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Journal Articles

Genotype-Phenotype Mapping Via Single-Cell Multi-Omics Identifies Therapeutic Vulnerabilities in Vexas Syndrome

Saravanan Ganesan, Rebecca Murray, Jesus Sotelo, Theo Botella, Elliot Eton, Nada Chraiki, Carolyne Croizier, Franco Izzo, Catherine Potenski, Benjamin Terrier, Mael Heiblig, Pierre Sujobert, Olivier Kosmider, David B Beck, Dan A. Landau

Blood (2023) 142 (Supplement 1): 813.

https://doi.org/10.1182/blood-2023-184313

Published: 2023

Journal Articles

JAK Inhibition Mediates Clonal Selection of RAS Pathway Mutations in Myeloproliferative Neoplasms

Blood (2022) 140 (Supplement 1): 795–796.

https://doi.org/10.1182/blood-2022-167719

Published: 2022

Journal Articles

Comprehensive Analysis of Mesenchymal Cells from Myeloproliferative Neoplasm (MPN) Patients Reveals the Role of HOXB7 in Myelofibrosis Induction

Saravanan Ganesan, Sarah Awan-Toor, Fabien Guidez, Nabih Maslah, Celine Aoun, Panhong Gou, Chloe Guiguen, Juliette Soret, Odonchimeg Ravdan, Valeria Bisio, Nicolas Dulphy, Marie-Hélène Schlageter, Michele Souyri, Stephane Giraudier, Jean-Jacques Kiladjian, Christine Chomienne, Bruno Cassinat

Blood (2022) 140 (Supplement 1): 3852–3854.

https://doi.org/10.1182/blood-2022-157490

Published: 2022

Journal Articles

Targeting Extracellular Vesicle Secretion As a Strategy to Overcome Microenvironment Mediated Drug Resistance in Acute Myeloid Leukemia

Palani Kumar Kumar, PhD, Saravanan Ganesan, PhD, Nithya Balasundaram, MSc, Sachin David, M.Sc, Arvind Venkatraman, M.Tech, Uday Prakash Kulkarni, MD DM, Anu Korula, MD DM, Biju George, MDDM, Poonkuzhali Balasubramanian, PhD, Vikram Mathews, MD DM

Blood (2019) 134 (Supplement_1): 3733.

https://doi.org/10.1182/blood-2019-126389

Published: 2019

Journal Articles

Bone Marrow Stromal Cell Mediated Drug Resistance in AML Cells: Role of Extracellular Vesicles and AKT Signaling

Hamenth kumar Palani, MSc, Saravanan Ganesan, MSc, Nithya Balasundaram, MSc, Ansu Abu Alex, MSc, Sachin David, MSc, Uday Prakash Kulkarni, MD DM, Alok Srivastava, MD, Biju George, MDDM, Poonkuzhali Balasubramanian, MSc, PhD, Vikram Mathews, MD DM

Blood (2017) 130 (Supplement 1): 1160.

https://doi.org/10.1182/blood.V130.Suppl_1.1160.1160

Published: 2017

Journal Articles

Stromal-Cells Downregulate MiR-23a-5p Levels in Myeloid Leukemic Cells to Activate Protective-Autophagy Against Chemotherapeutic Agents

Saravanan Ganesan, MSc, Hamenth kumar Palani, MSc, Vairavan Lakshmanan, B.Tech, Nithya Balasundaram, MSc, Ansu Abu Alex, MSc, Sachin David, MSc, Arvind Venkatraman, M.Tech, Uday Prakash Kulkarni, MD DM, Biju George, MDDM, Alok Srivastava, MD, Poonkuzhali Balasubramanian, MSc, PhD, Keshava K Datta, MSc, Harsha Gowda, PhD, Dasaradhi Palakodeti, PhD, Neha Vyas, PhD, Vikram Mathews, MD DM

Blood (2017) 130 (Supplement 1): 3780.

https://doi.org/10.1182/blood.V130.Suppl_1.3780.3780

Published: 2017

Journal Articles

Fate of Ikaros in Multiple Myeloma Cells upon Treatment with Lenalidomide and Proteasome Inhibitor

