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Tiziana Ottone
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Journal Articles

Selected Genomic Structural Variants Refine ELN-Based Prognostic Stratification of Patients with Acute Myeloid Leukemia and Normal Karyotype

Niccolò Bartalucci, Francesco Mannelli, Simone Romagnoli, Danilo Tarantino, Barbara Scappini, Alessio Enderti, Giacomo Gianfaldoni, Fiorenza Irushani, Matteo Piccini, Silvia Salmoiraghi, Tiziana Ottone, Alfonso Piciocchi, Silvia Orsi, Marco Vignetti, Alessia Civini, Chiara Pavoni, Renato Bassan, Stefania Bortoluzzi, Adriano Venditti, Alessandro Rambaldi, Maria Teresa Voso, Paola Guglielmelli, Alessandro Maria Vannucchi
Journal: Blood
Blood (2023) 142 (Supplement 1): 4317.
https://doi.org/10.1182/blood-2023-178599
Published: 2023
Journal Articles

A Population-Based Study on Survival of Higher Risks Myelofibrosis Patients Treated with Ruxolitinib in the Italian Lombardy Region

Barbara Mora, Giacomo Pellegrini, Matteo Franchi, Margherita Maffioli, Marco Brociner, Paola Guglielmelli, Maria Teresa Voso, Tiziana Ottone, Marta Ubezio, Giulia Maggioni, Michele Merli, Alessandro M. Vannucchi, Matteo G. Della Porta, Giovanni Corrao, Francesco Passamonti
Journal: Blood
Blood (2022) 140 (Supplement 1): 9737–9739.
https://doi.org/10.1182/blood-2022-164575
Published: 2022
Journal Articles

Results of the 6-Year Follow-up of the Gimema AML1310 Trial: A Risk-Adapted, MRD-Directed Therapy for Young Adults with Newly Diagnosed Acute Myeloid Leukemia

Adriano Venditti, Alfonso Piciocchi, Raffaele Palmieri, Valentina Arena, Anna Candoni, Valeria Calafiore, Lorella MA Melillo, Roberto Cairoli, Paolo De Fabritiis, Gabriella Storti, Prassede Salutari, Francesco Lanza, Giovanni Martinelli, Mario Luppi, Saveria Capria, Luca Maurillo, Maria Ilaria Del Principe, Giovangiacinto Paterno, Elisa Buzzatti, Maria Teresa Voso, Tiziana Ottone, Maria irno Consalvo, Paola Fazi, Marco Vignetti, William Arcese, Sergio Amadori, Francesco Buccisano
Journal: Blood
Blood (2021) 138 (Supplement 1): 2359.
https://doi.org/10.1182/blood-2021-147200
Published: 2021
Journal Articles

Clinical Relevance of- Limit of Detection (LOD) - Limit of Quantification (LOQ) - Based Flow Cytometry Approach for Measurable Residual Disease (MRD) Assessment in Acute Myeloid Leukemia (AML)

Raffaele Palmieri, MD, Alfonso Piciocchi, Valentina Arena, MS, Luca Maurillo, Maria Ilaria Del Principe, Giovangiacinto Paterno, Tiziana Ottone, Mariadomenica Divona, Serena Lavorgna, Maria Irno Consalvo, Consuelo Conti, Cristina Attrotto, Daniela Fraboni, Maria Teresa Voso, MD, William Arcese, MD PhD, Adriano Venditti, MD, Francesco Buccisano, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 37–38.
https://doi.org/10.1182/blood-2020-139557
Published: 2020
Journal Articles

Validation of ELN2017 Risk Stratification in a Post-Hoc Analysis of the Prospective Biomarker-Based Gimema AML1310 Protocol

Raffaele Palmieri, MD, Francesco Buccisano, MD, Alfonso Piciocchi, MS, Valentina Arena, MS, Anna Candoni, Lorella MA Melillo, MD, Valeria Calafiore, Roberto Cairoli, MD, Paolo De Fabritiis, MD, Gabriella Storti, Prassede Salutari, MD, Francesco Lanza, MD, Giovanni Martinelli, MD, Mario Luppi, Saveria Capria, MD, Luca Maurillo, Maria Ilaria Del Principe, Giovangiacinto Paterno, Maria Teresa Voso, MD, Tiziana Ottone, Serena Lavorgna, Paola Fazi, MD, Marco Vignetti, MD, William Arcese, MD PhD, Adriano Venditti, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 34–35.
https://doi.org/10.1182/blood-2020-139773
Published: 2020
Journal Articles

