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Maria Paola Martelli
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Journal Articles

Optimal Duration of CPX-351 Treatment and Best Timing for Consolidation with Allogeneic Stem Cell Transplantation: Evidence from a Large Real-World Italian Study

Fabio Guolo, Luana Fianchi, Maria Paola Martelli, Patrizia Chiusolo, Federico Lussana, Francesco Grimaldi, Federica Pilo, Michela Rondoni, Carla Fili, Debora Capelli, Massimo Breccia, Sara Mastaglio, Monica Bocchia, Monica Fumagalli, Sara Galimberti, Valentina Mancini, Anna Lina Piccioni, Luca Maurillo, Raffaele Palmieri, Andrea Corbingi, Calogero Vetro, Alessandra Sperotto, Federica Gigli, Patrizia Zappasodi, Antonio Mulé, Erika Borlenghi, Michelina Dargenio, Federica Lessi, Marco Cerrano, Alessandro Isidori, Lorenzo Brunetti, Cristina Papayannidis, Monia Lunghi, Caterina Alati, Samuele Gatani, Francesco Mannelli, Nicola Fracchiolla, Michele Gottardi, Roberto Cairoli, Felicetto Ferrara, Roberto Massimo Lemoli, Adriano Venditti, Livio Pagano, Elisabetta Todisco
Journal: Blood
Blood (2023) 142 (Supplement 1): 731.
https://doi.org/10.1182/blood-2023-189025
Published: 2023
Journal Articles

Synergistic Growth Inhibition of NPM1 Mutant AML PDX By Combined Therapy with BCL-2 Inhibitor Venetoclax (ABT-199) and Menin Inhibitor DS-1594b In Vivo

Valerio Ciaurro, Marina Y. Konopleva, Naval Daver, Anna Skwarska, Maria Paola Martelli
Journal: Blood
Blood (2023) 142 (Supplement 1): 4169.
https://doi.org/10.1182/blood-2023-182026
Published: 2023
Journal Articles

Real World Outcome of Unfit Patients with Acute Myeloid Leukemia Treated with the Combination Venetoclax Plus Hypomethylating Agents in the Gimema AML2320 Observational Trial

Adriano Venditti, Alfonso Piciocchi, Stefano Soddu, Marco Frigeni, Raffaele Palmieri, Erika Borlenghi, Nicola Fracchiolla, Maria Paola Martelli, Ernesta Audisio, Giacomo Gianfaldoni, Calogero Vetro, Nicola di Rienzo, Daniela Esposito, Ambra Di Veroli, Carmine Selleri, Federica Gigli, Antonio Curti, Antonino Mulè, Catello Califano, Sara Bigliardi, Massimo Breccia, Claudio Fozza, Monica Bocchia, Albana Lico, Federico Simonetti, Elisabetta Pierdomenico, Francesco Buccisano, Maria Ilaria Del Principe, Luca Maurillo, Paola Fazi, Marco Vignetti, Felicetto Ferrara, Roberto Cairoli, Giuseppe Rossi, Alessandro Rambaldi
Journal: Blood
Blood (2023) 142 (Supplement 1): 1514.
https://doi.org/10.1182/blood-2023-178505
Published: 2023
Journal Articles

Single Agent Tagraxofusp in Relapsed/Refractory CD123-Positive Acute Myeloid Leukemia: A Preliminary Analysis of Italian Gimema AML2020 Trial

Paola Minetto, Sara Rosellini, Fabio Guolo, Elisabetta Tedone, Ernesta Audisio, Chiara Cattaneo, Monica Bocchia, Nicola Fracchiolla, Maria Paola Martelli, Enrico Crea, Enrico Carminati, Livia Gorreo Renzulli, Giuseppina Fugazza, Alfonso Piciocchi, Giovanni Ottonelli, Maurizio Miglino, Michele Cea, Antonio Curti, Livio Pagano, Adriano Venditti, Tariq Mughal, Roberto Massimo Lemoli
Journal: Blood
Blood (2023) 142 (Supplement 1): 2918.
https://doi.org/10.1182/blood-2023-189417
Published: 2023
Journal Articles

Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN):Multi-Center Collaboration and Global Registry Program

Astghik Voskanyan, Maria Badikyan, Marina Y. Konopleva, Alvaro J. Alencar, Arusyak Ivanyan, Carolyn Owen, Consolato Sergi, Ching-Tien Peng, Dickran Kazandjian, Funda Tekkesin, Hasanein Ghali, Karen Bedirian, Maria Paola Martelli, Enrico Attardi, Maria Teresa Voso, Mariam Abramashvili, Mazin Faisal Al-Jadiry, Michalis Michael, Min-Yu Su, Nare Martirosyan, Nino Totogashvili, Pavel P Kotoucek, Rejin Kebudi, Robin Ohannessian, Ruzanna Papyan, Salma Elashwah, Sameer Bakhshi, Samvel Bardakhchyan, Samvel Danelyan, Shaimaa El-Ashwah, Tezer Kutluk, Gevorg Tamamyan, Naveen Pemmaraju
Journal: Blood
Blood (2023) 142 (Supplement 1): 1543.
https://doi.org/10.1182/blood-2023-188546
Published: 2023
Journal Articles

