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Journal Articles

Removal of Macrophages From the Erythroid Niche Impairs Stress Erythropoiesis but Improves Pathophysiology of Polycythemia Vera and Beta-Thalassemia

Pedro Ramos, PhD, Carla Casu, PhD, Sara Gardenghi, PhD, Laura Breda, Ph.D, Bart J Crielaard, PhD, Ritama Gupta, Undergraduate student, Ella Guy, Maria F Mariongiu, PhD, Ross L. Levine, Omar Abdel-Wahab, PhD, Benjamin L. Ebert, Nico van Rooijen, PhD, Saghi Ghaffari, MD, PhD, Robert W Grady, PhD, Patricia Giardina, MD, Stefano Rivella, PhD

Blood (2012) 120 (21): 81.

https://doi.org/10.1182/blood.V120.21.81.81

Published: 2012

Journal Articles

Decreased hepcidin expression in murine β-thalassemia is associated with suppression of Bmp/Smad signaling

Nermi L. Parrow, Sara Gardenghi, Pedro Ramos, Carla Casu, Robert W. Grady, Erik R. Anderson, Yatrik M. Shah, Huihui Li, Yelena Z. Ginzburg, Robert E. Fleming, Stefano Rivella

Blood (2012) 119 (13): 3187–3189.

https://doi.org/10.1182/blood-2012-01-405563

Published: 2012

Journal Articles

Potential Therapeutic Applications of Jak2 Inhibitors in Beta-Thalassemia and Sickle Cell Disease,

Carla Casu, PhD, Pedro Ramos, PhD, Luca Melchiori, PhD, Ella Guy, Eliezer A. Rachmilewitz, Patricia Giardina, MD, Robert W Grady, PhD, Maria de Sousa, MD, PhD, Stefano Rivella, PhD

Blood (2011) 118 (21): 3187.

https://doi.org/10.1182/blood.V118.21.3187.3187

Published: 2011

Journal Articles

The Regulation of Hepcidin in β-Thalassemia

Nermi Parrow, PhD, Sara Gardenghi, PhD, Pedro Ramos, PhD, Yatrik Shah, PhD, Robert Fleming, MD, Carla Casu, PhD, Robert W Grady, PhD, Stefano Rivella, PhD

Blood (2011) 118 (21): 901.

https://doi.org/10.1182/blood.V118.21.901.901

Published: 2011

Journal Articles

Macrophages Impair Erythroid Development in β-Thalassemia Intermedia

Carla Casu, PhD, Pedro Ramos, PhD, Ella Guy, Nico van Rooijen, PhD, Robert W Grady, PhD, Stefano Rivella, PhD

Blood (2011) 118 (21): 1035.

https://doi.org/10.1182/blood.V118.21.1035.1035

Published: 2011

Journal Articles

Investigating the Role of Cytokines and Hepcidin in Anemia of Inflammation

Sara Gardenghi, PhD, Thomas M. Renaud, MD, Alessandra Meloni, PhD, Pedro Ramos, PhD, Carla Casu, PhD, Keegan S Cooke, Barbra J Sasu, PhD, Patricia Giardina, MD, Robert W Grady, PhD, Stefano Rivella, PhD

Blood (2011) 118 (21): 1046.

https://doi.org/10.1182/blood.V118.21.1046.1046

Published: 2011

Journal Articles

Enhanced erythropoiesis in Hfe -KO mice indicates a role for Hfe in the modulation of erythroid iron homeostasis

Pedro Ramos, Ella Guy, Nan Chen, Catia C. Proenca, Sara Gardenghi, Carla Casu, Antonia Follenzi, Nico Van Rooijen, Robert W. Grady, Maria de Sousa, Stefano Rivella

Blood (2011) 117 (4): 1379–1389.

https://doi.org/10.1182/blood-2010-09-307462

Published: 2011

Includes: Supplemental data

Journal Articles

ß-Thalassemic Mice Require Functional Hfe to Modulate Hepcidin Expression In Response to Iron Overload

Pedro Ramos, Sara Gardenghi, PhD, Robert W Grady, PhD, Maria de Sousa, MD, PhD, Stefano Rivella, PhD

Blood (2010) 116 (21): 2063.

