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Journal Articles

Multiple Myeloma Pathogenesis: The Role of Junb in Bone Marrow Angiogenesis

Blood (2019) 134 (Supplement_1): 4341.

https://doi.org/10.1182/blood-2019-128854

Published: 2019

Journal Articles

Expanding on Current Definitions of Hematologic Improvement in MDS, CMML and AML: Landmark Analyses of 1301 Patients Treated with Azacitidine in the Austrian Registry of Hypomethylating Agents By the AGMT-Study Group

Blood (2019) 134 (Supplement_1): 3821.

https://doi.org/10.1182/blood-2019-128153

Published: 2019

Journal Articles

Combined Targeting of Distinct c-Myc and JunB Transcriptional Programs for Multiple Myelioma Therapy

Judith Lind, PhD, Felix Czernilofsky, Sonia Vallet, MD, Fengjuan Fan, PhD, Martin Sattler, PhD, Latifa Bakiri, Erwin F Wagner, PhD, Martin Percherstorfer, MD, Klaus Podar, MD PhD

Blood (2019) 134 (Supplement_1): 4415.

https://doi.org/10.1182/blood-2019-125202

Published: 2019

Journal Articles

The Pathophysiologic Role of JunB in Multiple Myeloma Pathogenesis: Focus on Bone Marrow Angiogenesis

Stefano Malvestiti, Fengjuan Fan, PhD, Muhammad Hasan Bashari, MD, Eugenio Morelli, MD, Sonia Vallet, MD, Martin Sattler, PhD, Latifa Bakiri, PhD, Anja Seckinger, MD, Dirk Hose, MD, Hartmut Goldschmidt, MD, Inka Zörnig, PhD, Martin Pecherstorfer, MD, Erwin Wagner, PhD, Pierfrancesco Tassone, MD, Dirk Jäger, MD, Klaus Podar, MD MSc PhD

Blood (2016) 128 (22): 2091.

https://doi.org/10.1182/blood.V128.22.2091.2091

Published: 2016

Journal Articles

The AP-1 Transcription Factor JunB Promotes Multiple Myeloma (MM) Cell Proliferation, Survival and Drug Resistance in the Bone Marrow Microenvironment

Fengjuan Fan, PhD, Sonia Vallet, MD, Martin Sattler, PhD, Giovanni Tonon, MDPhD, Muhammad Hasan Bashari, Latifa Bakiri, PhD, Hartmut Goldschmidt, MD, Erwin F. Wagner, PhD, Dirk Jaeger, MD, Klaus Podar, MD PhD

Blood (2014) 124 (21): 3446.

https://doi.org/10.1182/blood.V124.21.3446.3446

Published: 2014

Journal Articles

Increased Sclerostin Secretion in Multiple Myeloma Results in Stimulation of Osteoclastogenesis and Inhibition of Osteoblastogenesis

Homare Eda, MD, PhD, Loredana Santo, MD, Diana D. Cirstea, MD, Samantha Pozzi, MD, Miriam Canavese, PhD, Tyler A. Scullen, BA, Sonia Vallet, MD, Noopur S. Raje, MD

Blood (2011) 118 (21): 1819.

https://doi.org/10.1182/blood.V118.21.1819.1819

Published: 2011

Journal Articles

Targeting Bruton's Tyrosine Kinase As a Novel Approach to Inhibit Osteoclast Function in Multiple Myeloma

Homare Eda, MD, PhD, Loredana Santo, MD, Diana D. Cirstea, MD, Samantha Pozzi, MD, Miriam Canavese, PhD, Tyler A. Scullen, BA, Sonia Vallet, MD, Erica Evans, PhD, Juswinder Singh, PhD, Noopur S. Raje, MD

Blood (2011) 118 (21): 2882.

https://doi.org/10.1182/blood.V118.21.2882.2882

Published: 2011

Journal Articles

Molecular Profiling of Extramedullary and Medullary Plasmacytomas Compared to Multiple Myeloma

Anuj Mahindra, MD, Samir B. Amin, MBBS, Aliyah R. Sohani, MD, Gabriela Motyckova, MD, PhD, Kishan Patel, Sonia Vallet, MD, Samantha Pozzi, Loredana Santo, Diana Cirstea, M.D., Christiana E. Toomey, James S. Michaelson, PhD, Ephraim P. Hochberg, MD, Paola Dal Cin, PhD, Scott J Rodig, Teru Hideshima, Kenneth C. Anderson, Nikhil C. Munshi, MD, Noopur Raje, MD

Blood (2010) 116 (21): 4042.

https://doi.org/10.1182/blood.V116.21.4042.4042

Published: 2010

Journal Articles

Lenalidomide In Combination with the Activin Receptor Type II Murine Fc Protein RAP-011: Preclinical Rationale for a Novel Anti-Myeloma Strategy

Sonia Vallet, MD, Kishan Patel, Diana Cirstea, MD, Katie Luly, Samantha Pozzi, MD, Loredana Santo, MD, Homare Eda, MD, Jasbir Seehra, Anuj Mahindra, MD, David T. Scadden, MD, Noopur Raje, MD

