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Journal Articles

A pre-emptive bridge-to-transplant therapy for measurable residual disease with venetoclax and azacitidine in NPM1-mutated Acute Myeloid Leukemia: Updates from the ongoing GIMEMA AML2521 phase 2 trial

Free
Chiara Sartor, Anna Candoni, Alfonso Piciocchi, Giovanni Marsili, Paola Fazi, Cristina Papayannidis, Jacopo Nanni, Stefania Paolini, Luca Maurillo, Mario Tiribelli, Antonino Mule', Melissa Campanelli, Marianna Norata, Roberto Cairoli, Emanuela Ottaviani, Giulia Azteni, Maria Teresa Voso, Francesca Bonifazi, Enrico Maffini, Lorenzo Brunetti, Cristina Skert, Francesco Di Raimondo, Roberto Lemoli, Pellegrino Musto, Maria Paola Martelli, Brunangelo Falini, Adriano Venditti, Francesco Buccisano, Antonio Curti
Journal: Blood
Blood (2025) 146 (Supplement 1): 3516.
https://doi.org/10.1182/blood-2025-3516
Published: 2025
Journal Articles

First interim analysis of venetoclax real-world observational study on newly-diagnosed AML patients in Italy (VERO): Focus on patient and diseases characteristics and quality of life at baseline

Free
Ivana Lotesoriere, Caterina Alati, lorenzo celona, Monia Lunghi, gianluca martini, jacopo nanni, Vincenzo Federico, Antonino Mule', MARINA PARISI, PRASSEDE SALUTARI, Ida Carmosino, Valeria Cardinali, ANDREA PASQUINI, Marco Frigeni, Roberto Cairoli, FEDERICO MORETTI, Anna Candoni, SELENIA VITIELLO, Irene Zacheo, Benedetta Neri, PAOLA FINSINGER, LUIGI DI CAPRIO, GIULIANA GUALBERTI, LUDOVICA MAGI, CARMEN STEFANINI, Marta Ubezio
Journal: Blood
Blood (2025) 146 (Supplement 1): 5159.
https://doi.org/10.1182/blood-2025-5159
Published: 2025
Journal Articles

Diagnostic evaluation methods and prognostic impact of FLT3-ITD microclones in Acute Myeloid Leukemia (AML): A retrospective multicenter study on behalf of the EHA AML-specialized working group (SWG)

Free
Carmelo Gurnari, Tiziana Ottone, Alfonso Piciocchi, Daniela Späth, Annika Meid, Giovanni Marsili, Emiliano Fabiani, Francesca Romano, Maria Rosaria Pascale, Patrizia Chiusolo, Mauro Di Ianni, Marta Sobas, Lorenzo Brunetti, Guadalupe Oñate, Joana Brioso Infante, Jacopo Nanni, Calogero Vetro, Matilde Boada, Anna Candoni, Jorge Sierra, Nicola Potter, Amanda Gilkes, Sean Johnson, Ian Thomas, Brain Huntley, Nigel Russell, Richard Dillon, Hartmut Döhner, Konstanze Döhner, Maria Teresa Voso
Journal: Blood
Blood (2025) 146 (Supplement 1): 217.
https://doi.org/10.1182/blood-2025-217
Published: 2025
Journal Articles

NPM1 and IDH1/2 mutations show limited prognostic impact in relapsed AML: Evidence from the avalon cohort

Free
Calogero Vetro, Irene Azzali, Elisabetta Petracci, Cristina Papayannidis, Eleonora Eleuteri, Fanny Erika Palumbo, Vincenzo Federico, Nicola Stefano Fracchiolla, Patrizia Zappasodi, Maria Paola Martelli, Maria Benedetta Giannini, Lorenzo Brunetti, Raffaele Palmieri, jacopo nanni, Giorgia Simonetti, Fabio Guolo, Paola Minetto, Luca Maurillo, Federica Gigli, Atto Billio, Elisabetta Todisco, Giovanni Martinelli, Giovanni Marconi
Journal: Blood
Blood (2025) 146 (Supplement 1): 6967.
https://doi.org/10.1182/blood-2025-6967
Published: 2025
Journal Articles

