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Sam Agresta, MD
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Journal Articles

Clonal Heterogeneity in Differentiation Response and Resistance to the IDH2 Inhibitor Enasidenib in Acute Myeloid Leukemia

Lynn Quek, FRCPath, DPhil, MBBS, Muriel David, Alison Kennedy, MSc, Marlen Metzner, MSc, Michael Amatangelo, PhD, Alan H. Shih, MD PhD, Bilyana Stoilova, PhD, Dimitris Karamitros, PhD, Cyril Quivoron, Mael Heiblig, MD, Christophe Willekens, MD, Veronique Saada, Andrew Peniket, Olivier Bernard, Sam Agresta, MD, Katharine Yen, Eytan M. Stein, MD, Stephane De Botton, Anjan Thakurta, PhD, Ross L. Levine, MD, Virginie Penard-Lacronique, PhD, Paresh Vyas, DPhil, FRCP, FRCPath, MRCP, MRCPath
Journal: Blood
Blood (2017) 130 (Supplement 1): 724.
https://doi.org/10.1182/blood.V130.Suppl_1.724.724
Published: 2017
Journal Articles

Ivosidenib (AG-120) in Mutant IDH1 AML and Advanced Hematologic Malignancies: Results of a Phase 1 Dose Escalation and Expansion Study

Courtney D. DiNardo, MDMSc, Stephane De Botton, Eytan M. Stein, MD, Gail J. Roboz, MD, Alice S. Mims, MD MSCR, Daniel A. Pollyea, MD, Ronan T. Swords, MD PhD FRCPI, FRCPath, Jessica K. Altman, MD, Robert H. Collins, MD, Gabriel N. Mannis, MD, Geoffrey L. Uy, MD, Will Donnellan, MD, Arnaud Pigneux, MD PhD, Amir T. Fathi, MD MD BS, Anthony S. Stein, MD, Harry P. Erba, MD PhD, Gabrielle T. Prince, MD, James M. Foran, MD, Elie Traer, MD PhD, Robert K. Stuart, MD, Martha L. Arellano, MD, James L. Slack, MD, Mikkael A. Sekeres, MD MS, Katharine Yen, Stephanie M. Kapsalis, Hua Liu, Meredith Goldwasser, Sam Agresta, MD, Eyal C. Attar, MD, Martin S. Tallman, MD, Richard M. Stone, MD, Hagop M. Kantarjian, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 725.
https://doi.org/10.1182/blood.V130.Suppl_1.725.725
Published: 2017
Journal Articles

Longitudinal Pharmacokinetic/Pharmacodynamic Profile of AG-120, a Potent Inhibitor of the IDH1 Mutant Protein, in a Phase 1 Study of IDH1-Mutant Advanced Hematologic Malignancies

Bin Fan, PhD, Kha Le, PhD, Erika Manyak, BASc, Hua Liu, Malia Prahl, Chris J Bowden, Scott Biller, Sam Agresta, MD, Hua Yang, PhD
Journal: Blood
Blood (2015) 126 (23): 1310.
https://doi.org/10.1182/blood.V126.23.1310.1310
Published: 2015
Journal Articles

Population Pharmacokinetics and Pharmacodynamics of AG-348 in Healthy Human Volunteers Guide Dose Selection for the Treatment of Pyruvate Kinase Deficiency

Kha Le, PhD, Marvin Cohen, Yue Chen, Hyeryun Kim, Bruce Silver, Sam Agresta, MD, Elizabeth Merica, Charles Kung, Penelope Kosinski, Lee Silverman, Scott Biller, Hua Yang, PhD
Journal: Blood
Blood (2015) 126 (23): 3336.
https://doi.org/10.1182/blood.V126.23.3336.3336
Published: 2015
Journal Articles

Evaluation of the Pharmacokinetics of AG-221, a Potent Mutant IDH2 Inhibitor, in Patients with IDH2-Mutation Positive Advanced Hematologic Malignancies in a Phase 1/2 Trial

Yue Gao, PhD, Bin Fan, PhD, Kha Le, PhD, Erika Manyak, BASc, Hua Yang, PhD, Katherine Yen, PhD, Sam Agresta, MD, Eyal C. Attar, MD, Jian Chen, PhD, Qiang Xu, PhD, Alessandra Tosolini, BS, Jay M. Mei, MD PhD, Anjan Thakurta, Robert D. Knight, MD, Yan Li, PhD
Journal: Blood
Blood (2015) 126 (23): 2509.
https://doi.org/10.1182/blood.V126.23.2509.2509
Published: 2015
Journal Articles

DRIVE PK: A Phase 2 Trial of AG-348 in Patients with Pyruvate Kinase Deficiency

Ann Barbier, Bruce Silver, Elizabeth Merica, Marvin Cohen, Charles Kung, Hua Yang, PhD, Rachael F. Grace, MD, Bertil Glader, MD PhD, Sam Agresta, MD
Journal: Blood
Blood (2015) 126 (23): 4548.
https://doi.org/10.1182/blood.V126.23.4548.4548
Published: 2015