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Journal Articles

Final Analysis of the Randomized Phase II/III Study of Standard R-CHOP Versus CHOP Combined with Dose-Dense Weekly Rituximab for DLBCL: JCOG0601

Ken Ohmachi, Tomohiro Kinoshita, Dai Maruyama, Gakuto Ogawa, Yusuke Sano, Nobuhiko Yamauchi, Noriko Fukuhara, Toshiki Uchida, Kazuhito Yamamoto, Kana Miyazaki, Norifumi Tsukamoto, Shinsuke Iida, Isao Yoshida, Yasuhiro Suzuki, Yasufumi Masaki, Tohru Murayama, Yoshihiro Yakushijin, Youko Suehiro, Kisato Nosaka, Nobuaki Dobashi, Junya Kuroda, Wataru Munakata, Kiyoshi Ando, Kenichi Ishizawa, Michinori Ogura, Tadashi Yoshino, Tomomitsu Hotta, Kunihiro Tsukasaki, Kensei Tobinai, Hirokazu Nagai
Journal: Blood
Blood (2023) 142 (Supplement 1): 1724.
https://doi.org/10.1182/blood-2023-178551
Published: 2023
Journal Articles

Valemetostat for Relapsed or Refractory B-Cell Lymphomas: Primary Results from a Phase 1 Trial

Koji Izutsu, Kenji Ishitsuka, Dai Maruyama, Kunihiro Tsukasaki, Shigeru Kusumoto, Yasuyuki Kakurai, Hideyuki Yamauchi, Ai Inoue, Masaya Tachibana, Shinji Tsutsumi, Kensei Tobinai
Journal: Blood
Blood (2023) 142 (Supplement 1): 1731.
https://doi.org/10.1182/blood-2023-179301
Published: 2023
Journal Articles

Valemetostat for Relapsed or Refractory Peripheral T-Cell Lymphomas: Primary Results from a Phase 1 Trial

Eric Jacobsen, Dai Maruyama, Pierluigi Porcu, Kensei Tobinai, Pamela B. Allen, Kenji Ishitsuka, Kunihiro Tsukasaki, Shigeru Kusumoto, Francine M. Foss, Nobuhiko Yamauchi, Satoko Morishima, Yoshitaka Imaizumi, Koji Izutsu, Tatyana Feldman, Toyotaka Kawamata, Yasuyuki Kakurai, Hideyuki Yamauchi, Noha Biserna, Ai Inoue, Shinji Tsutsumi, Steven M. Horwitz
Journal: Blood
Blood (2023) 142 (Supplement 1): 303.
https://doi.org/10.1182/blood-2023-172512
Published: 2023
Journal Articles

Impact of Mogamulizumab-Containing Chemotherapy on HBV Reactivation in Patients with T-Cell Lymphoma: A Multicenter Retrospective Observational Study (PROACTIVE-MOGA)

Kisato Nosaka, Shigeru Kusumoto, Yoshitaka Imaizumi, Hiroya Hashimoto, Junya Makiyama, Makoto Yoshimitsu, Takeharu Kato, Hidenori Sasaki, Youko Suehiro, Ki-Ryang Koh, Toyotaka Kawamata, Toshikazu Miyakawa, Yoshifusa Takatsuka, Takayuki Sato, Yuko Shirouchi, Koji Kato, Koji Izutsu, Tohru Murayama, Takehiro Higashi, Hiromi Iwasaki, Satoru Kosugi, Hitoji Uchiyama, Kunihiro Tsukasaki, Yusuke Yamashita, Fumiya Ogasawara, Emiko Sakaida, Takero Shindo, Kimikazu Yakushijin, Keiichi Akizuki, Ken-ichiro Etoh, Noriaki Kawano, Tetsuyuki Igarashi, Noriko Fukuhara, Nobuhiko Nakamura, Isao Yoshida, Nobuaki Nakano, Tomoharu Yoshizumi, Masashi Mizokami
Journal: Blood
Blood (2023) 142 (Supplement 1): 6192.
https://doi.org/10.1182/blood-2023-185878
Published: 2023
Journal Articles

An open-label, single-arm phase 2 trial of valemetostat for relapsed or refractory adult T-cell leukemia/lymphoma

