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Journal Articles

The Atypical Protein Kinase WNK1 Controls Leukemia Progression in TAL/LMO T-Cell Acute Lymphoblastic Leukemia

Anna Montanaro, Anna D'Antuono, Lucas Moron Dalla Tor, Pietro Andrei, Filippo Cavazzini, Elisa Cerretani, Federica Vento, Elisa Simoncini, Andrea Gherli, Raffaella Zamponi, Bruno Lorusso, Giannalisa Todaro, Mariateresa Giaimo, Roberta La Starza, Cristina Mecucci, Gabriella Sammarelli, Matteo Marchesini, Luca Pagliaro, Giovanni Roti

Blood (2023) 142 (Supplement 1): 118.

https://doi.org/10.1182/blood-2023-188375

Published: 2023

Journal Articles

Identification of the Atypical Protein Kinase WNK1 As a New Target in T-Cell Acute Lymphoblastic Leukemia

Anna Montanaro, Anna D'Antuono, Lucas Moron Dalla Tor, Pietro Andrei, Alessia Ciringione, Elisa Cerretani, Federica Vento, Luca Pagliaro, Andrea Gherli, Bruno Lorusso, Elisa Simoncini, Raffaella Zamponi, Costanza Salvatori, Giannalisa Todaro, Roberta La Starza, Cristina Mecucci, Gabriella Sammarelli, Matteo Marchesini, Giovanni Roti

Blood (2022) 140 (Supplement 1): 3130–3131.

https://doi.org/10.1182/blood-2022-163069

Published: 2022

Journal Articles

Orthogonal Proteogenomic Approaches Identify the Druggable PA2G4-MYC Axis in 3q26 AML

Matteo Marchesini, Andrea Gherli, Elisa Simoncini, Anna Montanaro, Natthakan Thongon, Luca Pagliaro, Federica Vento, Lucas Moron Dalla Tor, Chiara Liverani, Raffaella Zamponi, Elena Follini, Benedetta Cambò, Bruno Lorusso, Roberta La Starza, Antonio Cuneo, Cristina Mecucci, Simona Colla, Federico Quaini, Giovanni Roti

Blood (2022) 140 (Supplement 1): 673–674.

https://doi.org/10.1182/blood-2022-158990

Published: 2022

Journal Articles

14q32 rearrangements deregulating BCL11B mark a distinct subgroup of T-lymphoid and myeloid immature acute leukemia

Blood (2021) 138 (9): 773–784.

https://doi.org/10.1182/blood.2020010510

Published: 2021

Includes: Supplemental data

Journal Articles

Targeting the Activating Mutations of NOTCH1 in T-Cell Lymphoblastic Leukemia with a New SERCA Inhibitor CAD204520

Matteo Marchesini, PhD, Andrea Gherli, Anna Montanaro, Samuel Kitara, Claudia Sorrentino, Luca Pagliaro, Anne-Marie Lund Winter, Chiara Rompietti, Donatella Stilli, Federica Rizzi, Kimberly Stegmaier, MD, Paolo Sportoletti, William Dalby-Brown, Giovanni Roti

Blood (2019) 134 (Supplement_1): 407.

https://doi.org/10.1182/blood-2019-125616

Published: 2019

Journal Articles

Identification of EHMT2 As a New Target in T-Cell Acute Lymphoblastic Leukemia

Samuel Kitara, Angela Su, Claudio Deluca, Franco Aversa, MD, Birgit Knoechel, MDPhD, Jian Jin, PhD, Kimberly Stegmaier, MD, Giovanni Roti, MD PhD

Blood (2017) 130 (Supplement 1): 2548.

https://doi.org/10.1182/blood.V130.Suppl_1.2548.2548

Published: 2017

Journal Articles

Leukemia-Specific Delivery of Mutant NOTCH1 Targeted Therapy

Giovanni Roti, MD PhD, Jun Qi, PhD, Samuel Kitara, Anthony C. Varca, Marta Sanchez-Martin, PhD, Andrew L. Kung, MD PhD, Adolfo A. Ferrando, MD PhD, James E. Bradner, MD, Kimberly Stegmaier, MD

Blood (2016) 128 (22): 889.

https://doi.org/10.1182/blood.V128.22.889.889

Published: 2016

Journal Articles

Selectively Targeting Mutated NOTCH1 with a Folate-Thapsigargin Derivative

Giovanni Roti, MD, Jun Qi, PhD, Angela Su, B.S., Antony Varca, B.S., Jon C Aster, MD PhD, James E. Bradner, Kimberly Stegmaier, MD

Blood (2014) 124 (21): 2158.

https://doi.org/10.1182/blood.V124.21.2158.2158

Published: 2014

Journal Articles

Intersecting High-Throughput Screens Identifies SERCA As a Target for Modulating NOTCH1 In Hematopoietic Malignancies

Giovanni Roti, MD.Ph.D, Annie Carlton, B.S., Kenneth N. Ross, Ph.D, Michele Markstein, Ph.D, Kostandin Pajcini, Ph.D, Norbert Perrimon, Ph.D, Andrew L. Kung, MD, PhD, Warren S. Pear, MD, PhD, Stephen C. Blacklow, MD, PhD, Jon C Aster, MD, PhD, Kimberly Stegmaier, MD

Blood (2011) 118 (21): 555.

https://doi.org/10.1182/blood.V118.21.555.555

Published: 2011

Journal Articles

Expression-Based Screen Identifies the Calcium Channel Antagonist Bepridil as a Notch1 Modulator in T-ALL.