Impact of NPM1 / FLT3 -ITD genotypes defined by the 2017 European LeukemiaNet in patients with acute myeloid leukemia

Clinical Trials & Observations
Konstanze Döhner, Christian Thiede, Nikolaus Jahn, Ekaterina Panina, Agnes Gambietz, Richard A. Larson, Thomas W. Prior, Guido Marcucci, Dan Jones, Jürgen Krauter, Michael Heuser, Maria Teresa Voso, Tiziana Ottone, Josep F. Nomdedeu, Sumithra J. Mandrekar, Rebecca B. Klisovic, Andrew H. Wei, Jorge Sierra, Miguel A. Sanz, Joseph M. Brandwein, Theo de Witte, Joop H. Jansen, Dietger Niederwieser, Frederick R. Appelbaum, Bruno C. Medeiros, Martin S. Tallman, Richard F. Schlenk, Arnold Ganser, Hubert Serve, Gerhard Ehninger, Sergio Amadori, Insa Gathmann, Axel Benner, Celine Pallaud, Richard M. Stone, Hartmut Döhner, Clara D. Bloomfield
Journal: Blood
Blood (2020) 135 (5): 371–380.
https://doi.org/10.1182/blood.2019002697
Published: 2020
Includes: Supplemental data
Journal Articles

Multiparametric Flow-Cytometry Is a Reliable Tool for Measurable Residual Disease Assessment and Risk-Stratification of FLT3-Mutated AML Patients

Raffaele Palmieri, MD, Luca Maurillo, Alfonso Piciocchi, Maria Ilaria Del Principe, Valentina Arena, Stefano Soddu, Ambra Di Veroli, MD, Giovangiacinto Paterno, Eleonora De Bellis, Raffaella Cerretti, Gottardo De Angelis, Benedetta Mariotti, Tiziana Ottone, Mariadomenica Divona, Serena Lavorgna, Maria Irno Consalvo, Consuelo Conti, Cristina Attrotto, Daniela Fraboni, William Arcese, Maria Teresa Voso, MD, Adriano Venditti, Francesco Buccisano, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5083.
https://doi.org/10.1182/blood-2019-129184
Published: 2019
Journal Articles

Mutational Profile of Leukemic Stem Cells in FLT3 -ITD Mutated AML

Tiziana Ottone, Serena Travaglini, Valentina Alfonso, PhD, Daniela Angelini, PhD, Gisella Guerrera, PhD, Serena Lavorgna, Mariadomenica Divona, Anna Maria Nardozza, Antonio Cristiano, Maria irno Consalvo, PhD, Marco de Bardi, PhD, Benedetta Neri, MD, Francesco Marchesi, Carmelo Gurnari, MD, Giovangiacinto Paterno, Vincenza Martini, MD, Luca Battistini, MD, PhD, Adriano Venditti, Francesco Buccisano, MD, William Arcese, Francesco Lo-Coco, Maria Teresa Voso, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1458.
https://doi.org/10.1182/blood-2019-126040
Published: 2019
Journal Articles

GIMEMA AML1310 trial of risk-adapted, MRD-directed therapy for young adults with newly diagnosed acute myeloid leukemia

Clinical Trials & Observations
Adriano Venditti, Alfonso Piciocchi, Anna Candoni, Lorella Melillo, Valeria Calafiore, Roberto Cairoli, Paolo de Fabritiis, Gabriella Storti, Prassede Salutari, Francesco Lanza, Giovanni Martinelli, Mario Luppi, Patrizio Mazza, Maria Paola Martelli, Antonio Cuneo, Francesco Albano, Francesco Fabbiano, Agostino Tafuri, Anna Chierichini, Alessia Tieghi, Nicola Stefano Fracchiolla, Debora Capelli, Robin Foà, Caterina Alati, Edoardo La Sala, Paola Fazi, Marco Vignetti, Luca Maurillo, Francesco Buccisano, Maria Ilaria Del Principe, Maria Irno-Consalvo, Tiziana Ottone, Serena Lavorgna, Maria Teresa Voso, Francesco Lo-Coco, William Arcese, Sergio Amadori
Journal: Blood
Blood (2019) 134 (12): 935–945.
https://doi.org/10.1182/blood.2018886960
Published: 2019
Includes: Supplemental data
Journal Articles