Applicability of SIE/Sies/GITMO Fitness Criteria to Therapy-Related and AML-MRC Receiving CPX-351: Results from a Large, Retrospective, Multicentric, Observational Study

Raffaele Palmieri, Fabio Guolo, Luana Fianchi, Felicetto Ferrara, Maria Paola Martelli, Michela Rondoni, Capria Saveria, Paola Minetto, Clara Minotti, Sofia Sciabolacci, Federica Pilo, Salvatore Perrone, Andrea Corbingi, Francesco Grimaldi, Giulia De Luca, Carla Fili, Caterina Alati, Francesco Mannelli, Federica Lessi, Francesco Marchesi, Lorenzo Brunetti, Debora Capelli, Anna Lina Piccioni, Calogero Vetro, Carla Mazzone, Alessandra Sperotto, Giovanni Luzi, Michelina Dargenio, Sabrina Mariani, Marco Cerrano, Antonino Mulè, Ambra Di Veroli, Cristina Papayannidis, Alessandro Isidori, Francesco Lanza, Michele Gottardi, Elisabetta Todisco, Livio Pagano, Roberto Massimo Lemoli, Francesco Buccisano, Adriano Venditti
Journal: Blood
Blood (2023) 142 (Supplement 1): 2891.
https://doi.org/10.1182/blood-2023-181142
Published: 2023
Journal Articles

Overlapping features of therapy-related and de novo NPM1 -mutated AML

Clinical Trials & Observations
Jad Othman, Manja Meggendorfer, Enrico Tiacci, Christian Thiede, Richard Schlenk, Richard Dillon, Sebastian Stasik, Alessandra Venanzi, Sarah Bertoli, Eric Delabesse, Pierre-Yves Dumas, Arnaud Pigneux, Audrey Bidet, Amanda F. Gilkes, Ian Thomas, Maria Teresa Voso, Alessandro Rambaldi, Lorenzo Brunetti, Vincenzo M. Perriello, Vibeke Andresen, Bjorn T. Gjertsen, Maria Paola Martelli, Christian Récher, Christoph Röllig, Martin Bornhäuser, Hubert Serve, Carsten Müller-Tidow, Claudia D. Baldus, Tortsten Haferlach, Nigel Russell, Brunangelo Falini
Journal: Blood
Blood (2023) 141 (15): 1846–1857.
https://doi.org/10.1182/blood.2022018108
Published: 2023
Includes: Supplemental data
Journal Articles

HLA-Matched Treg/Tcon Allogeneic Hematopoietic Cell Transplantation Is Safe and Ensures Remarkable Chronic GvHD/Leukemia Free Survival in High-Risk Leukemia Patients

Antonio Pierini, Loredana Ruggeri, Simonetta Saldi, Sara Tricarico, Francesca Marzuttini, Valerio Viglione, Rebecca Sembenico, Tiziana Zei, Roberta Iacucci Ostini, Antonella Mancusi, Roberto Limongello, Olivia Minelli, Gianluca Ingrosso, Adelmo Terenzi, Maria Paola Martelli, Maurizio Caniglia, Cristina Mecucci, Andrea Velardi, Massimo Fabrizio Martelli, Cynthia Aristei, Alessandra Carotti
Journal: Blood
Blood (2022) 140 (Supplement 1): 2133–2134.
https://doi.org/10.1182/blood-2022-169351
Published: 2022
Journal Articles

Tuned IL3-Zetakine Coupled to a CD33 Costimulatory Receptor As a Dual CAR for Safer and Selective Targeting of Acute Myeloid Leukemia

Vincenzo Maria Perriello, Maria Caterina Rotiroti, Ilaria Pisani, Stefania Galimberti, Gaia Alberti, Giulia Pianigiani, Valerio Ciaurro, Andrea Marra, Marcella Sabino, Valentina Tini, Federica Mezzasoma, Francesco Morena, Sabata Martino, Domenico Salerno, Julian François Ashby, Brittany Wingham, Marta Serafini, Maria Paola Martelli, Brunangelo Falini, Andrea Biondi, Sarah Tettamanti
Journal: Blood
Blood (2022) 140 (Supplement 1): 10237–10238.
https://doi.org/10.1182/blood-2022-166555
Published: 2022
Journal Articles

