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Journal Articles

Decitabine in older patients with AML: quality of life results of the EORTC-GIMEMA-GMDS-SG randomized phase 3 trial

Clinical Trials & Observations
Fabio Efficace, Michal Kicinski, Corneel Coens, Stefan Suciu, Walter J. F. M. van der Velden, Richard Noppeney, Sylvain Chantepie, Laimonas Griskevicius, Andreas Neubauer, Ernesta Audisio, Mario Luppi, Stephan Fuhrmann, Robin Foà, Martina Crysandt, Gianluca Gaidano, Radovan Vrhovac, Adriano Venditti, Eduardus F. M. Posthuma, Anna Candoni, Frédéric Baron, Olivier Legrand, Andrea Mengarelli, Paola Fazi, Marco Vignetti, Anne Giraut, Pierre W. Wijermans, Gerwin Huls, Michael Lübbert
Journal: Blood
Blood (2024) 144 (5): 541–551.
https://doi.org/10.1182/blood.2023023625
Published: 2024
Includes: Supplemental data
Journal Articles

Real World Outcome of Unfit Patients with Acute Myeloid Leukemia Treated with the Combination Venetoclax Plus Hypomethylating Agents in the Gimema AML2320 Observational Trial

Adriano Venditti, Alfonso Piciocchi, Stefano Soddu, Marco Frigeni, Raffaele Palmieri, Erika Borlenghi, Nicola Fracchiolla, Maria Paola Martelli, Ernesta Audisio, Giacomo Gianfaldoni, Calogero Vetro, Nicola di Rienzo, Daniela Esposito, Ambra Di Veroli, Carmine Selleri, Federica Gigli, Antonio Curti, Antonino Mulè, Catello Califano, Sara Bigliardi, Massimo Breccia, Claudio Fozza, Monica Bocchia, Albana Lico, Federico Simonetti, Elisabetta Pierdomenico, Francesco Buccisano, Maria Ilaria Del Principe, Luca Maurillo, Paola Fazi, Marco Vignetti, Felicetto Ferrara, Roberto Cairoli, Giuseppe Rossi, Alessandro Rambaldi
Journal: Blood
Blood (2023) 142 (Supplement 1): 1514.
https://doi.org/10.1182/blood-2023-178505
Published: 2023
Journal Articles

Single Agent Tagraxofusp in Relapsed/Refractory CD123-Positive Acute Myeloid Leukemia: A Preliminary Analysis of Italian Gimema AML2020 Trial

Paola Minetto, Sara Rosellini, Fabio Guolo, Elisabetta Tedone, Ernesta Audisio, Chiara Cattaneo, Monica Bocchia, Nicola Fracchiolla, Maria Paola Martelli, Enrico Crea, Enrico Carminati, Livia Gorreo Renzulli, Giuseppina Fugazza, Alfonso Piciocchi, Giovanni Ottonelli, Maurizio Miglino, Michele Cea, Antonio Curti, Livio Pagano, Adriano Venditti, Tariq Mughal, Roberto Massimo Lemoli
Journal: Blood
Blood (2023) 142 (Supplement 1): 2918.
https://doi.org/10.1182/blood-2023-189417
Published: 2023
Journal Articles

Sequential Chemotherapy and Blinatumomab to Improve Minimal Residual Disease in Adult Ph- B-Lineage Acute Lymphoblastic Leukemia. Final Results of the Phase II Gimema LAL2317 Trial

Sabina Chiaretti, Irene Della Starza, Alessandra Santoro, Orietta Spinelli, Loredana Elia, Maria Stefania De Propris, Matteo Piccini, Patrizia Chiusolo, Felicetto Ferrara, Patrizia Zappasodi, Erika Borlenghi, Catello Califano, Monica Bocchia, Elisa Mauro, Fabrizio Pane, Anna Candoni, Albana Lico, Ernesta Audisio, Monia Lunghi, Anna Maria Mianulli, Mariangela Di Trani, Valentina Arena, Monica Messina, Alfonso Piciocchi, Paola Fazi, Alessandro Rambaldi, Robin Foà, Renato Bassan
Journal: Blood
Blood (2023) 142 (Supplement 1): 826.
https://doi.org/10.1182/blood-2023-174973
Published: 2023
Journal Articles

Lifestyle Behaviors and Health-Related Quality of Life in Long-Term Survivors of Acute Myeloid Leukemia: An International Survivorship Study By the Gimema, EORTC Quality of Life and Leukemia Groups