Blood (2010) 116 (21): 4075.

https://doi.org/10.1182/blood.V116.21.4075.4075

Published: 2010

Journal Articles

AT9283, a Small Molecule Multi-Targeted Kinase Inhibitor with Potent Activity Against Aurora Kinase and STAT3 In Combination with Lenalidomide Results In Synergistic Anti-Myeloma Activity

Loredana Santo, MD, Teru Hideshima, MD, PhD, Diana Cirstea, MD, Madhavi L Bandi, PhD, Erik A Nelson, PhD, Hiroshi Ikeda, MD, Sonia Vallet, MD, Samantha Pozzi, MD, Kishan Patel, Gullu Gorgun, PhD, Naoya Mimura, MD, Claire Fabre, MD, Yiguo Hu, PhD, Dharminder Chauhan, PhD, Matthew S Squires, PhD, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD, Noopur Raje, MD

Blood (2010) 116 (21): 2994.

https://doi.org/10.1182/blood.V116.21.2994.2994

Published: 2010

Journal Articles

CYC065, a Potent Derivative of Seliciclib Is Active In Multiple Myeloma In Preclinical Studies

Samantha Pozzi, MD, Diana Cirstea, M.D., Loredana Santo, MD, Doris M Nabikejje, Kishan Patel, Kathryn M Luly, Gaurav Gharti-Chhetry, Sonia Vallet, MD, Homare Eda, MD, PhD, Teru Hideshima, MD, Simon R Green, Kenneth C. Anderson, MD, David T. Scadden, MD, Noopur Raje, MD

Blood (2010) 116 (21): 2999.

https://doi.org/10.1182/blood.V116.21.2999.2999

Published: 2010

Journal Articles

Molecular Sequaele of Activin A-Dependent Osteoblast Inhibition in Myeloma.

Blood (2009) 114 (22): 1789.

https://doi.org/10.1182/blood.V114.22.1789.1789

Published: 2009

Journal Articles

Niche Induced Myelodysplasia and Secondary Hematopoietic Neoplasia Caused by Deletion of Dicer1 in Osteoprogenitor Cells.

Marc HGP Raaijmakers, MD, PhD, Siddhartha Mukherjee, M.D., Shangqin Guo, PhD, Tatsuya Kobayashi, PhD, Jesse Schoonmaker, Zinmar Aung, Benjamin L. Ebert, MD, DPhil, Fatima Al-Shahrour, Robert P Hasserjian, MD, Sonia Vallet, MD, Edward Scadden, Charles P Lin, David T. Scadden, MD

Blood (2009) 114 (22): 247.

https://doi.org/10.1182/blood.V114.22.247.247

Published: 2009

Journal Articles

AT9283, a Small Molecule Multi-Targeted Kinase Inhibitor Induces Antimyeloma Activity Via Potent Aurora Kinase and STAT3 Inhibition.

Loredana Santo, M.D., Teru Hideshima, MD., Ph.D., Erik A. Nelson, Ph.D, Diana Cirstea, MD, Madhavi Bandi, Ph.D, Hiroshi Ikeda, MD, PhD, Gullu Gorgun, PhD, Sonia Vallet, MD., Samantha Pozzi, MD, Giulia Perrone, MD, Kishan Patel, Yiguo Hu, Ph.D, Matthew S Squires, Murray Yule, Elisabetta Calabrese, MD., Dharminder Chauhan, Ph.D, Nikhil C. Munshi, Kenneth C. Anderson, MD, Noopur Raje, MD.

Blood (2009) 114 (22): 3833.

https://doi.org/10.1182/blood.V114.22.3833.3833

Published: 2009

Journal Articles

CCL3 Impairs Osteoblast Function Via Downregulation of Osteocalcin.

Sonia Vallet, MD., Kishan Patel, Nileshwari Vaghela, Mariateresa Fulciniti, PhD, Petter Veiby, Teru Hideshima, M.D., Ph.D., Samantha Pozzi, MD, Loredana Santo, MD, Siddhartha Mukherjee, M.D., Diana Cirstea, MD, David T Scadden, MD, Kenneth C. Anderson, MD, Noopur Raje, MD.

Blood (2009) 114 (22): 739.

https://doi.org/10.1182/blood.V114.22.739.739

Published: 2009

Journal Articles

Overcoming p53 Loss with a Multi-Targeted Small Molecule Inhibitor in Multiple Myeloma.

Diana Cirstea, MD, Teru Hideshima, MD, PhD, Loredana Santo, MD, Sonia Vallet, MD, Samantha Pozzi, MD, Kishan Patel, Hiroshi Ikeda, MD, PhD, Hannes Loferer, PhD, Giulia Perrone, MD, Gullu Gorgun, PhD, Yiguo Hu, MD, PhD, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD, Noopur Raje, MD

Blood (2009) 114 (22): 4915.

https://doi.org/10.1182/blood.V114.22.4915.4915

Published: 2009

Journal Articles

Molecular Profiling of Extramedullary and Medullary Plasmacytomas.

