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Andrei Krivtsov
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Journal Articles

The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia

Clinical Trials & Observations
Eytan M. Stein, Guillermo Garcia-Manero, David A. Rizzieri, Raoul Tibes, Jesus G. Berdeja, Michael R. Savona, Mojca Jongen-Lavrenic, Jessica K. Altman, Blythe Thomson, Stephen J. Blakemore, Scott R. Daigle, Nigel J. Waters, A. Benjamin Suttle, Alicia Clawson, Roy Pollock, Andrei Krivtsov, Scott A. Armstrong, Jorge DiMartino, Eric Hedrick, Bob Löwenberg, Martin S. Tallman
Journal: Blood
Blood (2018) 131 (24): 2661–2669.
https://doi.org/10.1182/blood-2017-12-818948
Published: 2018
Includes: Supplemental data
Journal Articles

LSD1 inhibition exerts its antileukemic effect by recommissioning PU.1- and C/EBPα-dependent enhancers in AML

Monica Cusan, Sheng F. Cai, Helai P. Mohammad, Andrei Krivtsov, Alan Chramiec, Evangelia Loizou, Matthew D. Witkin, Kimberly N. Smitheman, Daniel G. Tenen, Min Ye, Britta Will, Ulrich Steidl, Ryan G. Kruger, Ross L. Levine, Hugh Y. Rienhoff, Jr, Richard P. Koche, Scott A. Armstrong
Journal: Blood
Blood (2018) 131 (15): 1730–1742.
https://doi.org/10.1182/blood-2017-09-807024
Published: 2018
Includes: Supplemental data
Journal Articles

Loss of Lysine Histone Methyltransferase Setd2 Disrupts Normal Hematopoiesis, Lineage Commitment and Reveals a Novel Role for H3K36me3 in Immunoglobulin VDJ Recombination

S. Haihua Chu, PhD, Jonathan R Chabon, BS, Janna Minehart, BS, Richard Koche, PhD, Katie Li, BS, Matthew Witkin, BS, Andrei Krivtsov, PhD, Scott A. Armstrong, MD PhD
Journal: Blood
Blood (2016) 128 (22): 423.
https://doi.org/10.1182/blood.V128.22.423.423
Published: 2016
Journal Articles

Peptidomimetic Blockade of MYB in Acute Myeloid Leukemia

Kavitha Ramaswamy, MD, Lauren Forbes, Fiona C Brown, PhD, Richard Koche, PhD, Tatyana Gindin, MDPhD, Gerard Minuesa, PhD, Michael G. Kharas, PhD, Andrei Krivtsov, PhD, Scott A. Armstrong, MD PhD, Eric Still, Elisa de Stanchina, PhD, Randi Isenhart, Guangwu Guo, Birgit Knoechel, MDPhD, Alex Kentsis, MD PhD
Journal: Blood
Blood (2016) 128 (22): 3945.
https://doi.org/10.1182/blood.V128.22.3945.3945
Published: 2016
Journal Articles

Inhibition of MEK and DDR Pathways Induces Synergistic Killing of Novel Mll-Af4 B-ALL Model Harboring Activated Ras Mutations

Evelyn J Song, BS, S. Haihua Chu, PhD, Janna Minehart, BS, Jonathan Chabon, BS, Richard Koche, PhD, Andrei Krivtsov, PhD, Scott A. Armstrong, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1511.
https://doi.org/10.1182/blood.V128.22.1511.1511
Published: 2016
Journal Articles

An Epigenetic Regulator Screen Identifies Novel Targets That Sensitize MLL -Rearranged Leukemia to DOT1L Inhibition

Chun-Wei David Chen, PhD, Christopher Delaney, BS, Haiming Xu, PhD, Richard Koche, PhD, Amaya Lujambio Goizueta, PhD, Takayuki Hoshii, PhD, Monica Cusan, MD PhD, Jonathan Chabon, BS, Daria Gianina Valerio, MD, Michael Kuehn, MD, Xi Wang, BS, Sheng Cai, MD PhD, S. Haihua Chu, PhD, Yining Kevin Chen, Justin He, Chun-Hao Huang, PhD, Zhaohui Feng, BM, BS, Andrei Krivtsov, PhD, Jun Qi, PhD, James E. Bradner, MD, Scott W. Lowe, PhD, Scott A. Armstrong, MD PhD
Journal: Blood
Blood (2016) 128 (22): 571.
https://doi.org/10.1182/blood.V128.22.571.571
Published: 2016
Journal Articles

Tumor-specific HSP90 inhibition as a therapeutic approach in JAK-mutant acute lymphoblastic leukemias

Brief Report
Nicole Kucine, Sachie Marubayashi, Neha Bhagwat, Efthymia Papalexi, Priya Koppikar, Marta Sanchez Martin, Lauren Dong, Marty S. Tallman, Elisabeth Paietta, Kai Wang, Jie He, Doron Lipson, Phil Stephens, Vince Miller, Jacob M. Rowe, Julie Teruya-Feldstein, Charles G. Mullighan, Adolfo A. Ferrando, Andrei Krivtsov, Scott Armstrong, Laura Leung, Stefan O. Ochiana, Gabriela Chiosis, Ross L. Levine, Maria Kleppe
Journal: Blood
Blood (2015) 126 (22): 2479–2483.
https://doi.org/10.1182/blood-2015-03-635821
Published: 2015
Includes: Supplemental data
Journal Articles

Hoxa9+Meis1a Efficiently Transform Hematopoietic Stem Cells but Not Committed Progenitors.

Yingzi Wang, PhD, Andrei Krivtsov, Ph.D., Grigoriy Losyev, Scott A. Armstrong, M.D., Ph.D.
Journal: Blood
Blood (2007) 110 (11): 3375.
https://doi.org/10.1182/blood.V110.11.3375.3375
Published: 2007
Journal Articles

Induction of Bim Facilitates Apoptosis in Leukemia Cells Treated with HDAC Inhibitors.

Matthew C. Stubbs, PhD, Teresa Kim, Andrei Krivtsov, Ph.D., Peter Atadja, Scott A. Armstrong, M.D., Ph.D., Andrew L. Kung, M.D., Ph.D.
Journal: Blood
Blood (2006) 108 (11): 1994.
https://doi.org/10.1182/blood.V108.11.1994.1994
Published: 2006
Journal Articles

MLL-AF9 and FLT3 Cooperation during Myeloid Leukemogenesis: Development of a Model for Rapid Testing of New Therapeutics.

Matthew C. Stubbs, PhD, Andrei Krivtsov, PhD, Yong-mi Kim, MD, Renee D. Wright, Zhaohui Feng, Jyoti Agarwal, Andrew L. Kung, MD, PhD, Scott A. Armstrong, MD, PhD
Journal: Blood
Blood (2005) 106 (11): 1605.
https://doi.org/10.1182/blood.V106.11.1605.1605
Published: 2005