Fabio Efficace, Laura Cannella, Xavier Thomas, Meltem Kurt Yuksel, Silvia Maria Trisolini, Capria Saveria, Alberto Brini, Ernesta Audisio, Luca Maurillo, Roberto Massimo Lemoli, Annalisa Imovilli, Irina Panovska Stavridis, Martina Quattrone, Maria Ciccone, Nunzio Filardi, Nicola Fracchiolla, Daniele Vallisa, Monica Crugnola, Lorella Maria Antonia Melillo, Matevz Skerget, Marco Vignetti, Frederic Baron
Journal: Blood
Blood (2023) 142 (Supplement 1): 3801.
https://doi.org/10.1182/blood-2023-179248
Published: 2023
Journal Articles

Measurable Residual Disease Assessment in Patients with Acute Myeloid Leukemia Aged ≥60 Years Treated with a 10-Day Decitabine Schedule Versus Intensive Chemotherapy in the AML21 Study (NCT02172872)

Adriano Venditti, Michal Kicinski, Ernesta Audisio, Mario Luppi, Gianluca Gaidano, Robin Foà, Anna Candoni, Andrea Mengarelli, Attilio Olivieri, Annalisa Imovilli, Maurizio Musso, Paolo De Fabritiis, Eliana Zuffa, Nicola Cascavilla, Agostino Tafuri, Maria Ilaria Del Principe, Stefan Suciu, Anne Giraut, Stéphanie Antunes, Pierre W. Wijermans, Michael Lübbert, Geert A. Huls, Marco Vignetti, Francesco Buccisano
Journal: Blood
Blood (2023) 142 (Supplement 1): 2948.
https://doi.org/10.1182/blood-2023-184851
Published: 2023
Journal Articles

Centralized MRD Assessment at Early Timepoints in Gimema AML1718 Trial, a Phase 2 Open-Label Study of Venetoclax, Fludarabine, Idarubicin and Cytarabine (V-FLAI) in the Induction Therapy of Non Low-Risk AML

Paola Minetto, Fabio Guolo, Sara Rosellini, Alfonso Piciocchi, Giovanni Marconi, Ernesta Audisio, Giorgio Priolo, Cristina Papayannidis, Maurizio Martelli, Francesca Paola Paoloni, Monica Bocchia, Francesco Lanza, Albana Lico, Fabio Ciceri, Matteo Giovanni Della Porta, Marco Frigeni, Luisa Giaccone, Germana Beltrami, Erika Borlenghi, Maria Chiara Di Chio, Carmine Selleri, Enrico Crea, Irene Urbino, Chiara Sartor, Clara Minotti, Valentina Arena, Jacopo Nanni, Giorgia Simonetti, Maria Teresa Bochicchio, Giuseppe Saglio, Adriano Venditti, Marco Vignetti, Paola Fazi, Elisabetta Tedone, Giovanni Martinelli, Roberto M. Lemoli
Journal: Blood
Blood (2023) 142 (Supplement 1): 1567.
https://doi.org/10.1182/blood-2023-189777
Published: 2023
Journal Articles

Final Analysis for the Primary End-Point of Gimema AML1718, a Safety Run-in and Phase 2 Open-Label Study of Venetoclax, Fludarabine, Idarubicin and Cytarabine (V-FLAI) in the Induction Therapy of Non Low-Risk Acute Myeloid Leukemia

Giovanni Marconi, Alfonso Piciocchi, Ernesta Audisio, Cristina Papayannidis, Fabio Guolo, Marco Cerrano, Valentina Arena, Capria Saveria, Michela Rondoni, Matteo Giovanni Della Porta, Geramana Beltrami, Monica Bocchia, Albana Lico, Luisa Giaccone, Marianna Rossi, Catello Califano, Matteo Giovanni Carrabba, Chiara Cattaneo, Marco Frigeni, Maria Chiara Di Chio, Bianca Serio, Roberto Freilone, Antonio Curti, Paola Minetto, Giovanni Marsili, Clara Minotti, Beatrice Zannetti, Francesca Cotugno, Jacopo Nanni, Giorgia Simonetti, Maria Teresa Bochicchio, Sara Rosellini, Elisabetta Tedone, Adriano Venditti, Roberto Massimo Lemoli, Marco Vignetti, Paola Fazi, Giovanni Martinelli
Journal: Blood
Blood (2023) 142 (Supplement 1): 1536.
https://doi.org/10.1182/blood-2023-184678
Published: 2023
Journal Articles