https://doi.org/10.1182/blood.V116.21.2063.2063

Published: 2010

Journal Articles

Hfe Modulates the Response to Erythopoietic Stress In Wt Mice by Two Distinct Mechanisms

Pedro Ramos, PhD, Ella Guy, Robert W Grady, PhD, Maria de Sousa, MD, PhD, Stefano Rivella, PhD

Blood (2010) 116 (21): 4251.

https://doi.org/10.1182/blood.V116.21.4251.4251

Published: 2010

Journal Articles

Optimizing the Use of Deferasirox: Evidence of Synergy When Combined with Deferoxamine

Robert W Grady, PhD, Renzo Galanello, MD, Dorothy A Kleinert, NP, MPH, Carole S. Paley, MD, Patricia J. Giardina, MD

Blood (2010) 116 (21): 5163.

https://doi.org/10.1182/blood.V116.21.5163.5163

Published: 2010

Journal Articles

Hepcidin as a Therapeutic Tool to Limit Iron Overload and Improve Anemia In β-Thalassemia

Sara Gardenghi, PhD, Pedro Ramos, Cindy N. Roy, PhD, Nancy C. Andrews, MD, PhD, Elizabeta Nemeth, PhD, Xiuli An, MD, PhD, Mohandas Narla, DSc, Yelena Ginzburg, MD, Eliezer A. Rachmilewitz, MD, Patricia Giardina, MD, Robert W Grady, Stefano Rivella, PhD

Blood (2010) 116 (21): 1009.

https://doi.org/10.1182/blood.V116.21.1009.1009

Published: 2010

Journal Articles

Bone loss caused by iron overload in a murine model: importance of oxidative stress

Jaime Tsay, Zheiwei Yang, F. Patrick Ross, Susanna Cunningham-Rundles, Hong Lin, Rhima Coleman, Philipp Mayer-Kuckuk, Stephen B. Doty, Robert W. Grady, Patricia J. Giardina, Adele L. Boskey, Maria G. Vogiatzi

Blood (2010) 116 (14): 2582–2589.

https://doi.org/10.1182/blood-2009-12-260083

Published: 2010

Includes: Supplemental data

Journal Articles

Use of Jak2 Inhibitors to Limit Ineffective Erythropoiesis and Iron Absorption in Mice Affected by β-Thalassemia and Other Disorders of Red Cell Production.

Luca Melchiori, Sara Gardenghi, PhD, Ella C. Guy, Eliezer Rachmilewitz, M.D, Patricia J Giardina, MD, Robert W. Grady, PhD, Mohandas Narla, DSc, Xiuli An, MD, PhD, Stefano Rivella, PhD

Blood (2009) 114 (22): 2020.

https://doi.org/10.1182/blood.V114.22.2020.2020

Published: 2009

Journal Articles

Macrophage Depletion Leads to Modification of Thalassemic Phenotype.

Pedro Ramos, Ella Guy, Nan Chen, Robert W. Grady, PhD, Barry S. Coller, MD, Maria De Sousa, MD, Stefano Rivella, PhD

Blood (2009) 114 (22): 2023.

https://doi.org/10.1182/blood.V114.22.2023.2023

Published: 2009

Journal Articles

Iron Chelation with Deferasirox in Thalassemia Major Patients with Low Iron Burdens and Moderate to High Transfusion Regimens.

Elizabeth Evans, Dorothy A. Kleinert, NP, Kevin Mennitt, MD, Robert W. Grady, PhD, Patricia J. Giardina, MD

Blood (2009) 114 (22): 4070.

https://doi.org/10.1182/blood.V114.22.4070.4070

Published: 2009

Journal Articles

Absence of the Hemochromatosis Gene Hfe Confers Protection Under Conditions of Stress Erythropoiesis.

Pedro Ramos, Ella Guy, Nan Chen, Sara Gardenghi, Robert W. Grady, PhD, Maria De Sousa, MD, Stefano Rivella, PhD

Blood (2009) 114 (22): 4044.

https://doi.org/10.1182/blood.V114.22.4044.4044

Published: 2009

Journal Articles

The Effect of Dietary Iron on Tissue Iron Levels in Intact and Splenectomized Mice Affected by β-Thalassemia.

