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Journal Articles

Preliminary results from RIVER-81, a phase 2 study of romaciclib (RVU120) + venetoclax in patients with acute myeloid leukemia failing first-line venetoclax + hypomethylating agent (HMA)

Free
Pau Montesinos, Adolfo De La Fuente Burguera, Sara Garcia Avila, Thomas Cluzeau, Sylvain Garciaz, Krzysztof Madry, Witold Prejzner, Milena Mazan, Urszula Pakulska, Urszula Glowniak, Jan Kulis, Diego Coelho, Marta Obacz, Agnieszka Sroka-Porada, Gary Wilkinson, Renata Windak, Renata Dudziak, Chadi Saba, Tomasz Rzymski, Hendrik Nogai, Cristina Papayannidis, Giovanni Marconi, Jaroslaw Dybko, Juan Miguel Bergua Burgues, Maria Benedetta Giannini, Ernesta Audisio
Journal: Blood
Blood (2025) 146 (Supplement 1): 3424.
https://doi.org/10.1182/blood-2025-3424
Published: 2025
Journal Articles

Interim analysis after 3 months of AML patients treated with venetoclax + azacitidine – first effectiveness and safety data from the prospective real world vero study

Free
Elisabetta Todisco, Caterina Alati, Ernesta Audisio, Monia Lunghi, Patrizia Zappasodi, Antonio Curti, Vincenzo Federico, Antonino Mule', MARINA PARISI, PRASSEDE SALUTARI, Massimo Breccia, Valeria Cardinali, Federico Lussana, matteo piccini, Marta Riva, Nicola Stefano Fracchiolla, Luca Maurillo, DEBORA CAPELLI, Anna Candoni, Eleonora De Bellis, SELENIA VITIELLO, PAOLA FINSINGER, LUIGI DI CAPRIO, Benedetta Neri, MELANIA RONFANI, ALESSANDRA FASANO, SIMONA MALGIERI, Matteo Della Porta
Journal: Blood
Blood (2025) 146 (Supplement 1): 3384.
https://doi.org/10.1182/blood-2025-3384
Published: 2025
Journal Articles

Venetoclax and decitabine in myeloproliferative neoplasm-blast Phase (MPN-BP): Results of enable, a gimema and airc-mynerva multicenter, Phase 2 trial

Free
Alessandro Vannucchi, Francesco Mannelli, Francesca Crupi, Jessica Caroprese, Mirko Lomi, Alessio Enderti, Stefano Soddu, Alfonso Piciocchi, Alessandro Rambaldi, Giovanni Caocci, Monica Bocchia, Ernesta Audisio, Antonio Curti, Fabrizio Pane, Erika Borlenghi, Massimo Breccia, Niccolò Bartalucci, Marco Frigeni, Olga Mulas, Corrado Zuanelli Brambilla, Chiara Frairia, Cristina Papayannidis, Francesco Grimaldi, Lorenzo Masina, Monica Rondi, Marco Sanna, Pellegrino Musto, Prassede Salutari, Patrizia Chiusolo, Elisa Coviello, Mario Luppi, Daniela Cilloni, leonardo Signori, Luca Malcovati, Maria Paola Martelli, Matteo Della Porta, Rossella Manfredini, Maria Teresa Voso, Paola Fazi, Marco Vignetti, Paola Guglielmelli
Journal: Blood
Blood (2025) 146 (Supplement 1): 1025.
https://doi.org/10.1182/blood-2025-1025
Published: 2025
Journal Articles

Elevation of fetal hemoglobin is a biomarker for response to decitabine in AML: Results of the AML21 randomized phase III trial of the EORTC leukemia group, gimema and german MDS study group

Free
Julia Stomper, Michal Kicinski, Tobias Ma, Thomas Meyer, Sylvain Chantepie, Richard Noppeney, Mario Luppi, Ernesta Audisio, Laimonas Griškevičius, Andreas Neubauer, Robin Foà, Walter Van der Velden, Anna Candoni, Radovan Vrhovac, Gianluca Gaidano, Marjolein Van Der Poel, Mels Hoogendoorn, Stéphanie Antunes, Frederic Baron, Adriano Venditti, Joop Jansen, Pierre Wijermans, Gerwin A. Huls, Michael Lübbert
Journal: Blood
Blood (2025) 146 (Supplement 1): 1709.
https://doi.org/10.1182/blood-2025-1709
Published: 2025
Journal Articles

Mynerva-gimema AML1919 ameliorate Trial: EARLY intensification in FLT3-mutated ACUTE myeloid leukemia based on peripheral blast clearance