Pharmacogenetics and Pharmacokinetics of Posaconazole in Patients with Acute Myeloid Leukemia: Useful Tools for Antifungal Stewardship

Silvia Corcione, Cecilia Grosso, Ernesta Audisio, Jessica Cusato, Miriam Antonucci, Alessandro Busca, Benedetto Bruno, Annamaria Gulla, Antonio d'Avolio, francesco Giuseppe de Rosa
Journal: Blood
Blood (2023) 142 (Supplement 1): 5849.
https://doi.org/10.1182/blood-2023-190034
Published: 2023
Journal Articles

Gimema AML1718 Part 1: Planned Interim Analysis of a Safety Run-in and Phase 2 Open-Label Study of Venetoclax, Fludarabine, Idarubicin and Cytarabine (V-FLAI) in the Induction Therapy of Non Low-Risk Acute Myeloid Leukemia

Giovanni Marconi, Alfonso Piciocchi, Ernesta Audisio, Giorgio Priolo, Cristina Papayannidis, Maurizio Martelli, Francesca Paoloni, Roberto Massimo Lemoli, Monica Bocchia, Francesco Lanza, Albana Lico, Fabio Ciceri, Matteo G. Della Porta, Marco Frigeni, Luisa Giaccone, Germana Beltrami, Erika Borlenghi, Maria Chiara Di Chio, Carmine Selleri, Enrico Crea, Irene Urbino, Chiara Sartor, Clara Minotti, Fabio Guolo, Edoardo La Sala, Jacopo Nanni, Giorgia Simonetti, Maria Teresa Bochicchio, Giuseppe Saglio, Adriano Venditti, Marco Vignetti, Paola Fazi, Giovanni Martinelli
Journal: Blood
Blood (2022) 140 (Supplement 1): 1705–1707.
https://doi.org/10.1182/blood-2022-157393
Published: 2022
Journal Articles

10-Day Decitabine Versus Intensive Chemotherapy Followed By Transplantation in Fit AML Patients Aged ≥60 Years: Health-Related Quality of Life Outcomes of the Randomized Phase III Trial AML21 of the EORTC Leukemia Group, Gimema, Celg, and Gmds-SG

Fabio Efficace, Gerwin A. Huls, Michal Kicinski, Walter JFM Van Der Velden, Richard Noppeney, Sylvain Chantepie, Laimonas Griskevicius, Andreas Neubauer, Ernesta Audisio, Mario Luppi, Stephan Fuhrmann, Robin Foà, Martina Crysandt, Gianluca Gaidano, Radovan Vrhovac, Adriano Venditti, Eduardus F.M. Posthuma, Anna Candoni, Frederic Baron, Olivier Legrand, Andrea Mengarelli, Marco Vignetti, Anne Giraut, Corneel Coens, Stefan Suciu, P.W. Wijermans, Michael Luebbert
Journal: Blood
Blood (2022) 140 (Supplement 1): 1281–1283.
https://doi.org/10.1182/blood-2022-166544
Published: 2022
Journal Articles

Gimema ALL2418: Interim Analysis of a Phase Iia Study of Feasibility and Effectiveness of Inotuzumab Ozogamicin in Adult Patients with B-Cell Acute Lymphoblastic Leukemia with Positive Minimal Residual Disease before Any Hematopoietic Stem Cell Transplantation

Giovanni Marconi, Alfonso Piciocchi, Sabina Chiaretti, Cristina Papayannidis, Monia Lunghi, Prassede Salutari, Patrizia Zappasodi, Alessandro Rambaldi, Attilio Olivieri, Maurizio Cavallari, Stefano Soddu, Nicola S Fracchiolla, Federica Gigli, Chiara Cattaneo, Daniele Giovanni Mattei, Anna Candoni, Giovanni Grillo, Maria Chiara Abbenante, Ernesta Audisio, Massimiliano Bonifacio, Albana Lico, Roberto Massimo Lemoli, Paolo De Fabritiis, Felicetto Ferrara, Martina Rachele Marino, Monica Messina, Anna Ferrari, Valentina Robustelli, Jacopo Nanni, Irene Della Starza, Giorgia Simonetti, Maria Stefania De Propris, Maria Teresa Bochicchio, Marco Vignetti, Paola Fazi, Giovanni Martinelli
Journal: Blood
Blood (2022) 140 (Supplement 1): 6119–6121.
https://doi.org/10.1182/blood-2022-157937
Published: 2022
Journal Articles