A Chemo-Free Bridge-to-Transplant Strategy with Venetoclax and Azacitidine for NPM1 -Mutated Acute Myeloid Leukemia in Molecular Failure

Chiara Sartor, Lorenzo Brunetti, Ernesta Audisio, Alessandro Cignetti, Letizia Zannoni, Gianluca Cristiano, Jacopo Nanni, Emanuela Ottaviani, Lorenza Bandini, Sarah Parisi, Stefania Paolini, Sofia Sciabolacci, Valeria Cardinali, Cristina Papayannidis, Michele Cavo, Maria Paola Martelli, Antonio Curti
Journal: Blood
Blood (2022) 140 (Supplement 1): 9034–9035.
https://doi.org/10.1182/blood-2022-165914
Published: 2022
Journal Articles

Novel NPM1 exon 5 mutations and gene fusions leading to aberrant cytoplasmic nucleophosmin in AML

Brief Report
Maria Paola Martelli, Roberta Rossi, Alessandra Venanzi, Manja Meggendorfer, Vincenzo Maria Perriello, Giovanni Martino, Orietta Spinelli, Raffaella Ciurnelli, Emanuela Varasano, Lorenzo Brunetti, Stefano Ascani, Corinne Quadalti, Valeria Cardinali, Federica Mezzasoma, Ilaria Gionfriddo, Francesca Milano, Roberta Pacini, Alessia Tabarrini, Barbara Bigerna, Francesco Albano, Giorgina Specchia, Calogero Vetro, Francesco Di Raimondo, Ombretta Annibali, Giuseppe Avvisati, Alessandro Rambaldi, Franca Falzetti, Enrico Tiacci, Paolo Sportoletti, Torsten Haferlach, Claudia Haferlach, Brunangelo Falini
Journal: Blood
Blood (2021) 138 (25): 2696–2701.
https://doi.org/10.1182/blood.2021012732
Published: 2021
Includes: Supplemental data
Journal Articles

CD123 and CD33 Co-Targeting By Balanced Signaling on CAR-CIK Cells Reduces Potential Off-Target Toxicity While Preserving the Anti-Leukemic Activity of Acute Myeloid Leukemia

Vincenzo Maria Perriello, Maria Caterina Rotiroti, Ilaria Pisani, Gaia Alberti, Giulia Pianigiani, Roberta Rossi, Valerio Ciaurro, Marta Serafini, Maria Paola Martelli, Brunangelo Falini, Andrea Biondi, Sarah Tettamanti
Journal: Blood
Blood (2021) 138 (Supplement 1): 1699.
https://doi.org/10.1182/blood-2021-150487
Published: 2021
Journal Articles

How I diagnose and treat NPM1 -mutated AML

Brunangelo Falini, Lorenzo Brunetti, Maria Paola Martelli
Journal: Blood
Blood (2021) 137 (5): 589–599.
https://doi.org/10.1182/blood.2020008211
Published: 2021
Journal Articles

Italian Observational Study on Real-Life Use of Venetoclax in Acute Myeloid Leukemia (AVALON study): Results of Interim Analysis on Relapsed/Refractory Patients

Elisabetta Todisco, MDPhD, Nicola Fracchiolla, MD, Cristina Papayannidis, MD PhD, Maria Paola Martelli, MDPhD, Giuliana Rizzuto, Alessandro Cignetti, MD PhD, Nicola Di Renzo, MD, Patrizia Zappasodi, MD, Michele Gottardi, MD, Ernesta Audisio, MD, Monia Lunghi, MD, Federica Gigli, MD, Corrado Tarella, Chiara Zingaretti, Elisabetta Petracci, Roberta Volpi, Delia Cangini, Maria Benedetta Giannini, MD, Mariarita Sciumè, MD, Giuseppe Rossi, MD, Avalon Group, Giovanni Martinelli, MD, Claudio Cerchione, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 37–38.
https://doi.org/10.1182/blood-2020-143082
Published: 2020
Journal Articles

A Preliminary Analysis of FLAM (Italian Non-Interventional Multi-center Study of FLT3 mutated AML patients): FLT3 Receptor Gene Mutational Analysis and FLT3 Inhibitors Administration in the Real-Life Clinical Practice

Jacopo Nanni, MD, Ernesta Audisio, MD, Maria Benedetta Giannini, MD, Barbara MD Scappini, Benedetta Cambò, MD, Francesco Albano, Maria Paola Martelli, MDPhD, Alessandro Cignetti, MD PhD, Gian Matteo Rigolin, Nicola Fracchiolla, MD, Monica Bocchia, Claudio Romani, Elisabetta Todisco, MDPhD, Monia Lunghi, MD PhD, Anna Maria Mianulli, MD, Daniela Cilloni, MD PhD, Elisabetta Petracci, Irene Valli, Chiara Zingaretti, Claudio Cerchione, MD PhD, Delia Cangini, the FLAM collaborative Group, Cristina Papayannidis, MD PhD, Giovanni Martinelli, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 32–34.
https://doi.org/10.1182/blood-2020-139981
Published: 2020
Journal Articles

