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Shinji Tsutsumi
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Journal Articles

Valemetostat for Relapsed or Refractory Peripheral T-Cell Lymphomas: Primary Results from a Phase 1 Trial

Eric Jacobsen, Dai Maruyama, Pierluigi Porcu, Kensei Tobinai, Pamela B. Allen, Kenji Ishitsuka, Kunihiro Tsukasaki, Shigeru Kusumoto, Francine M. Foss, Nobuhiko Yamauchi, Satoko Morishima, Yoshitaka Imaizumi, Koji Izutsu, Tatyana Feldman, Toyotaka Kawamata, Yasuyuki Kakurai, Hideyuki Yamauchi, Noha Biserna, Ai Inoue, Shinji Tsutsumi, Steven M. Horwitz
Journal: Blood
Blood (2023) 142 (Supplement 1): 303.
https://doi.org/10.1182/blood-2023-172512
Published: 2023
Journal Articles

PRC2-Mediated Apoptosis Evasion Is a Therapeutic Target of MDS/AML Harboring Inv(3)/t(3;3) and -7

Hiroyoshi Kunimoto, Ayaka Miura, Maiko Sagisaka, Mieko Ito, Daisuke Honma, Shinji Tsutsumi, Takayuki Sakuma, Takuma Ohashi, Hiroshi Teranaka, Junji Ikeda, Takashi Toya, Yuka Harada, Noriko Doki, Sheng F. Cai, Akihide Yoshimi, Hiroaki Goto, Ross L Levine, Hideaki Nakajima
Journal: Blood
Blood (2023) 142 (Supplement 1): 2803.
https://doi.org/10.1182/blood-2023-178436
Published: 2023
Journal Articles

Valemetostat for Relapsed or Refractory B-Cell Lymphomas: Primary Results from a Phase 1 Trial

Koji Izutsu, Kenji Ishitsuka, Dai Maruyama, Kunihiro Tsukasaki, Shigeru Kusumoto, Yasuyuki Kakurai, Hideyuki Yamauchi, Ai Inoue, Masaya Tachibana, Shinji Tsutsumi, Kensei Tobinai
Journal: Blood
Blood (2023) 142 (Supplement 1): 1731.
https://doi.org/10.1182/blood-2023-179301
Published: 2023
Journal Articles

Durable Clinical Impacts and Mechanisms of Action and Resistance in EZH1/2-Targeting Epigenetic Therapy

Makoto Yamagishi, Yuta Kuze, Makoto Nakashima, Seiichiro Kobayashi, Satoko Morishima, Toyotaka Kawamata, Junya Makiyama, Kazumi Abe, Kiyomi Imamura, Eri Watanabe, Kazumi Tsuchiya, Isao Yasumatsu, Gensuke Takayama, Kazumi Ito, Yasuhito Nannya, Arinobu Tojo, Toshiki Watanabe, Shinji Tsutsumi, Yutaka Suzuki, Kaoru Uchimaru
Journal: Blood
Blood (2022) 140 (Supplement 1): 756–757.
https://doi.org/10.1182/blood-2022-159275
Published: 2022
Journal Articles

Highly Sensitive Detection Method Reveals Significant Anti-Tumor Activity of Valemetostat in Patients with Relapsed/Refractory Adult T Cell Leukemia

Gensuke Takayama, Yoshiyuki Hizukuri, Tomoyuki Fujioka, Kazuyuki Hashimoto, Kazumi Ito, Hironori Yamada, Makoto Yamagishi, Makoto Nakashima, Yutaka Suzuki, Yasuhito Nannya, Kaoru Uchimaru, Shinji Tsutsumi
Journal: Blood
Blood (2022) 140 (Supplement 1): 9304–9305.
https://doi.org/10.1182/blood-2022-165922
Published: 2022
Journal Articles

Targeting EZH1/2 to Restore Chemosensitivity in Dormant Myeloid Leukemia Stem Cells

Kyung Hee Chang, Mahesh Basyal, Zoe Alaniz, Daisuke Honma, Shinji Tsutsumi, Cedric E. Dos Santos, Naval Daver, Michael Andreeff
Journal: Blood
Blood (2021) 138 (Supplement 1): 2943.
https://doi.org/10.1182/blood-2021-152884
Published: 2021
Journal Articles

Anti-Tumor Effect of the EZH1/2 Dual Inhibitor Valemetostat Against Diffuse Large B-Cell Lymphoma Via Modulation of B-Cell Receptor Signaling and c-Myc Signaling Pathways

Yasuhiro Hama, PhD, Toshihiro Banjo, PhD, Daisuke Honma, PhD, Yoshimi Takata, Emi Nosaka, Machiko Shiroishi, Kenji Watanabe, Yuka Yamamoto, Tsuyoshi Hirata, Rika Nakano, Koichiro Inaki, PhD, Hiroki Goto, PhD, Yusuke Totoki, PhD, Miki Kataoka, Kyungtaek Lim, PhD, Chisa Wada, Eiji Kumazawa, PhD, Shinji Tsutsumi, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4642.
https://doi.org/10.1182/blood-2019-125436
Published: 2019