A Chemo-Free Bridge-to-Transplant Strategy with Venetoclax and Azacitidine for NPM1 -Mutated Acute Myeloid Leukemia in Molecular Failure

Chiara Sartor, Lorenzo Brunetti, Ernesta Audisio, Alessandro Cignetti, Letizia Zannoni, Gianluca Cristiano, Jacopo Nanni, Emanuela Ottaviani, Lorenza Bandini, Sarah Parisi, Stefania Paolini, Sofia Sciabolacci, Valeria Cardinali, Cristina Papayannidis, Michele Cavo, Maria Paola Martelli, Antonio Curti
Journal: Blood
Blood (2022) 140 (Supplement 1): 9034–9035.
https://doi.org/10.1182/blood-2022-165914
Published: 2022
Journal Articles

CPX-351 Induction in Secondary Acute Myeloblastic Leukemia: Extended Follow up from the Italian Compassionate Use Program

Paola Minetto, Fabio Guolo, Luana Fianchi, Marino Clavio, Michele Gottardi, Mauro Endri, Sara Galimberti, Giuliana Rizzuto, Margherita Sciumé, Michela Rondoni, Giambattista Bertani, Michelina Dargenio, Atto Billio, Barbara Scappini, Patrizia Zappasodi, Anna Maria Scattolin, Francesco Grimaldi, Giuseppe Pietrantuono, Pellegrino Musto, Cerrano Marco, Stefano D'Ardia, Ernesta Audisio, Alessandro Cignetti, Crescenza Pasciolla, Francesca Pavesi, Anna Candoni, Carmela Gurrieri, Monica Morselli, Caterina Alati, Nicola S Fracchiolla, Giovanni Rossi, Manuela Caizzi, Fabrizio Carnevale Schianca, Michele Cea, Agostino Tafuri, Giuseppe Rossi, Felicetto Ferrara, Livio Pagano, Roberto Massimo Lemoli
Journal: Blood
Blood (2021) 138 (Supplement 1): 1262.
https://doi.org/10.1182/blood-2021-153028
Published: 2021
Journal Articles

A Preliminary Analysis of FLAM (Italian Non-Interventional Multi-center Study of FLT3 mutated AML patients): FLT3 Receptor Gene Mutational Analysis and FLT3 Inhibitors Administration in the Real-Life Clinical Practice

Jacopo Nanni, MD, Ernesta Audisio, MD, Maria Benedetta Giannini, MD, Barbara MD Scappini, Benedetta Cambò, MD, Francesco Albano, Maria Paola Martelli, MDPhD, Alessandro Cignetti, MD PhD, Gian Matteo Rigolin, Nicola Fracchiolla, MD, Monica Bocchia, Claudio Romani, Elisabetta Todisco, MDPhD, Monia Lunghi, MD PhD, Anna Maria Mianulli, MD, Daniela Cilloni, MD PhD, Elisabetta Petracci, Irene Valli, Chiara Zingaretti, Claudio Cerchione, MD PhD, Delia Cangini, the FLAM collaborative Group, Cristina Papayannidis, MD PhD, Giovanni Martinelli, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 32–34.
https://doi.org/10.1182/blood-2020-139981
Published: 2020
Journal Articles

Italian Observational Study on Real-Life Use of Venetoclax in Acute Myeloid Leukemia (AVALON study): Results of Interim Analysis on Relapsed/Refractory Patients

Elisabetta Todisco, MDPhD, Nicola Fracchiolla, MD, Cristina Papayannidis, MD PhD, Maria Paola Martelli, MDPhD, Giuliana Rizzuto, Alessandro Cignetti, MD PhD, Nicola Di Renzo, MD, Patrizia Zappasodi, MD, Michele Gottardi, MD, Ernesta Audisio, MD, Monia Lunghi, MD, Federica Gigli, MD, Corrado Tarella, Chiara Zingaretti, Elisabetta Petracci, Roberta Volpi, Delia Cangini, Maria Benedetta Giannini, MD, Mariarita Sciumè, MD, Giuseppe Rossi, MD, Avalon Group, Giovanni Martinelli, MD, Claudio Cerchione, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 37–38.
https://doi.org/10.1182/blood-2020-143082
Published: 2020
Journal Articles