Centralized MRD Assessment in Gimema AML1718 Trial, a Phase 2 Open-Label Study of Venetoclax Combined with Intensified FLAI Chemotherapy (V-FLAI) As Induction Therapy of Non Low-Risk AML

Free
Paola Minetto, Fabio Guolo, Sara Rosellini, Alfonso Piciocchi, Giovanni Marconi, Ernesta Audisio, Giorgio Priolo, Cristina Papayannidis, Maurizio Martelli, Giovanni Marsili, Monica Bocchia, Francesco Lanza, Albana Lico, Fabio Ciceri, Matteo Giovanni Della Porta, Marco Frigeni, Luisa Giaccone, Germana Beltrami, Erika Borlenghi, Maria Chiara Di Chio, Carmine Selleri, Enrico Crea, Irene Urbino, Chiara Sartor, Clara Minotti, Valentina Arena, Jacopo Nanni, Giorgia Simonetti, Maria Teresa Bochicchio, Giuseppe Saglio, Adriano Venditti, Marco Vignetti, Paola Fazi, Elisabetta Tedone, Giovanni Martinelli, Roberto Massimo Lemoli
Journal: Blood
Blood (2024) 144 (Supplement 1): 1574.
https://doi.org/10.1182/blood-2024-198139
Published: 2024
Journal Articles

Survival Analysis of Gimema AML1718, a Safety Run-in and Phase 2 Open-Label Study of Venetoclax, Fludarabine, Idarubicin and Cytarabine (V-FLAI) in the Induction Therapy of Non Low-Risk Acute Myeloid Leukemia

Free
Giovanni Marconi, Alfonso Piciocchi, Ernesta Audisio, Cristina Papayannidis, Fabio Guolo, Marco Cerrano, Valentina Arena, Saveria Capria, Michela Rondoni, Matteo Giovanni Della Porta, Germana Beltrami, Monica Bocchia, Albana Lico, Luisa Giaccone, Marianna Rossi, Catello Califano, Matteo Giovanni Carrabba, Chiara Cattaneo, Marco Frigeni, Maria Chiara Di Chio, Bianca Serio, Roberto Freilone, Antonio Curti, Paola Minetto, Giovanni Marsili, Clara Minotti, Beatrice Anna Zannetti, Francesca Cotugno, Jacopo Nanni, Giorgia Simonetti, Maria Teresa Bochicchio, Sara Rosellini, Elisabetta Tedone, Adriano Venditti, Roberto Massimo Lemoli, Marco Vignetti, Paola Fazi, Giovanni Martinelli
Journal: Blood
Blood (2024) 144 (Supplement 1): 2891.
https://doi.org/10.1182/blood-2024-207842
Published: 2024
Journal Articles

T/NK Cell-Associated Transcriptomic Profile Informs Response to FLT3 Inhibitors in Acute Myeloid Leukemia

Free
Jacopo Nanni, Jayakumar Vadakekolathu, Lorenza Bandini, Marilena Ciciarello, Karyna Volkava, Samantha Bruno, Valentina Robustelli, Letizia Zannoni, Chiara Sartor, Gianluca Cristiano, Federico Zingarelli, Andrea Davide Romagnoli, Caterina Azzimondi, Federica Ardizzoia, Raffaele Ciruolo, Giovanni Marconi, Claudia Venturi, Ajsi Kanapari, Gaia Mazzocchetti, Giorgia Simonetti, Martina Ghetti, Nicoletta Testoni, Sarah Parisi, Stefania Paolini, Simona Soverini, Emanuela Ottaviani, Cristina Papayannidis, Michele Cavo, Sergio Rutella, Antonio Curti
Journal: Blood
Blood (2024) 144 (Supplement 1): 2916.
https://doi.org/10.1182/blood-2024-205994
Published: 2024
Journal Articles