Clinical Trials & Observations
Koji Izutsu, Shinichi Makita, Kisato Nosaka, Makoto Yoshimitsu, Atae Utsunomiya, Shigeru Kusumoto, Satoko Morishima, Kunihiro Tsukasaki, Toyotaka Kawamata, Takaaki Ono, Shinya Rai, Hiroo Katsuya, Jun Ishikawa, Hironori Yamada, Kazunobu Kato, Masaya Tachibana, Yasuyuki Kakurai, Nobuaki Adachi, Kensei Tobinai, Kentaro Yonekura, Kenji Ishitsuka
Journal: Blood
Blood (2023) 141 (10): 1159–1168.
https://doi.org/10.1182/blood.2022016862
Published: 2023
Includes: Supplemental data
Journal Articles

Oral Azacytidine in Patients with Relapsed/Refractory Angioimmunoblastic T-Cell Lymphoma: Final Analysis of the Oracle Phase III Study

Jehan Dupuis, Kunihiro Tsukasaki, Emmanuel Bachy, Franck Morschhauser, Guillaume Cartron, Noriko Fukuhara, Nicolas Daguindau, René-Olivier Casasnovas, Sylvia Snauwaert, Rémy Gressin, Christopher P. Fox, Francesco Annibale d'Amore, Philipp B. Staber, Argyrios Gkasiamis, Mitsufumi Nishio, Luc-Matthieu Fornecker, Marie-Helene Delfau, Nouhoum Sako, Sebastien Mule, Laurence De Leval, Philippe Gaulard, Francois Lemonnier
Journal: Blood
Blood (2022) 140 (Supplement 1): 2310–2312.
https://doi.org/10.1182/blood-2022-156789
Published: 2022
Journal Articles

Final Analysis of JCOG0203 for Advanced-Stage Indolent B-Cell Lymphoma 15 Years after the End of Enrollment: Pooled Analysis of Arms a and B for Follicular Lymphoma

Takashi Watanabe, Kensei Tobinai, Ｍasashi Wakabayashi, Dai Maruyama, Kazuhito Yamamoto, Nobuko Kubota, Kazuyuki Shimada, Kohsuke Asagoe, Motoko Yamaguchi, Kiyoshi Ando, Michinori Ogura, Junya Kuroda, Youko Suehiro, Yoshihiro Matsuno, Kunihiro Tsukasaki, Hirokazu Nagai
Journal: Blood
Blood (2022) 140 (Supplement 1): 3615–3617.
https://doi.org/10.1182/blood-2022-159967
Published: 2022
Journal Articles

Interim PET-Guided ABVD or ABVD/Escalated BEACOPP for Newly Diagnosed Advanced-Stage Classic Hodgkin Lymphoma (JCOG1305, INNOVATE-HL study)

Shigeru Kusumoto, Wataru Munakata, Ryunosuke Machida, Takashi Terauchi, Hiroaki Onaya, Masahiko Oguchi, Shinsuke Iida, Kisato Nosaka, Yasuhiro Suzuki, Yasuhiko Harada, Kana Miyazaki, Masaki Maruta, Noriko Fukuhara, Tomomi Toubai, Nobuko Kubota, Ken Ohmachi, Kazuhito Yamamoto, Takahiro Kumode, Ishikazu Mizuno, Takayuki Tabayashi, Hideki Tsujimura, Nobuyuki Takayama, Kohsuke Asagoe, Isao Yoshida, Yasushi Takamatsu, Suguru Fukuhara, Mai Takeuchi, Ukihide Tateishi, Dai Maruyama, Kunihiro Tsukasaki, Hirokazu Nagai
Journal: Blood
Blood (2022) 140 (Supplement 1): 3718–3720.
https://doi.org/10.1182/blood-2022-157006
Published: 2022
Journal Articles

Circulating miRNA Profiling of Plasma Samples from Patients with Newly Diagnosed Multiple Myeloma; A Biomarker Study to Predict the Response and Toxicity of Bortezomib-Containing Regimen: An Ancillary Study of JCOG1105 (JCOG1105A1)

Masaki Ri, Shimon Nakashima, Miki Nakajima, Shinsuke Iida, Dai Maruyama, Satoshi Osaga, Kensei Tobinai, Noriko Fukuhara, Kana Miyazaki, Norifumi Tsukamoto, Hideki Tsujimura, Makoto Yoshimitsu, Kenichi Miyamoto, Kunihiro Tsukasaki, Hirokazu Nagai
Journal: Blood
Blood (2022) 140 (Supplement 1): 12647–12649.
https://doi.org/10.1182/blood-2022-156875
Published: 2022
Journal Articles

