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Ryan G. Kruger
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Journal Articles

LSD1 inhibition exerts its antileukemic effect by recommissioning PU.1- and C/EBPα-dependent enhancers in AML

Monica Cusan, Sheng F. Cai, Helai P. Mohammad, Andrei Krivtsov, Alan Chramiec, Evangelia Loizou, Matthew D. Witkin, Kimberly N. Smitheman, Daniel G. Tenen, Min Ye, Britta Will, Ulrich Steidl, Ryan G. Kruger, Ross L. Levine, Hugh Y. Rienhoff, Jr, Richard P. Koche, Scott A. Armstrong
Journal: Blood
Blood (2018) 131 (15): 1730–1742.
https://doi.org/10.1182/blood-2017-09-807024
Published: 2018
Includes: Supplemental data
Journal Articles

LSD1 Inhibition Exerts Its Anti-Leukemic Effect By Recommissioning PU.1- and C/Ebpα-Dependent Enhancers in AML

Monica Cusan, MD, Sheng Cai, MD PhD, Helai P Mohammad, PhD, Andrei V. Krivtsov, PhD, Alan Chramiec, Evangelia Loizou, Daniel G. Tenen, MD, Min Ye, PhD, Britta Will, PhD, Ulrich G. Steidl, MDPhD, Ryan G. Kruger, PhD, Richard Koche, PhD, Scott Armstrong, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 242.
https://doi.org/10.1182/blood.V130.Suppl_1.242.242
Published: 2017
Journal Articles

Cooperative Gene Repression By DNA Methylation and LSD1-Mediated Enhancer Inactivation in Acute Myeloid Leukemia

Cihangir Duy, PhD, Matt Teater, M.S., Francine E. Garrett-Bakelman, MD PhD, Tak C Lee, M.S., Cem Meydan, PhD, Jacob Lowell Glass, MD PhD, Meng Li, PhD, Helai Mohammad, PhD, Kimberly Smitheman, Alan H. Shih, MD PhD, Omar Abdel-Wahab, MD, Elisabeth Paietta, PhD, Martin S. Tallman, MD, Monica L. Guzman, PhD, Ryan G. Kruger, PhD, Caretha L. Creasy, PhD, Ross L. Levine, MD, Martin Carroll, MD, Ari Melnick, MD
Journal: Blood
Blood (2016) 128 (22): 1048.
https://doi.org/10.1182/blood.V128.22.1048.1048
Published: 2016
Journal Articles

Identification of a First-in-Class PRMT5 Inhibitor with Potent in Vitro and in Vivo Activity in Preclinical Models of Mantle Cell Lymphoma

Elayne Penebre, PhD, Kristy G Kuplast, Christina R Majer, L. Danielle Johnston, MS, Nathalie Rioux, PhD, Michael Munchhof, PhD, Lei Jin, PhD, P. Ann Boriak-Sjodin, PhD, Tim J Wigle, PhD, Suzanne L Jacques, PhD, Kip A West, PhD, Trupti Lingaraj, Kimberly Stickland, PhD, Scott A Ribich, PhD, Alejandra Raimondi, MS, Margaret Porter-Scott, PhD, Nigel J Waters, PhD, Roy M Pollock, PhD, Jesse J Smith, PhD, Olena Barbash, PhD, Ryan G. Kruger, PhD, Robert A Copeland, PhD, Mikel P Moyer, PhD, Richard Chesworth, DPhil, Kenneth W Duncan, PhD
Journal: Blood
Blood (2014) 124 (21): 438.
https://doi.org/10.1182/blood.V124.21.438.438
Published: 2014
Journal Articles

Inhibition Of LSD1 As a Therapeutic Strategy For The Treatment Of Acute Myeloid Leukemia

Ryan G. Kruger, Ph.D., Helai Mohammad, Ph.D., Kimberly Smitheman, Monica Cusan, Yan Liu, Melissa Pappalardi, Kelly Federowicz, Glenn Van Aller, Jiri Kasparec, Xinrong Tian, Ph.D., Dominic Suarez, Meagan Rouse, Ph.D., Jessica Schneck, Jeffrey Carson, Patrick McDevitt, Thau Ho, Charles McHugh, William Miller, Ph.D., Neil Johnson, Ph.D., Scott A. Armstrong, MD, PhD, Peter Tummino, Ph.D.
Journal: Blood
Blood (2013) 122 (21): 3964.
https://doi.org/10.1182/blood.V122.21.3964.3964
Published: 2013