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Journal Articles

BCL2 Splice Isoform Switching Promotes Leukemia Stem Cell Survival and Sensitivity to a Novel Pan BCL2 Inhibitor

Blood (2011) 118 (21): 2735.

https://doi.org/10.1182/blood.V118.21.2735.2735

Published: 2011

Journal Articles

Increased Incidence of Therapy Related Myeloid Neoplasia (t-MN) After Initial Therapy for CLL with Fludarabine-Cyclophosphamide (FC) Vs Fludarabine (F): Long-Term Follow-up of US Intergroup Study E2997

Blood (2010) 116 (21): 924.

https://doi.org/10.1182/blood.V116.21.924.924

Published: 2010

Journal Articles

Comparison of in Vitro Apoptotic Response of Chronic Lymphocytic Leukemia (CLL) Cells to Bcl-2 Antagonist ABT-737 and IAP Antagonist BV6.

Shinichi Kitada, MD, PhD, Ryuji Yamaguchi, Ph.D., Laura Z. Rassenti, PhD, Thomas J. Kipps, MD, PhD, John C. Reed, MD, PhD

Blood (2009) 114 (22): 4386.

https://doi.org/10.1182/blood.V114.22.4386.4386

Published: 2009

Journal Articles

Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2–transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048)

Shinichi Kitada, Christina L. Kress, Maryla Krajewska, Lee Jia, Maurizio Pellecchia, John C. Reed

Blood (2008) 111 (6): 3211–3219.

https://doi.org/10.1182/blood-2007-09-113647

Published: 2008

Includes: Supplemental data

Journal Articles

A Novel Peptide Containing a Nine Amino Acid Sequence from Nur77 Induces Bcl-2-Dependent Apoptosis in AML.

Michael Andreeff, MD, PhD, Marina Konopleva, M.D., Ph.D., Julie C. Watt, Ismael J. Samudio, Ph.D., Arnold C. Satterthwait, Ph.D., Shinichi Kitada, M.D., Ph.D., Xiao-kun Zhang, Ph.D., John C. Reed, M.D., Ph.D.

Blood (2006) 108 (11): 2607.

https://doi.org/10.1182/blood.V108.11.2607.2607

Published: 2006

Journal Articles

Exploiting the Tr3 Interaction with Bcl-2 as a Novel Therapeutic Strategy of Cancer and Leukemia Therapy.

Dayong Zhai, PhD, Eduard Sergienko, Ph.D., Shinichi Kitada, M.D., Ph.D., Frederic Luciano, Ph.D., Arnold C. Satterswait, Ph.D., Xiaokun Zhang, B.S., John C. Reed, M.D., Ph.D.

Blood (2006) 108 (11): 256.

https://doi.org/10.1182/blood.V108.11.256.256

Published: 2006

Journal Articles

Bcl-2 Antagonist ApoGossypol (NSC736630) Displays Single-Agent Activity in Bcl-2 Transgenic Mice and Has Superior Efficacy and Pharmacology with Less Toxicity Compared to Gossypol (NSC19048).

Shinichi Kitada, MD, PhD, Lee Jia, Ph.D., Lori C. Coward, Ph.D., Greg S. Gorman, Ph.D., Patricia Noker, Ph.D., Maurizio Pellecchia, Ph.D., John C. Reed, M.D., Ph.D.

Blood (2006) 108 (11): 2487.

https://doi.org/10.1182/blood.V108.11.2487.2487

Published: 2006

Journal Articles

R-(−)-Gossypol (AT101) Binds to Bcl-2 Family Proteins and Induces Apoptosis in CLL.

Carlos E. Prada, MD, Januario E. Castro, MD, Dayong Zhai, PhD, Shinichi Kitada, MD, PhD, John C. Reed, MD, PhD, Thomas J. Kipps, MD, PhD

Blood (2005) 106 (11): 2978.

https://doi.org/10.1182/blood.V106.11.2978.2978

Published: 2005

Journal Articles

Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1α

Mitsufumi Nishio, Tomoyuki Endo, Nobuhiro Tsukada, Junko Ohata, Shinichi Kitada, John C. Reed, Nathan J. Zvaifler, Thomas J. Kipps

Blood (2005) 106 (3): 1012–1020.

https://doi.org/10.1182/blood-2004-03-0889

Published: 2005

Journal Articles

The Histone Deacetylase Inhibitor Depsipeptide Mediates Distinct Patterns of Histone Acetylation in Cells Overexpressing Bcl-2.