Pivotal Phase 2 Study of the EZH1 and EZH2 Inhibitor Valemetostat Tosylate (DS-3201b) in Patients with Relapsed or Refractory Adult T-Cell Leukemia/Lymphoma

Makoto Yoshimitsu, Koji Izutsu, Shinichi Makita, Kisato Nosaka, Atae Utsunomiya, Shigeru Kusumoto, Satoko Morishima, Kunihiro Tsukasaki, Toyotaka Kawamata, Takaaki Ono, Shinya Rai, Hiroo Katsuya, Jun Ishikawa, Hironori Yamada, Kazunobu Kato, Masaya Tachibana, Yasuyuki Kakurai, Nobuaki Adachi, Kensei Tobinai, Kentaro Yonekura, Kenji Ishitsuka
Journal: Blood
Blood (2021) 138 (Supplement 1): 303.
https://doi.org/10.1182/blood-2021-146657
Published: 2021
Journal Articles

The Echelon-2 Trial: 5-Year Results of a Randomized, Double-Blind, Phase 3 Study of Brentuximab Vedotin and CHP (A+CHP) Versus CHOP in Frontline Treatment of Patients with CD30-Positive Peripheral T-Cell Lymphoma

Steven M. Horwitz, MD, Owen A. O'Connor, MD, Barbara Pro, MD, Tim Illidge, MD PhD, Swami P. Iyer, MD, Ranjana Advani, MD, Nancy L. Bartlett, MD, Jacob Haaber Christensen, Franck Morschhauser, MD, Eva Domingo-Domenech, MD, Giuseppe Rossi, MD, Won Seog Kim, PhD, Tatyana A. Feldman, MD, Tobias Menne, MD PhD, David Belada, MD PhD, Árpád Illés, MD PhD, Kensei Tobinai, MD, Kunihiro Tsukasaki, MD PhD, Su-Peng Yeh, MD, Andrei R Shustov, MD, Andreas Hüttmann, MD, Kerry J. Savage, BSc, MD MSc, Sam Yuen, MBBS, FRACP, FRCPA, Pier Luigi Zinzani, MD, Harry Miao, MD, Veronica Bunn, PhD, Keenan Fenton, MA, Michelle A. Fanale, MD, Markus Puhlmann, MD, Lorenz Truemper, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 3–5.
https://doi.org/10.1182/blood-2020-134398
Published: 2020
Journal Articles

Favorable Outcomes of Newly Diagnosed Intravascular Large B-Cell Lymphoma Patients Treated with R-CHOP Combined with High-Dose Methotrexate Plus Intrathecal Chemotherapy: Results from a Multicenter Phase 2 Trial (PRIMEUR-IVL)

Kazuyuki Shimada, MD, Motoko Yamaguchi, MD PhD, Yoshiko Atsuta, MD PhD, Kosei Matsue, MD PhD, Keijiro Sato, MD, Shigeru Kusumoto, MD PhD, Hirokazu Nagai, MD PhD, Jun Takizawa, MD PhD, Noriko Fukuhara, MD PhD, Koji Nagafuji, MD PhD, Kana Miyazaki, MD PhD, Eiichi Ohtsuka, MD, Masataka Okamoto, MD PhD, Yasumasa Sugita, MD PhD, Toshiki Uchida, MD PhD, Satoshi Kayukawa, MD, Atsushi Wake, MD PhD, Daisuke Ennishi, MD PhD, Yukio Kondo, MD, Tohru Izumi, MD, Yoshihiro Kin, MD, Kunihiro Tsukasaki, MD PhD, Daigo Hashimoto, Masaaki Yuge, MD PhD, Atsumi Yanagisawa, Yachiyo Kuwatsuka, MD PhD, Satoko Shimada, MD, Yasufumi Masaki, MD PhD, Nozomi Niitsu, MD PhD, Hitoshi Kiyoi, MD PhD, Ritsuro Suzuki, MD PhD, Takashi Tokunaga, MD PhD, Shigeo Nakamura, MD, Tomohiro Kinoshita, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 350.
https://doi.org/10.1182/blood-2019-126798
Published: 2019
Journal Articles