Saravanan Ganesan, MSc, Nithya Balasundaram, MSc, Hamenth Kumar Palani, MSc, Ansu Abu Alex, MSc, Sachin David, MSc, Anup Joseph Devasia, MD DM, Biju George, MD DM, Poonkuzhali Balasubramanian, MSc PhD, Vikram Mathews, MD DM

Blood (2016) 128 (22): 3281.

https://doi.org/10.1182/blood.V128.22.3281.3281

Published: 2016

Journal Articles

Metabolic Rewiring Drives Resistance to Arsenic Trioxide in Acute Promyelocytic Leukemia

Nithya Balasundaram, MSc, Saravanan Ganesan, MSc, Hamenth Kumar Palani, MSc, Ansu Abu Alex, MSc, Sachin David, MSc, Anu Korula, MD DM, Biju George, MD DM, Christine Chomienne, MD PhD, Poonkuzhali Balasubramanian, MSc PhD, Vikram Mathews, MD DM

Blood (2016) 128 (22): 3956.

https://doi.org/10.1182/blood.V128.22.3956.3956

Published: 2016

Journal Articles

Osteoblast Differentiation of Stromal Cells Induced By Leukemic Cells

Saravanan Ganesan, MSc, Hamenth Kumar Palani, MSc, Vairavan Lakshmanan, B.Tech, Nithya Balasundaram, MSc, Ansu Abu Alex, MSc, Sachin David, MSc, Biju George, MD DM, Poonkuzhali Balasubramanian, MSc PhD, Neha Vyas, PhD, Dasaradhi Palakodeti, PhD, Vikram Mathews, MD DM

Blood (2016) 128 (22): 5062.

https://doi.org/10.1182/blood.V128.22.5062.5062

Published: 2016

Journal Articles

Role of miRNA in Micro-Environment Mediated Drug Resistance in Acute Promyelocytic Leukemia to Arsenic Trioxide

Saravanan Ganesan, MSc, Vairavan Lakshmanan, B.Tech, Hamenth Kumar Palani, MSc, Nithya Balasundaram, MSc, Ansu Abu Alex, MSc, Sachin David, MSc, Anu Korula, MD DM, Biju George, MD DM, Poonkuzhali Balasubramanian, MSc PhD, Harsha Gowda, PhD, Neha Vyas, PhD, Dasaradhi Palakodeti, PhD, Vikram Mathews, MD DM

Blood (2016) 128 (22): 5125.

https://doi.org/10.1182/blood.V128.22.5125.5125

Published: 2016

Journal Articles

Management of Relapsed Acute Promyelocytic Leukemia Post ATO Upfront Therapy: Open-Labeled Phase II Study Evaluating Role of Proteasome Inhibition

Vikram Mathews, MD DM, Anu Korula, MD DM, Uday Kulkarni, MD, Saravanan Ganesan, MSc, Sachin David, MSc, Ansu Abu Alex, MSc, Nisham PN, MD DM, Aby Abraham, MD DM, Alok Srivastava, Kavitha M Lakshmi, MSc, Poonkuzhali Balasubramanian, MSc PhD, Biju George, MD DM

Blood (2016) 128 (22): 446.

https://doi.org/10.1182/blood.V128.22.446.446

Published: 2016

Journal Articles

Arsenic Trioxide Resistance: More to It Than Mutations in PML-RARα

Ansu Abu Alex, MSc, Ezhilarasi Chendamarai, PhD, Saravanan Ganesan, MSc, Nithya Balasundaram, MSc, Hamenth Kumar Palani, MSc, Sachin David, MSc, Vikram Mathews, MD

Blood (2014) 124 (21): 3605.

https://doi.org/10.1182/blood.V124.21.3605.3605

Published: 2014

Journal Articles

Proteasome Activity Is Dispensable for the Degradation of PML-RARα: Efficacy of Bortezomib Along with Arsenic Trioxide in the Treatment of Arsenic Sensitive and Resistant Acute Promyelocytic Leukemia