David M. Lucas, PhD, Liwen Zhang, PhD, Melanie E. Davis, PhD, Xiaodan Su, Amy Sklenar, Mark R. Parthun, PhD, Michael A. Freitas, PhD, Shinichi Kitada, PhD, John C. Reed, MD, PhD, Guido Marcucci, MD, Michael R. Grever, MD, John C. Byrd, MD

Blood (2004) 104 (11): 2802.

https://doi.org/10.1182/blood.V104.11.2802.2802

Published: 2004

Journal Articles

Anti-CD20 Antibody Rituximab and Anti-CD23 Antibody IDEC-152 Induce Apoptosis of Malignant B-Cells in Combination with Chemical Antagonists of XIAP.

Massimo Mangiola, Ph.D, Kate Welsh, Ph.D, Shinichi Kitada, MD, Ph.D., Irene M. Pedersen, Ph.D., Nuzhat Pathan, Ph.D., Clementia Pinilla, Ph.D., Thomas J. Kipps, MD, Ph. D, John C. Reed, MD, Ph.D

Blood (2004) 104 (11): 1401.

https://doi.org/10.1182/blood.V104.11.1401.1401

Published: 2004

Journal Articles

Pro-Apoptotic Effects on CLL (Chronic Lymphocytic Leukemia) of ABT-737, a Novel Fully Synthetic Bcl-2/Bcl-XL Antagonist.

Shinichi Kitada, M.D., Ph.D., Edward Monosov, Ph.D., Sharon Chandler, Ph.D., Esther D. Avery, B.S., Thomas J. Kipps, M.D., Ph.D., Saul H. Rosenberg, Ph.D., John C. Reed, M.D., Ph.D.

Blood (2004) 104 (11): 952.

https://doi.org/10.1182/blood.V104.11.952.952

Published: 2004

Journal Articles

Critical Molecular Studies to Strategically Plan Therapy in Chronic Lymphocytic Leukemia (CLL): Correlating Cellular Proteins with Defined Prognostic Patient Subsets and Their Response to Treatment.

Shinichi Kitada, PhD, John C. Reed, MD PhD, David M. Lucas, PhD, Donna S. Neuberg, PhD, John G. Gribben, MD, Gordon W. Dewald, PhD, Ian W. Flinn, MD PhD, Martin S. Tallman, MD, John C. Byrd, MD, Michael R. Grever, MD

Blood (2004) 104 (11): 956.

https://doi.org/10.1182/blood.V104.11.956.956

Published: 2004

Journal Articles

BAFF Support Survival of Chronic Lymphocytic Leukemia B Cells by a Pathway Independent of Stromal Derived Factor-1α.

Mitsufumi Nishio, MD, PhD, Nobuhiro Tsukada, MD, PhD, Shinichi Kitada, MD, PhD, Junko Ohata, MD, PhD, Nathan J. Zvaifler, MD, John C. Reed, MD, PhD, Thomas J. Kipps, MD, PhD

Blood (2004) 104 (11): 1908.

https://doi.org/10.1182/blood.V104.11.1908.1908

Published: 2004

Journal Articles

Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8–mediated apoptosis and down-regulation of c-FLIP protein

Jennifer L. Aron, Mark R. Parthun, Guido Marcucci, Shinichi Kitada, Andrew P. Mone, Melanie E. Davis, Tiansheng Shen, Timothy Murphy, Joseph Wickham, Chris Kanakry, David M. Lucas, John C. Reed, Michael R. Grever, John C. Byrd

Blood (2003) 102 (2): 652–658.

https://doi.org/10.1182/blood-2002-12-3794

Published: 2003

Journal Articles

The triterpenoid CDDO induces apoptosis in refractory CLL B cells

Irene M. Pedersen, Shinichi Kitada, Aaron Schimmer, Youngsoo Kim, Juan M. Zapata, Lula Charboneau, Laura Rassenti, Michael Andreeff, Frank Bennett, Michael B. Sporn, Lance D. Liotta, Thomas J. Kipps, John C. Reed

Blood (2002) 100 (8): 2965–2972.

https://doi.org/10.1182/blood-2002-04-1174

Published: 2002

Journal Articles

Protection of CLL B cells by a follicular dendritic cell line is dependent on induction of Mcl-1