NPM1 -mutated acute myeloid leukemia: from bench to bedside

Brunangelo Falini, Lorenzo Brunetti, Paolo Sportoletti, Maria Paola Martelli
Journal: Blood
Blood (2020) 136 (15): 1707–1721.
https://doi.org/10.1182/blood.2019004226
Published: 2020
Journal Articles

GIMEMA AML1310 trial of risk-adapted, MRD-directed therapy for young adults with newly diagnosed acute myeloid leukemia

Clinical Trials & Observations
Adriano Venditti, Alfonso Piciocchi, Anna Candoni, Lorella Melillo, Valeria Calafiore, Roberto Cairoli, Paolo de Fabritiis, Gabriella Storti, Prassede Salutari, Francesco Lanza, Giovanni Martinelli, Mario Luppi, Patrizio Mazza, Maria Paola Martelli, Antonio Cuneo, Francesco Albano, Francesco Fabbiano, Agostino Tafuri, Anna Chierichini, Alessia Tieghi, Nicola Stefano Fracchiolla, Debora Capelli, Robin Foà, Caterina Alati, Edoardo La Sala, Paola Fazi, Marco Vignetti, Luca Maurillo, Francesco Buccisano, Maria Ilaria Del Principe, Maria Irno-Consalvo, Tiziana Ottone, Serena Lavorgna, Maria Teresa Voso, Francesco Lo-Coco, William Arcese, Sergio Amadori
Journal: Blood
Blood (2019) 134 (12): 935–945.
https://doi.org/10.1182/blood.2018886960
Published: 2019
Includes: Supplemental data
Journal Articles

Haploidentical Transplantation with Regulatory and Conventional T Cells Improves Outcome of Patients Affected By Acute Myeloid Leukemia with Complex Karyotype and/or Monosomy 7/Del(7q)

Antonio Pierini, Andrea Marra, MD, Alessandra Carotti, MD, Loredana Ruggeri, Adelmo Terenzi, MD, Franca Falzetti, MD, Sara Piccinelli, MD, Valeria Cardinali, MD, Antonella Mancusi, PhD, Cecilia Tardioli, Rita Felicini, MD, Amico Lucia, MD PhD, Genni Casarola, MD, Sara Tricarico, MD, Samanta Bonato, MD, Matteo Paradiso, MD, Mario Griselli, MD, Barbara Crescenzi, PhD, Roberta La Starza, MD PhD, Cristina Mecucci, MD PhD, Brunangelo Falini, MD PhD, Massimo Fabrizio Martelli, MD PhD, Maria Paola Martelli, MD PhD, Andrea Velardi
Journal: Blood
Blood (2018) 132 (Supplement 1): 2183.
https://doi.org/10.1182/blood-2018-99-116638
Published: 2018
Journal Articles

Acute Myeloid Leukemia with Mutated NPM1 Is Dependent on the Cytoplasmic Localization of NPM1c

Lorenzo Brunetti, MD, Michael Gundry, Anna Guzman, Ilaria Gionfriddo, PhD, Federica Mezzasoma, PhD, Francesca Milano, PhD, Maria Paola Martelli, MD PhD, Brunangelo Falini, MD, Margaret Goodell, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 877.
https://doi.org/10.1182/blood.V130.Suppl_1.877.877
Published: 2017
Journal Articles

The Mechanisms By Which Mutant-NPM1 Uncouples Differentiation from Proliferation Are Reversed By Several Drugs, Enabling Rational Multi-Component Non-Cytotoxic Differentiation Therapy

Xiaorong Gu, PhD, Quteba Ebrahem, MD, Reda Z. Mahfouz, MD PhD, Metis Hasipek, PhD, Francis Enane, PhD, Tomas Radivoyevitch, Nicolas Rapin, PhDMSc, Bartlomiej P. Przychodzen, MSc, Ramesh Balusu, PhD, Claudiu V Cotta, David Wald, MD PhD, Zhenbo Hu, MD PhD, Yosef Landesman, PhD, Maria Paola Martelli, MD PhD, Brunangelo Falini, MD, Hetty E. Carraway, MD MBA, Jaroslaw P. Maciejewski, PhD MD FACP, Babal K Jha, PhD, Yogenthiran Saunthararajah, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 878.
https://doi.org/10.1182/blood.V130.Suppl_1.878.878
Published: 2017