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Journal Articles

Impact of NPM1 / FLT3 -ITD genotypes defined by the 2017 European LeukemiaNet in patients with acute myeloid leukemia

Clinical Trials & Observations
Konstanze Döhner, Christian Thiede, Nikolaus Jahn, Ekaterina Panina, Agnes Gambietz, Richard A. Larson, Thomas W. Prior, Guido Marcucci, Dan Jones, Jürgen Krauter, Michael Heuser, Maria Teresa Voso, Tiziana Ottone, Josep F. Nomdedeu, Sumithra J. Mandrekar, Rebecca B. Klisovic, Andrew H. Wei, Jorge Sierra, Miguel A. Sanz, Joseph M. Brandwein, Theo de Witte, Joop H. Jansen, Dietger Niederwieser, Frederick R. Appelbaum, Bruno C. Medeiros, Martin S. Tallman, Richard F. Schlenk, Arnold Ganser, Hubert Serve, Gerhard Ehninger, Sergio Amadori, Insa Gathmann, Axel Benner, Celine Pallaud, Richard M. Stone, Hartmut Döhner, Clara D. Bloomfield
Journal: Blood
Blood (2020) 135 (5): 371–380.
https://doi.org/10.1182/blood.2019002697
Published: 2020
Includes: Supplemental data
Journal Articles

Azacytidine Inhibits Megakaryopoiesis Via the Induction of Immunogenic RNA Species and Activation of Type-I Interferon Signaling

Ujunwa Cynthia Okoye-Okafor, MS,PhD, Komal Kumar Javarappa, PhD, Dimitrios Tsallos, BSc(Hons),MSc, Joseph J Saad, MSc, BSc, Lumie Benard, Victor Thiruthuvanathan, M.S, Sally Cole, Madhuri Tatiparthy, M.S., Stephen Ruiz, B.Sc, Stefanie DeFronzo, Celine Pallaud, PhD, Pedro Marques Ramos, PhD, Amit Verma, MBBS, Aditi Shastri, MD, Caroline A Heckman, PhD, Britta Will, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1280.
https://doi.org/10.1182/blood-2019-131461
Published: 2019
Journal Articles

Prognostic Impact of Insertion Site in Acute Myeloid Leukemia (AML) with FLT3 Internal Tandem Duplication: Results from the Ratify Study (Alliance 10603)

Frank G. Rücker, MD, Ling Du, PhD, Tamara J. Blätte, MSc, Axel Benner, Julia Krzykalla, MSc, Insa Gathmann, Richard A. Larson, MD, Francesco Lo-Coco, MD, Sergio Amadori, MD, Thomas W Prior, MD, Joseph M. Brandwein, MD, Frederick R. Appelbaum, MD, Bruno C. Medeiros, MD, Martin S. Tallman, MD, Michelle Geddes, MD, Jorge Sierra, MD, Eva Tiecke, PhD, Celine Pallaud, PhD, Miguel A. Sanz, MD, Theo M de Witte, MD, Dietger Niederwieser, MD, Gerhard Ehninger, MD, Michael Heuser, MD, Arnold Ganser, MD, Lars Bullinger, MD, Clara D. Bloomfield, MD, Richard M. Stone, MD, Hartmut Döhner, MD, Christian Thiede, MD, Konstanze Dohner, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 435.
https://doi.org/10.1182/blood-2018-99-116149
Published: 2018
Journal Articles

Comprehensive Molecular Profiling of FLT3 -Mutated Acute Myeloid Leukemia (AML) Patients Treated within the Ratify Trial (Alliance C10603)

Nikolaus Jahn, MD, Ekaterina Panina, MD, Lars Bullinger, MD, Anna Dolnik, PhD, Julia Herzig, PhD, Tamara J. Blätte, MSc, Axel Benner, Julia Krzykalla, MSc, Insa Gathmann, Richard A. Larson, MD, Francesco Lo-Coco, MD, Sergio Amadori, MD, Thomas W Prior, MD, Joseph M. Brandwein, MD, Frederick R. Appelbaum, MD, Bruno C. Medeiros, MD, Martin S. Tallman, MD, Eva Tiecke, PhD, Celine Pallaud, PhD, Gerhard Ehninger, MD, Michael Heuser, MD, Arnold Ganser, MD, Richard M. Stone, MD, Christian Thiede, MD, Hartmut Döhner, MD, Clara D. Bloomfield, MD, Konstanze Döhner, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1534.
https://doi.org/10.1182/blood-2018-99-115842
Published: 2018
Journal Articles

Eltrombopag Promotes Megakaryocyte Survival and Signaling in the Presence of Specific Cytotoxic Agents

Komal Kumar Javarappa, PhD, Dimitrios Tsallos, BSc(Hons), MSc, Bulat Zagidullin, MSc, Joseph J Saad, MSc, BSc, Jing Tang, PhD, Pedro Marques Ramos, PhD, Celine Pallaud, PhD, Caroline A Heckman, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3836.
https://doi.org/10.1182/blood-2018-99-118449
Published: 2018
Journal Articles

Expanding the Utility of Midostaurin in Acute Myeloid Leukemia - Predictive Mutational Signatures in Patient Samples without FLT3 mutations and Clinically Applicable Synergistic Drug Combinations