First-in-Human Study of the EZH1/2 Dual Inhibitor Valemetostat in Relapsed or Refractory Non-Hodgkin Lymphoma (NHL) - Updated Results Focusing on Adult T-Cell Leukemia-Lymphoma (ATL)

Satoko Morishima, MD PhD, Kenji Ishitsuka, MD PhD, Koji Izutsu, MD PhD, Shigeru Kusumoto, MD PhD, Junya Makiyama, MD PhD, Atae Utsunomiya, MD, Kisato Nosaka, MD PhD, Takashi Ishida, MD PhD, Yoshitaka Imaizumi, MD PhD, Nobuhiko Yamauchi, MD, Kazushi Araki, DVM, PhD, Nobuaki Adachi, PhD, Tomonari Yamashita, Ryo Atsumi, PhD, Kunihiro Tsukasaki, MD PhD, Kensei Tobinai, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4025.
https://doi.org/10.1182/blood-2019-125507
Published: 2019
Journal Articles

Lipidomic Profiling of Plasma Samples in Patients with Newly Diagnosed Multiple Myeloma; A Biomarker Study for Predicting the Response and Toxicities of Melphalan, Prednisolone and Bortezomib (MPB) Regimen : An Ancillary Study of the JCOG1105 (JCOG1105A1)

Masaki Ri, Shinsuke Iida, MD PhD, Dai Maruyama, MD PhD, Kosuke Saito, Yoshiro Saito, Satoshi Osaga, Masahiro Tohkin, Naoki Miyata, Kensei Tobinai, MD PhD, Noriko Fukuhara, MD PhD, Kana Miyazaki, MD PhD, Yosuke Minami, MD PhD, Norifumi Tsukamoto, MD PhD, Hideki Tsujimura, MD PhD, Makoto Yoshimitsu, MD PhD, Kenichi Miyamoto, Kunihiro Tsukasaki, MD PhD, Hirokazu Nagai, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3156.
https://doi.org/10.1182/blood-2019-122218
Published: 2019
Journal Articles

The ECHELON-2 Trial: Results of a Randomized, Double-Blind, Active-Controlled Phase 3 Study of Brentuximab Vedotin and CHP (A+CHP) Versus CHOP in the Frontline Treatment of Patients with CD30+ Peripheral T-Cell Lymphomas

Steven M. Horwitz, MD, Owen A. O'Connor, MD, PhD, Barbara Pro, MD, Tim M. Illidge, MDPhD, Michelle A. Fanale, MD, Ranjana H Advani, MD, Nancy L. Bartlett, MD, Jacob Haaber Christensen, Franck Morschhauser, MD, Eva Domingo-Domenech, MD, Giuseppe Rossi, MD, Won Seog Kim, MD PhD, Tatyana A. Feldman, MD, Anne Lennard, MBBS,FRCP, FRCPath, David Belada, MD PhD, Árpád Illés, Kensei Tobinai, MD PhD, Kunihiro Tsukasaki, MD PhD, Su-Peng Yeh, MD, Andrei R. Shustov, MD, Andreas Hüttmann, MD, Kerry J Savage, BSc, MD MSc, Sam Yuen, Pier Luigi Zinzani, MD, Zhaowei Hua, Meredith Little, MPH, Shangbang Rao, PhD, Joseph Woolery, PharmD, Thomas Manley, MD, Lorenz Trümper, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 997.
https://doi.org/10.1182/blood-2018-99-110563
Published: 2018
Journal Articles

Randomized Phase II/III Study of Standard R-CHOP Versus CHOP Combined with Dose-Dense Weekly Rituximab (RW-CHOP) for Previously Untreated DLBCL: JCOG0601