Saravanan Ganesan, MSc, Ansu Abu Alex, MSc, Ezhilarasi Chendamarai, PhD, Nithya Balasundaram, MSc, Hamenth Kumar Palani, MSc, Sachin David, MSc, Jayandharan G Rao, PhD, Aby Abraham, MD, Auro Viswabandya, MD, Biju George, MD, Alok Srivastava, MD, Poonkuzhali Balasubramanian, PhD, Rose Ann Padua, PhD, Christine Chomienne, MD PhD, Vikram Mathews, MD

Blood (2014) 124 (21): 3741.

https://doi.org/10.1182/blood.V124.21.3741.3741

Published: 2014

Journal Articles

NK Cell Mediated Cytotoxicity Against Malignant Promyelocytes Enhanced By Arsenic Trioxide: Potential Clinical Relevance

Ansu Abu Alex, MSc, Hamenth Kumar P, MSc, Saravanan Ganesan, MSc, Nithya Balasundaram, MSc, Kavitha M Lakshmi, MSc, Biju George, MD, Aby Abraham, MD, Auro Viswabandya, MD, Alok Srivastava, MD, Rose Ann Padua, PhD, Christine Chomienne, MD, PhD, Poonkuzhali Balasubramanian, Ph.D, Vikram Mathews, MD

Blood (2013) 122 (21): 1455.

https://doi.org/10.1182/blood.V122.21.1455.1455

Published: 2013

Journal Articles

Clinical, Cellular and Molecular Differences Between Newly Diagnosed and Relapsed Patients with Acute Promyelocytic Leukemia: Insights Into Mechanisms of Resistance

Ezhilarasi Chendamarai, Ansu Abu Alex, MSc, Saravanan Ganesan, MSc, Vandana Kamath, MD, Sukesh C Nair, MD, Nancy Beryl Janet, MSc, Vivi M Srivastava, MD, Kavitha M Lakshmi, MSc, Poonkuzhali Balasubramanian, Ph.D, Rayaz Ahmed, MD, Aby Abraham, MD, Auro Viswabandya, MD, Biju George, MD, Alok Srivastava, MD, Vikram Mathews

Blood (2012) 120 (21): 1390.

https://doi.org/10.1182/blood.V120.21.1390.1390

Published: 2012

Journal Articles

Patterns of Immune Reconstitution in Patients with Acute Promyelocytic Leukemia Treated with Single Agent Arsenic Trioxide and Its Impact On Time to Molecular Remission

Ansu Abu Alex, MSc, Saravanan Ganesan, MSc, Poonkuzhali Balasubramanian, Ph.D, Rayaz Ahmed, MD, Aby Abraham, MD, Auro Viswabandya, MD, Biju George, MD, Ezhilarasi Chendamarai, Alok Srivastava, MD, Vikram Mathews

Blood (2012) 120 (21): 3552.

https://doi.org/10.1182/blood.V120.21.3552.3552

Published: 2012

Journal Articles

Community Based Evaluation of Prevalence of Inhibitors in Patients with Severe Hemophilia A in India and Their Correlation with Environmental and Genetic Factors

Sachin David, MSc, Vikram Mathews, Shashikant Apte, MD, Giridhara R Jayandharan, Ph.D, Sukesh C Nair, MD, Dolly Daniel, MD, Suresh Kumar, MSc, Ansu Abu Alex, MSc, Saravanan Ganesan, MSc, Kannan Subramanian, MD, Rayaz Ahmed, MD, Aby Abraham, MD, Auro Viswabandya, MD, Biju George, MD, Alok Srivastava, MD

Blood (2012) 120 (21): 3380.

https://doi.org/10.1182/blood.V120.21.3380.3380

Published: 2012

Journal Articles

Comprehensive Profiling of Somatic Mutations Which Define Primary Disease and Relapse in Various Acute Leukemia Subtypes

Blood (2012) 120 (21): 783.

https://doi.org/10.1182/blood.V120.21.783.783

Published: 2012

Journal Articles

Mechanism of Synergy Between Bortezomib and Arsenic Trioxide in Acute Promyelocytic Leukemia and Clinical Efficacy in Relapsed Patients