Identification of a Chromatin-Splicing Mutational Signature to Define Secondary Acute Myeloid Leukemia: A Report from the Northern Italy Leukemia Group (NILG) Prospective Trial 02/06

Chiara Caprioli, MD, Federico Lussana, MD, Silvia Salmoiraghi, BioSc, Roberta Cavagna, BioSc, Ksenija Buklijas, BioSc, Lara Elidi, BioSc, Pamela Zanghì, BioSc, Anna Michelato, PhD, Federica Delaini, MSc, Elena Oldani, MSc, Dario Ferrero, MD, Ernesta Audisio, MD, Filippo Marmont, MD, Elisabetta Terruzzi, MD, Lorella De Paoli, MD, Chiara Cattaneo, MD, Erika Borlenghi, MD, Irene Cavattoni, MD, Monica Tajana, MD, Anna Maria Scattolin, MD, Daniele Giovanni Mattei, MD, Paolo Corradini, Leonardo Campiotti, MD, Fabio Ciceri, MD, Massimo Bernardi, MD, Elisabetta Todisco, MD PhD, Agostino Cortelezzi, MD, Sergio Cortelazzo, MD, Giacomo Gianfaldoni, MD, Alberto Bosi, MD, Brunangelo Falini, MD PhD, Tamara Intermesoli, MD, Chiara Pavoni, Statistician, Renato Bassan, MD, Orietta Spinelli, PhD, Alessandro Rambaldi, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1443.
https://doi.org/10.1182/blood-2019-124497
Published: 2019
Journal Articles

Assesment of Frailty Scores Validating Fitness of Elderly AML Patients for Intensive Chemotherapy: A Single Centre Study

Semra Aydin, MD PhD, Marco Franzino, MD, Chiara Frairia, MD, Ernesta Audisio, MD, Stefano D'Ardia, MD, Irene Urbino, MD, Alessandro Busca, MD, Chiara Maria Dellacasa, MD, Giorgia Iovino, MD, Andrea Evangelista, Giovannino Ciccone, MD PhD, Umberto Vitolo
Journal: Blood
Blood (2018) 132 (Supplement 1): 5171.
https://doi.org/10.1182/blood-2018-99-116836
Published: 2018
Journal Articles

Clinical Impact of an Accurate Genetic Characterization of Older Acute Myeloid Leukemia Patients: A Report from the Northern Italy Leukemia Group (NILG) Randomized Trial 02/06

Chiara Caprioli, MD, Tamara Intermesoli, MD, Orietta Spinelli, PhD, Silvia Salmoiraghi, MSc, Pamela Zanghì, MSc, Roberta Cavagna, MSc, Anna Michelato, PhD, Ksenija Buklijas, MSc, Federica Delaini, MSc, Elena Oldani, MSc, Giacomo Gianfaldoni, MD, Dario Ferrero, MD, Elisabetta Terruzzi, MD, Lorella De Paoli, MD, Chiara Cattaneo, MD, Erika Borlenghi, MD, Irene Cavattoni, MD, Monica Tajana, MD, Anna Maria Scattolin, MD, Daniele Giovanni Mattei, MD, Paolo Corradini, MD, Leonardo Campiotti, MD, Fabio Ciceri, MD, Massimo Bernardi, MD, Elisabetta Todisco, MD, Agostino Cortelezzi, MD, Sergio Cortelazzo, MD, Ernesta Audisio, MD, Filippo Marmont, MD, Alberto Bosi, MD, Brunangelo Falini, MD PhD, Chiara Pavoni, Statistician, Renato Bassan, MD, Alessandro Rambaldi, MD, Federico Lussana, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 434.
https://doi.org/10.1182/blood-2018-99-113869
Published: 2018
Journal Articles

Sparing Anti-Bacterial Prophylaxis in Acute Myeloid Leukemia during Post Induction Aplasia Does Not Impact on Bacteriemiae Incidence and Early Death: A Retrospective Single Center Study

Chiara Frairia, MD, Irene Urbino, MD, Ernesta Audisio, MD, Semra Aydin, MD PhD, Stefano D'Ardia, MD, Messa Emanuela, MD, Giorgia Iovino, MD, Barbara Nicolino, MD, Umberto Vitolo
Journal: Blood
Blood (2018) 132 (Supplement 1): 4001.
https://doi.org/10.1182/blood-2018-99-117222
Published: 2018