Longitudinal Detection of DNMT3A R882H Transcripts in Patients with Acute Myeloid Leukemia

Tiziana Ottone, PhD, Valentina Alfonso, BS, Licia Iaccarino, BS, Syed Khizer Hasan, PhD, Melissa Mancini, PhD, Mariadomenica Divona, BS, Serena Lavorgna, PhD, Laura Cicconi, Paola Panetta, PhD, Luca Maurillo, MD, PhD, Maria Ilaria Del Principe, Maria irno Consalvo, PhD, Luca Franceschini, MD, PhD, Daniela Angelini, PhD, Luca Battistini, MD, PhD, Gisella Guerrera, PhD, Marco de Bardi, PhD, Emiliano Fabiani, PhD, Giulia Falconi, PhD, William Arcese, MD, Sergio Amadori, MD, Francesco Buccisano, MD, Adriano Venditti, MD, Maria Teresa Voso, MD, Francesco Lo Coco, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3959.
https://doi.org/10.1182/blood.V130.Suppl_1.3959.3959
Published: 2017
Journal Articles

Prognostic Impact of NPM1/FLT3-ITD genotypes from Randomized Patients with Acute Myeloid Leukemia (AML) Treated within the International Ratify Study

Konstanze Döhner, MD, Christian Thiede, MD, Richard A. Larson, MD, Thomas W Prior, MD, Guido Marcucci, MD, Dan Jones, MD, Jürgen Krauter, MD, Michael Heuser, MD, Francesco Lo Coco, MD, Tiziana Ottone, PhD, Josep Nomdedeu, Sumithra J Mandrekar, PhD, Ben L. Sanford, MS, Kristine Laumann, Susan M. Geyer, PhD, Rebecca B. Klisovic, MD, Andrew Wei, MBBS, PhD FRACP, FRCPA, Jorge Sierra, Miguel A. Sanz, MD, Joseph M. Brandwein, MD FRCPC, T. M. M de Witte, MD PhD, Joop H. Jansen, Dietger Niederwieser, MD, Frederick R. Appelbaum, MD, Bruno C Medeiros, MD, Martin S. Tallman, MD, Richard F. Schlenk, MD, Arnold Ganser, MD, Hubert Serve, Gerhard Ehninger, Sergio Amadori, MD, Yuan Cheng, PhD, Celine Pallaud, PhD, Richard M. Stone, MD, Hartmut Döhner, MD, Clara D. Bloomfield, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 467.
https://doi.org/10.1182/blood.V130.Suppl_1.467.467
Published: 2017
Journal Articles

Prolonged Arsenic Trioxide (ATO) and All- Trans Retinoic Acid (ATRA) Therapy for Relapsed Acute Promyelocytic Leukemia

Laura Cicconi, Massimo Breccia, MD, PhD, Luca Franceschini, MD, PhD, Roberto Latagliata, Matteo Molica, MD, Manuela Rizzo, MD, Mariadomenica Divona, BS, Licia Iaccarino, BS, Tiziana Ottone, PhD, Valentina Alfonso, BS, Robin Foa, MD, Maria Teresa Voso, MD, Francesco Lo Coco, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 147.
https://doi.org/10.1182/blood.V130.Suppl_1.147.147
Published: 2017
Journal Articles

The hidden genomic landscape of acute myeloid leukemia: subclonal structure revealed by undetected mutations

Margherita Bodini, Chiara Ronchini, Luciano Giacò, Anna Russo, Giorgio E. M. Melloni, Lucilla Luzi, Domenico Sardella, Sara Volorio, Syed K. Hasan, Tiziana Ottone, Serena Lavorgna, Francesco Lo-Coco, Anna Candoni, Renato Fanin, Eleonora Toffoletti, Ilaria Iacobucci, Giovanni Martinelli, Alessandro Cignetti, Corrado Tarella, Loris Bernard, Pier Giuseppe Pelicci, Laura Riva
Journal: Blood
Blood (2015) 125 (4): 600–605.
https://doi.org/10.1182/blood-2014-05-576157
Published: 2015
Includes: Supplemental data
Journal Articles

Results of the “Evaluation of NGS in AML-Diagnostics (ELAN)” Study – an Inter-Laboratory Comparison Performed in 10 European Laboratories

