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Roberta Mannucci
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Journal Articles

BRAF inhibitors reverse the unique molecular signature and phenotype of hairy cell leukemia and exert potent antileukemic activity

Clinical Trials & Observations
Valentina Pettirossi, Alessia Santi, Elisa Imperi, Guido Russo, Alessandra Pucciarini, Barbara Bigerna, Gianluca Schiavoni, Elisabetta Fortini, Ariele Spanhol-Rosseto, Paolo Sportoletti, Roberta Mannucci, Maria Paola Martelli, Ludger Klein-Hitpass, Brunangelo Falini, Enrico Tiacci
Journal: Blood
Blood (2015) 125 (8): 1207–1216.
https://doi.org/10.1182/blood-2014-10-603100
Published: 2015
Includes: Supplemental data
Journal Articles

Targeting The BRAF-MEK-ERK Pathway In Hairy Cell Leukemia

Valentina Pettirossi, Alessia Santi, Guido Russo, Alessandra Pucciarini, Barbara Bigerna, Elisabetta Fortini, Elisa Imperi, Roberta Mannucci, Ildo Nicoletti, Maria Paola Martelli, Enrico Tiacci, Brunangelo Falini
Journal: Blood
Blood (2013) 122 (21): 3064.
https://doi.org/10.1182/blood.V122.21.3064.3064
Published: 2013
Journal Articles

Mutated nucleophosmin detects clonal multilineage involvement in acute myeloid leukemia: impact on WHO classification

Clinical Trials & Observations
Laura Pasqualucci, Arcangelo Liso, Maria Paola Martelli, Niccolò Bolli, Roberta Pacini, Alessia Tabarrini, Manola Carini, Barbara Bigerna, Alessandra Pucciarini, Roberta Mannucci, Ildo Nicoletti, Enrico Tiacci, Giovanna Meloni, Giorgina Specchia, Nicola Cantore, Francesco Di Raimondo, Stefano Pileri, Cristina Mecucci, Franco Mandelli, Massimo Fabrizio Martelli, Brunangelo Falini
Journal: Blood
Blood (2006) 108 (13): 4146–4155.
https://doi.org/10.1182/blood-2006-06-026716
Published: 2006
Includes: Supplemental data
Journal Articles

Reciprocal Interaction between NPM Leukemic Mutants and Arf: Structural Basis and Functional Consequences.

Niccolo’ Bolli, Maria Paola Martelli, Barbara Bigerna, Alessandra Pucciarini, Barbara Verducci, Teresa Pallotta, Felicetta de Marco, Valentina Pettirossi, Roberta Mannucci, Elisabetta Bonifacio, Antonio Tabilio, Ildo Nicoletti, Brunangelo Falini
Journal: Blood
Blood (2006) 108 (11): 1939.
https://doi.org/10.1182/blood.V108.11.1939.1939
Published: 2006
Journal Articles

Immunohistochemistry predicts nucleophosmin (NPM) mutations in acute myeloid leukemia

Clinical Trials & Observations
Brunangelo Falini, Maria Paola Martelli, Niccolò Bolli, Rossella Bonasso, Emanuela Ghia, Maria Teresa Pallotta, Daniela Diverio, Ildo Nicoletti, Roberta Pacini, Alessia Tabarrini, Barbara Verducci Galletti, Roberta Mannucci, Giovanni Roti, Roberto Rosati, Giorgina Specchia, Arcangelo Liso, Enrico Tiacci, Myriam Alcalay, Lucilla Luzi, Sara Volorio, Loris Bernard, Anna Guarini, Sergio Amadori, Franco Mandelli, Fabrizio Pane, Francesco Lo-Coco, Giuseppe Saglio, Pier-Giuseppe Pelicci, Massimo F. Martelli, Cristina Mecucci, for the GIMEMA Acute Leukemia Working Party
Journal: Blood
Blood (2006) 108 (6): 1999–2005.
https://doi.org/10.1182/blood-2006-03-007013
Published: 2006
Journal Articles

Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc + AML

Brunangelo Falini, Niccolò Bolli, Jing Shan, Maria Paola Martelli, Arcangelo Liso, Alessandra Pucciarini, Barbara Bigerna, Laura Pasqualucci, Roberta Mannucci, Roberto Rosati, Paolo Gorello, Daniela Diverio, Giovanni Roti, Enrico Tiacci, Giovanni Cazzaniga, Andrea Biondi, Suzanne Schnittger, Torsten Haferlach, Wolfgang Hiddemann, Massimo F. Martelli, Wei Gu, Cristina Mecucci, Ildo Nicoletti
Journal: Blood
Blood (2006) 107 (11): 4514–4523.
https://doi.org/10.1182/blood-2005-11-4745
Published: 2006
Includes: Supplemental data
Journal Articles

Mechanism of Altered Nucleo-Cytoplasmic Traffic of Nucleophosmin in Acute Myelogenous Leukemia Carrying Exon-12 NPM Mutations (NPMc+ AML).

Brunangelo Falini, Niccolo Bolli, Jing Shan, Maria Paola Martelli, Ildo Nicoletti, Arcangelo Liso, Laura Pasqualucci, Roberto Rosati, Giovanni Roti, Daniela Diverio, Roberta Mannucci, Giovanni Cazzaniga, Andrea Biondi, Giuseppe Saglio, Fabrizio Pane, Francesco Lo-Coco, Pier-Giuseppe Pelicci, Massimo F. Martelli, Wei Gu, Cristina Mecucci
Journal: Blood
Blood (2005) 106 (11): 4396.
https://doi.org/10.1182/blood.V106.11.4396.4396
Published: 2005
Journal Articles

Exon-12 Nucleophosmin ( NPM ) Mutation and Aberrant Cytoplasmic Expression of NPM Protein in Leukemia Cell Line OCI-AML3.

Hilmar Quentmeier, PhD, Maria P. Martelli, PhD, Wilhelm G. Dirks, PhD, Niccolo Bolli, PhD, Arcangelo Liso, PhD, Roderick A.F. MacLeod, PhD, Ildo Nicoletti, PhD, Roberta Mannucci, PhD, Alessandra Pucciarini, PhD, Barbara Bigerna, PhD, Massimo F. Martelli, PhD, Cristina Mecucci, PhD, Hans G. Drexler, MD, PhD, Brunangelo Falini, PhD
Journal: Blood
Blood (2005) 106 (11): 2376.
https://doi.org/10.1182/blood.V106.11.2376.2376
Published: 2005