Maria Franca Marongiu, Kristen Muirhead, Sara Gardenghi, Ella Guy, Stefano Rivella, Robert W Grady

Blood (2008) 112 (11): 1876.

https://doi.org/10.1182/blood.V112.11.1876.1876

Published: 2008

Journal Articles

Potential Use of Jak2 Inhibitors to Limit Ineffective Erythropoiesis and Reverse Splenomegaly in β-Thalassemia.

Luca Melchiori, Ella Guy, Ilaria Libani, Ph.D, Raffaella Schirò, MD, Ph.D, Pedro Ramos, Laura Breda, Ph.D, Amy Chadburn, MD, Yi-Fang Liu, Maria De Sousa, MD, Eliezer Rachmilewitz, M.D, Patricia J Giardina, MD, Robert W Grady, Ph.D, Stefano Rivella, Ph.D

Blood (2008) 112 (11): 1877.

https://doi.org/10.1182/blood.V112.11.1877.1877

Published: 2008

Journal Articles

Increased Hepcidin Expression in Mice Affected by β-Thalassemia Reduces Iron Overload with No Effect on Anemia

Sara Gardenghi, PhD, Maria Franca Marongiu, Kristen Muirhead, Pedro Ramos, Cindy N. Roy, PhD, Nancy C. Andrews, MD, PhD, Elizabeta Nemeth, PhD, Antonia Follenzi, Eliezer Rachmilewitz, M.D, Patricia Giardina, MD, Robert W Grady, PhD, Stefano Rivella, PhD

Blood (2008) 112 (11): 128.

https://doi.org/10.1182/blood.V112.11.128.128

Published: 2008

Journal Articles

Absence of the Hemochromatosis Gene HFE Confers Protection Under Conditions of Stress Erythropoiesis.

Pedro Ramos, Ella Guy, Laura Breda, PhD, Sara Gardenghi, PhD, Robert W Grady, Ph.D, Maria De Sousa, MD, Stefano Rivella, PhD

Blood (2008) 112 (11): 3848.

https://doi.org/10.1182/blood.V112.11.3848.3848

Published: 2008

NARROW

Removal of Macrophages From the Erythroid Niche Impairs Stress Erythropoiesis but Improves Pathophysiology of Polycythemia Vera and Beta-Thalassemia

Decreased hepcidin expression in murine β-thalassemia is associated with suppression of Bmp/Smad signaling

Potential Therapeutic Applications of Jak2 Inhibitors in Beta-Thalassemia and Sickle Cell Disease,

The Regulation of Hepcidin in β-Thalassemia

Macrophages Impair Erythroid Development in β-Thalassemia Intermedia

Investigating the Role of Cytokines and Hepcidin in Anemia of Inflammation

Enhanced erythropoiesis in Hfe -KO mice indicates a role for Hfe in the modulation of erythroid iron homeostasis

ß-Thalassemic Mice Require Functional Hfe to Modulate Hepcidin Expression In Response to Iron Overload

Hfe Modulates the Response to Erythopoietic Stress In Wt Mice by Two Distinct Mechanisms

Optimizing the Use of Deferasirox: Evidence of Synergy When Combined with Deferoxamine

Hepcidin as a Therapeutic Tool to Limit Iron Overload and Improve Anemia In β-Thalassemia

Bone loss caused by iron overload in a murine model: importance of oxidative stress

Use of Jak2 Inhibitors to Limit Ineffective Erythropoiesis and Iron Absorption in Mice Affected by β-Thalassemia and Other Disorders of Red Cell Production.

Macrophage Depletion Leads to Modification of Thalassemic Phenotype.

Iron Chelation with Deferasirox in Thalassemia Major Patients with Low Iron Burdens and Moderate to High Transfusion Regimens.

Absence of the Hemochromatosis Gene Hfe Confers Protection Under Conditions of Stress Erythropoiesis.

The Effect of Dietary Iron on Tissue Iron Levels in Intact and Splenectomized Mice Affected by β-Thalassemia.

Potential Use of Jak2 Inhibitors to Limit Ineffective Erythropoiesis and Reverse Splenomegaly in β-Thalassemia.

Increased Hepcidin Expression in Mice Affected by β-Thalassemia Reduces Iron Overload with No Effect on Anemia

Absence of the Hemochromatosis Gene HFE Confers Protection Under Conditions of Stress Erythropoiesis.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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