Christian Thiede, MD, Lars Bullinger, MD PhD, Jesús M Hernández-Rivas, MDPhD, Michael Heuser, MD, Claude Preudhomme, PhD, Steven Best, PhD, Dolors Colomer, PhD, Francesco Lo Coco, MD, Giovanni Martinelli, MD, Anna Schuh, MDPhD, Rocí­o Benito, PhD, Anna Dolnik, Anna Enjuanes, PhD, Sandrine Geffroy, Serena Lavorgna, PhD, Nicholas Lea, PhD, Joanne Mason, PhD, Emanuela Ottaviani, Anne Otto, Felicitas Thol, MD, Sabin Bhuju, Konstanze Döhner, MD, Christian Eberlein, PhD, Angela Hamblin, MDPhD, Olivier Nibourel, PhD, Tiziana Ottone, PhD, Maria Antonella Laginestra, Marta Pratcorona, MD PhD, Mónica del Rey, PhD, Felix Schlesinger, PhD
Journal: Blood
Blood (2014) 124 (21): 2374.
https://doi.org/10.1182/blood.V124.21.2374.2374
Published: 2014
Journal Articles

Cytogenetic and molecular diagnostic characterization combined to postconsolidation minimal residual disease assessment by flow cytometry improves risk stratification in adult acute myeloid leukemia

Clinical Trials & Observations
Francesco Buccisano, Luca Maurillo, Alessandra Spagnoli, Maria Ilaria Del Principe, Daniela Fraboni, Paola Panetta, Tiziana Ottone, Maria Irno Consalvo, Serena Lavorgna, Pietro Bulian, Emanuele Ammatuna, Daniela F. Angelini, Adamo Diamantini, Selenia Campagna, Licia Ottaviani, Chiara Sarlo, Valter Gattei, Giovanni Del Poeta, William Arcese, Sergio Amadori, Francesco Lo Coco, Adriano Venditti
Journal: Blood
Blood (2010) 116 (13): 2295–2303.
https://doi.org/10.1182/blood-2009-12-258178
Published: 2010
Includes: Supplemental data
Journal Articles

A monoclonal antibody against mutated nucleophosmin 1 for the molecular diagnosis of acute myeloid leukemias

Alicja M. Gruszka, Serena Lavorgna, Maria Irno Consalvo, Tiziana Ottone, Chiara Martinelli, Mario Cinquanta, Giuseppe Ossolengo, Giancarlo Pruneri, Francesco Buccisano, Mariadomenica Divona, Michele Cedrone, Emanuele Ammatuna, Adriano Venditti, Ario de Marco, Francesco Lo-Coco, Pier Giuseppe Pelicci
Journal: Blood
Blood (2010) 116 (12): 2096–2102.
https://doi.org/10.1182/blood-2010-01-266908
Published: 2010
Includes: Supplemental data
Journal Articles

Molecular analysis of t(15;17) genomic breakpoints in secondary acute promyelocytic leukemia arising after treatment of multiple sclerosis

Syed Khizer Hasan, Ashley N. Mays, Tiziana Ottone, Antonio Ledda, Giorgio La Nasa, Chiara Cattaneo, Erika Borlenghi, Lorella Melillo, Enrico Montefusco, José Cervera, Christopher Stephen, Gnanam Satchi, Anne Lennard, Marta Libura, Jo Ann W. Byl, Neil Osheroff, Sergio Amadori, Carolyn A. Felix, Maria Teresa Voso, Wolfgang R. Sperr, Jordi Esteve, Miguel A. Sanz, David Grimwade, Francesco Lo-Coco
Journal: Blood
Blood (2008) 112 (8): 3383–3390.
https://doi.org/10.1182/blood-2007-10-115600
Published: 2008
Journal Articles

Nucleophosmin Gene Mutations Exhibit High Spontaneous Apoptosis and Favorable Prognosis in Acute Myeloid Leukemia.

Giovanni Del Poeta, MD, Emanuele Ammatuna, M.D., Serena Zaza, Ph.D., Francesco Buccisano, M.D., Tiziana Ottone, Ph.D., Maria Ilaria Del Principe, M.D., Serena Lavorgna, Ph.D., Gianfranco Catalano, M.D., Luca Maurillo, M.D., Fabrizio Luciano, Ph.D., Paolo de Fabritiis, M.D., Adriano Venditti, M.D., Sergio Amadori, M.D., Francesco Lo Coco, M.D.
Journal: Blood
Blood (2007) 110 (11): 3480.
https://doi.org/10.1182/blood.V110.11.3480.3480
Published: 2007