Giovanni Roti, MD, Kenneth N. Ross, PhD, Adolfo A. Ferrando, MD, PhD, Stephen C Blacklow, M.D., Ph.D., Jon Aster, MD, PhD, Kimberly Stegmaier, MD

Blood (2009) 114 (22): 366.

https://doi.org/10.1182/blood.V114.22.366.366

Published: 2009

Journal Articles

Identification of AML1-ETO modulators by chemical genomics

Steven M. Corsello, Giovanni Roti, Kenneth N. Ross, Kwan T. Chow, Ilene Galinsky, Daniel J. DeAngelo, Richard M. Stone, Andrew L. Kung, Todd R. Golub, Kimberly Stegmaier

Blood (2009) 113 (24): 6193–6205.

https://doi.org/10.1182/blood-2008-07-166090

Published: 2009

Includes: Supplemental data

Journal Articles

Chemical Genomic Screen Identifies Ionophores as Modulators of Notch1 in T-ALL

Giovanni Roti, MD, Kenneth N. Ross, PhD, Cristina Mecucci, MD, PhD, Adolfo A. Ferrando, MD, PhD, Jon C. Aster, MD, PhD, Kimberly Stegmaier, MD

Blood (2008) 112 (11): 200.

https://doi.org/10.1182/blood.V112.11.200.200

Published: 2008

Journal Articles

Immunohistochemistry predicts nucleophosmin (NPM) mutations in acute myeloid leukemia

Blood (2006) 108 (6): 1999–2005.

https://doi.org/10.1182/blood-2006-03-007013

Published: 2006

Journal Articles

Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc + AML

Blood (2006) 107 (11): 4514–4523.

https://doi.org/10.1182/blood-2005-11-4745

Published: 2006

Includes: Supplemental data

Journal Articles

Quantitative Detection of NPM1 Mutations as Marker of Minimal Residual Disease (MRD) in the Large Majority of AML with Normal Karyotype.

Giuseppe Saglio, MD, Paolo Gorello, PhD, Giovanni Cazzaniga, PhD, Enrico Gottardi, Maria Grazia Dell’Oro, MD, Roberto Rosati, PhD, Giovanni Roti, MD, Federica Alberti, PhD, Daniela Diverio, PhD, Massimo Fabrizio Martelli, MD, Francesco Lo Coco, MD, Andrea Biondi, MD, Brunangelo Falini, MD, Cristina Mecucci, MD, PhD

Blood (2005) 106 (11): 225.

https://doi.org/10.1182/blood.V106.11.225.225

Published: 2005

Journal Articles

Mechanism of Altered Nucleo-Cytoplasmic Traffic of Nucleophosmin in Acute Myelogenous Leukemia Carrying Exon-12 NPM Mutations (NPMc+ AML).

Blood (2005) 106 (11): 4396.

https://doi.org/10.1182/blood.V106.11.4396.4396

Published: 2005

Journal Articles

Proangiogenic properties of human myeloma cells: production of angiopoietin-1 and its potential relationship to myeloma-induced angiogenesis

Blood (2003) 102 (2): 638–645.

https://doi.org/10.1182/blood-2002-10-3257

Published: 2003

NARROW

The Atypical Protein Kinase WNK1 Controls Leukemia Progression in TAL/LMO T-Cell Acute Lymphoblastic Leukemia

Identification of the Atypical Protein Kinase WNK1 As a New Target in T-Cell Acute Lymphoblastic Leukemia

Orthogonal Proteogenomic Approaches Identify the Druggable PA2G4-MYC Axis in 3q26 AML

14q32 rearrangements deregulating BCL11B mark a distinct subgroup of T-lymphoid and myeloid immature acute leukemia

Targeting the Activating Mutations of NOTCH1 in T-Cell Lymphoblastic Leukemia with a New SERCA Inhibitor CAD204520

Identification of EHMT2 As a New Target in T-Cell Acute Lymphoblastic Leukemia

Leukemia-Specific Delivery of Mutant NOTCH1 Targeted Therapy

Selectively Targeting Mutated NOTCH1 with a Folate-Thapsigargin Derivative

Intersecting High-Throughput Screens Identifies SERCA As a Target for Modulating NOTCH1 In Hematopoietic Malignancies

Expression-Based Screen Identifies the Calcium Channel Antagonist Bepridil as a Notch1 Modulator in T-ALL.

Identification of AML1-ETO modulators by chemical genomics

Chemical Genomic Screen Identifies Ionophores as Modulators of Notch1 in T-ALL

Immunohistochemistry predicts nucleophosmin (NPM) mutations in acute myeloid leukemia

Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc + AML

Quantitative Detection of NPM1 Mutations as Marker of Minimal Residual Disease (MRD) in the Large Majority of AML with Normal Karyotype.

Mechanism of Altered Nucleo-Cytoplasmic Traffic of Nucleophosmin in Acute Myelogenous Leukemia Carrying Exon-12 NPM Mutations (NPMc+ AML).

Proangiogenic properties of human myeloma cells: production of angiopoietin-1 and its potential relationship to myeloma-induced angiogenesis

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American Society of Hematology

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American Society of Hematology

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