Free
Francesco Mannelli, Giacomo Gianfaldoni, Alfonso Piciocchi, Giovanni Marsili, Roberto Caporale, Ernesta Audisio, Antonino Mule', Alessandro Pulsoni, Antonio Curti, Crescenza Pasciolla, Patrizia Zappasodi, Chiara Cattaneo, Alessia Tieghi, Roberto Sartori, Luca Frison, Francesco Albano, Prassede Salutari, Sara Bencini, Benedetta Peruzzi, Matteo Piccini, Barbara Scappini, Francesca Crupi, Gaia Ciolli, Livia Gorreo Renzulli, Marco Chiarini, Francesco Buccisano, Adriano Venditti, Paola Fazi, Francesco Annunziato, Paola Guglielmelli, Alessandro Vannucchi
Journal: Blood
Blood (2025) 146 (Supplement 1): 5243.
https://doi.org/10.1182/blood-2025-5243
Published: 2025
Journal Articles

Real-world validation of ELN2024 and BEAT-AML2024 risk-stratification in patients with Acute Myeloid Leukemia unfit for intensive chemotherapy in a multicenter italian cohort.

Free
Arianna Savi, Giovanni Fornari, Johanna Umurungi, Beatrice Sani, Alessandro Cignetti, Ernesta Audisio, Elisabetta Todisco, Enrico Santinelli, Marianna Norata, Cristina Papayannidis, Raffaele Palmieri, Adriano Venditti, Monia Marchetti, Daniela Cilloni
Journal: Blood
Blood (2025) 146 (Supplement 1): 1624.
https://doi.org/10.1182/blood-2025-1624
Published: 2025
Journal Articles

10-day decitabine versus conventional chemotherapy (“3+7”) followed by allografting in AML patients ≥ 60 years: Long-term follow-up results of the randomized phase III trial AML21 of the EORTC leukemia group, GIMEMA and german MDS Study group

Free
Michael Lübbert, Pierre Wijermans, Michal Kicinski, Sylvain Chantepie, Walter Van der Velden, Richard Noppeney, Laimonas Griškevičius, Andreas Neubauer, Martina Crysandt, Radovan Vrhovac, Mario Luppi, Stephan Fuhrmann, Ernesta Audisio, Anna Candoni, Ollivier Legrand, Robin Foà, Gianluca Gaidano, Danielle van Lammeren-Venema, Eduardus Posthuma, Mels Hoogendoorn, Anne Giraut, Stéphanie Antunes, Marian Stevens-Kroef, Joop Jansen, Aniek De Graaf, Fabio Efficace, Emanuele Ammatuna, Jean Pierre Vilque, Ralph Wäsch, Heiko Becker, Nicole Blijlevens, Ulrich Dührsen, Frederic Baron, Stefan Suciu, Sergio Amadori, Adriano Venditti, Gerwin A. Huls
Journal: Blood
Blood (2025) 146 (Supplement 1): 1676.
https://doi.org/10.1182/blood-2025-1676
Published: 2025
Journal Articles

Up-front blinatumomab improves MRD clearance and outcome in adult Ph – B-lineage ALL: the GIMEMA LAL2317 phase 2 study

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Clinical Trials & Observations
Renato Bassan, Sabina Chiaretti, Irene Della Starza, Alessandra Santoro, Orietta Spinelli, Manuela Tosi, Loredana Elia, Deborah Cardinali, Maria Stefania De Propris, Matteo Piccini, Federico Lussana, Mario Annunziata, Patrizia Chiusolo, Patrizia Zappasodi, Erika Borlenghi, Matteo Leoncin, Catello Califano, Monica Bocchia, Francesco Di Raimondo, Francesco Grimaldi, Mario Tiribelli, Anna Candoni, Albana Lico, Ernesta Audisio, Monia Lunghi, Anna Maria Mianulli, Mariangela Di Trani, Valentina Arena, Monica Messina, Alfonso Piciocchi, Paola Fazi, Alessandro Rambaldi, Robin Foà
Journal: Blood
Blood (2025) 145 (21): 2447–2459.
https://doi.org/10.1182/blood.2024027500
Published: 2025
Includes: Supplemental data
Journal Articles

Centralized MRD Assessment in Gimema AML1718 Trial, a Phase 2 Open-Label Study of Venetoclax Combined with Intensified FLAI Chemotherapy (V-FLAI) As Induction Therapy of Non Low-Risk AML

