hydrops fetalis syndrome

Krüppeling erythropoiesis: an unexpected broad spectrum of human red blood cell disorders due to KLF1 variants

Characterisation of Three Unique Head-to-Tail Alpha Globin Cluster Duplications Contributing to Beta Thalassemia Intermedia in 3 Families

The LRF/ZBTB7A Transcription Factor Is a BCL11A-Independent Repressor of Fetal Hemoglobin

α-Globin as a molecular target in the treatment of β-thalassemia

Mutations in Krüppel-like factor 1 cause transfusion-dependent hemolytic anemia and persistence of embryonic globin gene expression

Discovering Regulatory SNPs by Genome-Wide Analysis of Differential Scl/TAL-1 Occupancy in Human Primary Erythroid Cells,

Codanin-1 mutations in congenital dyserythropoietic anemia type 1 affect HP1α localization in erythroblasts

Global gene expression analysis of human erythroid progenitors

Codanin-1 Mutations In Congenital Dyserythropoietic Anemia Type 1 Affect HP1α Localization In Erythroblasts

Does Transcription of Remote α- Globin Regulatory Elements Affect Their Function?.

Chromosome looping at the human α-globin locus is mediated via the major upstream regulatory element (HS −40)

Switching Genes On and Off During Hematopoiesis.

A Transgenic Mouse Model for Congenital Dyserythropoietic Anemia Type I

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American Society of Hematology

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