Absolute Lymphocyte Count As a Novel Prognostic Predictor Compared to Minimal Residual Disease and Molecular Status in Patients with Acute Myeloid Leukemiatreated with Intensive Chemotherapy

Free
Gianluca Cristiano, Jacopo Nanni, Letizia Zannoni, Federico Zingarelli, Federica Ardizzoia, Chiara Sartor, Sarah Parisi, Stefania Paolini, Cristina Papayannidis, Michele Cavo, Antonio Curti
Journal: Blood
Blood (2024) 144 (Supplement 1): 6116.
https://doi.org/10.1182/blood-2024-209333
Published: 2024
Journal Articles

Impact of MTHFR Polymorphisms C677T and A1298C in Acute Lymphoblastic Leukemia and Burkitt Lymphoma Patients Exposed to Methotrexate and Asparaginase

Free
Chiara Sartor, Benedetta Pagano, Soara Menabò, Gianluca Cristiano, Jacopo Nanni, Letizia Zannoni, Federico Zingarelli, Sarah Parisi, Alessandro Broccoli, Stefania Paolini, Pier Luigi Zinzani, Michele Cavo, Cristina Papayannidis, Antonio Curti
Journal: Blood
Blood (2023) 142 (Supplement 1): 5812.
https://doi.org/10.1182/blood-2023-189495
Published: 2023
Journal Articles

Novel Mechanisms of Venetoclax Resistance in Acute Myeloid Leukemia Based on Genomic Rearrangements

Free
Irene Zacheo, Anna Ferrari, Eugenio Fonzi, Maria Teresa Bochicchio, Giorgia Capirossi, Jacopo Nanni, Matteo Paganelli, Chiara Servilli, Lorenzo Ledda, Martina Ghetti, Mouna Jandoubi, Matteo Marchesini, Agnese Mattei, Giovanni Martinelli, Giovanni Marconi, Giorgia Simonetti
Journal: Blood
Blood (2023) 142 (Supplement 1): 4165.
https://doi.org/10.1182/blood-2023-189435
Published: 2023
Journal Articles

Final Analysis for the Primary End-Point of Gimema AML1718, a Safety Run-in and Phase 2 Open-Label Study of Venetoclax, Fludarabine, Idarubicin and Cytarabine (V-FLAI) in the Induction Therapy of Non Low-Risk Acute Myeloid Leukemia

Free
Giovanni Marconi, Alfonso Piciocchi, Ernesta Audisio, Cristina Papayannidis, Fabio Guolo, Marco Cerrano, Valentina Arena, Capria Saveria, Michela Rondoni, Matteo Giovanni Della Porta, Geramana Beltrami, Monica Bocchia, Albana Lico, Luisa Giaccone, Marianna Rossi, Catello Califano, Matteo Giovanni Carrabba, Chiara Cattaneo, Marco Frigeni, Maria Chiara Di Chio, Bianca Serio, Roberto Freilone, Antonio Curti, Paola Minetto, Giovanni Marsili, Clara Minotti, Beatrice Zannetti, Francesca Cotugno, Jacopo Nanni, Giorgia Simonetti, Maria Teresa Bochicchio, Sara Rosellini, Elisabetta Tedone, Adriano Venditti, Roberto Massimo Lemoli, Marco Vignetti, Paola Fazi, Giovanni Martinelli
Journal: Blood
Blood (2023) 142 (Supplement 1): 1536.
https://doi.org/10.1182/blood-2023-184678
Published: 2023
Journal Articles

Iron-Related Laboratory Profile May Predict Response and MRD Negativity Rate in Acute Myeloid Leukemia Patients

Free
Federico Zingarelli, Gianluca Cristiano, Chiara Sartor, Letizia Zannoni, Jacopo Nanni, Martina Barone, Lorenza Bandini, Emanuela Ottaviani, Valentina Robustelli, Nicoletta Testoni, Mario Arpinati, Cristina Papayannidis, Michele Cavo, Antonio Curti
Journal: Blood
Blood (2023) 142 (Supplement 1): 6052.
https://doi.org/10.1182/blood-2023-188709
Published: 2023
Journal Articles