Free
Paola Minetto, Fabio Guolo, Sara Rosellini, Alfonso Piciocchi, Giovanni Marconi, Ernesta Audisio, Giorgio Priolo, Cristina Papayannidis, Maurizio Martelli, Giovanni Marsili, Monica Bocchia, Francesco Lanza, Albana Lico, Fabio Ciceri, Matteo Giovanni Della Porta, Marco Frigeni, Luisa Giaccone, Germana Beltrami, Erika Borlenghi, Maria Chiara Di Chio, Carmine Selleri, Enrico Crea, Irene Urbino, Chiara Sartor, Clara Minotti, Valentina Arena, Jacopo Nanni, Giorgia Simonetti, Maria Teresa Bochicchio, Giuseppe Saglio, Adriano Venditti, Marco Vignetti, Paola Fazi, Elisabetta Tedone, Giovanni Martinelli, Roberto Massimo Lemoli
Journal: Blood
Blood (2024) 144 (Supplement 1): 1574.
https://doi.org/10.1182/blood-2024-198139
Published: 2024
Journal Articles

Measurable Residual Disease Monitoring for Philadelphia Positive Acute Lymphoblastic Leukemia (Ph+ALL) in the Setting of the Gimema ALL2820 Trial

Free
Marco Beldinanzi, Vittorio Bellomarino, Deborah Cardinali, Irene Della Starza, Mabel Matarazzo, Mariangela Di Trani, Matteo Leoncin, Clara Minotti, Lara Pochintesta, Erika Borlenghi, Caterina Alati, Simona Sica, Valentina Mancini, Barbara Scappini, Bianca Serio, Marina Parisi, Lucia Ammirati, Antonella Cucca, Federico Lussana, Ernesta Audisio, Federico Mosna, Patrizia Zappasodi, Monica Bocchia, Silvia Imbergamo, Mario Luppi, Valeria Cardinali, Crescenza Pasciolla, Claudio Romani, Albana Lico, Benedetta Cambò, Massimiliano Bonifacio, Monica Messina, Daniele G. Mattei, Sara Mastaglio, Lara Aprile, Monia Lunghi, Anna Guarini, Robin Foà, Sabina Chiaretti
Journal: Blood
Blood (2024) 144 (Supplement 1): 2836.
https://doi.org/10.1182/blood-2024-210731
Published: 2024
Journal Articles

Survival Analysis of Gimema AML1718, a Safety Run-in and Phase 2 Open-Label Study of Venetoclax, Fludarabine, Idarubicin and Cytarabine (V-FLAI) in the Induction Therapy of Non Low-Risk Acute Myeloid Leukemia

Free
Giovanni Marconi, Alfonso Piciocchi, Ernesta Audisio, Cristina Papayannidis, Fabio Guolo, Marco Cerrano, Valentina Arena, Saveria Capria, Michela Rondoni, Matteo Giovanni Della Porta, Germana Beltrami, Monica Bocchia, Albana Lico, Luisa Giaccone, Marianna Rossi, Catello Califano, Matteo Giovanni Carrabba, Chiara Cattaneo, Marco Frigeni, Maria Chiara Di Chio, Bianca Serio, Roberto Freilone, Antonio Curti, Paola Minetto, Giovanni Marsili, Clara Minotti, Beatrice Anna Zannetti, Francesca Cotugno, Jacopo Nanni, Giorgia Simonetti, Maria Teresa Bochicchio, Sara Rosellini, Elisabetta Tedone, Adriano Venditti, Roberto Massimo Lemoli, Marco Vignetti, Paola Fazi, Giovanni Martinelli
Journal: Blood
Blood (2024) 144 (Supplement 1): 2891.
https://doi.org/10.1182/blood-2024-207842
Published: 2024
Journal Articles

Efficacy and Toxicity of Frontline Ponatinib Plus Blinatumomab for Adult Ph+ ALL Patients of All Ages. Intermediate Analysis of the Gimema ALL2820

Free
Sabina Chiaretti, Matteo Leoncin, Loredana Elia, Stefano Soddu, Alfonso Piciocchi, Mabel Matarazzo, Mariangela Di Trani, Maurizio Martelli, Erika Borlenghi, Marina Parisi, Valentina Mancini, Caterina Alati, Daniele G. Mattei, Maria Paola Martelli, Prassede Salutari, Patrizia Chiusolo, Ernesta Audisio, Mario Luppi, Lara Pochintesta, Crescenza Pasciolla, Bianca Serio, Barbara Scappini, Antonella Cucca, Martina Chiarucci, Massimiliano Bonifacio, Nicola Fracchiolla, Silvia Imbergamo, Lucia Ammirati, Federico Mosna, Patrizia Zappasodi, Sara Mastaglio, Daniela Pietrasanta, Monica Bocchia, Monia Lunghi, Elisabetta Todisco, Paola Fazi, Alessandro Rambaldi, Robin Foà
Journal: Blood
Blood (2024) 144 (Supplement 1): 835.
https://doi.org/10.1182/blood-2024-207892
Published: 2024
Journal Articles