Anuj Mahindra, MD, Samir B Amin, MBBS, Gabriela Motyckova, MD, PhD, Aliyah R. Sohani, MD, Kishan Patel, Sonia Vallet, MD., Gaurav Chetri, Adam Ackerman, Samantha Pozzi, MD, Loredana Santo, MD, Diana Cirstea, MD, Christiana E. Toomey, Ephraim P. Hochberg, MD, Paola Dal Cin, Teru Hideshima, MD, PhD, Kenneth C. Anderson, MD, Nikhil Munshi, Noopur Raje, MD

Blood (2009) 114 (22): 1806.

https://doi.org/10.1182/blood.V114.22.1806.1806

Published: 2009

Journal Articles

Potential Therapeutic Role of the Selective Adhesion Molecule (SAM) Inhibitor Natalizumab in Multiple Myeloma.

Klaus Podar, MD, PhD, Alexander Zimmerhackl, DI, Ursula Hainz, PhD, Mariateresa Fulciniti, PhD, Sonia Vallet, MD., Dian Olsen, MSc, Yu-Tzu Tai, PhD, Teru Hideshima, MD, PhD, Dharminder Chauhan, Ph.D, Kenneth C. Anderson, MD

Blood (2009) 114 (22): 1850.

https://doi.org/10.1182/blood.V114.22.1850.1850

Published: 2009

Journal Articles

Restoration of Bone Balance Via Activin a Inhibition Results in Anti-Myeloma Activity

Blood (2008) 112 (11): 645.

https://doi.org/10.1182/blood.V112.11.645.645

Published: 2008

Journal Articles

C-Myc- Dependent Stabilization of Hif-1alpha in MM: Therapeutic Implications

Klaus Podar, MD, MSc, PhD, Jing Zhang, MS, Giovanni Tonon, MD, PHD, Clemens Grabher, MSc, PHD, Samir Lababidi, PHD, Marc S Raab, MD, Sonia Vallet, MD, Yiming Zhou, PHD, Marie-Astrid Cartron, MS, Martin Sattler, PhD, Dharminder Chauhan, JD, PHD, Kenneth C Anderson, MD

Blood (2008) 112 (11): 2750.

https://doi.org/10.1182/blood.V112.11.2750.2750

Published: 2008

NARROW

Multiple Myeloma Pathogenesis: The Role of Junb in Bone Marrow Angiogenesis

Expanding on Current Definitions of Hematologic Improvement in MDS, CMML and AML: Landmark Analyses of 1301 Patients Treated with Azacitidine in the Austrian Registry of Hypomethylating Agents By the AGMT-Study Group

Combined Targeting of Distinct c-Myc and JunB Transcriptional Programs for Multiple Myelioma Therapy

The Pathophysiologic Role of JunB in Multiple Myeloma Pathogenesis: Focus on Bone Marrow Angiogenesis

The AP-1 Transcription Factor JunB Promotes Multiple Myeloma (MM) Cell Proliferation, Survival and Drug Resistance in the Bone Marrow Microenvironment

Increased Sclerostin Secretion in Multiple Myeloma Results in Stimulation of Osteoclastogenesis and Inhibition of Osteoblastogenesis

Targeting Bruton's Tyrosine Kinase As a Novel Approach to Inhibit Osteoclast Function in Multiple Myeloma

Molecular Profiling of Extramedullary and Medullary Plasmacytomas Compared to Multiple Myeloma

Lenalidomide In Combination with the Activin Receptor Type II Murine Fc Protein RAP-011: Preclinical Rationale for a Novel Anti-Myeloma Strategy

AT9283, a Small Molecule Multi-Targeted Kinase Inhibitor with Potent Activity Against Aurora Kinase and STAT3 In Combination with Lenalidomide Results In Synergistic Anti-Myeloma Activity

CYC065, a Potent Derivative of Seliciclib Is Active In Multiple Myeloma In Preclinical Studies

Molecular Sequaele of Activin A-Dependent Osteoblast Inhibition in Myeloma.

Niche Induced Myelodysplasia and Secondary Hematopoietic Neoplasia Caused by Deletion of Dicer1 in Osteoprogenitor Cells.

AT9283, a Small Molecule Multi-Targeted Kinase Inhibitor Induces Antimyeloma Activity Via Potent Aurora Kinase and STAT3 Inhibition.

CCL3 Impairs Osteoblast Function Via Downregulation of Osteocalcin.

Overcoming p53 Loss with a Multi-Targeted Small Molecule Inhibitor in Multiple Myeloma.

Molecular Profiling of Extramedullary and Medullary Plasmacytomas.

Potential Therapeutic Role of the Selective Adhesion Molecule (SAM) Inhibitor Natalizumab in Multiple Myeloma.

Restoration of Bone Balance Via Activin a Inhibition Results in Anti-Myeloma Activity

C-Myc- Dependent Stabilization of Hif-1alpha in MM: Therapeutic Implications

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American Society of Hematology

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