T Cell/Natural Killer (NK) Cell Transcriptional Profiles Are Associated with Response to Gilteritinib in FLT3 -Mutated Acute Myeloid Leukemia

Free
Jacopo Nanni, Jayakumar Vadakekolathu, Lorenza Bandini, Samantha Bruno, Letizia Zannoni, Chiara Sartor, Gianluca Cristiano, Sarah Parisi, Federico Zingarelli, Raffaele Ciruolo, Giovanni Marconi, Claudia Venturi, Marilena Ciciarello, Aisi Kanapari, Gaia Mazzocchetti, Giorgia Simonetti, Martina Ghetti, Nicoletta Testoni, Stefania Paolini, Simona Soverini, Emanuela Ottaviani, Cristina Papayannidis, Michele Cavo, Sergio Rutella, Antonio Curti
Journal: Blood
Blood (2023) 142 (Supplement 1): 2947.
https://doi.org/10.1182/blood-2023-184741
Published: 2023
Journal Articles

Centralized MRD Assessment at Early Timepoints in Gimema AML1718 Trial, a Phase 2 Open-Label Study of Venetoclax, Fludarabine, Idarubicin and Cytarabine (V-FLAI) in the Induction Therapy of Non Low-Risk AML

Free
Paola Minetto, Fabio Guolo, Sara Rosellini, Alfonso Piciocchi, Giovanni Marconi, Ernesta Audisio, Giorgio Priolo, Cristina Papayannidis, Maurizio Martelli, Francesca Paola Paoloni, Monica Bocchia, Francesco Lanza, Albana Lico, Fabio Ciceri, Matteo Giovanni Della Porta, Marco Frigeni, Luisa Giaccone, Germana Beltrami, Erika Borlenghi, Maria Chiara Di Chio, Carmine Selleri, Enrico Crea, Irene Urbino, Chiara Sartor, Clara Minotti, Valentina Arena, Jacopo Nanni, Giorgia Simonetti, Maria Teresa Bochicchio, Giuseppe Saglio, Adriano Venditti, Marco Vignetti, Paola Fazi, Elisabetta Tedone, Giovanni Martinelli, Roberto M. Lemoli
Journal: Blood
Blood (2023) 142 (Supplement 1): 1567.
https://doi.org/10.1182/blood-2023-189777
Published: 2023
Journal Articles

Gimema ALL2418: Interim Analysis of a Phase Iia Study of Feasibility and Effectiveness of Inotuzumab Ozogamicin in Adult Patients with B-Cell Acute Lymphoblastic Leukemia with Positive Minimal Residual Disease before Any Hematopoietic Stem Cell Transplantation

Free
Giovanni Marconi, Alfonso Piciocchi, Sabina Chiaretti, Cristina Papayannidis, Monia Lunghi, Prassede Salutari, Patrizia Zappasodi, Alessandro Rambaldi, Attilio Olivieri, Maurizio Cavallari, Stefano Soddu, Nicola S Fracchiolla, Federica Gigli, Chiara Cattaneo, Daniele Giovanni Mattei, Anna Candoni, Giovanni Grillo, Maria Chiara Abbenante, Ernesta Audisio, Massimiliano Bonifacio, Albana Lico, Roberto Massimo Lemoli, Paolo De Fabritiis, Felicetto Ferrara, Martina Rachele Marino, Monica Messina, Anna Ferrari, Valentina Robustelli, Jacopo Nanni, Irene Della Starza, Giorgia Simonetti, Maria Stefania De Propris, Maria Teresa Bochicchio, Marco Vignetti, Paola Fazi, Giovanni Martinelli
Journal: Blood
Blood (2022) 140 (Supplement 1): 6119–6121.
https://doi.org/10.1182/blood-2022-157937
Published: 2022
Journal Articles