Saravanan Ganesan, MSc, Ezhilarasi Chendamarai, Ansu Abu Alex, MSc, Sachin David, MSc, Giridhara R Jayandharan, Ph.D, Poonkuzhali Balasubramanian, Ph.D, Rayaz Ahmed, MD, Aby Abraham, MD, Auro Viswabandya, MD, Biju George, MD, Alok Srivastava, MD, Vikram Mathews

Blood (2012) 120 (21): 3607.

https://doi.org/10.1182/blood.V120.21.3607.3607

Published: 2012

Journal Articles

Role of minimal residual disease monitoring in acute promyelocytic leukemia treated with arsenic trioxide in frontline therapy

Ezhilarasi Chendamarai, Poonkuzhali Balasubramanian, Biju George, Auro Viswabandya, Aby Abraham, Rayaz Ahmed, Ansu Abu Alex, Saravanan Ganesan, Kavitha M. Lakshmi, Usha Sitaram, Sukesh Chandran Nair, Mammen Chandy, Nancy Beryl Janet, Vivi M. Srivastava, Alok Srivastava, Vikram Mathews

Blood (2012) 119 (15): 3413–3419.

https://doi.org/10.1182/blood-2011-11-393264

Published: 2012

Includes: Supplemental data

NARROW

Genotype-Phenotype Mapping Via Single-Cell Multi-Omics Identifies Therapeutic Vulnerabilities in Vexas Syndrome

JAK Inhibition Mediates Clonal Selection of RAS Pathway Mutations in Myeloproliferative Neoplasms

Comprehensive Analysis of Mesenchymal Cells from Myeloproliferative Neoplasm (MPN) Patients Reveals the Role of HOXB7 in Myelofibrosis Induction

Targeting Extracellular Vesicle Secretion As a Strategy to Overcome Microenvironment Mediated Drug Resistance in Acute Myeloid Leukemia

Bone Marrow Stromal Cell Mediated Drug Resistance in AML Cells: Role of Extracellular Vesicles and AKT Signaling

Stromal-Cells Downregulate MiR-23a-5p Levels in Myeloid Leukemic Cells to Activate Protective-Autophagy Against Chemotherapeutic Agents

Fate of Ikaros in Multiple Myeloma Cells upon Treatment with Lenalidomide and Proteasome Inhibitor

Metabolic Rewiring Drives Resistance to Arsenic Trioxide in Acute Promyelocytic Leukemia

Osteoblast Differentiation of Stromal Cells Induced By Leukemic Cells

Role of miRNA in Micro-Environment Mediated Drug Resistance in Acute Promyelocytic Leukemia to Arsenic Trioxide

Management of Relapsed Acute Promyelocytic Leukemia Post ATO Upfront Therapy: Open-Labeled Phase II Study Evaluating Role of Proteasome Inhibition

Arsenic Trioxide Resistance: More to It Than Mutations in PML-RARα

Proteasome Activity Is Dispensable for the Degradation of PML-RARα: Efficacy of Bortezomib Along with Arsenic Trioxide in the Treatment of Arsenic Sensitive and Resistant Acute Promyelocytic Leukemia

NK Cell Mediated Cytotoxicity Against Malignant Promyelocytes Enhanced By Arsenic Trioxide: Potential Clinical Relevance

Clinical, Cellular and Molecular Differences Between Newly Diagnosed and Relapsed Patients with Acute Promyelocytic Leukemia: Insights Into Mechanisms of Resistance

Patterns of Immune Reconstitution in Patients with Acute Promyelocytic Leukemia Treated with Single Agent Arsenic Trioxide and Its Impact On Time to Molecular Remission

Community Based Evaluation of Prevalence of Inhibitors in Patients with Severe Hemophilia A in India and Their Correlation with Environmental and Genetic Factors

Comprehensive Profiling of Somatic Mutations Which Define Primary Disease and Relapse in Various Acute Leukemia Subtypes

Mechanism of Synergy Between Bortezomib and Arsenic Trioxide in Acute Promyelocytic Leukemia and Clinical Efficacy in Relapsed Patients

Role of minimal residual disease monitoring in acute promyelocytic leukemia treated with arsenic trioxide in frontline therapy

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American Society of Hematology

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