Ken Ohmachi, MD, Tomohiro Kinoshita, MD PhD, Kensei Tobinai, MD PhD, Gakuto Ogawa, MD PhD, Tomonori Mizutani, MD PhD, Nobuhiko Yamauchi, MD, Noriko Fukuhara, MD PhD, Toshiki Uchida, MD PhD, Kazuhito Yamamoto, MD PhD, Kana Miyazaki, MD PhD, Norifumi Tsukamoto, MD PhD, Shinsuke Iida, MD PhD, Takahiko Utsumi, MD PhD, Isao Yoshida, MD PhD, Yoshitaka Imaizumi, MD, PhD, Takashi Tokunaga, MD PhD, Shinichiro Yoshida, MD PhD, Yasufumi Masaki, MD PhD, Tohru Murayama, MD PhD, Yoshihiro Yakushijin, MD PhD, Youko Suehiro, MD PhD, Kisato Nosaka, MD PhD, Nobuaki Dobashi, MD, Junya Kuroda, MD PhD, Yasushi Takamatsu, MD PhD, Dai Maruyama, MD PhD, Kiyoshi Ando, MD PhD, Kenichi Ishizawa, MD PhD, Michinori Ogura, MD PhD, Tadashi Yoshino, MD PhD, Tomomitsu Hotta, MD PhD, Kunihiro Tsukasaki, MD PhD, Hirokazu Nagai, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4194.
https://doi.org/10.1182/blood-2018-99-110201
Published: 2018
Journal Articles

DS-3201, a Potent EZH1/2 Dual Inhibitor, Demonstrates Antitumor Activity Against Non-Hodgkin Lymphoma (NHL) Regardless of EZH2 Mutation

Daisuke Honma, PhD, Emi Nosaka, Machiko Shiroishi, Yoshimi Takata, Yasuhiro Hama, Yuka Yamamoto, Nobuaki Adachi, PhD, Dai Maruyama, MD PhD, Kensei Tobinai, MD PhD, Takashi Ishida, MD PhD, Shigeru Kusumoto, MD, Kenji Ishitsuka, MD PhD, Yoshitaka Imaizumi, MD, PhD, Shogo Takeuchi, MD, Kunihiro Tsukasaki, MD PhD, Tomoyuki Fujioka, Jun Watanabe, Osamu Kanno, PhD, Eiji Kumazawa, PhD, Sumiaki Fujitani, MSc, Kazushi Araki, DVM, PhD, Kosaku Fujiwara, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2217.
https://doi.org/10.1182/blood-2018-99-113379
Published: 2018
Journal Articles

Possibility of a Risk-Adapted Treatment Strategy for Untreated Aggressive Adult T-Cell Leukemia-Lymphoma (ATL) Based on the ATL Prognostic Index: A Supplementary Analysis of the JCOG9801 Study

Kosuke Toyoda, MD, Kunihiro Tsukasaki, MD PhD, Ryunosuke Machida, Tomohiro Kadota, MD PhD, Takuya Fukushima, MD PhD, Kenji Ishitsuka, MD PhD, Dai Maruyama, MD PhD, Hirokazu Nagai, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1645.
https://doi.org/10.1182/blood-2018-99-112734
Published: 2018
Journal Articles

EZH1/2, SWI/SNF, and MLL2 Dependent Heterochromatin Formation and Abnormal Transcriptome in Hematological Malignancies

Makoto Yamagishi, PhD, Dai Fujikawa, PhD, Makoto Hori, Daisuke Honma, PhD, Nobuaki Adachi, PhD, Seiichiro Kobayashi, MD, PhD, Masako Iwanaga, MD PhD MPH, Atae Utsunomiya, MD, Seiji Okada, MD, PhD, Kunihiro Tsukasaki, MD PhD, Kensei Tobinai, MD PhD, Kazushi Araki, D.V.M., PhD, Toshiki Watanabe, MD, PhD, Kaoru Uchimaru, MD, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1200.
https://doi.org/10.1182/blood.V130.Suppl_1.1200.1200
Published: 2017
Journal Articles

First-in-Human Study of the EZH1/2 Dual Inhibitor DS-3201b in Patients with Relapsed or Refractory Non-Hodgkin Lymphomas — Preliminary Results

Dai Maruyama, MD PhD, Kensei Tobinai, MD PhD, Shinichi Makita, MD, PhD, Takashi Ishida, MD PhD, Shigeru Kusumoto, MD, Kenji Ishitsuka, MD PhD, Makoto Yoshimitsu, MD PhD, Yoshitaka Imaizumi, MD PhD, Yasushi Sawayama, MD, PhD, Shogo Takeuchi, MD, Atae Utsunomiya, MD, PhD, Kunihiro Tsukasaki, MD PhD, Sumiaki Fujitani, MSc, Kazushi Araki, D.V.M., PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4070.
https://doi.org/10.1182/blood.V130.Suppl_1.4070.4070
Published: 2017