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Samuel Agresta
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Journal Articles

Preliminary Results from a Phase 1 Dose Escalation Study of FHD-286, a Novel BRG1/BRM (SMARCA4/SMARCA2) Inhibitor, Administered As an Oral Monotherapy in Patients with Advanced Hematologic Malignancies

Courtney D. DiNardo, Michael R. Savona, Ashwin Kishtagari, Amir T. Fathi, Kapil N. Bhalla, Samuel Agresta, Sarah Reilly, Caroline Almon, Murphy Hentemann, Denice Hickman, Dillon Corrigan, Meghan Macaraeg, Jessica Piel, Kim Horrigan, Salah Nabhan, Paul Martin, Eytan M. Stein
Journal: Blood
Blood (2023) 142 (Supplement 1): 4284.
https://doi.org/10.1182/blood-2023-178090
Published: 2023
Journal Articles

IDH1 Mutant Inhibitor Induces Cellular Differentiation and Offers a Combination Benefit With Ara-C In a Primary Human Idh1 Mutant AML Xenograft Model

Katharine Yen, Ph.D., Rene Lemieux, Ph.D., Janeta Popovici-Muller, Yue Chen, Ph.D., Hua Yang, Kim Straley, Sung Choe, Marion Dorsch, Samuel Agresta, MD, David P. Schenkein, MD, Scott Biller, Michael Su, Fang Wang
Journal: Blood
Blood (2013) 122 (21): 3946.
https://doi.org/10.1182/blood.V122.21.3946.3946
Published: 2013
Journal Articles

Small Molecule Activation Of Pyruvate Kinase Normalizes Metabolic Activity In Red Cells From Patients With Pyruvate Kinase Deficiency-Associated Hemolytic Anemia

Charles Kung, Ph.D., Jeff Hixon, Penelope Kosinski, Gavin Histen, Collin Hill, Yaguang Si, Andrew Kernytsky, Yue Chen, Ph.D., Byron DeLaBarre, Michelle Clasquin, Helen Ho, Furha I. Cossor, MD MS, Ellis J. Neufeld, MD, PhD, Frank Salituro, Janeta Popovici-Muller, Samuel Agresta, MD, Lee Silverman, Lenny Dang
Journal: Blood
Blood (2013) 122 (21): 2180.
https://doi.org/10.1182/blood.V122.21.2180.2180
Published: 2013
Journal Articles

AG-221 Offers a Survival Advantage In a Primary Human IDH2 Mutant AML Xenograft Model

Katharine Yen, Ph.D., Fang Wang, Jeremy Travins, Yue Chen, Ph.D., Hua Yang, Kim Straley, Sung Choe, Marion Dorsch, David P. Schenkein, MD, Samuel Agresta, MD, Scott Biller, Michael Su
Journal: Blood
Blood (2013) 122 (21): 240.
https://doi.org/10.1182/blood.V122.21.240.240
Published: 2013
Journal Articles

Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia

Courtney D. DiNardo, Kathleen J. Propert, Alison W. Loren, Elisabeth Paietta, Zhuoxin Sun, Ross L. Levine, Kimberly S. Straley, Katharine Yen, Jay P. Patel, Samuel Agresta, Omar Abdel-Wahab, Alexander E. Perl, Mark R. Litzow, Jacob M. Rowe, Hillard M. Lazarus, Hugo F. Fernandez, David J. Margolis, Martin S. Tallman, Selina M. Luger, Martin Carroll
Journal: Blood
Blood (2013) 121 (24): 4917–4924.
https://doi.org/10.1182/blood-2013-03-493197
Published: 2013
Includes: Supplemental data
Journal Articles

Prospective serial evaluation of 2-hydroxyglutarate, during treatment of newly diagnosed acute myeloid leukemia, to assess disease activity and therapeutic response

Brief Report
Amir T. Fathi, Hossein Sadrzadeh, Darrell R. Borger, Karen K. Ballen, Philip C. Amrein, Eyal C. Attar, Julia Foster, Meghan Burke, Hector U. Lopez, Christina R. Matulis, Katherine M. Edmonds, A. John Iafrate, Kimberly S. Straley, Katharine E. Yen, Samuel Agresta, David P. Schenkein, Cedric Hill, Ashkan Emadi, Donna S. Neuberg, Richard M. Stone, Yi-Bin Chen
Journal: Blood
Blood (2012) 120 (23): 4649–4652.
https://doi.org/10.1182/blood-2012-06-438267
Published: 2012
Includes: Supplemental data
Journal Articles

Serum 2-Hydroxyglutarate Levels Predict Isocitrate Dehydrogenase Mutations and Clinical Outcome in Acute Myeloid Leukemia.

Courtney D. DiNardo, MD, Ross L. Levine, Kathleen J Propert, ScD, Alison W. Loren, MD, Elisabeth Paietta, PhD, Zhouxin Sun, PhD, Kimberly Straley, BS, Katharine Yen, Jay P. Patel, Samuel Agresta, MD, Omar Abdel-Wahab, Alexander E Perl, MD, Hugo F Fernandez, MD, David Margolis, MD, MSCE, Martin S. Tallman, MD, Selina M. Luger, MD, Martin Carroll, MD
Journal: Blood
Blood (2012) 120 (21): 2481.
https://doi.org/10.1182/blood.V120.21.2481.2481
Published: 2012
Journal Articles

Mutation Selective IDH Inhibitors Mediate Histone and DNA Methylation Changes

Katharine Yen, Fang Wang, Stefanie Schalm, Erica Hansen, Kimberly Straley, BS, Andrew Kernytsky, Sung Choe, Wei Liu, Janeta Popovici-Muller, Jeremy Travins, Hua Yang, Lee Silverman, Julie Losman Aurore, William G. Kaelin, Jr., MD, Stefan Gross, Lenny Dang, Frank Salituro, Jeffrey Saunders, Marion Dorsch, Samuel Agresta, MD, David P. Schenkein, MD, Michael Su, Scott Biller
Journal: Blood
Blood (2012) 120 (21): 3509.
https://doi.org/10.1182/blood.V120.21.3509.3509
Published: 2012