Disease Course and Treatment Patterns of Acute Myeloid Leukemia with FLT3 Mutations and Myeloid Sarcoma Reveal High Efficacy of Gilteritinib: A Multicentric Retrospective Study

Free
Francesco Angotzi, Erika Borlenghi, Chiara Sartor, Maria Benedetta Giannini, Giovanni Marconi, Edoardo Tamellini, Mauro Turrini, Federica Loscocco, Ernesta Audisio, Vincenzo Federico, Calogero Vetro, Andrea Visentin, Carmela Gurrieri, Livio Trentin, Felicetto Ferrara, Federica Lessi
Journal: Blood
Blood (2024) 144 (Supplement 1): 1523.
https://doi.org/10.1182/blood-2024-209605
Published: 2024
Journal Articles

Decitabine in older patients with AML: quality of life results of the EORTC-GIMEMA-GMDS-SG randomized phase 3 trial

Free
Clinical Trials & Observations
Fabio Efficace, Michal Kicinski, Corneel Coens, Stefan Suciu, Walter J. F. M. van der Velden, Richard Noppeney, Sylvain Chantepie, Laimonas Griskevicius, Andreas Neubauer, Ernesta Audisio, Mario Luppi, Stephan Fuhrmann, Robin Foà, Martina Crysandt, Gianluca Gaidano, Radovan Vrhovac, Adriano Venditti, Eduardus F. M. Posthuma, Anna Candoni, Frédéric Baron, Olivier Legrand, Andrea Mengarelli, Paola Fazi, Marco Vignetti, Anne Giraut, Pierre W. Wijermans, Gerwin Huls, Michael Lübbert
Journal: Blood
Blood (2024) 144 (5): 541–551.
https://doi.org/10.1182/blood.2023023625
Published: 2024
Includes: Supplemental data
Journal Articles

Real World Outcome of Unfit Patients with Acute Myeloid Leukemia Treated with the Combination Venetoclax Plus Hypomethylating Agents in the Gimema AML2320 Observational Trial

Free
Adriano Venditti, Alfonso Piciocchi, Stefano Soddu, Marco Frigeni, Raffaele Palmieri, Erika Borlenghi, Nicola Fracchiolla, Maria Paola Martelli, Ernesta Audisio, Giacomo Gianfaldoni, Calogero Vetro, Nicola di Rienzo, Daniela Esposito, Ambra Di Veroli, Carmine Selleri, Federica Gigli, Antonio Curti, Antonino Mulè, Catello Califano, Sara Bigliardi, Massimo Breccia, Claudio Fozza, Monica Bocchia, Albana Lico, Federico Simonetti, Elisabetta Pierdomenico, Francesco Buccisano, Maria Ilaria Del Principe, Luca Maurillo, Paola Fazi, Marco Vignetti, Felicetto Ferrara, Roberto Cairoli, Giuseppe Rossi, Alessandro Rambaldi
Journal: Blood
Blood (2023) 142 (Supplement 1): 1514.
https://doi.org/10.1182/blood-2023-178505
Published: 2023
Journal Articles

Final Analysis for the Primary End-Point of Gimema AML1718, a Safety Run-in and Phase 2 Open-Label Study of Venetoclax, Fludarabine, Idarubicin and Cytarabine (V-FLAI) in the Induction Therapy of Non Low-Risk Acute Myeloid Leukemia

Free
Giovanni Marconi, Alfonso Piciocchi, Ernesta Audisio, Cristina Papayannidis, Fabio Guolo, Marco Cerrano, Valentina Arena, Capria Saveria, Michela Rondoni, Matteo Giovanni Della Porta, Geramana Beltrami, Monica Bocchia, Albana Lico, Luisa Giaccone, Marianna Rossi, Catello Califano, Matteo Giovanni Carrabba, Chiara Cattaneo, Marco Frigeni, Maria Chiara Di Chio, Bianca Serio, Roberto Freilone, Antonio Curti, Paola Minetto, Giovanni Marsili, Clara Minotti, Beatrice Zannetti, Francesca Cotugno, Jacopo Nanni, Giorgia Simonetti, Maria Teresa Bochicchio, Sara Rosellini, Elisabetta Tedone, Adriano Venditti, Roberto Massimo Lemoli, Marco Vignetti, Paola Fazi, Giovanni Martinelli
Journal: Blood
Blood (2023) 142 (Supplement 1): 1536.
https://doi.org/10.1182/blood-2023-184678
Published: 2023
Journal Articles