Markus Vaha-Koskela, PhD, Muhammad Ammad-ud-din, PhD, Kirsi Siivola, MSc, Tanja Ruokoranta, MSc, Laura Turunen, PhD, Kimmo Porkka, MD PhD, Pedro Marques Ramos, PhD, Celine Pallaud, PhD, Tero Aittokallio, PhD, Krister Wennerberg, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2743.
https://doi.org/10.1182/blood-2018-99-116391
Published: 2018
Journal Articles

Quantitative Multiplex Immunohistochemistry Identifies Immunosuppression in the AML Bone Marrow and NK-Cells As Prognostic Biomarker in Intermediate-Risk Patients

Oscar Brück, MD, Olli Dufva, Sami Blom, MSc, Riku Turkki, MSc, Mette Ilander, PhD, Sanna M. Siitonen, MD PhD, Panu Kovanen, MD PhD, Celine Pallaud, PhD, Pedro Marques Ramos, PhD, Hanna Lähteenmäki, Katja Välimäki, Antonio Ribeiro, BSc, Olli Kallioniemi, MD PhD, Kimmo Porkka, MD PhD, Teijo Pellinen, PhD, Satu Mustjoki, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2774.
https://doi.org/10.1182/blood-2018-99-116628
Published: 2018
Journal Articles

FLT3 mutation Assay Laboratory Cross Validation: Results from the CALGB 10603/Ratify Trial in Patients with Newly Diagnosed FLT3 -Mutated Acute Myeloid Leukemia (AML)

Christian Thiede, MD, Thomas W Prior, MD, Serena Lavorgna, PhD, Jürgen Krauter, MD, Eva Barragán, Josep Nomdedeu, MD PhD, Joop H. Jansen, Andrew H Wei, MBBS, PhD, Weiqiang Zhao, MD PhD, Xiaohong Li, Celine Pallaud, PhD, Eva Tiecke, PhD, Richard A. Larson, MD, Clara D. Bloomfield, MD, Hartmut Döhner, MD, Gerhard Ehninger, MD, Richard M. Stone, MD, Konstanze Döhner, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2800.
https://doi.org/10.1182/blood-2018-99-112127
Published: 2018
Journal Articles

Prognostic Impact of NPM1/FLT3-ITD genotypes from Randomized Patients with Acute Myeloid Leukemia (AML) Treated within the International Ratify Study

Konstanze Döhner, MD, Christian Thiede, MD, Richard A. Larson, MD, Thomas W Prior, MD, Guido Marcucci, MD, Dan Jones, MD, Jürgen Krauter, MD, Michael Heuser, MD, Francesco Lo Coco, MD, Tiziana Ottone, PhD, Josep Nomdedeu, Sumithra J Mandrekar, PhD, Ben L. Sanford, MS, Kristine Laumann, Susan M. Geyer, PhD, Rebecca B. Klisovic, MD, Andrew Wei, MBBS, PhD FRACP, FRCPA, Jorge Sierra, Miguel A. Sanz, MD, Joseph M. Brandwein, MD FRCPC, T. M. M de Witte, MD PhD, Joop H. Jansen, Dietger Niederwieser, MD, Frederick R. Appelbaum, MD, Bruno C Medeiros, MD, Martin S. Tallman, MD, Richard F. Schlenk, MD, Arnold Ganser, MD, Hubert Serve, Gerhard Ehninger, Sergio Amadori, MD, Yuan Cheng, PhD, Celine Pallaud, PhD, Richard M. Stone, MD, Hartmut Döhner, MD, Clara D. Bloomfield, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 467.
https://doi.org/10.1182/blood.V130.Suppl_1.467.467
Published: 2017
Journal Articles

Exploring the Clinical Utility of Renal Safety Biomarkers during Iron Chelation Therapy in Patients with β-Thalassemia and Other Anemias

Maria Domenica Cappellini, MD, Erhard Quebe-Fehling, PhD, Celine Pallaud, Frank Dieterle, John B. Porter, BA MB BChir MRCP(Path) FRCP(Path) MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4762.
https://doi.org/10.1182/blood.V130.Suppl_1.4762.4762
Published: 2017
Journal Articles

Pre-Clinical Modeling of Concomitant Therapy with Azacytidine and Eltrombopag in MDS/AML

Sally Cole, Lumie Benard, Luis A. Carvajal, PhD, Amit Verma, MD, Ulrich G. Steidl, MDPhD, Pedro Marques Ramos, PhD, Celine Pallaud, PhD, Britta Will, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2950.
https://doi.org/10.1182/blood.V130.Suppl_1.2950.2950
Published: 2017
Journal Articles

Panobinostat induces CD38 upregulation and augments the antimyeloma efficacy of daratumumab

Clinical Trials & Observations
Estefanía García-Guerrero, Tea Gogishvili, Sophia Danhof, Martin Schreder, Celine Pallaud, Jose Antonio Pérez-Simón, Hermann Einsele, Michael Hudecek
Journal: Blood
Blood (2017) 129 (25): 3386–3388.
https://doi.org/10.1182/blood-2017-03-770776
Published: 2017
Includes: Supplemental data
Journal Articles

Panobinostat Induces Upregulation of CD38 and Augments the Anti-Myeloma Efficacy of Daratumumab in Pre-Clinical Models

Estefania Garcia-Guerrero, Tea Gogishvili, PhD, Sophia Danhof, MD, Martin Schreder, MD, Celine Pallaud, PhD, Thomas Lehmann, PhD, Hermann Einsele, MD, Michael Hudecek, MD
Journal: Blood
Blood (2016) 128 (22): 4481.
https://doi.org/10.1182/blood.V128.22.4481.4481
Published: 2016