Irene M. Pedersen, Shinichi Kitada, Lorenzo M. Leoni, Juan M. Zapata, James G. Karras, Nobuhiro Tsukada, Thomas J. Kipps, Yong Sung Choi, Frank Bennett, John C. Reed

Blood (2002) 100 (5): 1795–1801.

https://doi.org/10.1182/blood.V100.5.1795.h81702001795_1795_1801

Published: 2002

Journal Articles

The mechanism of tumor cell clearance by rituximab in vivo in patients with B-cell chronic lymphocytic leukemia: evidence of caspase activation and apoptosis induction

John C. Byrd, Shinichi Kitada, Ian W. Flinn, Jennifer L. Aron, Michael Pearson, David Lucas, John C. Reed

Blood (2002) 99 (3): 1038–1043.

https://doi.org/10.1182/blood.V99.3.1038

Published: 2002

Journal Articles

Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia

Shinichi Kitada, Juan M. Zapata, Michael Andreeff, John C. Reed

Blood (2000) 96 (2): 393–397.

https://doi.org/10.1182/blood.V96.2.393

Published: 2000

Journal Articles

Expression of Apoptosis-Regulating Proteins in Chronic Lymphocytic Leukemia: Correlations With In Vitro and In Vivo Chemoresponses

Shinichi Kitada, Janet Andersen, Sophie Akar, Juan M. Zapata, Shinichi Takayama, Stanislaw Krajewski, Hong-Gang Wang, Xin Zhang, Florencia Bullrich, Carlo M. Croce, Kanti Rai, John Hines, John C. Reed

Blood (1998) 91 (9): 3379–3389.

https://doi.org/10.1182/blood.V91.9.3379

Published: 1998

NARROW

BCL2 Splice Isoform Switching Promotes Leukemia Stem Cell Survival and Sensitivity to a Novel Pan BCL2 Inhibitor

Increased Incidence of Therapy Related Myeloid Neoplasia (t-MN) After Initial Therapy for CLL with Fludarabine-Cyclophosphamide (FC) Vs Fludarabine (F): Long-Term Follow-up of US Intergroup Study E2997

Comparison of in Vitro Apoptotic Response of Chronic Lymphocytic Leukemia (CLL) Cells to Bcl-2 Antagonist ABT-737 and IAP Antagonist BV6.

Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2–transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048)

A Novel Peptide Containing a Nine Amino Acid Sequence from Nur77 Induces Bcl-2-Dependent Apoptosis in AML.

Exploiting the Tr3 Interaction with Bcl-2 as a Novel Therapeutic Strategy of Cancer and Leukemia Therapy.

Bcl-2 Antagonist ApoGossypol (NSC736630) Displays Single-Agent Activity in Bcl-2 Transgenic Mice and Has Superior Efficacy and Pharmacology with Less Toxicity Compared to Gossypol (NSC19048).

R-(−)-Gossypol (AT101) Binds to Bcl-2 Family Proteins and Induces Apoptosis in CLL.

Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1α

The Histone Deacetylase Inhibitor Depsipeptide Mediates Distinct Patterns of Histone Acetylation in Cells Overexpressing Bcl-2.

Anti-CD20 Antibody Rituximab and Anti-CD23 Antibody IDEC-152 Induce Apoptosis of Malignant B-Cells in Combination with Chemical Antagonists of XIAP.

Pro-Apoptotic Effects on CLL (Chronic Lymphocytic Leukemia) of ABT-737, a Novel Fully Synthetic Bcl-2/Bcl-XL Antagonist.

Critical Molecular Studies to Strategically Plan Therapy in Chronic Lymphocytic Leukemia (CLL): Correlating Cellular Proteins with Defined Prognostic Patient Subsets and Their Response to Treatment.

BAFF Support Survival of Chronic Lymphocytic Leukemia B Cells by a Pathway Independent of Stromal Derived Factor-1α.

Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8–mediated apoptosis and down-regulation of c-FLIP protein

The triterpenoid CDDO induces apoptosis in refractory CLL B cells

Protection of CLL B cells by a follicular dendritic cell line is dependent on induction of Mcl-1

The mechanism of tumor cell clearance by rituximab in vivo in patients with B-cell chronic lymphocytic leukemia: evidence of caspase activation and apoptosis induction

Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia

Expression of Apoptosis-Regulating Proteins in Chronic Lymphocytic Leukemia: Correlations With In Vitro and In Vivo Chemoresponses

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American Society of Hematology

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American Society of Hematology

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