Single Agent Tagraxofusp in Relapsed/Refractory CD123-Positive Acute Myeloid Leukemia: A Preliminary Analysis of Italian Gimema AML2020 Trial

Free
Paola Minetto, Sara Rosellini, Fabio Guolo, Elisabetta Tedone, Ernesta Audisio, Chiara Cattaneo, Monica Bocchia, Nicola Fracchiolla, Maria Paola Martelli, Enrico Crea, Enrico Carminati, Livia Gorreo Renzulli, Giuseppina Fugazza, Alfonso Piciocchi, Giovanni Ottonelli, Maurizio Miglino, Michele Cea, Antonio Curti, Livio Pagano, Adriano Venditti, Tariq Mughal, Roberto Massimo Lemoli
Journal: Blood
Blood (2023) 142 (Supplement 1): 2918.
https://doi.org/10.1182/blood-2023-189417
Published: 2023
Journal Articles

Measurable Residual Disease Assessment in Patients with Acute Myeloid Leukemia Aged ≥60 Years Treated with a 10-Day Decitabine Schedule Versus Intensive Chemotherapy in the AML21 Study (NCT02172872)

Free
Adriano Venditti, Michal Kicinski, Ernesta Audisio, Mario Luppi, Gianluca Gaidano, Robin Foà, Anna Candoni, Andrea Mengarelli, Attilio Olivieri, Annalisa Imovilli, Maurizio Musso, Paolo De Fabritiis, Eliana Zuffa, Nicola Cascavilla, Agostino Tafuri, Maria Ilaria Del Principe, Stefan Suciu, Anne Giraut, Stéphanie Antunes, Pierre W. Wijermans, Michael Lübbert, Geert A. Huls, Marco Vignetti, Francesco Buccisano
Journal: Blood
Blood (2023) 142 (Supplement 1): 2948.
https://doi.org/10.1182/blood-2023-184851
Published: 2023
Journal Articles

Centralized MRD Assessment at Early Timepoints in Gimema AML1718 Trial, a Phase 2 Open-Label Study of Venetoclax, Fludarabine, Idarubicin and Cytarabine (V-FLAI) in the Induction Therapy of Non Low-Risk AML

Free
Paola Minetto, Fabio Guolo, Sara Rosellini, Alfonso Piciocchi, Giovanni Marconi, Ernesta Audisio, Giorgio Priolo, Cristina Papayannidis, Maurizio Martelli, Francesca Paola Paoloni, Monica Bocchia, Francesco Lanza, Albana Lico, Fabio Ciceri, Matteo Giovanni Della Porta, Marco Frigeni, Luisa Giaccone, Germana Beltrami, Erika Borlenghi, Maria Chiara Di Chio, Carmine Selleri, Enrico Crea, Irene Urbino, Chiara Sartor, Clara Minotti, Valentina Arena, Jacopo Nanni, Giorgia Simonetti, Maria Teresa Bochicchio, Giuseppe Saglio, Adriano Venditti, Marco Vignetti, Paola Fazi, Elisabetta Tedone, Giovanni Martinelli, Roberto M. Lemoli
Journal: Blood
Blood (2023) 142 (Supplement 1): 1567.
https://doi.org/10.1182/blood-2023-189777
Published: 2023
Journal Articles

Sequential Chemotherapy and Blinatumomab to Improve Minimal Residual Disease in Adult Ph- B-Lineage Acute Lymphoblastic Leukemia. Final Results of the Phase II Gimema LAL2317 Trial

Free
Sabina Chiaretti, Irene Della Starza, Alessandra Santoro, Orietta Spinelli, Loredana Elia, Maria Stefania De Propris, Matteo Piccini, Patrizia Chiusolo, Felicetto Ferrara, Patrizia Zappasodi, Erika Borlenghi, Catello Califano, Monica Bocchia, Elisa Mauro, Fabrizio Pane, Anna Candoni, Albana Lico, Ernesta Audisio, Monia Lunghi, Anna Maria Mianulli, Mariangela Di Trani, Valentina Arena, Monica Messina, Alfonso Piciocchi, Paola Fazi, Alessandro Rambaldi, Robin Foà, Renato Bassan
Journal: Blood
Blood (2023) 142 (Supplement 1): 826.
https://doi.org/10.1182/blood-2023-174973
Published: 2023