Absolute Lymphocyte Count Is an Independent Survival Predictor in Patients with Acute Myeloid Leukemia Treated with Intensive Chemotherapy

Free
Gianluca Cristiano, Jacopo Nanni, Letizia Zannoni, Federico Zingarelli, Chiara Sartor, Sarah Parisi, Stefania Paolini, Cristina Papayannidis, Michele Cavo, Antonio Curti
Journal: Blood
Blood (2022) 140 (Supplement 1): 11793–11794.
https://doi.org/10.1182/blood-2022-167035
Published: 2022
Journal Articles

Gimema AML1718 Part 1: Planned Interim Analysis of a Safety Run-in and Phase 2 Open-Label Study of Venetoclax, Fludarabine, Idarubicin and Cytarabine (V-FLAI) in the Induction Therapy of Non Low-Risk Acute Myeloid Leukemia

Free
Giovanni Marconi, Alfonso Piciocchi, Ernesta Audisio, Giorgio Priolo, Cristina Papayannidis, Maurizio Martelli, Francesca Paoloni, Roberto Massimo Lemoli, Monica Bocchia, Francesco Lanza, Albana Lico, Fabio Ciceri, Matteo G. Della Porta, Marco Frigeni, Luisa Giaccone, Germana Beltrami, Erika Borlenghi, Maria Chiara Di Chio, Carmine Selleri, Enrico Crea, Irene Urbino, Chiara Sartor, Clara Minotti, Fabio Guolo, Edoardo La Sala, Jacopo Nanni, Giorgia Simonetti, Maria Teresa Bochicchio, Giuseppe Saglio, Adriano Venditti, Marco Vignetti, Paola Fazi, Giovanni Martinelli
Journal: Blood
Blood (2022) 140 (Supplement 1): 1705–1707.
https://doi.org/10.1182/blood-2022-157393
Published: 2022
Journal Articles

A Chemo-Free Bridge-to-Transplant Strategy with Venetoclax and Azacitidine for NPM1 -Mutated Acute Myeloid Leukemia in Molecular Failure

Free
Chiara Sartor, Lorenzo Brunetti, Ernesta Audisio, Alessandro Cignetti, Letizia Zannoni, Gianluca Cristiano, Jacopo Nanni, Emanuela Ottaviani, Lorenza Bandini, Sarah Parisi, Stefania Paolini, Sofia Sciabolacci, Valeria Cardinali, Cristina Papayannidis, Michele Cavo, Maria Paola Martelli, Antonio Curti
Journal: Blood
Blood (2022) 140 (Supplement 1): 9034–9035.
https://doi.org/10.1182/blood-2022-165914
Published: 2022
Journal Articles

Mesenchymal Stromal Cells Protect Acute Myeloid Leukemia Cells from Venetoclax-Induced Apoptosis through Contact-Dependent Mechanisms

Free
Giulia Corradi, Samantha Bruno, Gaia Mazzocchetti, Jacopo Nanni, Andrea Polimeno, Michele Cavo, Marilena Ciciarello, Antonio Curti
Journal: Blood
Blood (2022) 140 (Supplement 1): 11424–11425.
https://doi.org/10.1182/blood-2022-166792
Published: 2022
Journal Articles

Toxicity and Outcomes in Octo- and Nonagenarians with AML Treated with Venetoclax and Hypomethylating Agent Therapy

Free
Ellen Madarang, Jillian Lykon, Wei Zhao, Mikkael A. Sekeres, Terrence Bradley, Namrata Sonia Chandhok, Justin Taylor, Tulay Koru-Sengul, Sunil G. Iyer, Jacopo Nanni, Cristina Papayannidis, Ryan M Miller, Ashwin Kishtagari, Michael R. Savona, Jason Gilbert, Daniel A. Pollyea, David A. Sallman, Najla Al Ali, Rami S. Komrokji, Justin Watts
Journal: Blood
Blood (2022) 140 (Supplement 1): 3306–3308.
https://doi.org/10.1182/blood-2022-170771
Published: 2022